Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle

Circulation: Arrhythmia and Electrophysiology

Volumn 7, Issue 6, 2014, Pages 1205-1213

  Edwards, Andrew G ^a   Grandi, Eleonora ^c   Hake, Johan E ^d   Patel, Sonia ^a   Li, Pan ^d   Miyamoto, Shigeki ^b   Omens, Jeffrey H ^a   Brown, Joan Heller ^b   Bers, Donald M ^c   McCulloch, Andrew D ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b San Diego   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SIMULA RESEARCH LABORATORY   (Norway)

Author keywords

Arrhythmias, cardiac; Calcium calmodulin dependent protein kinase type 2; Electrophysiology; Sodium calcium exchanger 1

Indexed keywords

CAFFEINE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II DELTA C; LIDOCAINE; SODIUM CHANNEL; TETRODOTOXIN; UNCLASSIFIED DRUG; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM; CAMK2D PROTEIN, MOUSE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CHANNEL BLOCKING AGENT;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARRHYTHMOGENESIS; ARTICLE; CELL POPULATION; CONTROLLED STUDY; EARLY AFTERDEPOLARIZATION; FEMALE; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART FAILURE; HEART REPOLARIZATION; HEART VENTRICLE; MALE; MOUSE; MUSCLE CELL; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; SODIUM CALCIUM EXCHANGE; SODIUM CURRENT; ANIMAL; BIOLOGICAL MODEL; CARDIAC MUSCLE CELL; COMPUTER SIMULATION; DRUG EFFECTS; GENETICS; HEART VENTRICLE FUNCTION; METABOLISM; TIME FACTOR; TRANSGENIC MOUSE;

ACTION POTENTIALS; ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; COMPUTER SIMULATION; FEMALE; HEART VENTRICLES; MALE; MICE, TRANSGENIC; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC; SARCOPLASMIC RETICULUM; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM-CALCIUM EXCHANGER; TIME FACTORS; VENTRICULAR FUNCTION;

EID: 84924612571     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.113.001666     Document Type: Article

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