Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor

Journal of the American Chemical Society

Volumn 137, Issue 8, 2015, Pages 2996-3003

  Dziedzic, Pawel ^a   Cisneros, José A ^a   Robertson, Michael J ^a   Hare, Alissa A ^a   Danford, Nadia E ^a   Baxter, Richard H G ^a   Jorgensen, William L ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; COMPLEXATION; CRYSTALLOGRAPHY; DISEASES; FREE ENERGY; MACROPHAGES; X RAY CRYSTALLOGRAPHY;

FREE ENERGY PERTURBATION; HUMAN MACROPHAGES; INFLAMMATORY DISEASE; MIGRATION INHIBITORY FACTORS; PHENOLIC HYDROXYL GROUP; PROINFLAMMATORY CYTOKINES; PROTEIN CRYSTALLOGRAPHY; X RAY CRYSTAL STRUCTURES;

HYDROGEN BONDS;

BIARYLTRIAZOLE DERIVATIVE; MACROPHAGE MIGRATION INHIBITION FACTOR; MACROPHAGE MIGRATION INHIBITION FACTOR TAUTOMERASE INHIBITOR; PHENOL; PROTEIN INHIBITOR; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; ISOMERASE; MIF PROTEIN, HUMAN; WATER;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG DESIGN; DRUG SYNTHESIS; HYDROGEN BOND; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HUMAN; PROTEIN CONFORMATION; SOLUBILITY; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CHEMISTRY TECHNIQUES, SYNTHETIC; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; INTRAMOLECULAR OXIDOREDUCTASES; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MODELS, MOLECULAR; PROTEIN CONFORMATION; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; WATER;

EID: 84924310028     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja512112j     Document Type: Article

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