Discovery of novel inhibitors targeting the macrophage migration inhibitory factor via structure-based virtual screening and bioassays

Journal of Medicinal Chemistry

Volumn 57, Issue 9, 2014, Pages 3737-3745

  Xu, Lei ^a   Zhang, Yu ^b   Zheng, Longtai ^b   Qiao, Chunhua ^b   Li, Youyong ^b   Li, Dan ^a   Zhen, Xuechu ^b   Hou, Tingjun ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 HYDROXYPHENYL) 4,5 DIHYDRO 5 ISOXAZOLE ACETIC ACID METHYL ESTER; MACROPHAGE MIGRATION INHIBITION FACTOR; MACROPHAGE MIGRATION INHIBITION FACTOR INHIBITOR; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOASSAY; BIOLOGICAL FUNCTIONS; CARDIOVASCULAR DISEASE; CELL VIABILITY; CHEMOTAXIS; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVITY; IC 50; IN VITRO STUDY; MACROPHAGE; MACROPHAGE MIGRATION; MOUSE; NONHUMAN;

ANIMALS; BIOLOGICAL ASSAY; CELL LINE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; INHIBITORY CONCENTRATION 50; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MACROPHAGES; MICE; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE;

EID: 84900340562     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401908w     Document Type: Article

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