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Volumn 4, Issue , 2013, Pages

Transferring a synthetic gene circuit from yeast to mammalian cells

Author keywords

[No Author keywords available]

Indexed keywords

SILICON; SYNTHETIC DNA;

EID: 84874619884     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms2471     Document Type: Article
Times cited : (73)

References (60)
  • 1
    • 77951107086 scopus 로고    scopus 로고
    • Synthetic biology: Applications come of age
    • Khalil, A. S. & Collins, J. J. Synthetic biology: applications come of age. Nat. Rev. Genet. 11, 367-379 (2010)
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 367-379
    • Khalil, A.S.1    Collins, J.J.2
  • 2
    • 66249088017 scopus 로고    scopus 로고
    • The second wave of synthetic biology: From modules to systems
    • Purnick, P. E. & Weiss, R. The second wave of synthetic biology: from modules to systems. Nat. Rev. Mol. Cell. Biol. 10, 410-422 (2009)
    • (2009) Nat. Rev. Mol. Cell. Biol. , vol.10 , pp. 410-422
    • Purnick, P.E.1    Weiss, R.2
  • 3
    • 33846950348 scopus 로고    scopus 로고
    • Challenges in engineering microbes for biofuels production
    • Stephanopoulos, G. Challenges in engineering microbes for biofuels production. Science 315, 801-804 (2007)
    • (2007) Science , vol.315 , pp. 801-804
    • Stephanopoulos, G.1
  • 4
    • 33645870422 scopus 로고    scopus 로고
    • Production of the antimalarial drug precursor artemisinic acid in engineered yeast
    • Ro, D. K. et al. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440, 940-943 (2006)
    • (2006) Nature , vol.440 , pp. 940-943
    • Ro, D.K.1
  • 5
    • 17844374314 scopus 로고    scopus 로고
    • A synthetic multicellular system for programmed pattern formation
    • DOI 10.1038/nature03461
    • Basu, S., Gerchman, Y., Collins, C. H., Arnold, F. H. & Weiss, R. A synthetic multicellular system for programmed pattern formation. Nature 434, 1130-1134 (2005) (Pubitemid 40663491)
    • (2005) Nature , vol.434 , Issue.7037 , pp. 1130-1134
    • Basu, S.1    Gerchman, Y.2    Collins, C.H.3    Arnold, F.H.4    Weiss, R.5
  • 6
    • 0034688173 scopus 로고    scopus 로고
    • A synthetic oscillatory network of transcriptional regulators
    • DOI 10.1038/35002125
    • Elowitz, M. B. & Leibler, S. A synthetic oscillatory network of transcriptional regulators. Nature 403, 335-338 (2000) (Pubitemid 30062393)
    • (2000) Nature , vol.403 , Issue.6767 , pp. 335-338
    • Elowitz, M.B.1    Leibier, S.2
  • 7
    • 0034688174 scopus 로고    scopus 로고
    • Construction of a genetic toggle switch in Escherichia coli
    • DOI 10.1038/35002131
    • Gardner, T. S., Cantor, C. R. & Collins, J. J. Construction of a genetic toggle switch in Escherichia coli. Nature 403, 339-342 (2000) (Pubitemid 30062394)
    • (2000) Nature , vol.403 , Issue.6767 , pp. 339-342
    • Gardner, T.S.1    Cantor, C.R.2    Collins, J.J.3
  • 9
    • 67549145283 scopus 로고    scopus 로고
    • A synthetic genetic edge detection program
    • Tabor, J. J. et al. A synthetic genetic edge detection program. Cell 137, 1272-1281 (2009)
    • (2009) Cell , vol.137 , pp. 1272-1281
    • Tabor, J.J.1
  • 10
    • 54249113318 scopus 로고    scopus 로고
    • Higher-order cellular information processing with synthetic RNA devices
    • Win, M. N. & Smolke, C. D. Higher-order cellular information processing with synthetic RNA devices. Science 322, 456-460 (2008)
    • (2008) Science , vol.322 , pp. 456-460
    • Win, M.N.1    Smolke, C.D.2
  • 11
    • 73549083223 scopus 로고    scopus 로고
    • Spatiotemporal modulation of biodiversity in a synthetic chemical-mediated ecosystem
    • Song, H., Payne, S., Gray, M. & You, L. Spatiotemporal modulation of biodiversity in a synthetic chemical-mediated ecosystem. Nat. Chem. Biol. 5, 929-935 (2009)
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 929-935
    • Song, H.1    Payne, S.2    Gray, M.3    You, L.4
  • 12
    • 34447505900 scopus 로고    scopus 로고
    • A tunable genetic switch based on RNAi and repressor proteins for regulating gene expression in mammalian cells
    • DOI 10.1016/j.cell.2007.05.045, PII S0092867407006848
    • Deans, T. L., Cantor, C. R. & Collins, J. J. A tunable genetic switch based on RNAi and repressor proteins for regulating gene expression in mammalian cells. Cell 130, 363-372 (2007) (Pubitemid 47081136)
    • (2007) Cell , vol.130 , Issue.2 , pp. 363-372
    • Deans, T.L.1    Cantor, C.R.2    Collins, J.J.3
  • 13
    • 79957457314 scopus 로고    scopus 로고
    • De novo design and construction of an inducible gene expression system in mammalian cells
    • Karlsson, M., Weber, W. & Fussenegger, M. De novo design and construction of an inducible gene expression system in mammalian cells. Methods Enzymol. 497, 239-253 (2011)
    • (2011) Methods Enzymol. , vol.497 , pp. 239-253
    • Karlsson, M.1    Weber, W.2    Fussenegger, M.3
  • 14
    • 80051486871 scopus 로고    scopus 로고
    • Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template
    • Bleris, L. et al. Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template. Mol. Syst. Biol. 7, 519 (2011)
    • (2011) Mol. Syst. Biol. , vol.7 , pp. 519
    • Bleris, L.1
  • 16
    • 77956431677 scopus 로고    scopus 로고
    • Rationally designed logic integration of regulatory signals in mammalian cells
    • Leisner, M., Bleris, L., Lohmueller, J., Xie, Z. & Benenson, Y. Rationally designed logic integration of regulatory signals in mammalian cells. Nat. Nanotechnol. 5, 666-670 (2010)
    • (2010) Nat. Nanotechnol. , vol.5 , pp. 666-670
    • Leisner, M.1    Bleris, L.2    Lohmueller, J.3    Xie, Z.4    Benenson, Y.5
  • 17
    • 84863644753 scopus 로고    scopus 로고
    • Synthetic memory circuits for tracking human cell fate
    • Burrill, D. R., Inniss, M. C., Boyle, P. M. & Silver, P. A. Synthetic memory circuits for tracking human cell fate. Genes Dev. 26, 1486-1497 (2012)
    • (2012) Genes Dev. , vol.26 , pp. 1486-1497
    • Burrill, D.R.1    Inniss, M.C.2    Boyle, P.M.3    Silver, P.A.4
  • 20
    • 78649429678 scopus 로고    scopus 로고
    • Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins
    • Culler, S. J., Hoff, K. G. & Smolke, C. D. Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins. Science 330, 1251-1255 (2010)
    • (2010) Science , vol.330 , pp. 1251-1255
    • Culler, S.J.1    Hoff, K.G.2    Smolke, C.D.3
  • 21
    • 80052456127 scopus 로고    scopus 로고
    • Multi-input RNAi-based logic circuit for identification of specific cancer cells
    • Xie, Z., Wroblewska, L., Prochazka, L., Weiss, R. & Benenson, Y. Multi-input RNAi-based logic circuit for identification of specific cancer cells. Science 333, 1307-1311 (2011)
    • (2011) Science , vol.333 , pp. 1307-1311
    • Xie, Z.1    Wroblewska, L.2    Prochazka, L.3    Weiss, R.4    Benenson, Y.5
  • 22
    • 80052484996 scopus 로고    scopus 로고
    • Synthetic biology moving into the clinic
    • Ruder, W. C., Lu, T. & Collins, J. J. Synthetic biology moving into the clinic. Science 333, 1248-1252 (2011)
    • (2011) Science , vol.333 , pp. 1248-1252
    • Ruder, W.C.1    Lu, T.2    Collins, J.J.3
  • 25
    • 0035491607 scopus 로고    scopus 로고
    • Conditional control of gene expression in the mouse
    • DOI 10.1038/35093537
    • Lewandoski, M. Conditional control of gene expression in the mouse. Nat. Rev. Genet. 2, 743-755 (2001) (Pubitemid 33685572)
    • (2001) Nature Reviews Genetics , vol.2 , Issue.10 , pp. 743-755
    • Lewandoski, M.1
  • 26
    • 0024024137 scopus 로고
    • Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression
    • Triezenberg, S. J., Kingsbury, R. C. & McKnight, S. L. Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression. Genes Dev. 2, 718-729 (1988)
    • (1988) Genes Dev. , vol.2 , pp. 718-729
    • Triezenberg, S.J.1    Kingsbury, R.C.2    McKnight, S.L.3
  • 27
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen, M. & Bujard, H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl Acad. Sci. USA 89, 5547-5551 (1992)
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 28
    • 57849135041 scopus 로고    scopus 로고
    • RtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse
    • Morimoto, M. & Kopan, R. rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse. Dev. Biol. 325, 171-178 (2009)
    • (2009) Dev. Biol. , vol.325 , pp. 171-178
    • Morimoto, M.1    Kopan, R.2
  • 29
    • 0032170171 scopus 로고    scopus 로고
    • Tetracycline repressor, tetR, rather than the tetR-mammalian cell transcription factor fusion derivatives, regulates inducible gene expression in mammalian cells
    • Yao, F. et al. Tetracycline repressor, tetR, rather than the tetR-mammalian cell transcription factor fusion derivatives, regulates inducible gene expression in mammalian cells. Hum. Gene Ther. 9, 1939-1950 (1998) (Pubitemid 28439099)
    • (1998) Human Gene Therapy , vol.9 , Issue.13 , pp. 1939-1950
    • Yao, F.1    Svensjo, T.2    Winkler, T.3    Lu, M.4    Eriksson, C.5    Eriksson, E.6
  • 30
    • 0023666091 scopus 로고
    • The inducible lac operator-repressor system is functional in mammalian cells
    • Hu, M. C. & Davidson, N. The inducible lac operator-repressor system is functional in mammalian cells. Cell 48, 555-566 (1987)
    • (1987) Cell , vol.48 , pp. 555-566
    • Hu, M.C.1    Davidson, N.2
  • 31
    • 0041930790 scopus 로고    scopus 로고
    • Artificial regulatory networks and cascades for discrete multilevel transgene control in mammalian cells
    • DOI 10.1002/bit.10731
    • Kramer, B. P., Weber, W. & Fussenegger, M. Artificial regulatory networks and cascades for discrete multilevel transgene control in mammalian cells. Biotechnol. Bioeng. 83, 810-820 (2003) (Pubitemid 37039602)
    • (2003) Biotechnology and Bioengineering , vol.83 , Issue.7 , pp. 810-820
    • Kramer, B.P.1    Weber, W.2    Fussenegger, M.3
  • 32
    • 41649103031 scopus 로고    scopus 로고
    • Turning the gene tap off; implications of regulating gene expression for cancer therapeutics
    • DOI 10.1158/1535-7163.MCT-07-2328
    • Curtin, J. F., Candolfi, M., Xiong, W., Lowenstein, P. R. & Castro, M. G. Turning the gene tap off; implications of regulating gene expression for cancer therapeutics. Mol. Cancer Ther. 7, 439-448 (2008) (Pubitemid 351482126)
    • (2008) Molecular Cancer Therapeutics , vol.7 , Issue.3 , pp. 439-448
    • Curtin, J.F.1    Candolfi, M.2    Xiong, W.3    Lowenstein, P.R.4    Castro, M.G.5
  • 33
    • 50549093286 scopus 로고    scopus 로고
    • Gene transfer: The challenge of regulated gene expression
    • Guo, Z. S., Li, Q., Bartlett, D. L., Yang, J. Y. & Fang, B. Gene transfer: the challenge of regulated gene expression. Trends Mol. Med. 14, 410-418 (2008)
    • (2008) Trends Mol. Med. , vol.14 , pp. 410-418
    • Guo, Z.S.1    Li, Q.2    Bartlett, D.L.3    Yang, J.Y.4    Fang, B.5
  • 34
    • 33748195107 scopus 로고    scopus 로고
    • A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules
    • DOI 10.1016/j.cell.2006.07.025, PII S0092867406010130
    • Banaszynski, L. A., Chen, L. C., Maynard-Smith, L. A., Ooi, A. G. & Wandless, T. J. A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell 126, 995-1004 (2006) (Pubitemid 44310772)
    • (2006) Cell , vol.126 , Issue.5 , pp. 995-1004
    • Banaszynski, L.A.1    Chen, L.-c.2    Maynard-Smith, L.A.3    Ooi, A.G.L.4    Wandless, T.J.5
  • 35
    • 62549083590 scopus 로고    scopus 로고
    • Negative autoregulation linearizes the dose-response and suppresses the heterogeneity of gene expression
    • Nevozhay, D., Adams, R. M., Murphy, K. F., Josic, K. & Balázsi, G. Negative autoregulation linearizes the dose-response and suppresses the heterogeneity of gene expression. Proc. Natl Acad. Sci. USA 106, 5123-5128 (2009)
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 5123-5128
    • Nevozhay, D.1    Adams, R.M.2    Murphy, K.F.3    Josic, K.4    Balázsi, G.5
  • 37
    • 0022371467 scopus 로고
    • A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus
    • Boshart, M. et al. A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus. Cell 41, 521-530 (1985) (Pubitemid 16219422)
    • (1985) Cell , vol.41 , Issue.2 , pp. 521-530
    • Boshart, M.1    Weber, F.2    Jahn, G.3
  • 38
    • 0015762456 scopus 로고
    • A human cell line from a pleural effusion derived from a breast carcinoma
    • Soule, H. D., Vazguez, J., Long, A., Albert, S. & Brennan, M. A human cell line from a pleural effusion derived from a breast carcinoma. J. Natl Cancer Inst. 51, 1409-1416 (1973)
    • (1973) J. Natl Cancer Inst. , vol.51 , pp. 1409-1416
    • Soule, H.D.1    Vazguez, J.2    Long, A.3    Albert, S.4    Brennan, M.5
  • 39
    • 0027501690 scopus 로고
    • Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements
    • DOI 10.1016/0968-0004(93)90009-C
    • Gossen, M., Bonin, A. L. & Bujard, H. Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements. Trends Biochem. Sci. 18, 471-475 (1993) (Pubitemid 23362304)
    • (1993) Trends in Biochemical Sciences , vol.18 , Issue.12 , pp. 471-475
    • Gossen, M.1    Bonin, A.L.2    Bujard, H.3
  • 41
    • 77952492425 scopus 로고    scopus 로고
    • Tuning and controlling gene expression noise in synthetic gene networks
    • Murphy, K. F., Adams, R. M., Wang, X., Balázsi, G. & Collins, J. J. Tuning and controlling gene expression noise in synthetic gene networks. Nucleic Acids Res. 38, 2712-2726 (2010)
    • (2010) Nucleic Acids Res. , vol.38 , pp. 2712-2726
    • Murphy, K.F.1    Adams, R.M.2    Wang, X.3    Balázsi, G.4    Collins, J.J.5
  • 42
    • 0038780670 scopus 로고    scopus 로고
    • Eukaryotic intron loss
    • DOI 10.1126/science.1080559
    • Mourier, T. & Jeffares, D. C. Eukaryotic intron loss. Science 300, 1393 (2003) (Pubitemid 36638151)
    • (2003) Science , vol.300 , Issue.5624 , pp. 1393
    • Mourier, T.1    Jeffares, D.C.2
  • 44
    • 0025906388 scopus 로고
    • A generic intron increases gene expression in transgenic mice
    • Choi, T., Huang, M., Gorman, C. & Jaenisch, R. A generic intron increases gene expression in transgenic mice. Mol. Cell. Biol. 11, 3070-3074 (1991) (Pubitemid 21895693)
    • (1991) Molecular and Cellular Biology , vol.11 , Issue.6 , pp. 3070-3074
    • Choi, T.1    Huang, M.2    Gorman, C.3    Jaenisch, R.4
  • 45
    • 51149120433 scopus 로고    scopus 로고
    • Intron-mediated regulation of gene expression
    • Rose, A. B. Intron-mediated regulation of gene expression. Curr. Top Microbiol. Immunol. 326, 277-290 (2008)
    • (2008) Curr. Top Microbiol. Immunol. , vol.326 , pp. 277-290
    • Rose, A.B.1
  • 46
    • 0025269031 scopus 로고
    • Intervening sequences increase efficiency of RNA 3' processing and accumulation of cytoplasmic RNA
    • Huang, M. T. & Gorman, C. M. Intervening sequences increase efficiency of RNA 3' processing and accumulation of cytoplasmic RNA. Nucleic Acids Res. 18, 937-947 (1990)
    • (1990) Nucleic Acids Res. , vol.18 , pp. 937-947
    • Huang, M.T.1    Gorman, C.M.2
  • 47
    • 0018688932 scopus 로고
    • Comparison of total sequence of a cloned rabbit β-globin gene and its flanking regions with a homologous mouse sequence
    • van Ooyen, A., van den Berg, J., Mantei, N. & Weissmann, C. Comparison of total sequence of a cloned rabbit beta-globin gene and its flanking regions with a homologous mouse sequence. Science 206, 337-344 (1979) (Pubitemid 10244190)
    • (1979) Science , vol.206 , Issue.4416 , pp. 337-344
    • Van Ooyen, A.1    Van Den Berg, J.2    Mantei, N.3    Weissmann, C.4
  • 48
    • 0033516966 scopus 로고    scopus 로고
    • Codon optimization effect on translational efficiency of DNA vaccine in mammalian cells: Analysis of plasmid DNA encoding a CTL epitope derived from microorganisms
    • DOI 10.1006/bbrc.1999.1050
    • Nagata, T., Uchijima, M., Yoshida, A., Kawashima, M. & Koide, Y. Codon optimization effect on translational efficiency of DNA vaccine in mammalian cells: analysis of plasmid DNA encoding a CTL epitope derived from microorganisms. Biochem. Biophys. Res. Commun. 261, 445-451 (1999) (Pubitemid 29392495)
    • (1999) Biochemical and Biophysical Research Communications , vol.261 , Issue.2 , pp. 445-451
    • Nagata, T.1    Uchijima, M.2    Yoshida, A.3    Kawashima, M.4    Koide, Y.5
  • 49
    • 0029909407 scopus 로고    scopus 로고
    • Optimized codon usage and chromophore mutations provide enhanced sensitivity with the green fluorescent protein
    • DOI 10.1093/nar/24.22.4592
    • Yang, T. T., Cheng, L. & Kain, S. R. Optimized codon usage and chromophore mutations provide enhanced sensitivity with the green fluorescent protein. Nucleic Acids Res. 24, 4592-4593 (1996) (Pubitemid 26388650)
    • (1996) Nucleic Acids Research , vol.24 , Issue.22 , pp. 4592-4593
    • Yang, T.-T.1    Cheng, L.2    Kain, S.R.3
  • 50
    • 0021716406 scopus 로고
    • A short amino acid sequence able to specify nuclear location
    • Kalderon, D., Roberts, B. L., Richardson, W. D. & Smith, A. E. A short amino acid sequence able to specify nuclear location. Cell 39, 499-509 (1984) (Pubitemid 15198589)
    • (1984) Cell , vol.39 , Issue.3 , pp. 499-509
    • Kalderon, D.1    Roberts, B.L.2    Richardson, W.D.3    Smith, A.E.4
  • 51
    • 33645103149 scopus 로고    scopus 로고
    • Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expression
    • Schambach, A. et al. Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expression. Gene Ther. 13, 641-645 (2006)
    • (2006) Gene Ther. , vol.13 , pp. 641-645
    • Schambach, A.1
  • 52
    • 0023665902 scopus 로고
    • An analysis of 50-noncoding sequences from 699 vertebrate messenger RNAs
    • Kozak, M. An analysis of 50-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15, 8125-8148 (1987)
    • (1987) Nucleic Acids Res. , vol.15 , pp. 8125-8148
    • Kozak, M.1
  • 53
    • 33750345805 scopus 로고    scopus 로고
    • Rational design of a super core promoter that enhances gene expression
    • DOI 10.1038/nmeth937, PII NMETH937
    • Juven-Gershon, T., Cheng, S. & Kadonaga, J. T. Rational design of a super core promoter that enhances gene expression. Nat. Methods 3, 917-922 (2006) (Pubitemid 44614727)
    • (2006) Nature Methods , vol.3 , Issue.11 , pp. 917-922
    • Juven-Gershon, T.1    Cheng, S.2    Kadonaga, J.T.3
  • 56
    • 57849135041 scopus 로고    scopus 로고
    • RtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse
    • Morimoto, M. & Kopan, R. rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse. Dev. Biol. 325, 171-178 (2009)
    • (2009) Dev. Biol. , vol.325 , pp. 171-178
    • Morimoto, M.1    Kopan, R.2
  • 57
    • 0026463972 scopus 로고
    • Transgenic mice with a rhodopsin mutation (Pro23His): A mouse model of autosomal dominant retinitis pigmentosa
    • Olsson, J. E. et al. Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa. Neuron 9, 815-830 (1992)
    • (1992) Neuron , vol.9 , pp. 815-830
    • Olsson, J.E.1
  • 58
    • 46949091517 scopus 로고    scopus 로고
    • Refinement and standardization of synthetic biological parts and devices
    • DOI 10.1038/nbt1413, PII NBT1413
    • Canton, B., Labno, A. & Endy, D. Refinement and standardization of synthetic biological parts and devices. Nat. Biotechnol. 26, 787-793 (2008) (Pubitemid 351961452)
    • (2008) Nature Biotechnology , vol.26 , Issue.7 , pp. 787-793
    • Canton, B.1    Labno, A.2    Endy, D.3
  • 59
    • 65949097067 scopus 로고    scopus 로고
    • FlowCore: A bioconductor package for high throughput flow cytometry
    • Hahne, F. et al. flowCore: a bioconductor package for high throughput flow cytometry. BMC Bioinform. 10, 106 (2009)
    • (2009) BMC Bioinform. , vol.10 , pp. 106
    • Hahne, F.1
  • 60
    • 17644372713 scopus 로고    scopus 로고
    • Dizzy: Stochastic simulation of large-scale genetic regulatory networks (supplementary material)
    • DOI 10.1142/S0219720005001144, PII S0219720005001144
    • Ramsey, S., Orrell, D. & Bolouri, H. Dizzy: stochastic simulation of large-scale genetic regulatory networks (supplementary material). J. Bioinform. Comput. Biol. 3, 437-454 (2005). (Pubitemid 40561396)
    • (2005) Journal of Bioinformatics and Computational Biology , vol.3 , Issue.2 , pp. 437-454
    • Ramsey, S.1    Orrell, D.2    Bolouri, H.3


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