Transient blockade of delta-like notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation

Journal of Immunology

Volumn 194, Issue 6, 2015, Pages 2899-2908

  Wood, Sherri ^a   Feng, Jiane ^a   Chung, Jooho ^b   Radojcic, Vedran ^a,b   Sandy Sloat, Ashley R ^b   Friedman, Ann ^b   Shelton, Amy ^c   Yan, Minhong ^c   Siebel, Christian W ^b   Bishop, D Keith ^a   Maillard, Ivan ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIBODY; DELTA LIKE NOTCH LIGAND; DELTA LIKE NOTCH LIGAND 1 ANTIBODY; DELTA LIKE NOTCH LIGAND 4 ANTIBODY; GAMMA INTERFERON; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 4; NOTCH RECEPTOR; UNCLASSIFIED DRUG; DLK1 PROTEIN, MOUSE; DLL4 PROTEIN, MOUSE; MEMBRANE PROTEIN; NEUTRALIZING ANTIBODY; SIGNAL PEPTIDE;

ALLOGRAFT; ALLOIMMUNITY; ANIMAL CELL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; B LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; CELL PROTECTION; CELL SPECIFICITY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HUMORAL IMMUNITY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE DEPLETION; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PLASMABLAST; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; ALLOTRANSPLANTATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; C57BL MOUSE; DRUG EFFECTS; FLOW CYTOMETRY; IMMUNITY; IMMUNOLOGY; METABOLISM; PROCEDURES; SIGNAL TRANSDUCTION; TIME; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, NEUTRALIZING; CD8-POSITIVE T-LYMPHOCYTES; FLOW CYTOMETRY; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNITY; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERFERON-GAMMA; INTERLEUKIN-4; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 84924599216     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1402034     Document Type: Article

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