A novel ent-kaurane diterpenoid executes antitumor function in colorectal cancer cells by inhibiting Wnt/β-catenin signaling

Carcinogenesis

Volumn 36, Issue 3, 2014, Pages 318-326

  Ye, Qi ^a   Yao, Guangmin ^a   Zhang, Mengke ^a   Guo, Guoli ^a   Hu, Yufeng ^a   Jiang, Jue ^a   Cheng, Ling ^a   Shi, Jianguo ^b   Li, Hua ^a   Zhang, Yonghui ^a   Liu, Hudan ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

11ALPHA, 12ALPHA EPOXYLEUKAMENIN E; ANTINEOPLASTIC AGENT; BETA CATENIN; CASPASE 3; CYCLINE; FLUOROURACIL; HERBACEOUS AGENT; KAURANE DERIVATIVE; MYC PROTEIN; SURVIVIN; UNCLASSIFIED DRUG; WNT PROTEIN; 11ALPHA,12ALPHA-EPOXYLEUKAMENIN E; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; TCF4 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; COLON MUCOSA; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DRUG POTENTIATION; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; TUMOR VOLUME; TUMOR XENOGRAFT; WNT SIGNALING PATHWAY; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BAGG ALBINO MOUSE; CHEMISTRY; COLORECTAL NEOPLASMS; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; HCT116 CELL LINE; METABOLISM; MOLECULAR DOCKING; MOLECULARLY TARGETED THERAPY; PATHOLOGY; TUMOR CELL CULTURE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BETA CATENIN; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DITERPENES, KAURANE; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; MICE, INBRED BALB C; MOLECULAR DOCKING SIMULATION; MOLECULAR TARGETED THERAPY; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; WNT SIGNALING PATHWAY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84924485514     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgv003     Document Type: Article

References (34)

1. Jemal, A. et al. (2011) Global cancer statistics. CA. Cancer J. Clin., 61, 69-90.
2. Cunningham, D. et al. (2010) Colorectal cancer. Lancet, 375, 1030-1047.
3. Clevers, H. et al. (2012) Wnt/β-catenin signaling and disease. Cell, 149, 1192-1205.
4. Schuijers, J. et al. (2014) Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF. EMBO J., 33, 146-156.
5. Reya, T. et al. (2005) Wnt signalling in stem cells and cancer. Nature, 434, 843-850.
6. Green, D.W. et al. (2001) Beta-catenin antisense treatment decreases beta-catenin expression and tumor growth rate in colon carcinoma xenografts. J. Surg. Res., 101, 16-20.
7. Kwong, K.Y. et al. (2002) The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway. Oncogene, 21, 8340-8346.
8. Barker, N. et al. (2006) Mining the Wnt pathway for cancer therapeutics. Nat. Rev. Drug Discov., 5, 997-1014.
9. Lepourcelet, M. et al. (2004) Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell, 5, 91-102.
10. Zheng, H. et al. (2013) Cytotoxic ent-kaurane diterpenoids from Salvia cavaleriei. J. Nat. Prod., 76, 2253-2262.
11. Oztekin, N. et al. (2010) Isolation and analysis of bioactive diterpenoids in Salvia species (Salvia chionantha and Salvia kronenburgiii) by micellar electrokinetic capillary chromatography. J. Pharm. Biomed. Anal., 51, 439-442.
12. Wang, S. et al. (2013) Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat. Chem. Biol., 9, 579-585.
13. Ren, P. et al. (2014) ATF4 and N-Myc coordinate glutamine metabolism in MYCN-amplified neuroblastoma cells through ASCT2 activation. J Pathol., 235, 90-100.
14. Liu, H. et al. (2010) Notch dimerization is required for leukemogenesis and T-cell development. Genes Dev., 24, 2395-2407.
15. Qing, G. et al. (2010) Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha. Cancer Res., 70, 10351-10361.
16. Eweas, A.F. et al. (2013) Design, synthesis, anti-schistosomal activity and molecular docking of novel 8-hydroxyquinoline-5-sufonyl 1,4-diazepine derivatives. Bioorg. Chem., 46, 17-25.
17. Chou, T.C. (2010) Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res., 70, 440-446.
18. Guo, G. et al. (2014) N-methylhemeanthidine chloride, a novel Amaryllidaceae alkaloid, inhibits pancreatic cancer cell proliferation via down-regulating AKT activation. Toxicol. Appl. Pharmacol., 280, 475-483.
19. Tian, F. et al. (2012) Curcumin potentiates the antitumor effects of 5-FU in treatment of esophageal squamous carcinoma cells through downregulating the activation of NF-κB signaling pathway in vitro and in vivo. Acta Biochim. Biophys. Sin. (Shanghai), 44, 847-855.
20. Qing, G. et al. (2012) ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. Cancer Cell, 22, 631-644.
21. Sahi, J. et al. (1998) Cl- transport in an immortalized human epithelial cell line (NCM460) derived from the normal transverse colon. Am. J. Physiol., 275(4 Pt 1), C1048-C1057.
22. Pan, Y. et al. (2013) Curcumin analogue T83 exhibits potent antitumor activity and induces radiosensitivity through inactivation of Jab1 in nasopharyngeal carcinoma. BMC Cancer, 13, 323-331.
23. Wang, Q. et al. (2013) The association of TP53 mutations with the resistance of colorectal carcinoma to the insulin-like growth factor-1 receptor inhibitor picropodophyllin. BMC Cancer, 13, 521-530.
24. Korinek, V. et al. (1997) Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science, 275, 1784-1787.
25. Morin, P.J. et al. (1997) Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science, 275, 1787-1790.
26. He, T.C. et al. (1998) Identification of c-MYC as a target of the APC pathway. Science, 281, 1509-1512.
27. Zhang, T. et al. (2001) Evidence that APC regulates survivin expression:a possible mechanism contributing to the stem cell origin of colon cancer. Cancer Res., 61, 8664-8667.
28. Huang, S.M. et al. (2009) Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature, 461, 614-620.
29. Graham, T.A. et al. (2000) Crystal structure of a beta-catenin/Tcf complex. Cell, 103, 885-896.
30. Polakis, P. (2012) Drugging Wnt signalling in cancer. EMBO J., 31, 2737-2746.
31. van de Wetering, M. et al. (2002) The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell, 111, 241-250.
32. Xu, W. et al. (2007) Mechanistic insights from structural studies of betacatenin and its binding partners. J. Cell Sci., 120(Pt 19), 3337-3344.
33. Tarapore, R.S. et al. (2012) Modulation of Wnt/β-catenin signaling pathway by bioactive food components. Carcinogenesis, 33, 483-491.
34. Li, X.Y. et al. (2013) Henryin, an ent-kaurane diterpenoid, inhibits wnt signaling through interference with beta-catenin/TCF4 interaction in colorectal cancer cells. Plos One, 8, e62603.