Age-related carbonylation of fibrocartilage structural proteins drives tissue degenerative modification

Chemistry and Biology

Volumn 20, Issue 7, 2013, Pages 922-934

  Scharf, Brian ^a   Clement, Cristina C ^a   Yodmuang, Supansa ^b   Urbanska, Aleksandra M ^a   Suadicani, Sylvia O ^a   Aphkhazava, David ^a   Thi, Mia M ^a   Perino, Giorgio ^c   Hardin, John A ^a   Cobelli, Neil ^a   Vunjak Novakovic, Gordana ^b   Santambrogio, Laura ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; BETA ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE 4; DECORIN; FIBRONECTIN; HYDROXYL RADICAL; STRUCTURAL PROTEIN; TRYPTOPHAN; VERSICAN;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBONYLATION; CIRCULAR DICHROISM; ENZYMATIC DEGRADATION; FIBROCARTILAGE; FLUORESCENCE; INTERVERTEBRAL DISK DEGENERATION; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TANDEM MASS SPECTROMETRY;

AGING; AMINO ACID SEQUENCE; ANIMALS; BIOMECHANICAL PHENOMENA; COLLAGEN; FIBROCARTILAGE; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MALE; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; OXIDATIVE STRESS; PROTEIN CARBONYLATION; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEOLYSIS;

EID: 84880862785     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2013.06.006     Document Type: Article

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