Amine oxidative N-dealkylation via cupric hydroperoxide Cu-OOH homolytic cleavage followed by site-specific fenton chemistry

Journal of the American Chemical Society

Volumn 137, Issue 8, 2015, Pages 2867-2874

  Kim, Sunghee ^a   Ginsbach, Jake W ^b   Lee, Jung Yoon ^a   Peterson, Ryan L ^a   Liu, Jeffrey J ^a   Siegler, Maxime A ^a   Sarjeant, Amy A ^a   Solomon, Edward I ^b   Karlin, Kenneth D ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; COMPUTATIONAL CHEMISTRY; COPPER; FREE RADICAL REACTIONS; FUEL CELLS; INORGANIC COMPOUNDS; LIGANDS; MOLECULAR OXYGEN; REACTION KINETICS; SYNTHESIS (CHEMICAL);

CHEMICAL OXIDATION; COMPUTATIONAL ANALYSIS; DEALKYLATED PRODUCTS; ELECTRON-TRANSFER OXIDATION; HETEROLYTIC CLEAVAGE; REACTION MECHANISM; SUBSTITUTED BENZALDEHYDES; TETRADENTATE LIGANDS;

COPPER COMPOUNDS;

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; CUPRIC HYDROPEROXIDE; DIBENZYLAMINE; HYDROPEROXIDE DERIVATIVE; HYDROXYL RADICAL; UNCLASSIFIED DRUG; AMINE; COPPER; FENTON'S REAGENT; HYDROGEN PEROXIDE; IRON; PEROXIDE;

ARTICLE; CHEMICAL BOND; CHEMICAL REACTION; COVALENT BOND; DEALKYLATION; DENSITY FUNCTIONAL THEORY; ELECTRON SPIN RESONANCE; ELECTRON TRANSPORT; FENTON REACTION; HYDROGEN BOND; HYDROXYLATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON TRANSPORT; REACTION ANALYSIS; BINDING SITE; CHEMISTRY; CONFORMATION; MOLECULAR MODEL; OXIDATION REDUCTION REACTION;

AMINES; BINDING SITES; COPPER; DEALKYLATION; HYDROGEN PEROXIDE; HYDROXYL RADICAL; IRON; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OXIDATION-REDUCTION; PEROXIDES;

EID: 84924243268     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja508371q     Document Type: Article

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