Total synthesis and biological evaluation of (-)-englerin A and B: Synthesis of analogues with improved activity profile

Angewandte Chemie - International Edition

Volumn 50, Issue 17, 2011, Pages 3998-4002

  Radtke, Lea ^a   Willot, Matthieu ^a   Sun, Hongyan ^c   Ziegler, Slava ^c   Sauerland, Stephanie ^a   Strohmann, Carsten ^a   Fröhlich, Roland ^b   Habenberger, Peter ^d   Waldmann, Herbert ^a   Christmann, Mathias ^a  

^a TU DORTMUND UNIVERSITY   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^d Lead Discovery Center GmbH   (Germany)

Author keywords

guaianes; renal cancer; structure activity relationships; terpenes; total synthesis

Indexed keywords

GUAIANES; RENAL CANCER; STRUCTURE-ACTIVITY RELATIONSHIPS; TERPENES; TOTAL SYNTHESIS;

DISEASES; OLEFINS;

LIPIDS;

ANTINEOPLASTIC AGENT; ENGLERIN A; ENGLERIN B; SESQUITERPENE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; IC 50; KIDNEY TUMOR; PATHOLOGY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; INHIBITORY CONCENTRATION 50; KIDNEY NEOPLASMS; MOLECULAR STRUCTURE; SESQUITERPENES, GUAIANE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79954576625     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201007790     Document Type: Article

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