Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 10, 2015, Pages 3080-3085

  Sugita, Shurei ^a   Hosaka, Yoko ^a   Okada, Keita ^a   Mori, Daisuke ^a   Yano, Fumiko ^a   Kobayashi, Hiroshi ^a   Taniguchi, Yuki ^a   Mori, Yoshifumi ^a   Okuma, Tomotake ^a   Chang, Song Ho ^a   Kawata, Manabu ^a   Taketomi, Shuji ^a   Chikuda, Hirotaka ^a   Akiyama, Haruhiko ^b   Kageyama, Ryoichiro ^c   Chung, Ung Il ^a   Tanaka, Sakae ^a   Kawaguchi, Hiroshi ^a,d   Ohba, Shinsuke ^a   Saito, Taku ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b GIFU UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d TOKYO KOSEI NENKIN HOSPITAL   (Japan)

Author keywords

CaMK2; Hes1; Osteoarthritis

Indexed keywords

AGGRECANASE 2; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; COLLAGEN TYPE 2; COLLAGENASE 3; CRE RECOMBINASE; NOTCH RECEPTOR; THROMBOSPONDIN 1; TRANSCRIPTION FACTOR HES 1; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HES1 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN;

3' UNTRANSLATED REGION; ALLELE; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTICULAR CARTILAGE; BIOMECHANICS; BONE GROWTH; CARTILAGE CELL; CARTILAGE DEGENERATION; CARTILAGE MATRIX; CONSENSUS SEQUENCE; EMBRYO; FEMALE; GENE EXPRESSION; GENE ONTOLOGY; GENETIC TRANSFECTION; GENOTYPE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INFLAMMATION; INTERNAL RIBOSOME ENTRY SITE; INTRON; LIGAND BINDING; LUCIFERASE ASSAY; MECHANICAL STRESS; MICROARRAY ANALYSIS; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; REPORTER GENE; TRANSACTIVATION; TRANSCRIPTION INITIATION; ANIMAL; C57BL MOUSE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HEK293 CELL LINE; HELA CELL LINE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

MUS;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; GENE EXPRESSION REGULATION; HEK293 CELLS; HELA CELLS; HOMEODOMAIN PROTEINS; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OSTEOARTHRITIS; TRANSCRIPTION, GENETIC;

EID: 84924309914     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1419699112     Document Type: Article

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