-
1
-
-
80051580618
-
Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths
-
Siegel R., Ward E., Brawley O., Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J. Clin. 2011, 61:212-236.
-
(2011)
CA Cancer J. Clin.
, vol.61
, pp. 212-236
-
-
Siegel, R.1
Ward, E.2
Brawley, O.3
Jemal, A.4
-
2
-
-
0033456260
-
The Mainz classification of renal cell tumors
-
Diaz J.I., Mora L.B., Hakam A. The Mainz classification of renal cell tumors. Cancer Control 1999, 6:571-579.
-
(1999)
Cancer Control
, vol.6
, pp. 571-579
-
-
Diaz, J.I.1
Mora, L.B.2
Hakam, A.3
-
3
-
-
17044452288
-
HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron
-
Mandriota S.J., Turner K.J., Davies D.R., Murray P.G., Morgan N.V., Sowter H.M., Wykoff C.C., Maher E.R., Harris A.L., Ratcliffe P.J., Maxwell P.H. HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Cancer Cell 2002, 1:459-468.
-
(2002)
Cancer Cell
, vol.1
, pp. 459-468
-
-
Mandriota, S.J.1
Turner, K.J.2
Davies, D.R.3
Murray, P.G.4
Morgan, N.V.5
Sowter, H.M.6
Wykoff, C.C.7
Maher, E.R.8
Harris, A.L.9
Ratcliffe, P.J.10
Maxwell, P.H.11
-
4
-
-
2342583527
-
Searching for the hereditary causes of renal-cell carcinoma
-
Pavlovich C.P., Schmidt L.S. Searching for the hereditary causes of renal-cell carcinoma. Nat. Rev. Cancer 2004, 4:381-393.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 381-393
-
-
Pavlovich, C.P.1
Schmidt, L.S.2
-
6
-
-
9144249602
-
Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma
-
Vanharanta S., Buchta M., McWhinney S.R., Virta S.K., Peczkowska M., Morrison C.D., Lehtonen R., Januszewicz A., Jarvinen H., Juhola M., Mecklin J.P., Pukkala E., Herva R., Kiuru M., Nupponen N.N., Aaltonen L.A., Neumann H.P., Eng C. Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma. Am. J. Hum. Genet. 2004, 74:153-159.
-
(2004)
Am. J. Hum. Genet.
, vol.74
, pp. 153-159
-
-
Vanharanta, S.1
Buchta, M.2
McWhinney, S.R.3
Virta, S.K.4
Peczkowska, M.5
Morrison, C.D.6
Lehtonen, R.7
Januszewicz, A.8
Jarvinen, H.9
Juhola, M.10
Mecklin, J.P.11
Pukkala, E.12
Herva, R.13
Kiuru, M.14
Nupponen, N.N.15
Aaltonen, L.A.16
Neumann, H.P.17
Eng, C.18
-
7
-
-
0034602950
-
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma
-
Baysal B.E., Ferrell R.E., Willett-Brozick J.E., Lawrence E.C., Myssiorek D., Bosch A., van der Mey A., Taschner P.E., Rubinstein W.S., Myers E.N., Richard C.W., Cornelisse C.J., Devilee P., Devlin B. Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science 2000, 287:848-851.
-
(2000)
Science
, vol.287
, pp. 848-851
-
-
Baysal, B.E.1
Ferrell, R.E.2
Willett-Brozick, J.E.3
Lawrence, E.C.4
Myssiorek, D.5
Bosch, A.6
van der Mey, A.7
Taschner, P.E.8
Rubinstein, W.S.9
Myers, E.N.10
Richard, C.W.11
Cornelisse, C.J.12
Devilee, P.13
Devlin, B.14
-
8
-
-
3142626559
-
Molecular genetic analysis of FIH-1, FH, and SDHB candidate tumour suppressor genes in renal cell carcinoma
-
Morris M.R., Maina E., Morgan N.V., Gentle D., Astuti D., Moch H., Kishida T., Yao M., Schraml P., Richards F.M., Latif F., Maher E.R. Molecular genetic analysis of FIH-1, FH, and SDHB candidate tumour suppressor genes in renal cell carcinoma. J. Clin. Pathol. 2004, 57:706-711.
-
(2004)
J. Clin. Pathol.
, vol.57
, pp. 706-711
-
-
Morris, M.R.1
Maina, E.2
Morgan, N.V.3
Gentle, D.4
Astuti, D.5
Moch, H.6
Kishida, T.7
Yao, M.8
Schraml, P.9
Richards, F.M.10
Latif, F.11
Maher, E.R.12
-
9
-
-
0041633905
-
Inactivation of BHD in sporadic renal tumors
-
Khoo S.K., Kahnoski K., Sugimura J., Petillo D., Chen J., Shockley K., Ludlow J., Knapp R., Giraud S., Richard S., Nordenskjold M., Teh B.T. Inactivation of BHD in sporadic renal tumors. Cancer Res. 2003, 63:4583-4587.
-
(2003)
Cancer Res.
, vol.63
, pp. 4583-4587
-
-
Khoo, S.K.1
Kahnoski, K.2
Sugimura, J.3
Petillo, D.4
Chen, J.5
Shockley, K.6
Ludlow, J.7
Knapp, R.8
Giraud, S.9
Richard, S.10
Nordenskjold, M.11
Teh, B.T.12
-
10
-
-
0032813906
-
Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype
-
Lubensky I.A., Schmidt L., Zhuang Z., Weirich G., Pack S., Zambrano N., Walther M.M., Choyke P., Linehan W.M., Zbar B. Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype. Am. J. Pathol. 1999, 155:517-526.
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 517-526
-
-
Lubensky, I.A.1
Schmidt, L.2
Zhuang, Z.3
Weirich, G.4
Pack, S.5
Zambrano, N.6
Walther, M.M.7
Choyke, P.8
Linehan, W.M.9
Zbar, B.10
-
11
-
-
0035914269
-
Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas
-
Parry L., Maynard J.H., Patel A., Clifford S.C., Morrissey C., Maher E.R., Cheadle J.P., Sampson J.R. Analysis of the TSC1 and TSC2 genes in sporadic renal cell carcinomas. Br. J. Cancer 2001, 85:1226-1230.
-
(2001)
Br. J. Cancer
, vol.85
, pp. 1226-1230
-
-
Parry, L.1
Maynard, J.H.2
Patel, A.3
Clifford, S.C.4
Morrissey, C.5
Maher, E.R.6
Cheadle, J.P.7
Sampson, J.R.8
-
12
-
-
0344010917
-
Analysis of the Birt-Hogg-Dube (BHD) tumour suppressor gene in sporadic renal cell carcinoma and colorectal cancer
-
da Silva N.F., Gentle D., Hesson L.B., Morton D.G., Latif F., Maher E.R. Analysis of the Birt-Hogg-Dube (BHD) tumour suppressor gene in sporadic renal cell carcinoma and colorectal cancer. J. Med. Genet. 2003, 40:820-824.
-
(2003)
J. Med. Genet.
, vol.40
, pp. 820-824
-
-
da Silva, N.F.1
Gentle, D.2
Hesson, L.B.3
Morton, D.G.4
Latif, F.5
Maher, E.R.6
-
13
-
-
1342267014
-
Lack of mutation of the folliculin gene in sporadic chromophobe renal cell carcinoma and renal oncocytoma
-
Nagy A., Zoubakov D., Stupar Z., Kovacs G. Lack of mutation of the folliculin gene in sporadic chromophobe renal cell carcinoma and renal oncocytoma. Int. J. Cancer 2004, 109:472-475.
-
(2004)
Int. J. Cancer
, vol.109
, pp. 472-475
-
-
Nagy, A.1
Zoubakov, D.2
Stupar, Z.3
Kovacs, G.4
-
14
-
-
16644373473
-
Role of VHL gene mutation in human cancer
-
Kim W.Y., Kaelin W.G. Role of VHL gene mutation in human cancer. J. Clin. Oncol. 2004, 22:4991-5004.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 4991-5004
-
-
Kim, W.Y.1
Kaelin, W.G.2
-
15
-
-
0033233243
-
2 homeostasis by hypoxia-inducible factor 1
-
2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol. 1999, 15:551-578.
-
(1999)
Annu. Rev. Cell Dev. Biol.
, vol.15
, pp. 551-578
-
-
Semenza, G.L.1
-
16
-
-
43649093915
-
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
-
Kaelin W.G., Ratcliffe P.J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 2008, 30:393-402.
-
(2008)
Mol. Cell
, vol.30
, pp. 393-402
-
-
Kaelin, W.G.1
Ratcliffe, P.J.2
-
17
-
-
0023865666
-
Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma
-
Seizinger B.R., Rouleau G.A., Ozelius L.J., Lane A.H., Farmer G.E., Lamiell J.M., Haines J., Yuen J.W., Collins D., Majoor-Krakauer D., Bonner T., Mathew C., Rubenstein A., Halperin J., McConkie-Rosell A., Green J.S., Trofatter J.A., Ponder B.A., Eierman L., Bowmer M.I., Schimke R., Oostra B., Aronin N., Smith D.I., Drabkin H., Waziri M.H., Hobbs W.J., Martuza R.L., Conneally P.M., Hsia Y.E., Gusella J.F. Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. Nature 1988, 332:268-269.
-
(1988)
Nature
, vol.332
, pp. 268-269
-
-
Seizinger, B.R.1
Rouleau, G.A.2
Ozelius, L.J.3
Lane, A.H.4
Farmer, G.E.5
Lamiell, J.M.6
Haines, J.7
Yuen, J.W.8
Collins, D.9
Majoor-Krakauer, D.10
Bonner, T.11
Mathew, C.12
Rubenstein, A.13
Halperin, J.14
McConkie-Rosell, A.15
Green, J.S.16
Trofatter, J.A.17
Ponder, B.A.18
Eierman, L.19
Bowmer, M.I.20
Schimke, R.21
Oostra, B.22
Aronin, N.23
Smith, D.I.24
Drabkin, H.25
Waziri, M.H.26
Hobbs, W.J.27
Martuza, R.L.28
Conneally, P.M.29
Hsia, Y.E.30
Gusella, J.F.31
more..
-
18
-
-
0027240519
-
Identification of the von Hippel-Lindau disease tumor suppressor gene
-
Latif F., Tory K., Gnarra J., Yao M., Duh F.M., Orcutt M.L., Stackhouse T., Kuzmin I., Modi W., Geil L., Schmidt L., Zhou F., Li H., Chen F., Glenn G., Choyke P., Walther M.M., Weng Y., Duan D.R., Dean M., Glavac D., Richards F.M., Crossey P.A., Ferguson-Smith M.A., Le Paslier D., Chumakov I., Cohen D., Chinault A.C., Maher E.R., Linehan W.M., Zbar B., Lerman M.I. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 1993, 260:1317-1320.
-
(1993)
Science
, vol.260
, pp. 1317-1320
-
-
Latif, F.1
Tory, K.2
Gnarra, J.3
Yao, M.4
Duh, F.M.5
Orcutt, M.L.6
Stackhouse, T.7
Kuzmin, I.8
Modi, W.9
Geil, L.10
Schmidt, L.11
Zhou, F.12
Li, H.13
Chen, F.14
Glenn, G.15
Choyke, P.16
Walther, M.M.17
Weng, Y.18
Duan, D.R.19
Dean, M.20
Glavac, D.21
Richards, F.M.22
Crossey, P.A.23
Ferguson-Smith, M.A.24
Le Paslier, D.25
Chumakov, I.26
Cohen, D.27
Chinault, A.C.28
Maher, E.R.29
Linehan, W.M.30
Zbar, B.31
Lerman, M.I.32
more..
-
19
-
-
0029785321
-
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein
-
Iliopoulos O., Levy A.P., Jiang C., Kaelin W.G., Goldberg M.A. Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:10595-10599.
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 10595-10599
-
-
Iliopoulos, O.1
Levy, A.P.2
Jiang, C.3
Kaelin, W.G.4
Goldberg, M.A.5
-
20
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis [see comments]
-
Maxwell P.H., Wiesener M.S., Chang G.W., Clifford S.C., Vaux E.C., Cockman M.E., Wykoff C.C., Pugh C.W., Maher E.R., Ratcliffe P.J. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis [see comments]. Nature 1999, 399:271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
21
-
-
0037709883
-
Von Hippel-Lindau disease
-
Lonser R.R., Glenn G.M., Walther M., Chew E.Y., Libutti S.K., Linehan W.M., Oldfield E.H. von Hippel-Lindau disease. Lancet 2003, 361:2059-2067.
-
(2003)
Lancet
, vol.361
, pp. 2059-2067
-
-
Lonser, R.R.1
Glenn, G.M.2
Walther, M.3
Chew, E.Y.4
Libutti, S.K.5
Linehan, W.M.6
Oldfield, E.H.7
-
22
-
-
0031834186
-
Genotype-phenotype correlations in von Hippel-Lindau disease
-
Neumann H.P., Bender B.U. Genotype-phenotype correlations in von Hippel-Lindau disease. J. Intern. Med. 1998, 243:541-545.
-
(1998)
J. Intern. Med.
, vol.243
, pp. 541-545
-
-
Neumann, H.P.1
Bender, B.U.2
-
23
-
-
0035339044
-
Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease
-
Clifford S.C., Cockman M.E., Smallwood A.C., Mole D.R., Woodward E.R., Maxwell P.H., Ratcliffe P.J., Maher E.R. Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease. Hum. Mol. Genet. 2001, 10:1029-1038.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 1029-1038
-
-
Clifford, S.C.1
Cockman, M.E.2
Smallwood, A.C.3
Mole, D.R.4
Woodward, E.R.5
Maxwell, P.H.6
Ratcliffe, P.J.7
Maher, E.R.8
-
24
-
-
0035336706
-
Von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF
-
Hoffman M.A., Ohh M., Yang H., Klco J.M., Ivan M., Kaelin W.G. von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF. Hum. Mol. Genet. 2001, 10:1019-1027.
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 1019-1027
-
-
Hoffman, M.A.1
Ohh, M.2
Yang, H.3
Klco, J.M.4
Ivan, M.5
Kaelin, W.G.6
-
25
-
-
40949136438
-
The VHL tumor suppressor and HIF: insights from genetic studies in mice
-
Kapitsinou P.P., Haase V.H. The VHL tumor suppressor and HIF: insights from genetic studies in mice. Cell Death Differ. 2008, 15:650-659.
-
(2008)
Cell Death Differ.
, vol.15
, pp. 650-659
-
-
Kapitsinou, P.P.1
Haase, V.H.2
-
27
-
-
0035969508
-
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
-
Makino Y., Cao R., Svensson K., Bertilsson G., Asman M., Tanaka H., Cao Y., Berkenstam A., Poellinger L. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 2001, 414:550-554.
-
(2001)
Nature
, vol.414
, pp. 550-554
-
-
Makino, Y.1
Cao, R.2
Svensson, K.3
Bertilsson, G.4
Asman, M.5
Tanaka, H.6
Cao, Y.7
Berkenstam, A.8
Poellinger, L.9
-
28
-
-
37249001223
-
Dominant-negative HIF-3 alpha 4 suppresses VHL-null renal cell carcinoma progression
-
Maynard M.A., Evans A.J., Shi W., Kim W.Y., Liu F.F., Ohh M. Dominant-negative HIF-3 alpha 4 suppresses VHL-null renal cell carcinoma progression. Cell Cycle 2007, 6:2810-2816.
-
(2007)
Cell Cycle
, vol.6
, pp. 2810-2816
-
-
Maynard, M.A.1
Evans, A.J.2
Shi, W.3
Kim, W.Y.4
Liu, F.F.5
Ohh, M.6
-
29
-
-
0345491599
-
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
-
Hu C.J., Wang L.Y., Chodosh L.A., Keith B., Simon M.C. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol. Cell. Biol. 2003, 23:9361-9374.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 9361-9374
-
-
Hu, C.J.1
Wang, L.Y.2
Chodosh, L.A.3
Keith, B.4
Simon, M.C.5
-
30
-
-
77958177671
-
Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia
-
Kapitsinou P.P., Liu Q., Unger T.L., Rha J., Davidoff O., Keith B., Epstein J.A., Moores S.L., Erickson-Miller C.L., Haase V.H. Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Blood 2010, 116:3039-3048.
-
(2010)
Blood
, vol.116
, pp. 3039-3048
-
-
Kapitsinou, P.P.1
Liu, Q.2
Unger, T.L.3
Rha, J.4
Davidoff, O.5
Keith, B.6
Epstein, J.A.7
Moores, S.L.8
Erickson-Miller, C.L.9
Haase, V.H.10
-
31
-
-
77953854244
-
Hypoxic regulation of erythropoiesis and iron metabolism
-
Haase V.H. Hypoxic regulation of erythropoiesis and iron metabolism. Am. J. Physiol. Renal Physiol. 2010, 299:F1-F13.
-
(2010)
Am. J. Physiol. Renal Physiol.
, vol.299
-
-
Haase, V.H.1
-
33
-
-
33746655373
-
Hypoxia-inducible factors in the kidney
-
Haase V.H. Hypoxia-inducible factors in the kidney. Am. J. Physiol. Renal Physiol. 2006, 291:F271-F281.
-
(2006)
Am. J. Physiol. Renal Physiol.
, vol.291
-
-
Haase, V.H.1
-
34
-
-
5644240828
-
Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (HIF) in regulating HIF transcriptional target genes
-
Stolze I.P., Tian Y.M., Appelhoff R.J., Turley H., Wykoff C.C., Gleadle J.M., Ratcliffe P.J. Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (HIF) in regulating HIF transcriptional target genes. J. Biol. Chem. 2004, 279:42719-42725.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 42719-42725
-
-
Stolze, I.P.1
Tian, Y.M.2
Appelhoff, R.J.3
Turley, H.4
Wykoff, C.C.5
Gleadle, J.M.6
Ratcliffe, P.J.7
-
35
-
-
13244281831
-
Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene and VHL-haplotype analysis in patients with presumable congenital erythrocytosis
-
Cario H., Schwarz K., Jorch N., Kyank U., Petrides P.E., Schneider D.T., Uhle R., Debatin K.M., Kohne E. Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene and VHL-haplotype analysis in patients with presumable congenital erythrocytosis. Haematologica 2005, 90:19-24.
-
(2005)
Haematologica
, vol.90
, pp. 19-24
-
-
Cario, H.1
Schwarz, K.2
Jorch, N.3
Kyank, U.4
Petrides, P.E.5
Schneider, D.T.6
Uhle, R.7
Debatin, K.M.8
Kohne, E.9
-
36
-
-
79960146286
-
Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia
-
Russell R.C., Sufan R.I., Zhou B., Heir P., Bunda S., Sybingco S.S., Greer S.N., Roche O., Heathcote S.A., Chow V.W., Boba L.M., Richmond T.D., Hickey M.M., Barber D.L., Cheresh D.A., Simon M.C., Irwin M.S., Kim W.Y., Ohh M. Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. Nat. Med. 2011, 17:845-853.
-
(2011)
Nat. Med.
, vol.17
, pp. 845-853
-
-
Russell, R.C.1
Sufan, R.I.2
Zhou, B.3
Heir, P.4
Bunda, S.5
Sybingco, S.S.6
Greer, S.N.7
Roche, O.8
Heathcote, S.A.9
Chow, V.W.10
Boba, L.M.11
Richmond, T.D.12
Hickey, M.M.13
Barber, D.L.14
Cheresh, D.A.15
Simon, M.C.16
Irwin, M.S.17
Kim, W.Y.18
Ohh, M.19
-
37
-
-
36849013228
-
Von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis
-
Hickey M.M., Lam J.C., Bezman N.A., Rathmell W.K., Simon M.C. von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis. J. Clin. Invest. 2007, 117:3879-3889.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3879-3889
-
-
Hickey, M.M.1
Lam, J.C.2
Bezman, N.A.3
Rathmell, W.K.4
Simon, M.C.5
-
38
-
-
18744373593
-
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia
-
Ang S.O., Chen H., Hirota K., Gordeuk V.R., Jelinek J., Guan Y., Liu E., Sergueeva A.I., Miasnikova G.Y., Mole D., Maxwell P.H., Stockton D.W., Semenza G.L., Prchal J.T. Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia. Nat. Genet. 2002, 32:614-621.
-
(2002)
Nat. Genet.
, vol.32
, pp. 614-621
-
-
Ang, S.O.1
Chen, H.2
Hirota, K.3
Gordeuk, V.R.4
Jelinek, J.5
Guan, Y.6
Liu, E.7
Sergueeva, A.I.8
Miasnikova, G.Y.9
Mole, D.10
Maxwell, P.H.11
Stockton, D.W.12
Semenza, G.L.13
Prchal, J.T.14
-
39
-
-
33746398489
-
Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology
-
Smith T.G., Brooks J.T., Balanos G.M., Lappin T.R., Layton D.M., Leedham D.L., Liu C., Maxwell P.H., McMullin M.F., McNamara C.J., Percy M.J., Pugh C.W., Ratcliffe P.J., Talbot N.P., Treacy M., Robbins P.A. Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology. PLoS Med. 2006, 3:e290.
-
(2006)
PLoS Med.
, vol.3
-
-
Smith, T.G.1
Brooks, J.T.2
Balanos, G.M.3
Lappin, T.R.4
Layton, D.M.5
Leedham, D.L.6
Liu, C.7
Maxwell, P.H.8
McMullin, M.F.9
McNamara, C.J.10
Percy, M.J.11
Pugh, C.W.12
Ratcliffe, P.J.13
Talbot, N.P.14
Treacy, M.15
Robbins, P.A.16
-
40
-
-
0031042949
-
Renal cysts, renal cancer and von Hippel-Lindau disease [editorial]
-
Neumann H.P., Zbar B. Renal cysts, renal cancer and von Hippel-Lindau disease [editorial]. Kidney Int. 1997, 51:16-26.
-
(1997)
Kidney Int.
, vol.51
, pp. 16-26
-
-
Neumann, H.P.1
Zbar, B.2
-
41
-
-
33745819269
-
Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein
-
Esteban M.A., Harten S.K., Tran M.G., Maxwell P.H. Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein. J. Am. Soc. Nephrol. 2006, 17:1801-1806.
-
(2006)
J. Am. Soc. Nephrol.
, vol.17
, pp. 1801-1806
-
-
Esteban, M.A.1
Harten, S.K.2
Tran, M.G.3
Maxwell, P.H.4
-
42
-
-
34248151938
-
Role of primary cilia in the pathogenesis of polycystic kidney disease
-
Yoder B.K. Role of primary cilia in the pathogenesis of polycystic kidney disease. J. Am. Soc. Nephrol. 2007, 18:1381-1388.
-
(2007)
J. Am. Soc. Nephrol.
, vol.18
, pp. 1381-1388
-
-
Yoder, B.K.1
-
43
-
-
84859835511
-
The shift towards renal tubular HIF-2a expression causes cellular transformation, leading to fibrosis and cyst development
-
Schietke R., Hackenbeck T., Rosenberger C., Koesters R., Bachmann S., Eckardt K.U., Maxwell P., Wiesener M. The shift towards renal tubular HIF-2a expression causes cellular transformation, leading to fibrosis and cyst development. American Society of Nephrology Annual Meeting, J. Am. Soc. Nephrol., San Diego, CA 2009, TH-FC016.
-
(2009)
American Society of Nephrology Annual Meeting, J. Am. Soc. Nephrol., San Diego, CA
-
-
Schietke, R.1
Hackenbeck, T.2
Rosenberger, C.3
Koesters, R.4
Bachmann, S.5
Eckardt, K.U.6
Maxwell, P.7
Wiesener, M.8
-
44
-
-
34047167041
-
Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway
-
Pollard P.J., Spencer-Dene B., Shukla D., Howarth K., Nye E., El-Bahrawy M., Deheragoda M., Joannou M., McDonald S., Martin A., Igarashi P., Varsani-Brown S., Rosewell I., Poulsom R., Maxwell P., Stamp G.W., Tomlinson I.P. Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. Cancer Cell 2007, 11:311-319.
-
(2007)
Cancer Cell
, vol.11
, pp. 311-319
-
-
Pollard, P.J.1
Spencer-Dene, B.2
Shukla, D.3
Howarth, K.4
Nye, E.5
El-Bahrawy, M.6
Deheragoda, M.7
Joannou, M.8
McDonald, S.9
Martin, A.10
Igarashi, P.11
Varsani-Brown, S.12
Rosewell, I.13
Poulsom, R.14
Maxwell, P.15
Stamp, G.W.16
Tomlinson, I.P.17
-
45
-
-
34247863920
-
PVHL and GSK3beta are components of a primary cilium-maintenance signalling network
-
Thoma C.R., Frew I.J., Hoerner C.R., Montani M., Moch H., Krek W. pVHL and GSK3beta are components of a primary cilium-maintenance signalling network. Nat. Cell Biol. 2007, 9:588-595.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 588-595
-
-
Thoma, C.R.1
Frew, I.J.2
Hoerner, C.R.3
Montani, M.4
Moch, H.5
Krek, W.6
-
46
-
-
33751209189
-
The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth
-
Schermer B., Ghenoiu C., Bartram M., Muller R.U., Kotsis F., Hohne M., Kuhn W., Rapka M., Nitschke R., Zentgraf H., Fliegauf M., Omran H., Walz G., Benzing T. The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth. J. Cell Biol. 2006, 175:547-554.
-
(2006)
J. Cell Biol.
, vol.175
, pp. 547-554
-
-
Schermer, B.1
Ghenoiu, C.2
Bartram, M.3
Muller, R.U.4
Kotsis, F.5
Hohne, M.6
Kuhn, W.7
Rapka, M.8
Nitschke, R.9
Zentgraf, H.10
Fliegauf, M.11
Omran, H.12
Walz, G.13
Benzing, T.14
-
47
-
-
33746886185
-
Primary cilium formation requires von Hippel-Lindau gene function in renal-derived cells
-
Lutz M.S., Burk R.D. Primary cilium formation requires von Hippel-Lindau gene function in renal-derived cells. Cancer Res. 2006, 66:6903-6907.
-
(2006)
Cancer Res.
, vol.66
, pp. 6903-6907
-
-
Lutz, M.S.1
Burk, R.D.2
-
48
-
-
75149188170
-
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
-
Dalgliesh G.L., Furge K., Greenman C., Chen L., Bignell G., Butler A., Davies H., Edkins S., Hardy C., Latimer C., Teague J., Andrews J., Barthorpe S., Beare D., Buck G., Campbell P.J., Forbes S., Jia M., Jones D., Knott H., Kok C.Y., Lau K.W., Leroy C., Lin M.L., McBride D.J., Maddison M., Maguire S., McLay K., Menzies A., Mironenko T., Mulderrig L., Mudie L., O'Meara S., Pleasance E., Rajasingham A., Shepherd R., Smith R., Stebbings L., Stephens P., Tang G., Tarpey P.S., Turrell K., Dykema K.J., Khoo S.K., Petillo D., Wondergem B., Anema J., Kahnoski R.J., Teh B.T., Stratton M.R., Futreal P.A. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 2010, 463:360-363.
-
(2010)
Nature
, vol.463
, pp. 360-363
-
-
Dalgliesh, G.L.1
Furge, K.2
Greenman, C.3
Chen, L.4
Bignell, G.5
Butler, A.6
Davies, H.7
Edkins, S.8
Hardy, C.9
Latimer, C.10
Teague, J.11
Andrews, J.12
Barthorpe, S.13
Beare, D.14
Buck, G.15
Campbell, P.J.16
Forbes, S.17
Jia, M.18
Jones, D.19
Knott, H.20
Kok, C.Y.21
Lau, K.W.22
Leroy, C.23
Lin, M.L.24
McBride, D.J.25
Maddison, M.26
Maguire, S.27
McLay, K.28
Menzies, A.29
Mironenko, T.30
Mulderrig, L.31
Mudie, L.32
O'Meara, S.33
Pleasance, E.34
Rajasingham, A.35
Shepherd, R.36
Smith, R.37
Stebbings, L.38
Stephens, P.39
Tang, G.40
Tarpey, P.S.41
Turrell, K.42
Dykema, K.J.43
Khoo, S.K.44
Petillo, D.45
Wondergem, B.46
Anema, J.47
Kahnoski, R.J.48
Teh, B.T.49
Stratton, M.R.50
Futreal, P.A.51
more..
-
49
-
-
33645090169
-
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B
-
Krishnamachary B., Zagzag D., Nagasawa H., Rainey K., Okuyama H., Baek J.H., Semenza G.L. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res. 2006, 66:2725-2731.
-
(2006)
Cancer Res.
, vol.66
, pp. 2725-2731
-
-
Krishnamachary, B.1
Zagzag, D.2
Nagasawa, H.3
Rainey, K.4
Okuyama, H.5
Baek, J.H.6
Semenza, G.L.7
-
50
-
-
33645748171
-
Regulation of E-cadherin expression by VHL and hypoxia-inducible factor
-
Esteban M.A., Tran M.G., Harten S.K., Hill P., Castellanos M.C., Chandra A., Raval R., O'Brien S., Maxwell T.P.H. Regulation of E-cadherin expression by VHL and hypoxia-inducible factor. Cancer Res. 2006, 66:3567-3575.
-
(2006)
Cancer Res.
, vol.66
, pp. 3567-3575
-
-
Esteban, M.A.1
Tran, M.G.2
Harten, S.K.3
Hill, P.4
Castellanos, M.C.5
Chandra, A.6
Raval, R.7
O'Brien, S.8
Maxwell, T.P.H.9
-
51
-
-
33845724527
-
VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail
-
Evans A.J., Russell R.C., Roche O., Burry T.N., Fish J.E., Chow V.W., Kim W.Y., Saravanan A., Maynard M.A., Gervais M.L., Sufan R.I., Roberts A.M., Wilson L.A., Betten M., Vandewalle C., Berx G., Marsden P.A., Irwin M.S., Teh B.T., Jewett M.A., Ohh M. VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Mol. Cell. Biol. 2007, 27:157-169.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 157-169
-
-
Evans, A.J.1
Russell, R.C.2
Roche, O.3
Burry, T.N.4
Fish, J.E.5
Chow, V.W.6
Kim, W.Y.7
Saravanan, A.8
Maynard, M.A.9
Gervais, M.L.10
Sufan, R.I.11
Roberts, A.M.12
Wilson, L.A.13
Betten, M.14
Vandewalle, C.15
Berx, G.16
Marsden, P.A.17
Irwin, M.S.18
Teh, B.T.19
Jewett, M.A.20
Ohh, M.21
more..
-
52
-
-
32944457801
-
Von Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms
-
Calzada M.J., Esteban M.A., Feijoo-Cuaresma M., Castellanos M.C., Naranjo-Suarez S., Temes E., Mendez F., Yanez-Mo M., Ohh M., Landazuri M.O. von Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms. Cancer Res. 2006, 66:1553-1560.
-
(2006)
Cancer Res.
, vol.66
, pp. 1553-1560
-
-
Calzada, M.J.1
Esteban, M.A.2
Feijoo-Cuaresma, M.3
Castellanos, M.C.4
Naranjo-Suarez, S.5
Temes, E.6
Mendez, F.7
Yanez-Mo, M.8
Ohh, M.9
Landazuri, M.O.10
-
53
-
-
40249100323
-
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400
-
Young A.P., Schlisio S., Minamishima Y.A., Zhang Q., Li L., Grisanzio C., Signoretti S., Kaelin W.G. VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400. Nat. Cell Biol. 2008, 10:361-369.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 361-369
-
-
Young, A.P.1
Schlisio, S.2
Minamishima, Y.A.3
Zhang, Q.4
Li, L.5
Grisanzio, C.6
Signoretti, S.7
Kaelin, W.G.8
-
54
-
-
77956690871
-
Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress
-
Welford S.M., Dorie M.J., Li X., Haase V.H., Giaccia A.J. Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress. Mol. Cell. Biol. 2010, 30:4595-4603.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 4595-4603
-
-
Welford, S.M.1
Dorie, M.J.2
Li, X.3
Haase, V.H.4
Giaccia, A.J.5
-
55
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
-
Ravi R., Mookerjee B., Bhujwalla Z.M., Sutter C.H., Artemov D., Zeng Q., Dillehay L.E., Madan A., Semenza G.L., Bedi A. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev. 2000, 14:34-44.
-
(2000)
Genes Dev.
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
Sutter, C.H.4
Artemov, D.5
Zeng, Q.6
Dillehay, L.E.7
Madan, A.8
Semenza, G.L.9
Bedi, A.10
-
56
-
-
33646140913
-
P53 stabilization and transactivation by a von Hippel-Lindau protein
-
Roe J.S., Kim H., Lee S.M., Kim S.T., Cho E.J., Youn H.D. p53 stabilization and transactivation by a von Hippel-Lindau protein. Mol. Cell 2006, 22:395-405.
-
(2006)
Mol. Cell
, vol.22
, pp. 395-405
-
-
Roe, J.S.1
Kim, H.2
Lee, S.M.3
Kim, S.T.4
Cho, E.J.5
Youn, H.D.6
-
57
-
-
0032568150
-
Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
-
An W.G., Kanekal M., Simon M.C., Maltepe E., Blagosklonny M.V., Neckers L.M. Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature 1998, 392:405-408.
-
(1998)
Nature
, vol.392
, pp. 405-408
-
-
An, W.G.1
Kanekal, M.2
Simon, M.C.3
Maltepe, E.4
Blagosklonny, M.V.5
Neckers, L.M.6
-
58
-
-
34948883495
-
PVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2
-
Yang H., Minamishima Y.A., Yan Q., Schlisio S., Ebert B.L., Zhang X., Zhang L., Kim W.Y., Olumi A.F., Kaelin W.G. pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2. Mol. Cell 2007, 28:15-27.
-
(2007)
Mol. Cell
, vol.28
, pp. 15-27
-
-
Yang, H.1
Minamishima, Y.A.2
Yan, Q.3
Schlisio, S.4
Ebert, B.L.5
Zhang, X.6
Zhang, L.7
Kim, W.Y.8
Olumi, A.F.9
Kaelin, W.G.10
-
59
-
-
34047156190
-
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
-
Gordan J.D., Bertout J.A., Hu C.J., Diehl J.A., Simon M.C. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 2007, 11:335-347.
-
(2007)
Cancer Cell
, vol.11
, pp. 335-347
-
-
Gordan, J.D.1
Bertout, J.A.2
Hu, C.J.3
Diehl, J.A.4
Simon, M.C.5
-
60
-
-
0032795938
-
The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells
-
Koochekpour S., Jeffers M., Wang P.H., Gong C., Taylor G.A., Roessler L.M., Stearman R., Vasselli J.R., Stetler-Stevenson W.G., Kaelin W.G., Linehan W.M., Klausner R.D., Gnarra J.R., Vande Woude G.F. The von Hippel-Lindau tumor suppressor gene inhibits hepatocyte growth factor/scatter factor-induced invasion and branching morphogenesis in renal carcinoma cells. Mol. Cell. Biol. 1999, 19:5902-5912.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 5902-5912
-
-
Koochekpour, S.1
Jeffers, M.2
Wang, P.H.3
Gong, C.4
Taylor, G.A.5
Roessler, L.M.6
Stearman, R.7
Vasselli, J.R.8
Stetler-Stevenson, W.G.9
Kaelin, W.G.10
Linehan, W.M.11
Klausner, R.D.12
Gnarra, J.R.13
Vande Woude, G.F.14
-
61
-
-
33749238874
-
The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells
-
Peruzzi B., Athauda G., Bottaro D.P. The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:14531-14536.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 14531-14536
-
-
Peruzzi, B.1
Athauda, G.2
Bottaro, D.P.3
-
62
-
-
0037478437
-
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
-
Pennacchietti S., Michieli P., Galluzzo M., Mazzone M., Giordano S., Comoglio P.M. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 2003, 3:347-361.
-
(2003)
Cancer Cell
, vol.3
, pp. 347-361
-
-
Pennacchietti, S.1
Michieli, P.2
Galluzzo, M.3
Mazzone, M.4
Giordano, S.5
Comoglio, P.M.6
-
63
-
-
61949090107
-
Regulation of endocytosis via the oxygen-sensing pathway
-
Wang Y., Roche O., Yan M.S., Finak G., Evans A.J., Metcalf J.L., Hast B.E., Hanna S.C., Wondergem B., Furge K.A., Irwin M.S., Kim W.Y., Teh B.T., Grinstein S., Park M., Marsden P.A., Ohh M. Regulation of endocytosis via the oxygen-sensing pathway. Nat. Med. 2009, 15:319-324.
-
(2009)
Nat. Med.
, vol.15
, pp. 319-324
-
-
Wang, Y.1
Roche, O.2
Yan, M.S.3
Finak, G.4
Evans, A.J.5
Metcalf, J.L.6
Hast, B.E.7
Hanna, S.C.8
Wondergem, B.9
Furge, K.A.10
Irwin, M.S.11
Kim, W.Y.12
Teh, B.T.13
Grinstein, S.14
Park, M.15
Marsden, P.A.16
Ohh, M.17
-
64
-
-
20444485232
-
Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer
-
Smith K., Gunaratnam L., Morley M., Franovic A., Mekhail K., Lee S. Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer. Cancer Res. 2005, 65:5221-5230.
-
(2005)
Cancer Res.
, vol.65
, pp. 5221-5230
-
-
Smith, K.1
Gunaratnam, L.2
Morley, M.3
Franovic, A.4
Mekhail, K.5
Lee, S.6
-
65
-
-
20744445650
-
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
-
Raval R.R., Lau K.W., Tran M.G., Sowter H.M., Mandriota S.J., Li J.L., Pugh C.W., Maxwell P.H., Harris A.L., Ratcliffe P.J. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol. Cell. Biol. 2005, 25:5675-5686.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 5675-5686
-
-
Raval, R.R.1
Lau, K.W.2
Tran, M.G.3
Sowter, H.M.4
Mandriota, S.J.5
Li, J.L.6
Pugh, C.W.7
Maxwell, P.H.8
Harris, A.L.9
Ratcliffe, P.J.10
-
66
-
-
0036606006
-
VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells
-
Bindra R.S., Vasselli J.R., Stearman R., Linehan W.M., Klausner R.D. VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells. Cancer Res. 2002, 62:3014-3019.
-
(2002)
Cancer Res.
, vol.62
, pp. 3014-3019
-
-
Bindra, R.S.1
Vasselli, J.R.2
Stearman, R.3
Linehan, W.M.4
Klausner, R.D.5
-
67
-
-
0036645091
-
Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease
-
Zatyka M., da Silva N.F., Clifford S.C., Morris M.R., Wiesener M.S., Eckardt K.U., Houlston R.S., Richards F.M., Latif F., Maher E.R. Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease. Cancer Res. 2002, 62:3803-3811.
-
(2002)
Cancer Res.
, vol.62
, pp. 3803-3811
-
-
Zatyka, M.1
da Silva, N.F.2
Clifford, S.C.3
Morris, M.R.4
Wiesener, M.S.5
Eckardt, K.U.6
Houlston, R.S.7
Richards, F.M.8
Latif, F.9
Maher, E.R.10
-
68
-
-
1942533531
-
Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene
-
Wykoff C.C., Sotiriou C., Cockman M.E., Ratcliffe P.J., Maxwell P., Liu E., Harris A.L. Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene. Br. J. Cancer 2004, 90:1235-1243.
-
(2004)
Br. J. Cancer
, vol.90
, pp. 1235-1243
-
-
Wykoff, C.C.1
Sotiriou, C.2
Cockman, M.E.3
Ratcliffe, P.J.4
Maxwell, P.5
Liu, E.6
Harris, A.L.7
-
69
-
-
38949161122
-
Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2
-
Kurban G., Duplan E., Ramlal N., Hudon V., Sado Y., Ninomiya Y., Pause A. Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2. Oncogene 2008, 27:1004-1012.
-
(2008)
Oncogene
, vol.27
, pp. 1004-1012
-
-
Kurban, G.1
Duplan, E.2
Ramlal, N.3
Hudon, V.4
Sado, Y.5
Ninomiya, Y.6
Pause, A.7
-
70
-
-
32944464205
-
Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis
-
Kurban G., Hudon V., Duplan E., Ohh M., Pause A. Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis. Cancer Res. 2006, 66:1313-1319.
-
(2006)
Cancer Res.
, vol.66
, pp. 1313-1319
-
-
Kurban, G.1
Hudon, V.2
Duplan, E.3
Ohh, M.4
Pause, A.5
-
71
-
-
0032085240
-
The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix
-
Ohh M., Yauch R.L., Lonergan K.M., Whaley J.M., Stemmer-Rachamimov A.O., Louis D.N., Gavin B.J., Kley N., Kaelin W.G., Iliopoulos O. The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol. Cell 1998, 1:959-968.
-
(1998)
Mol. Cell
, vol.1
, pp. 959-968
-
-
Ohh, M.1
Yauch, R.L.2
Lonergan, K.M.3
Whaley, J.M.4
Stemmer-Rachamimov, A.O.5
Louis, D.N.6
Gavin, B.J.7
Kley, N.8
Kaelin, W.G.9
Iliopoulos, O.10
-
72
-
-
0035136533
-
VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling
-
Davidowitz E.J., Schoenfeld A.R., Burk R.D. VHL induces renal cell differentiation and growth arrest through integration of cell-cell and cell-extracellular matrix signaling. Mol. Cell. Biol. 2001, 21:865-874.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 865-874
-
-
Davidowitz, E.J.1
Schoenfeld, A.R.2
Burk, R.D.3
-
73
-
-
8844284460
-
Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans
-
Bishop T., Lau K.W., Epstein A.C., Kim S.K., Jiang M., O'Rourke D., Pugh C.W., Gleadle J.M., Taylor M.S., Hodgkin J., Ratcliffe P.J. Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans. PLoS Biol. 2004, 2:e289.
-
(2004)
PLoS Biol.
, vol.2
-
-
Bishop, T.1
Lau, K.W.2
Epstein, A.C.3
Kim, S.K.4
Jiang, M.5
O'Rourke, D.6
Pugh, C.W.7
Gleadle, J.M.8
Taylor, M.S.9
Hodgkin, J.10
Ratcliffe, P.J.11
-
74
-
-
30044432434
-
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
-
Thomas G.V., Tran C., Mellinghoff I.K., Welsbie D.S., Chan E., Fueger B., Czernin J., Sawyers C.L. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat. Med. 2006, 12:122-127.
-
(2006)
Nat. Med.
, vol.12
, pp. 122-127
-
-
Thomas, G.V.1
Tran, C.2
Mellinghoff, I.K.3
Welsbie, D.S.4
Chan, E.5
Fueger, B.6
Czernin, J.7
Sawyers, C.L.8
-
75
-
-
0141828145
-
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
-
Staller P., Sulitkova J., Lisztwan J., Moch H., Oakeley E.J., Krek W. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003, 425:307-311.
-
(2003)
Nature
, vol.425
, pp. 307-311
-
-
Staller, P.1
Sulitkova, J.2
Lisztwan, J.3
Moch, H.4
Oakeley, E.J.5
Krek, W.6
-
76
-
-
0037093238
-
Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation
-
Turner K.J., Moore J.W., Jones A., Taylor C.F., Cuthbert-Heavens D., Han C., Leek R.D., Gatter K.C., Maxwell P.H., Ratcliffe P.J., Cranston D., Harris A.L. Expression of hypoxia-inducible factors in human renal cancer: relationship to angiogenesis and to the von Hippel-Lindau gene mutation. Cancer Res. 2002, 62:2957-2961.
-
(2002)
Cancer Res.
, vol.62
, pp. 2957-2961
-
-
Turner, K.J.1
Moore, J.W.2
Jones, A.3
Taylor, C.F.4
Cuthbert-Heavens, D.5
Han, C.6
Leek, R.D.7
Gatter, K.C.8
Maxwell, P.H.9
Ratcliffe, P.J.10
Cranston, D.11
Harris, A.L.12
-
77
-
-
56849096837
-
HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma
-
Gordan J.D., Lal P., Dondeti V.R., Letrero R., Parekh K.N., Oquendo C.E., Greenberg R.A., Flaherty K.T., Rathmell W.K., Keith B., Simon M.C., Nathanson K.L. HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell 2008, 14:435-446.
-
(2008)
Cancer Cell
, vol.14
, pp. 435-446
-
-
Gordan, J.D.1
Lal, P.2
Dondeti, V.R.3
Letrero, R.4
Parekh, K.N.5
Oquendo, C.E.6
Greenberg, R.A.7
Flaherty, K.T.8
Rathmell, W.K.9
Keith, B.10
Simon, M.C.11
Nathanson, K.L.12
-
78
-
-
0036528246
-
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
-
Kondo K., Klco J.M., Nakamura E., Lechpammer M., Kaelin W.G. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002, 1:237-246.
-
(2002)
Cancer Cell
, vol.1
, pp. 237-246
-
-
Kondo, K.1
Klco, J.M.2
Nakamura, E.3
Lechpammer, M.4
Kaelin, W.G.5
-
79
-
-
0036527785
-
The contribution of VHL substrate binding and HIF-1α to the phenotype of vhl loss in renal cell carcinoma
-
Maranchi J.K., Vasselli J.R., Riss J., Bonifacio J.S., Linehan W.M., Klausner R.D. The contribution of VHL substrate binding and HIF-1α to the phenotype of vhl loss in renal cell carcinoma. Cancer Cell 2002, 1:247-253.
-
(2002)
Cancer Cell
, vol.1
, pp. 247-253
-
-
Maranchi, J.K.1
Vasselli, J.R.2
Riss, J.3
Bonifacio, J.S.4
Linehan, W.M.5
Klausner, R.D.6
-
80
-
-
1342280515
-
Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors
-
Zimmer M., Doucette D., Siddiqui N., Iliopoulos O. Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors. Mol. Cancer Res. 2004, 2:89-95.
-
(2004)
Mol. Cancer Res.
, vol.2
, pp. 89-95
-
-
Zimmer, M.1
Doucette, D.2
Siddiqui, N.3
Iliopoulos, O.4
-
81
-
-
2342597973
-
Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth
-
Kondo K., Kim W.Y., Lechpammer M., Kaelin W.G. Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth. PLoS Biol. 2003, 1:E83.
-
(2003)
PLoS Biol.
, vol.1
-
-
Kondo, K.1
Kim, W.Y.2
Lechpammer, M.3
Kaelin, W.G.4
-
82
-
-
84655161946
-
HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression
-
Keith B., Johnson R.S., Simon M.C. HIF1alpha and HIF2alpha: sibling rivalry in hypoxic tumour growth and progression. Nat. Rev. Cancer 2011, 12:9-22.
-
(2011)
Nat. Rev. Cancer
, vol.12
, pp. 9-22
-
-
Keith, B.1
Johnson, R.S.2
Simon, M.C.3
-
83
-
-
51649090078
-
Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice
-
Rankin E.B., Rha J., Unger T.L., Wu C.H., Shutt H.P., Johnson R.S., Simon M.C., Keith B., Haase V.H. Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene 2008, 27:5354-5358.
-
(2008)
Oncogene
, vol.27
, pp. 5354-5358
-
-
Rankin, E.B.1
Rha, J.2
Unger, T.L.3
Wu, C.H.4
Shutt, H.P.5
Johnson, R.S.6
Simon, M.C.7
Keith, B.8
Haase, V.H.9
-
84
-
-
0037223823
-
Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL
-
Hergovich A., Lisztwan J., Barry R., Ballschmieter P., Krek W. Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. Nat. Cell Biol. 2003, 5:64-70.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 64-70
-
-
Hergovich, A.1
Lisztwan, J.2
Barry, R.3
Ballschmieter, P.4
Krek, W.5
-
85
-
-
78649865940
-
VHL inactivation induces HEF1 and Aurora kinase A
-
Xu J., Li H., Wang B., Xu Y., Yang J., Zhang X., Harten S.K., Shukla D., Maxwell P.H., Pei D., Esteban M.A. VHL inactivation induces HEF1 and Aurora kinase A. J. Am. Soc. Nephrol. 2010, 21:2041-2046.
-
(2010)
J. Am. Soc. Nephrol.
, vol.21
, pp. 2041-2046
-
-
Xu, J.1
Li, H.2
Wang, B.3
Xu, Y.4
Yang, J.5
Zhang, X.6
Harten, S.K.7
Shukla, D.8
Maxwell, P.H.9
Pei, D.10
Esteban, M.A.11
-
86
-
-
47049090632
-
PVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation
-
Frew I.J., Thoma C.R., Georgiev S., Minola A., Hitz M., Montani M., Moch H., Krek W. pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation. EMBO J. 2008, 27:1747-1757.
-
(2008)
EMBO J.
, vol.27
, pp. 1747-1757
-
-
Frew, I.J.1
Thoma, C.R.2
Georgiev, S.3
Minola, A.4
Hitz, M.5
Montani, M.6
Moch, H.7
Krek, W.8
-
87
-
-
47049111684
-
Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia
-
Frew I.J., Minola A., Georgiev S., Hitz M., Moch H., Richard S., Vortmeyer A.O., Krek W. Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia. Mol. Cell. Biol. 2008, 28:4536-4548.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 4536-4548
-
-
Frew, I.J.1
Minola, A.2
Georgiev, S.3
Hitz, M.4
Moch, H.5
Richard, S.6
Vortmeyer, A.O.7
Krek, W.8
-
88
-
-
53349162212
-
Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL
-
Chitalia V.C., Foy R.L., Bachschmid M.M., Zeng L., Panchenko M.V., Zhou M.I., Bharti A., Seldin D.C., Lecker S.H., Dominguez I., Cohen H.T. Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL. Nat. Cell Biol. 2008, 10:1208-1216.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 1208-1216
-
-
Chitalia, V.C.1
Foy, R.L.2
Bachschmid, M.M.3
Zeng, L.4
Panchenko, M.V.5
Zhou, M.I.6
Bharti, A.7
Seldin, D.C.8
Lecker, S.H.9
Dominguez, I.10
Cohen, H.T.11
-
89
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
91
-
-
37449024702
-
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
-
DeBerardinis R.J., Lum J.J., Hatzivassiliou G., Thompson C.B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 2008, 7:11-20.
-
(2008)
Cell Metab.
, vol.7
, pp. 11-20
-
-
DeBerardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
92
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
-
Hudson C.C., Liu M., Chiang G.G., Otterness D.M., Loomis D.C., Kaper F., Giaccia A.J., Abraham R.T. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol. Cell. Biol. 2002, 22:7004-7014.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
Otterness, D.M.4
Loomis, D.C.5
Kaper, F.6
Giaccia, A.J.7
Abraham, R.T.8
-
93
-
-
0035027828
-
Transcription factor hif-1 is a necessary mediator of the Pasteur effect in mammalian cells
-
Seagroves T.N., Ryan H.E., Lu H., Wouters B.G., Knapp M., Thibault P., Laderoute K., Johnson R.S. Transcription factor hif-1 is a necessary mediator of the Pasteur effect in mammalian cells. Mol. Cell. Biol. 2001, 21:3436-3444.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3436-3444
-
-
Seagroves, T.N.1
Ryan, H.E.2
Lu, H.3
Wouters, B.G.4
Knapp, M.5
Thibault, P.6
Laderoute, K.7
Johnson, R.S.8
-
94
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou I., Cairns R.A., Fontana L., Lim A.L., Denko N.C. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 2006, 3:187-197.
-
(2006)
Cell Metab.
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
95
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
-
Kim J.W., Tchernyshyov I., Semenza G.L., Dang C.V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006, 3:177-185.
-
(2006)
Cell Metab.
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
96
-
-
79957567239
-
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
-
Luo W., Hu H., Chang R., Zhong J., Knabel M., O'Meally R., Cole R.N., Pandey A., Semenza G.L. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 2011, 145:732-744.
-
(2011)
Cell
, vol.145
, pp. 732-744
-
-
Luo, W.1
Hu, H.2
Chang, R.3
Zhong, J.4
Knabel, M.5
O'Meally, R.6
Cole, R.N.7
Pandey, A.8
Semenza, G.L.9
-
97
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk H.R., Vander Heiden M.G., Harris M.H., Ramanathan A., Gerszten R.E., Wei R., Fleming M.D., Schreiber S.L., Cantley L.C. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008, 452:230-233.
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
Fleming, M.D.7
Schreiber, S.L.8
Cantley, L.C.9
-
98
-
-
77956674635
-
Evidence for an alternative glycolytic pathway in rapidly proliferating cells
-
Vander Heiden M.G., Locasale J.W., Swanson K.D., Sharfi H., Heffron G.J., Amador-Noguez D., Christofk H.R., Wagner G., Rabinowitz J.D., Asara J.M., Cantley L.C. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science 2010, 329:1492-1499.
-
(2010)
Science
, vol.329
, pp. 1492-1499
-
-
Vander Heiden, M.G.1
Locasale, J.W.2
Swanson, K.D.3
Sharfi, H.4
Heffron, G.J.5
Amador-Noguez, D.6
Christofk, H.R.7
Wagner, G.8
Rabinowitz, J.D.9
Asara, J.M.10
Cantley, L.C.11
-
99
-
-
78649659788
-
PH control mechanisms of tumor survival and growth
-
Parks S.K., Chiche J., Pouyssegur J. pH control mechanisms of tumor survival and growth. J. Cell. Physiol. 2011, 226:299-308.
-
(2011)
J. Cell. Physiol.
, vol.226
, pp. 299-308
-
-
Parks, S.K.1
Chiche, J.2
Pouyssegur, J.3
-
100
-
-
34247614521
-
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
-
Zhang H., Gao P., Fukuda R., Kumar G., Krishnamachary B., Zeller K.I., Dang C.V., Semenza G.L. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 2007, 11:407-420.
-
(2007)
Cancer Cell
, vol.11
, pp. 407-420
-
-
Zhang, H.1
Gao, P.2
Fukuda, R.3
Kumar, G.4
Krishnamachary, B.5
Zeller, K.I.6
Dang, C.V.7
Semenza, G.L.8
-
101
-
-
33947724515
-
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
-
Fukuda R., Zhang H., Kim J.W., Shimoda L., Dang C.V., Semenza G.L. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 2007, 129:111-122.
-
(2007)
Cell
, vol.129
, pp. 111-122
-
-
Fukuda, R.1
Zhang, H.2
Kim, J.W.3
Shimoda, L.4
Dang, C.V.5
Semenza, G.L.6
-
102
-
-
43649104579
-
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
-
Zhang H., Bosch-Marce M., Shimoda L.A., Tan Y.S., Baek J.H., Wesley J.B., Gonzalez F.J., Semenza G.L. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J. Biol. Chem. 2008, 283:10892-10903.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 10892-10903
-
-
Zhang, H.1
Bosch-Marce, M.2
Shimoda, L.A.3
Tan, Y.S.4
Baek, J.H.5
Wesley, J.B.6
Gonzalez, F.J.7
Semenza, G.L.8
-
103
-
-
68949098346
-
Hypoxia-inducible factor 2 regulates hepatic lipid metabolism
-
Rankin E.B., Rha J., Selak M.A., Unger T.L., Keith B., Liu Q., Haase V.H. Hypoxia-inducible factor 2 regulates hepatic lipid metabolism. Mol. Cell. Biol. 2009, 29:4527-4538.
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 4527-4538
-
-
Rankin, E.B.1
Rha, J.2
Selak, M.A.3
Unger, T.L.4
Keith, B.5
Liu, Q.6
Haase, V.H.7
-
104
-
-
66049097308
-
Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy
-
Krishnan J., Suter M., Windak R., Krebs T., Felley A., Montessuit C., Tokarska-Schlattner M., Aasum E., Bogdanova A., Perriard E., Perriard J.C., Larsen T., Pedrazzini T., Krek W. Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy. Cell Metab. 2009, 9:512-524.
-
(2009)
Cell Metab.
, vol.9
, pp. 512-524
-
-
Krishnan, J.1
Suter, M.2
Windak, R.3
Krebs, T.4
Felley, A.5
Montessuit, C.6
Tokarska-Schlattner, M.7
Aasum, E.8
Bogdanova, A.9
Perriard, E.10
Perriard, J.C.11
Larsen, T.12
Pedrazzini, T.13
Krek, W.14
-
105
-
-
77950523330
-
Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1
-
Pescador N., Villar D., Cifuentes D., Garcia-Rocha M., Ortiz-Barahona A., Vazquez S., Ordonez A., Cuevas Y., Saez-Morales D., Garcia-Bermejo M.L., Landazuri M.O., Guinovart J., del Peso L. Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1. PLoS One 2010, 5:e9644.
-
(2010)
PLoS One
, vol.5
-
-
Pescador, N.1
Villar, D.2
Cifuentes, D.3
Garcia-Rocha, M.4
Ortiz-Barahona, A.5
Vazquez, S.6
Ordonez, A.7
Cuevas, Y.8
Saez-Morales, D.9
Garcia-Bermejo, M.L.10
Landazuri, M.O.11
Guinovart, J.12
del Peso, L.13
-
106
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
Yang J.C., Haworth L., Sherry R.M., Hwu P., Schwartzentruber D.J., Topalian S.L., Steinberg S.M., Chen H.X., Rosenberg S.A. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N. Engl. J. Med. 2003, 349:427-434.
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
Hwu, P.4
Schwartzentruber, D.J.5
Topalian, S.L.6
Steinberg, S.M.7
Chen, H.X.8
Rosenberg, S.A.9
-
107
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer R.J., Hutson T.E., Tomczak P., Michaelson M.D., Bukowski R.M., Rixe O., Oudard S., Negrier S., Szczylik C., Kim S.T., Chen I., Bycott P.W., Baum C.M., Figlin R.A. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N. Engl. J. Med. 2007, 356:115-124.
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, M.D.4
Bukowski, R.M.5
Rixe, O.6
Oudard, S.7
Negrier, S.8
Szczylik, C.9
Kim, S.T.10
Chen, I.11
Bycott, P.W.12
Baum, C.M.13
Figlin, R.A.14
-
108
-
-
77949890945
-
Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial
-
Sternberg C.N., Davis I.D., Mardiak J., Szczylik C., Lee E., Wagstaff J., Barrios C.H., Salman P., Gladkov O.A., Kavina A., Zarba J.J., Chen M., McCann L., Pandite L., Roychowdhury D.F., Hawkins R.E. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J. Clin. Oncol. 2010, 28:1061-1068.
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 1061-1068
-
-
Sternberg, C.N.1
Davis, I.D.2
Mardiak, J.3
Szczylik, C.4
Lee, E.5
Wagstaff, J.6
Barrios, C.H.7
Salman, P.8
Gladkov, O.A.9
Kavina, A.10
Zarba, J.J.11
Chen, M.12
McCann, L.13
Pandite, L.14
Roychowdhury, D.F.15
Hawkins, R.E.16
-
109
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B., Eisen T., Stadler W.M., Szczylik C., Oudard S., Siebels M., Negrier S., Chevreau C., Solska E., Desai A.A., Rolland F., Demkow T., Hutson T.E., Gore M., Freeman S., Schwartz B., Shan M., Simantov R., Bukowski R.M. Sorafenib in advanced clear-cell renal-cell carcinoma. N. Engl. J. Med. 2007, 356:125-134.
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Siebels, M.6
Negrier, S.7
Chevreau, C.8
Solska, E.9
Desai, A.A.10
Rolland, F.11
Demkow, T.12
Hutson, T.E.13
Gore, M.14
Freeman, S.15
Schwartz, B.16
Shan, M.17
Simantov, R.18
Bukowski, R.M.19
-
110
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
Hudes G., Carducci M., Tomczak P., Dutcher J., Figlin R., Kapoor A., Staroslawska E., Sosman J., McDermott D., Bodrogi I., Kovacevic Z., Lesovoy V., Schmidt-Wolf I.G., Barbarash O., Gokmen E., O'Toole T., Lustgarten S., Moore L., Motzer R.J. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N. Engl. J. Med. 2007, 356:2271-2281.
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
Dutcher, J.4
Figlin, R.5
Kapoor, A.6
Staroslawska, E.7
Sosman, J.8
McDermott, D.9
Bodrogi, I.10
Kovacevic, Z.11
Lesovoy, V.12
Schmidt-Wolf, I.G.13
Barbarash, O.14
Gokmen, E.15
O'Toole, T.16
Lustgarten, S.17
Moore, L.18
Motzer, R.J.19
-
111
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial
-
Motzer R.J., Escudier B., Oudard S., Hutson T.E., Porta C., Bracarda S., Grunwald V., Thompson J.A., Figlin R.A., Hollaender N., Urbanowitz G., Berg W.J., Kay A., Lebwohl D., Ravaud A. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008, 372:449-456.
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
Hutson, T.E.4
Porta, C.5
Bracarda, S.6
Grunwald, V.7
Thompson, J.A.8
Figlin, R.A.9
Hollaender, N.10
Urbanowitz, G.11
Berg, W.J.12
Kay, A.13
Lebwohl, D.14
Ravaud, A.15
-
112
-
-
34748896515
-
Screening, diagnosis, and treatment of cancer in long-term dialysis patients
-
Holley J.L. Screening, diagnosis, and treatment of cancer in long-term dialysis patients. Clin. J. Am. Soc. Nephrol. 2007, 2:604-610.
-
(2007)
Clin. J. Am. Soc. Nephrol.
, vol.2
, pp. 604-610
-
-
Holley, J.L.1
|