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Volumn 318, Issue 9, 2012, Pages 1057-1067

Renal cancer: Oxygen meets metabolism

Author keywords

Glucose metabolism; Hypoxia inducible factor; Mitochondria; Oxygen; Renal cell cancer; VHL tumor suppressor

Indexed keywords

ACETYL COENZYME A; BEVACIZUMAB; CYCLIN D1; EVEROLIMUS; FLUORODEOXYGLUCOSE F 18; FUMARATE HYDRATASE; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 2ALPHA; I KAPPA B; LACTATE DEHYDROGENASE; MAMMALIAN TARGET OF RAPAMYCIN; MYC PROTEIN; OXYGEN; PAZOPANIB; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN P53; PYRUVATE DEHYDROGENASE KINASE; SORAFENIB; SUCCINATE DEHYDROGENASE; SUNITINIB; TEMSIROLIMUS; TIRAPAZAMINE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VON HIPPEL LINDAU PROTEIN;

EID: 84859869957     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2012.02.026     Document Type: Review
Times cited : (25)

References (112)
  • 1
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel R., Ward E., Brawley O., Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J. Clin. 2011, 61:212-236.
    • (2011) CA Cancer J. Clin. , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 2
    • 0033456260 scopus 로고    scopus 로고
    • The Mainz classification of renal cell tumors
    • Diaz J.I., Mora L.B., Hakam A. The Mainz classification of renal cell tumors. Cancer Control 1999, 6:571-579.
    • (1999) Cancer Control , vol.6 , pp. 571-579
    • Diaz, J.I.1    Mora, L.B.2    Hakam, A.3
  • 4
    • 2342583527 scopus 로고    scopus 로고
    • Searching for the hereditary causes of renal-cell carcinoma
    • Pavlovich C.P., Schmidt L.S. Searching for the hereditary causes of renal-cell carcinoma. Nat. Rev. Cancer 2004, 4:381-393.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 381-393
    • Pavlovich, C.P.1    Schmidt, L.S.2
  • 12
    • 0344010917 scopus 로고    scopus 로고
    • Analysis of the Birt-Hogg-Dube (BHD) tumour suppressor gene in sporadic renal cell carcinoma and colorectal cancer
    • da Silva N.F., Gentle D., Hesson L.B., Morton D.G., Latif F., Maher E.R. Analysis of the Birt-Hogg-Dube (BHD) tumour suppressor gene in sporadic renal cell carcinoma and colorectal cancer. J. Med. Genet. 2003, 40:820-824.
    • (2003) J. Med. Genet. , vol.40 , pp. 820-824
    • da Silva, N.F.1    Gentle, D.2    Hesson, L.B.3    Morton, D.G.4    Latif, F.5    Maher, E.R.6
  • 13
    • 1342267014 scopus 로고    scopus 로고
    • Lack of mutation of the folliculin gene in sporadic chromophobe renal cell carcinoma and renal oncocytoma
    • Nagy A., Zoubakov D., Stupar Z., Kovacs G. Lack of mutation of the folliculin gene in sporadic chromophobe renal cell carcinoma and renal oncocytoma. Int. J. Cancer 2004, 109:472-475.
    • (2004) Int. J. Cancer , vol.109 , pp. 472-475
    • Nagy, A.1    Zoubakov, D.2    Stupar, Z.3    Kovacs, G.4
  • 14
    • 16644373473 scopus 로고    scopus 로고
    • Role of VHL gene mutation in human cancer
    • Kim W.Y., Kaelin W.G. Role of VHL gene mutation in human cancer. J. Clin. Oncol. 2004, 22:4991-5004.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 4991-5004
    • Kim, W.Y.1    Kaelin, W.G.2
  • 15
    • 0033233243 scopus 로고    scopus 로고
    • 2 homeostasis by hypoxia-inducible factor 1
    • 2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol. 1999, 15:551-578.
    • (1999) Annu. Rev. Cell Dev. Biol. , vol.15 , pp. 551-578
    • Semenza, G.L.1
  • 16
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
    • Kaelin W.G., Ratcliffe P.J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 2008, 30:393-402.
    • (2008) Mol. Cell , vol.30 , pp. 393-402
    • Kaelin, W.G.1    Ratcliffe, P.J.2
  • 22
    • 0031834186 scopus 로고    scopus 로고
    • Genotype-phenotype correlations in von Hippel-Lindau disease
    • Neumann H.P., Bender B.U. Genotype-phenotype correlations in von Hippel-Lindau disease. J. Intern. Med. 1998, 243:541-545.
    • (1998) J. Intern. Med. , vol.243 , pp. 541-545
    • Neumann, H.P.1    Bender, B.U.2
  • 23
    • 0035339044 scopus 로고    scopus 로고
    • Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease
    • Clifford S.C., Cockman M.E., Smallwood A.C., Mole D.R., Woodward E.R., Maxwell P.H., Ratcliffe P.J., Maher E.R. Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease. Hum. Mol. Genet. 2001, 10:1029-1038.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1029-1038
    • Clifford, S.C.1    Cockman, M.E.2    Smallwood, A.C.3    Mole, D.R.4    Woodward, E.R.5    Maxwell, P.H.6    Ratcliffe, P.J.7    Maher, E.R.8
  • 24
    • 0035336706 scopus 로고    scopus 로고
    • Von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF
    • Hoffman M.A., Ohh M., Yang H., Klco J.M., Ivan M., Kaelin W.G. von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF. Hum. Mol. Genet. 2001, 10:1019-1027.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1019-1027
    • Hoffman, M.A.1    Ohh, M.2    Yang, H.3    Klco, J.M.4    Ivan, M.5    Kaelin, W.G.6
  • 25
    • 40949136438 scopus 로고    scopus 로고
    • The VHL tumor suppressor and HIF: insights from genetic studies in mice
    • Kapitsinou P.P., Haase V.H. The VHL tumor suppressor and HIF: insights from genetic studies in mice. Cell Death Differ. 2008, 15:650-659.
    • (2008) Cell Death Differ. , vol.15 , pp. 650-659
    • Kapitsinou, P.P.1    Haase, V.H.2
  • 26
    • 31444444162 scopus 로고    scopus 로고
    • Integration of oxygen signaling at the consensus HRE
    • Wenger R.H., Stiehl D.P., Camenisch G. Integration of oxygen signaling at the consensus HRE. Sci. STKE 2005, re12.
    • (2005) Sci. STKE
    • Wenger, R.H.1    Stiehl, D.P.2    Camenisch, G.3
  • 28
    • 37249001223 scopus 로고    scopus 로고
    • Dominant-negative HIF-3 alpha 4 suppresses VHL-null renal cell carcinoma progression
    • Maynard M.A., Evans A.J., Shi W., Kim W.Y., Liu F.F., Ohh M. Dominant-negative HIF-3 alpha 4 suppresses VHL-null renal cell carcinoma progression. Cell Cycle 2007, 6:2810-2816.
    • (2007) Cell Cycle , vol.6 , pp. 2810-2816
    • Maynard, M.A.1    Evans, A.J.2    Shi, W.3    Kim, W.Y.4    Liu, F.F.5    Ohh, M.6
  • 29
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    • Hu C.J., Wang L.Y., Chodosh L.A., Keith B., Simon M.C. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol. Cell. Biol. 2003, 23:9361-9374.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 9361-9374
    • Hu, C.J.1    Wang, L.Y.2    Chodosh, L.A.3    Keith, B.4    Simon, M.C.5
  • 31
    • 77953854244 scopus 로고    scopus 로고
    • Hypoxic regulation of erythropoiesis and iron metabolism
    • Haase V.H. Hypoxic regulation of erythropoiesis and iron metabolism. Am. J. Physiol. Renal Physiol. 2010, 299:F1-F13.
    • (2010) Am. J. Physiol. Renal Physiol. , vol.299
    • Haase, V.H.1
  • 33
    • 33746655373 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in the kidney
    • Haase V.H. Hypoxia-inducible factors in the kidney. Am. J. Physiol. Renal Physiol. 2006, 291:F271-F281.
    • (2006) Am. J. Physiol. Renal Physiol. , vol.291
    • Haase, V.H.1
  • 34
    • 5644240828 scopus 로고    scopus 로고
    • Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (HIF) in regulating HIF transcriptional target genes
    • Stolze I.P., Tian Y.M., Appelhoff R.J., Turley H., Wykoff C.C., Gleadle J.M., Ratcliffe P.J. Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (HIF) in regulating HIF transcriptional target genes. J. Biol. Chem. 2004, 279:42719-42725.
    • (2004) J. Biol. Chem. , vol.279 , pp. 42719-42725
    • Stolze, I.P.1    Tian, Y.M.2    Appelhoff, R.J.3    Turley, H.4    Wykoff, C.C.5    Gleadle, J.M.6    Ratcliffe, P.J.7
  • 35
    • 13244281831 scopus 로고    scopus 로고
    • Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene and VHL-haplotype analysis in patients with presumable congenital erythrocytosis
    • Cario H., Schwarz K., Jorch N., Kyank U., Petrides P.E., Schneider D.T., Uhle R., Debatin K.M., Kohne E. Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene and VHL-haplotype analysis in patients with presumable congenital erythrocytosis. Haematologica 2005, 90:19-24.
    • (2005) Haematologica , vol.90 , pp. 19-24
    • Cario, H.1    Schwarz, K.2    Jorch, N.3    Kyank, U.4    Petrides, P.E.5    Schneider, D.T.6    Uhle, R.7    Debatin, K.M.8    Kohne, E.9
  • 37
    • 36849013228 scopus 로고    scopus 로고
    • Von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis
    • Hickey M.M., Lam J.C., Bezman N.A., Rathmell W.K., Simon M.C. von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis. J. Clin. Invest. 2007, 117:3879-3889.
    • (2007) J. Clin. Invest. , vol.117 , pp. 3879-3889
    • Hickey, M.M.1    Lam, J.C.2    Bezman, N.A.3    Rathmell, W.K.4    Simon, M.C.5
  • 40
    • 0031042949 scopus 로고    scopus 로고
    • Renal cysts, renal cancer and von Hippel-Lindau disease [editorial]
    • Neumann H.P., Zbar B. Renal cysts, renal cancer and von Hippel-Lindau disease [editorial]. Kidney Int. 1997, 51:16-26.
    • (1997) Kidney Int. , vol.51 , pp. 16-26
    • Neumann, H.P.1    Zbar, B.2
  • 41
    • 33745819269 scopus 로고    scopus 로고
    • Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein
    • Esteban M.A., Harten S.K., Tran M.G., Maxwell P.H. Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein. J. Am. Soc. Nephrol. 2006, 17:1801-1806.
    • (2006) J. Am. Soc. Nephrol. , vol.17 , pp. 1801-1806
    • Esteban, M.A.1    Harten, S.K.2    Tran, M.G.3    Maxwell, P.H.4
  • 42
    • 34248151938 scopus 로고    scopus 로고
    • Role of primary cilia in the pathogenesis of polycystic kidney disease
    • Yoder B.K. Role of primary cilia in the pathogenesis of polycystic kidney disease. J. Am. Soc. Nephrol. 2007, 18:1381-1388.
    • (2007) J. Am. Soc. Nephrol. , vol.18 , pp. 1381-1388
    • Yoder, B.K.1
  • 45
    • 34247863920 scopus 로고    scopus 로고
    • PVHL and GSK3beta are components of a primary cilium-maintenance signalling network
    • Thoma C.R., Frew I.J., Hoerner C.R., Montani M., Moch H., Krek W. pVHL and GSK3beta are components of a primary cilium-maintenance signalling network. Nat. Cell Biol. 2007, 9:588-595.
    • (2007) Nat. Cell Biol. , vol.9 , pp. 588-595
    • Thoma, C.R.1    Frew, I.J.2    Hoerner, C.R.3    Montani, M.4    Moch, H.5    Krek, W.6
  • 47
    • 33746886185 scopus 로고    scopus 로고
    • Primary cilium formation requires von Hippel-Lindau gene function in renal-derived cells
    • Lutz M.S., Burk R.D. Primary cilium formation requires von Hippel-Lindau gene function in renal-derived cells. Cancer Res. 2006, 66:6903-6907.
    • (2006) Cancer Res. , vol.66 , pp. 6903-6907
    • Lutz, M.S.1    Burk, R.D.2
  • 49
    • 33645090169 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B
    • Krishnamachary B., Zagzag D., Nagasawa H., Rainey K., Okuyama H., Baek J.H., Semenza G.L. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res. 2006, 66:2725-2731.
    • (2006) Cancer Res. , vol.66 , pp. 2725-2731
    • Krishnamachary, B.1    Zagzag, D.2    Nagasawa, H.3    Rainey, K.4    Okuyama, H.5    Baek, J.H.6    Semenza, G.L.7
  • 54
    • 77956690871 scopus 로고    scopus 로고
    • Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress
    • Welford S.M., Dorie M.J., Li X., Haase V.H., Giaccia A.J. Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress. Mol. Cell. Biol. 2010, 30:4595-4603.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 4595-4603
    • Welford, S.M.1    Dorie, M.J.2    Li, X.3    Haase, V.H.4    Giaccia, A.J.5
  • 56
    • 33646140913 scopus 로고    scopus 로고
    • P53 stabilization and transactivation by a von Hippel-Lindau protein
    • Roe J.S., Kim H., Lee S.M., Kim S.T., Cho E.J., Youn H.D. p53 stabilization and transactivation by a von Hippel-Lindau protein. Mol. Cell 2006, 22:395-405.
    • (2006) Mol. Cell , vol.22 , pp. 395-405
    • Roe, J.S.1    Kim, H.2    Lee, S.M.3    Kim, S.T.4    Cho, E.J.5    Youn, H.D.6
  • 59
    • 34047156190 scopus 로고    scopus 로고
    • HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
    • Gordan J.D., Bertout J.A., Hu C.J., Diehl J.A., Simon M.C. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 2007, 11:335-347.
    • (2007) Cancer Cell , vol.11 , pp. 335-347
    • Gordan, J.D.1    Bertout, J.A.2    Hu, C.J.3    Diehl, J.A.4    Simon, M.C.5
  • 61
    • 33749238874 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells
    • Peruzzi B., Athauda G., Bottaro D.P. The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:14531-14536.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 14531-14536
    • Peruzzi, B.1    Athauda, G.2    Bottaro, D.P.3
  • 64
    • 20444485232 scopus 로고    scopus 로고
    • Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer
    • Smith K., Gunaratnam L., Morley M., Franovic A., Mekhail K., Lee S. Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer. Cancer Res. 2005, 65:5221-5230.
    • (2005) Cancer Res. , vol.65 , pp. 5221-5230
    • Smith, K.1    Gunaratnam, L.2    Morley, M.3    Franovic, A.4    Mekhail, K.5    Lee, S.6
  • 67
    • 0036645091 scopus 로고    scopus 로고
    • Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease
    • Zatyka M., da Silva N.F., Clifford S.C., Morris M.R., Wiesener M.S., Eckardt K.U., Houlston R.S., Richards F.M., Latif F., Maher E.R. Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease. Cancer Res. 2002, 62:3803-3811.
    • (2002) Cancer Res. , vol.62 , pp. 3803-3811
    • Zatyka, M.1    da Silva, N.F.2    Clifford, S.C.3    Morris, M.R.4    Wiesener, M.S.5    Eckardt, K.U.6    Houlston, R.S.7    Richards, F.M.8    Latif, F.9    Maher, E.R.10
  • 68
    • 1942533531 scopus 로고    scopus 로고
    • Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene
    • Wykoff C.C., Sotiriou C., Cockman M.E., Ratcliffe P.J., Maxwell P., Liu E., Harris A.L. Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene. Br. J. Cancer 2004, 90:1235-1243.
    • (2004) Br. J. Cancer , vol.90 , pp. 1235-1243
    • Wykoff, C.C.1    Sotiriou, C.2    Cockman, M.E.3    Ratcliffe, P.J.4    Maxwell, P.5    Liu, E.6    Harris, A.L.7
  • 69
    • 38949161122 scopus 로고    scopus 로고
    • Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2
    • Kurban G., Duplan E., Ramlal N., Hudon V., Sado Y., Ninomiya Y., Pause A. Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2. Oncogene 2008, 27:1004-1012.
    • (2008) Oncogene , vol.27 , pp. 1004-1012
    • Kurban, G.1    Duplan, E.2    Ramlal, N.3    Hudon, V.4    Sado, Y.5    Ninomiya, Y.6    Pause, A.7
  • 70
    • 32944464205 scopus 로고    scopus 로고
    • Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis
    • Kurban G., Hudon V., Duplan E., Ohh M., Pause A. Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis. Cancer Res. 2006, 66:1313-1319.
    • (2006) Cancer Res. , vol.66 , pp. 1313-1319
    • Kurban, G.1    Hudon, V.2    Duplan, E.3    Ohh, M.4    Pause, A.5
  • 72
    • 0035136533 scopus 로고    scopus 로고
    • VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling
    • Davidowitz E.J., Schoenfeld A.R., Burk R.D. VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling. Mol. Cell. Biol. 2001, 21:865-874.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 865-874
    • Davidowitz, E.J.1    Schoenfeld, A.R.2    Burk, R.D.3
  • 75
    • 0141828145 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    • Staller P., Sulitkova J., Lisztwan J., Moch H., Oakeley E.J., Krek W. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003, 425:307-311.
    • (2003) Nature , vol.425 , pp. 307-311
    • Staller, P.1    Sulitkova, J.2    Lisztwan, J.3    Moch, H.4    Oakeley, E.J.5    Krek, W.6
  • 78
    • 0036528246 scopus 로고    scopus 로고
    • Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
    • Kondo K., Klco J.M., Nakamura E., Lechpammer M., Kaelin W.G. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002, 1:237-246.
    • (2002) Cancer Cell , vol.1 , pp. 237-246
    • Kondo, K.1    Klco, J.M.2    Nakamura, E.3    Lechpammer, M.4    Kaelin, W.G.5
  • 79
    • 0036527785 scopus 로고    scopus 로고
    • The contribution of VHL substrate binding and HIF-1α to the phenotype of vhl loss in renal cell carcinoma
    • Maranchi J.K., Vasselli J.R., Riss J., Bonifacio J.S., Linehan W.M., Klausner R.D. The contribution of VHL substrate binding and HIF-1α to the phenotype of vhl loss in renal cell carcinoma. Cancer Cell 2002, 1:247-253.
    • (2002) Cancer Cell , vol.1 , pp. 247-253
    • Maranchi, J.K.1    Vasselli, J.R.2    Riss, J.3    Bonifacio, J.S.4    Linehan, W.M.5    Klausner, R.D.6
  • 80
    • 1342280515 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors
    • Zimmer M., Doucette D., Siddiqui N., Iliopoulos O. Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. Mol. Cancer Res. 2004, 2:89-95.
    • (2004) Mol. Cancer Res. , vol.2 , pp. 89-95
    • Zimmer, M.1    Doucette, D.2    Siddiqui, N.3    Iliopoulos, O.4
  • 81
    • 2342597973 scopus 로고    scopus 로고
    • Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth
    • Kondo K., Kim W.Y., Lechpammer M., Kaelin W.G. Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth. PLoS Biol. 2003, 1:E83.
    • (2003) PLoS Biol. , vol.1
    • Kondo, K.1    Kim, W.Y.2    Lechpammer, M.3    Kaelin, W.G.4
  • 82
    • 84655161946 scopus 로고    scopus 로고
    • HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression
    • Keith B., Johnson R.S., Simon M.C. HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression. Nat. Rev. Cancer 2011, 12:9-22.
    • (2011) Nat. Rev. Cancer , vol.12 , pp. 9-22
    • Keith, B.1    Johnson, R.S.2    Simon, M.C.3
  • 84
    • 0037223823 scopus 로고    scopus 로고
    • Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL
    • Hergovich A., Lisztwan J., Barry R., Ballschmieter P., Krek W. Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. Nat. Cell Biol. 2003, 5:64-70.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 64-70
    • Hergovich, A.1    Lisztwan, J.2    Barry, R.3    Ballschmieter, P.4    Krek, W.5
  • 86
  • 89
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 91
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis R.J., Lum J.J., Hatzivassiliou G., Thompson C.B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 2008, 7:11-20.
    • (2008) Cell Metab. , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 94
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou I., Cairns R.A., Fontana L., Lim A.L., Denko N.C. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 2006, 3:187-197.
    • (2006) Cell Metab. , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 95
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
    • Kim J.W., Tchernyshyov I., Semenza G.L., Dang C.V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006, 3:177-185.
    • (2006) Cell Metab. , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 99
    • 78649659788 scopus 로고    scopus 로고
    • PH control mechanisms of tumor survival and growth
    • Parks S.K., Chiche J., Pouyssegur J. pH control mechanisms of tumor survival and growth. J. Cell. Physiol. 2011, 226:299-308.
    • (2011) J. Cell. Physiol. , vol.226 , pp. 299-308
    • Parks, S.K.1    Chiche, J.2    Pouyssegur, J.3
  • 100
    • 34247614521 scopus 로고    scopus 로고
    • HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
    • Zhang H., Gao P., Fukuda R., Kumar G., Krishnamachary B., Zeller K.I., Dang C.V., Semenza G.L. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 2007, 11:407-420.
    • (2007) Cancer Cell , vol.11 , pp. 407-420
    • Zhang, H.1    Gao, P.2    Fukuda, R.3    Kumar, G.4    Krishnamachary, B.5    Zeller, K.I.6    Dang, C.V.7    Semenza, G.L.8
  • 101
    • 33947724515 scopus 로고    scopus 로고
    • HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
    • Fukuda R., Zhang H., Kim J.W., Shimoda L., Dang C.V., Semenza G.L. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 2007, 129:111-122.
    • (2007) Cell , vol.129 , pp. 111-122
    • Fukuda, R.1    Zhang, H.2    Kim, J.W.3    Shimoda, L.4    Dang, C.V.5    Semenza, G.L.6
  • 112
    • 34748896515 scopus 로고    scopus 로고
    • Screening, diagnosis, and treatment of cancer in long-term dialysis patients
    • Holley J.L. Screening, diagnosis, and treatment of cancer in long-term dialysis patients. Clin. J. Am. Soc. Nephrol. 2007, 2:604-610.
    • (2007) Clin. J. Am. Soc. Nephrol. , vol.2 , pp. 604-610
    • Holley, J.L.1


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