메뉴 건너뛰기




Volumn 112, Issue 9, 2015, Pages E1038-E1047

Mechanistic links between cellular trade-offs, gene expression, and growth

Author keywords

Evolutionarily stable strategy; Host circuit interactions; Mathematical cell model; Synthetic biology; Systems biology

Indexed keywords

ARTICLE; CELL ENERGY; CELL FUNCTION; CELL GROWTH; CELL INTERACTION; CELL POPULATION; CELL VOLUME; DAUGHTER CELL; DNA REPLICATION ORIGIN; ENERGY YIELD; ENZYME SUBSTRATE; ENZYME SYNTHESIS; ESCHERICHIA COLI; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GROWTH RATE; MICHAELIS CONSTANT; MICROBIAL GROWTH; MICROBIAL METABOLISM; MICROORGANISM; NEGATIVE FEEDBACK; NONHUMAN; NUTRIENT; PARALOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RIBOSOME; SACCHAROMYCES CEREVISIAE; STEADY STATE; SYNTHETIC BIOLOGY; TRANSCRIPTION ELONGATION; BACTERIAL PHENOMENA AND FUNCTIONS; BACTERIUM; BIOLOGICAL MODEL; CELL PROLIFERATION; METABOLISM; PHYSIOLOGY;

EID: 84924370996     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1416533112     Document Type: Article
Times cited : (301)

References (59)
  • 1
    • 72249097352 scopus 로고    scopus 로고
    • Growth rate-dependent global effects on gene expression in bacteria
    • Klumpp S, Zhang Z, Hwa T (2009) Growth rate-dependent global effects on gene expression in bacteria. Cell 139(7):1366-1375
    • (2009) Cell , vol.139 , Issue.7 , pp. 1366-1375
    • Klumpp, S.1    Zhang, Z.2    Hwa, T.3
  • 2
    • 78449268845 scopus 로고    scopus 로고
    • Interdependence of cell growth and gene expression: Origins and consequences
    • Scott M, Gunderson CW, Mateescu EM, Zhang Z, Hwa T (2010) Interdependence of cell growth and gene expression: Origins and consequences. Science 330(6007): 1099-1102
    • (2010) Science , vol.330 , Issue.6007 , pp. 1099-1102
    • Scott, M.1    Gunderson, C.W.2    Mateescu, E.M.3    Zhang, Z.4    Hwa, T.5
  • 3
    • 33845935641 scopus 로고    scopus 로고
    • Growth-rate regulated genes have profound impact on interpretation of transcriptome profiling in Saccharomyces cerevisiae
    • Regenberg B, et al. (2006) Growth-rate regulated genes have profound impact on interpretation of transcriptome profiling in Saccharomyces cerevisiae. Genome Biol 7(11):R107
    • (2006) Genome Biol , vol.7 , Issue.11 , pp. R107
    • Regenberg, B.1
  • 4
    • 38749112941 scopus 로고    scopus 로고
    • Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast
    • Brauer MJ, et al. (2008) Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast. Mol Biol Cell 19(1):352-367
    • (2008) Mol Biol Cell , vol.19 , Issue.1 , pp. 352-367
    • Brauer, M.J.1
  • 5
    • 84889244978 scopus 로고    scopus 로고
    • Promoters maintain their relative activity levels under different growth conditions
    • Keren L, et al. (2013) Promoters maintain their relative activity levels under different growth conditions. Mol Syst Biol 9:701
    • (2013) Mol Syst Biol , vol.9 , pp. 701
    • Keren, L.1
  • 6
    • 84873877553 scopus 로고    scopus 로고
    • Shared control of gene expression in bacteria by transcription factors and global physiology of the cell
    • Berthoumieux S, et al. (2013) Shared control of gene expression in bacteria by transcription factors and global physiology of the cell. Mol Syst Biol 9:634
    • (2013) Mol Syst Biol , vol.9 , pp. 634
    • Berthoumieux, S.1
  • 7
    • 84876548566 scopus 로고    scopus 로고
    • Dissecting specific and global transcriptional regulation of bacterial gene expression
    • Gerosa L, Kochanowski K, Heinemann M, Sauer U (2013) Dissecting specific and global transcriptional regulation of bacterial gene expression. Mol Syst Biol 9:658
    • (2013) Mol Syst Biol , vol.9 , pp. 658
    • Gerosa, L.1    Kochanowski, K.2    Heinemann, M.3    Sauer, U.4
  • 8
    • 84863322344 scopus 로고    scopus 로고
    • Contextualizing context for synthetic biology-identifying causes of failure of synthetic biological systems
    • Cardinale S, Arkin AP (2012) Contextualizing context for synthetic biology-identifying causes of failure of synthetic biological systems. Biotechnol J 7(7):856-866
    • (2012) Biotechnol J , vol.7 , Issue.7 , pp. 856-866
    • Cardinale, S.1    Arkin, A.P.2
  • 9
    • 84899694320 scopus 로고    scopus 로고
    • Principles of genetic circuit design
    • Brophy JAN, Voigt CA (2014) Principles of genetic circuit design. Nat Methods 11(5): 508-520
    • (2014) Nat Methods , vol.11 , Issue.5 , pp. 508-520
    • Brophy, J.A.N.1    Voigt, C.A.2
  • 10
  • 11
    • 84864258618 scopus 로고    scopus 로고
    • A whole-cell computational model predicts phenotype from genotype
    • Karr JR, et al. (2012) A whole-cell computational model predicts phenotype from genotype. Cell 150(2):389-401
    • (2012) Cell , vol.150 , Issue.2 , pp. 389-401
    • Karr, J.R.1
  • 12
    • 44949162900 scopus 로고    scopus 로고
    • A coarse-grained biophysical model of E. Coli and its application to perturbation of the rRNA operon copy number
    • Tadmor AD, Tlusty T (2008) A coarse-grained biophysical model of E. coli and its application to perturbation of the rRNA operon copy number. PLOS Comput Biol 4(4): e1000038
    • (2008) PLOS Comput Biol , vol.4 , Issue.4 , pp. e1000038
    • Tadmor, A.D.1    Tlusty, T.2
  • 13
    • 73149109962 scopus 로고    scopus 로고
    • Shifts in growth strategies reflect tradeoffs in cellular economics
    • Molenaar D, van Berlo R, de Ridder D, Teusink B (2009) Shifts in growth strategies reflect tradeoffs in cellular economics. Mol Syst Biol 5:323
    • (2009) Mol Syst Biol , vol.5 , pp. 323
    • Molenaar, D.1    Van Berlo, R.2    De Ridder, D.3    Teusink, B.4
  • 14
    • 84890818651 scopus 로고    scopus 로고
    • Optimal control of gene expression for fast proteome adaptation to environmental change
    • Pavlov MY, EhrenbergM(2013) Optimal control of gene expression for fast proteome adaptation to environmental change. Proc Natl Acad Sci USA 110(51):20527-20532
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.51 , pp. 20527-20532
    • Pavlov, M.Y.1    Ehrenberg, M.2
  • 15
    • 0001639179 scopus 로고
    • The growth of bacterial cultures
    • Monod J (1949) The growth of bacterial cultures. Annu Rev Microbiol 3:371-394
    • (1949) Annu Rev Microbiol , vol.3 , pp. 371-394
    • Monod, J.1
  • 16
    • 0001140586 scopus 로고
    • Dependency on medium and temperature of cell size and chemical composition during balanced grown of Salmonella typhimurium
    • Schaechter M, Maaloe O, Kjeldgaard NO (1958) Dependency on medium and temperature of cell size and chemical composition during balanced grown of Salmonella typhimurium. J Gen Microbiol 19(3):592-606
    • (1958) J Gen Microbiol , vol.19 , Issue.3 , pp. 592-606
    • Schaechter, M.1    Maaloe, O.2    Kjeldgaard, N.O.3
  • 17
    • 42649118786 scopus 로고    scopus 로고
    • Exposing the fitness contribution of duplicated genes
    • DeLuna A, et al. (2008) Exposing the fitness contribution of duplicated genes. Nat Genet 40(5):676-681
    • (2008) Nat Genet , vol.40 , Issue.5 , pp. 676-681
    • Deluna, A.1
  • 18
    • 0000892375 scopus 로고
    • Regulation of the protein synthesizing machinery - Ribosomes, tRNA, factors and so on
    • ed Goldberger RF Plenum, New York
    • Maaloe O (1979) Regulation of the protein synthesizing machinery - ribosomes, tRNA, factors and so on. Biological Regulation and Development, ed Goldberger RF (Plenum, New York), pp 487-542
    • (1979) Biological Regulation and Development , pp. 487-542
    • Maaloe, O.1
  • 19
    • 0000640710 scopus 로고    scopus 로고
    • Modulation of chemical composition and other parameters of the cell by growth rate
    • (American Soc Microbiology, Washington, DC)
    • Bremer H, Dennis PP (1996) Modulation of chemical composition and other parameters of the cell by growth rate. Escherichia coli and Salmonella: Cellular and Molecular Biology, ed Neidhardt FC (American Soc Microbiology, Washington, DC), pp 1553-1569
    • (1996) Escherichia Coli and Salmonella: Cellular and Molecular Biology, Ed Neidhardt FC , pp. 1553-1569
    • Bremer, H.1    Dennis, P.P.2
  • 20
    • 19544389317 scopus 로고    scopus 로고
    • Energy constraints on the evolution of gene expression
    • Wagner A (2005) Energy constraints on the evolution of gene expression. Mol Biol Evol 22(6):1365-1374
    • (2005) Mol Biol Evol , vol.22 , Issue.6 , pp. 1365-1374
    • Wagner, A.1
  • 21
    • 0021370660 scopus 로고
    • Costs of accuracy determined by a maximal growth rate constraint
    • Ehrenberg M, Kurland CG (1984) Costs of accuracy determined by a maximal growth rate constraint. Q Rev Biophys 17(1):45-82
    • (1984) Q Rev Biophys , vol.17 , Issue.1 , pp. 45-82
    • Ehrenberg, M.1    Kurland, C.G.2
  • 22
    • 79960943853 scopus 로고    scopus 로고
    • Bacterial growth laws and their applications
    • Scott M, Hwa T (2011) Bacterial growth laws and their applications. Curr Opin Biotechnol 22(4):559-565
    • (2011) Curr Opin Biotechnol , vol.22 , Issue.4 , pp. 559-565
    • Scott, M.1    Hwa, T.2
  • 23
    • 0016434646 scopus 로고
    • Cellular content of ribonucleic acid and protein in Saccharomyces cerevisiae as a function of exponential growth rate: Calculation of the apparent peptide chain elongation rate
    • Boehlke KW, Friesen JD (1975) Cellular content of ribonucleic acid and protein in Saccharomyces cerevisiae as a function of exponential growth rate: Calculation of the apparent peptide chain elongation rate. J Bacteriol 121(2):429-433
    • (1975) J Bacteriol , vol.121 , Issue.2 , pp. 429-433
    • Boehlke, K.W.1    Friesen, J.D.2
  • 24
    • 33645055663 scopus 로고    scopus 로고
    • Replication-associated gene dosage effects shape the genomes of fast-growing bacteria but only for transcription and translation genes
    • Couturier E, Rocha EP (2006) Replication-associated gene dosage effects shape the genomes of fast-growing bacteria but only for transcription and translation genes. Mol Microbiol 59(5):1506-1518
    • (2006) Mol Microbiol , vol.59 , Issue.5 , pp. 1506-1518
    • Couturier, E.1    Rocha, E.P.2
  • 25
    • 0014413357 scopus 로고
    • Chromosome replication and the division cycle of Escherichia coli B/r
    • Cooper S, Helmstetter CE (1968) Chromosome replication and the division cycle of Escherichia coli B/r. J Mol Biol 31(3):519-540
    • (1968) J Mol Biol , vol.31 , Issue.3 , pp. 519-540
    • Cooper, S.1    Helmstetter, C.E.2
  • 26
    • 0347033256 scopus 로고    scopus 로고
    • Role of duplicate genes in genetic robustness against null mutations
    • Gu Z, et al. (2003) Role of duplicate genes in genetic robustness against null mutations. Nature 421(6918):63-66
    • (2003) Nature , vol.421 , Issue.6918 , pp. 63-66
    • Gu, Z.1
  • 27
    • 77950585365 scopus 로고    scopus 로고
    • Need-based up-regulation of protein levels in response to deletion of their duplicate genes
    • DeLuna A, Springer M, Kirschner MW, Kishony R (2010) Need-based up-regulation of protein levels in response to deletion of their duplicate genes. PLoS Biol 8(3): e1000347
    • (2010) PLoS Biol , vol.8 , Issue.3 , pp. e1000347
    • Deluna, A.1    Springer, M.2    Kirschner, M.W.3    Kishony, R.4
  • 28
    • 79952645848 scopus 로고    scopus 로고
    • Informing biological design by integration of systems and synthetic biology
    • Smolke CD, Silver PA (2011) Informing biological design by integration of systems and synthetic biology. Cell 144(6):855-859
    • (2011) Cell , vol.144 , Issue.6 , pp. 855-859
    • Smolke, C.D.1    Silver, P.A.2
  • 29
    • 70350324632 scopus 로고    scopus 로고
    • Emergent bistability by a growth-modulating positive feedback circuit
    • Tan C, Marguet P, You L (2009) Emergent bistability by a growth-modulating positive feedback circuit. Nat Chem Biol 5(11):842-848
    • (2009) Nat Chem Biol , vol.5 , Issue.11 , pp. 842-848
    • Tan, C.1    Marguet, P.2    You, L.3
  • 30
    • 79952214973 scopus 로고    scopus 로고
    • Synthetic circuit identifies subpopulations with sustained memory of DNA damage
    • Burrill DR, Silver PA (2011) Synthetic circuit identifies subpopulations with sustained memory of DNA damage. Genes Dev 25(5):434-439
    • (2011) Genes Dev , vol.25 , Issue.5 , pp. 434-439
    • Burrill, D.R.1    Silver, P.A.2
  • 31
    • 79959936732 scopus 로고    scopus 로고
    • Empirical model and in vivo characterization of the bacterial response to synthetic gene expression show that ribosome allocation limits growth rate
    • Carrera J, Rodrigo G, Singh V, Kirov B, Jaramillo A (2011) Empirical model and in vivo characterization of the bacterial response to synthetic gene expression show that ribosome allocation limits growth rate. Biotechnol J 6(7):773-783
    • (2011) Biotechnol J , vol.6 , Issue.7 , pp. 773-783
    • Carrera, J.1    Rodrigo, G.2    Singh, V.3    Kirov, B.4    Jaramillo, A.5
  • 32
    • 84868625270 scopus 로고    scopus 로고
    • Queueing up for enzymatic processing: Correlated signaling through coupled degradation
    • Cookson NA, et al. (2011) Queueing up for enzymatic processing: Correlated signaling through coupled degradation. Mol Syst Biol 7:561
    • (2011) Mol Syst Biol , vol.7 , pp. 561
    • Cookson, N.A.1
  • 34
    • 84880371084 scopus 로고    scopus 로고
    • Towards a whole-cell modeling approach for synthetic biology
    • Purcell O, Jain B, Karr JR, Covert MW, Lu TK (2013) Towards a whole-cell modeling approach for synthetic biology. Chaos 23(2):025112
    • (2013) Chaos , vol.23 , Issue.2 , pp. 025112
    • Purcell, O.1    Jain, B.2    Karr, J.R.3    Covert, M.W.4    Lu, T.K.5
  • 35
    • 84874619884 scopus 로고    scopus 로고
    • Transferring a synthetic gene circuit from yeast to mammalian cells
    • Nevozhay D, Zal T, Balázsi G (2013) Transferring a synthetic gene circuit from yeast to mammalian cells. Nat Commun 4:1451
    • (2013) Nat Commun , vol.4 , pp. 1451
    • Nevozhay, D.1    Zal, T.2    Balázsi, G.3
  • 36
    • 0034688173 scopus 로고    scopus 로고
    • A synthetic oscillatory network of transcriptional regulators
    • Elowitz MB, Leibler S (2000) A synthetic oscillatory network of transcriptional regulators. Nature 403(6767):335-338
    • (2000) Nature , vol.403 , Issue.6767 , pp. 335-338
    • Elowitz, M.B.1    Leibler, S.2
  • 38
    • 0031904590 scopus 로고    scopus 로고
    • Demand theory of gene regulation I. Quantitative development of the theory
    • Savageau MA (1998) Demand theory of gene regulation. I. Quantitative development of the theory. Genetics 149(4):1665-1676
    • (1998) Genetics , vol.149 , Issue.4 , pp. 1665-1676
    • Savageau, M.A.1
  • 39
    • 33645222401 scopus 로고    scopus 로고
    • Rules for biological regulation based on error minimization
    • Shinar G, Dekel E, Tlusty T, Alon U (2006) Rules for biological regulation based on error minimization. Proc Natl Acad Sci USA 103(11):3999-4004
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.11 , pp. 3999-4004
    • Shinar, G.1    Dekel, E.2    Tlusty, T.3    Alon, U.4
  • 40
    • 84857672615 scopus 로고    scopus 로고
    • Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism
    • Buescher JM, et al. (2012) Global network reorganization during dynamic adaptations of Bacillus subtilis metabolism. Science 335(6072):1099-1103
    • (2012) Science , vol.335 , Issue.6072 , pp. 1099-1103
    • Buescher, J.M.1
  • 41
    • 34548719708 scopus 로고
    • The logic of animal conflict
    • Smith JM, Price GR (1973) The logic of animal conflict. Nature 246:15-18
    • (1973) Nature , vol.246 , pp. 15-18
    • Smith, J.M.1    Price, G.R.2
  • 43
    • 0038441327 scopus 로고    scopus 로고
    • Evolution experiments with microorganisms: The dynamics and genetic bases of adaptation
    • Elena SF, Lenski RE (2003) Evolution experiments with microorganisms: The dynamics and genetic bases of adaptation. Nat Rev Genet 4(6):457-469
    • (2003) Nat Rev Genet , vol.4 , Issue.6 , pp. 457-469
    • Elena, S.F.1    Lenski, R.E.2
  • 44
    • 58149166731 scopus 로고    scopus 로고
    • The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast
    • Gresham D, et al. (2008) The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast. PLoS Genet 4(12):e1000303
    • (2008) PLoS Genet , vol.4 , Issue.12 , pp. e1000303
    • Gresham, D.1
  • 45
    • 0035917865 scopus 로고    scopus 로고
    • Cooperation and competition in the evolution of ATP-producing pathways
    • Pfeiffer T, Schuster S, Bonhoeffer S (2001) Cooperation and competition in the evolution of ATP-producing pathways. Science 292(5516):504-507
    • (2001) Science , vol.292 , Issue.5516 , pp. 504-507
    • Pfeiffer, T.1    Schuster, S.2    Bonhoeffer, S.3
  • 46
    • 77749292011 scopus 로고    scopus 로고
    • The trade-off between rate and yield in the design of microbial metabolism
    • Frank SA (2010) The trade-off between rate and yield in the design of microbial metabolism. J Evol Biol 23(3):609-613
    • (2010) J Evol Biol , vol.23 , Issue.3 , pp. 609-613
    • Frank, S.A.1
  • 47
    • 84866315109 scopus 로고    scopus 로고
    • Pareto evolution of gene networks: An algorithm to optimize multiple fitness objectives
    • Warmflash A, François P, Siggia ED (2012) Pareto evolution of gene networks: An algorithm to optimize multiple fitness objectives. Phys Biol 9(5):056001
    • (2012) Phys Biol , vol.9 , Issue.5 , pp. 056001
    • Warmflash, A.1    François, P.2    Siggia, E.D.3
  • 49
    • 0016730809 scopus 로고
    • Effect of growth rate on the amounts of ribosomal and transfer ribonucleic acids in yeast
    • Waldron C, Lacroute F (1975) Effect of growth rate on the amounts of ribosomal and transfer ribonucleic acids in yeast. J Bacteriol 122(3):855-865
    • (1975) J Bacteriol , vol.122 , Issue.3 , pp. 855-865
    • Waldron, C.1    Lacroute, F.2
  • 50
    • 84885773167 scopus 로고    scopus 로고
    • Molecular crowding limits translation and cell growth
    • Klumpp S, Scott M, Pedersen S, Hwa T (2013) Molecular crowding limits translation and cell growth. Proc Natl Acad Sci USA 110(42):16754-16759
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.42 , pp. 16754-16759
    • Klumpp, S.1    Scott, M.2    Pedersen, S.3    Hwa, T.4
  • 51
    • 70350769418 scopus 로고    scopus 로고
    • Nonoptimal microbial response to antibiotics underlies suppressive drug interactions
    • Bollenbach T, Quan S, Chait R, Kishony R (2009) Nonoptimal microbial response to antibiotics underlies suppressive drug interactions. Cell 139(4):707-718
    • (2009) Cell , vol.139 , Issue.4 , pp. 707-718
    • Bollenbach, T.1    Quan, S.2    Chait, R.3    Kishony, R.4
  • 52
    • 84888791540 scopus 로고    scopus 로고
    • The innate growth bistability and fitness landscapes of antibiotic- resistant bacteria
    • Deris JB, et al. (2013) The innate growth bistability and fitness landscapes of antibiotic- resistant bacteria. Science 342(6162):1237435
    • (2013) Science , vol.342 , Issue.6162 , pp. 1237435
    • Deris, J.B.1
  • 53
    • 84859633048 scopus 로고    scopus 로고
    • Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids
    • Zhang F, Carothers JM, Keasling JD (2012) Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids. Nat Biotechnol 30(4):354-359
    • (2012) Nat Biotechnol , vol.30 , Issue.4 , pp. 354-359
    • Zhang, F.1    Carothers, J.M.2    Keasling, J.D.3
  • 54
    • 84871347056 scopus 로고    scopus 로고
    • Synthetic gene circuits for metabolic control: Design trade-offs and constraints
    • Oyarzún DA, Stan GBV (2013) Synthetic gene circuits for metabolic control: Design trade-offs and constraints. J R Soc Interface 10:20120671
    • (2013) J R Soc Interface , vol.10 , pp. 20120671
    • Oyarzún, D.A.1    Stan, G.B.V.2
  • 55
    • 0037363075 scopus 로고    scopus 로고
    • Does the ribosome translate cancer?
    • Ruggero D, Pandolfi PP (2003) Does the ribosome translate cancer? Nat Rev Cancer 3(3):179-192
    • (2003) Nat Rev Cancer , vol.3 , Issue.3 , pp. 179-192
    • Ruggero, D.1    Pandolfi, P.P.2
  • 56
    • 84907334654 scopus 로고    scopus 로고
    • Emergence of robust growth laws from optimal regulation of ribosome synthesis
    • Scott M, Klumpp S, Mateescu EM, Hwa T (2014) Emergence of robust growth laws from optimal regulation of ribosome synthesis. Mol Syst Biol 10:747
    • (2014) Mol Syst Biol , vol.10 , pp. 747
    • Scott, M.1    Klumpp, S.2    Mateescu, E.M.3    Hwa, T.4
  • 57
    • 84949114770 scopus 로고    scopus 로고
    • Bacterial growth laws reflect the evolutionary importance of energy efficiency
    • Maitra A, Dill KA (2015) Bacterial growth laws reflect the evolutionary importance of energy efficiency. Proc Natl Acad Sci USA 112(2):406-411
    • (2015) Proc Natl Acad Sci USA , vol.112 , Issue.2 , pp. 406-411
    • Maitra, A.1    Dill, K.A.2
  • 59
    • 79957743805 scopus 로고    scopus 로고
    • Sensitivity, robustness, and identifiability in stochastic chemical kinetics models
    • Komorowski M, Costa MJ, Rand DA, Stumpf MPH (2011) Sensitivity, robustness, and identifiability in stochastic chemical kinetics models. Proc Natl Acad Sci USA 108(21): 8645-8650.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.21 , pp. 8645-8650
    • Komorowski, M.1    Costa, M.J.2    Rand, D.A.3    Stumpf, M.P.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.