The association of TP53 mutations with the resistance of colorectal carcinoma to the insulin-like growth factor-1 receptor inhibitor picropodophyllin

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Wang, Quan ^a   Wei, Feng ^a   Lv, Guoyue ^a   Li, Chunsheng ^b   Liu, Tongjun ^b   Hadjipanayis, Costas G ^c   Zhang, Guikai ^c   Hao, Chunhai ^c   Bellail, Anita C ^c  

^a THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^b CHINA JAPAN UNION HOSPITAL OF JILIN UNIVERSITY   (China)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Colorectal carcinoma; ERK; IGF 1R; IGF 1R inhibitor; TP53

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; CASPASE 3; CASPASE 9; DNA FRAGMENT; DNA FRAGMENTATION FACTOR 45; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PICROPODOPHYLLIN; PROTEIN BAD; PROTEIN KINASE B; PROTEIN P53; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL VIABILITY; COLORECTAL CANCER; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; FEMALE; FLOW CYTOMETRY; GENE MUTATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; TP53 GENE; TUMOR XENOGRAFT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; DRUG RESISTANCE, NEOPLASM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MICE; MUTATION; PHOSPHORYLATION; PODOPHYLLOTOXIN; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, IGF TYPE 1; TUMOR BURDEN; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84886732562     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-521     Document Type: Article

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