Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization

Circulation

Volumn 123, Issue 16, 2011, Pages 1713-1720

  Wu, Lin ^a,d   Ma, Jihua ^b   Li, Hong ^a   Wang, Chao ^b   Grandi, Eleonora ^c   Zhang, Peihua ^b   Luo, Antao ^b   Bers, Donald M ^c   Shryock, John C ^a   Belardinelli, Luiz ^a  

^a Cardiovascular Therapeutics   (United States)

^b WUHAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NONE   (United States)

Author keywords

action potentials; arrhythmias; cardiac; electrophysiology; ion channels; long QT syndrome; torsades de pointes

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; RANOLAZINE; SOTALOL; TETRODOTOXIN;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CONTROLLED STUDY; FEMALE; HEART ARRHYTHMIA; HEART CYCLE; HEART MUSCLE CELL; HEART REPOLARIZATION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; SODIUM CURRENT; TORSADE DES POINTES;

ACETANILIDES; ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BRADYCARDIA; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEMALE; HEART RATE; LONG QT SYNDROME; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PIPERAZINES; PIPERIDINES; PYRIDINES; RABBITS; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TETRODOTOXIN; TORSADES DE POINTES;

EID: 79955559140     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.000661     Document Type: Article

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