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Volumn 2015, Issue , 2015, Pages

A comparative evaluation of a novel vaccine in APP/PS1 mouse models of alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN[1-42]; EB 101; FREUND ADJUVANT; IMMUNOLIPOSOME; SPHINGOSINE 1 PHOSPHATE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTIBODY; LYSOPHOSPHOLIPID; OLIGOPEPTIDE; PEPTIDE FRAGMENT; PS1 ANTIGEN; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE; VACCINE;

EID: 84924151448     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/807146     Document Type: Article
Times cited : (15)

References (63)
  • 2
    • 84860215480 scopus 로고    scopus 로고
    • Correlation of alzheimer disease neuropathologic changes with cognitive status: A review of the literature
    • P. T. Nelson, I. Alafuzoff, E. H. Bigio et al., "Correlation of alzheimer disease neuropathologic changes with cognitive status: a review of the literature," Journal of Neuropathology and Experimental Neurology, vol. 71, no. 5, pp. 362-381, 2012.
    • (2012) Journal of Neuropathology and Experimental Neurology , vol.71 , Issue.5 , pp. 362-381
    • Nelson, P.T.1    Alafuzoff, I.2    Bigio, E.H.3
  • 3
    • 0038117796 scopus 로고    scopus 로고
    • Correlationbetween elevated levels of amyloid β-peptide in the brain and cognitive decline
    • J. Näslund, V. Haroutunian, R. Mohs et al., "Correlationbetween elevated levels of amyloid β-peptide in the brain and cognitive decline," Journal of the American Medical Association, vol. 283, no. 12, pp. 1571-1577, 2000.
    • (2000) Journal of the American Medical Association , vol.283 , Issue.12 , pp. 1571-1577
    • Näslund, J.1    Haroutunian, V.2    Mohs, R.3
  • 4
    • 84863800460 scopus 로고    scopus 로고
    • Plasma amyloid-β as a predictor of dementia and cognitive decline: A systematic review and meta-analysis
    • A. Koyama, O. I. Okereke, T. Yang, D. Blacker, D. J. Selkoe, and F. Grodstein, "Plasma amyloid-β as a predictor of dementia and cognitive decline: a systematic review and meta-analysis," Archives of Neurology, vol. 69, no. 7, pp. 824-831, 2012.
    • (2012) Archives of Neurology , vol.69 , Issue.7 , pp. 824-831
    • Koyama, A.1    Okereke, O.I.2    Yang, T.3    Blacker, D.4    Selkoe, D.J.5    Grodstein, F.6
  • 5
    • 33947223454 scopus 로고    scopus 로고
    • Cerebrospinal fluid tau/β-amyloid42 ratio as a prediction of cognitive decline in nondemented older adults
    • A. M. Fagan, C. M. Roe, C. Xiong, M. A. Mintun, J. C. Morris, and D. M. Holtzman, "Cerebrospinal fluid tau/β-amyloid42 ratio as a prediction of cognitive decline in nondemented older adults," Archives of Neurology, vol. 64, no. 3, pp. 343-349, 2007.
    • (2007) Archives of Neurology , vol.64 , Issue.3 , pp. 343-349
    • Fagan, A.M.1    Roe, C.M.2    Xiong, C.3    Mintun, M.A.4    Morris, J.C.5    Holtzman, D.M.6
  • 6
    • 0034747316 scopus 로고    scopus 로고
    • Correlation between Aβ-40-, Aβ-42-, and Aβx-43-containing amyloid plaques and cognitive decline
    • S. Parvathy, P. Davies, V. Haroutunian et al., "Correlation between Aβ-40-, Aβ-42-, and Aβx-43-containing amyloid plaques and cognitive decline," Archives of Neurology, vol. 58, no. 12, pp. 2025-2032, 2001.
    • (2001) Archives of Neurology , vol.58 , Issue.12 , pp. 2025-2032
    • Parvathy, S.1    Davies, P.2    Haroutunian, V.3
  • 7
    • 80052266213 scopus 로고    scopus 로고
    • The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics
    • E. Karran, M. Mercken, and B. D. Strooper, "The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics," Nature Reviews Drug Discovery, vol. 10, no. 9, pp. 698-712, 2011.
    • (2011) Nature Reviews Drug Discovery , vol.10 , Issue.9 , pp. 698-712
    • Karran, E.1    Mercken, M.2    Strooper, B.D.3
  • 8
    • 1642555780 scopus 로고    scopus 로고
    • Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: Evidence for augmentation of a 42-specific γ secretase
    • J. L. Jankowsky, D. J. Fadale, J. Anderson et al., "Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase," Human Molecular Genetics, vol. 13, no. 2, pp. 159-170, 2004.
    • (2004) Human Molecular Genetics , vol.13 , Issue.2 , pp. 159-170
    • Jankowsky, J.L.1    Fadale, D.J.2    Anderson, J.3
  • 9
    • 0031914718 scopus 로고    scopus 로고
    • Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
    • L. Holcomb, M. N. Gordon, E. Mcgowan et al., "Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes," Nature Medicine, vol. 4, no. 1, pp. 97-100, 1998.
    • (1998) Nature Medicine , vol.4 , Issue.1 , pp. 97-100
    • Holcomb, L.1    Gordon, M.N.2    McGowan, E.3
  • 10
    • 84879990946 scopus 로고    scopus 로고
    • Comprehensive behavioral characterization of an APP/PS-1 double knockin mouse model of Alzheimer's disease
    • S. J. Webster, A. D. Bachstetter, and L. J. van Eldik, "Comprehensive behavioral characterization of an APP/PS-1 double knockin mouse model of Alzheimer's disease," Alzheimer's Research and Therapy, vol. 5, no. 3, article 28, 2013.
    • (2013) Alzheimer's Research and Therapy , vol.5 , Issue.3
    • Webster, S.J.1    Bachstetter, A.D.2    Van Eldik, L.J.3
  • 11
    • 80755125653 scopus 로고    scopus 로고
    • Biochemical and behavioral characterization of the double transgenic mouse model (APPswe/PS1dE9) of Alzheimer's disease
    • H. Xiong, D. Callaghan, J. Wodzinska et al., "Biochemical and behavioral characterization of the double transgenic mouse model (APPswe/PS1dE9) of Alzheimer's disease," Neuroscience Bulletin, vol. 27, no. 4, pp. 221-232, 2011.
    • (2011) Neuroscience Bulletin , vol.27 , Issue.4 , pp. 221-232
    • Xiong, H.1    Callaghan, D.2    Wodzinska, J.3
  • 12
    • 78650178613 scopus 로고    scopus 로고
    • Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice
    • M. Garcia-Alloza, L. A. Borrelli, B. T. Hyman, and B. J. Bacskai, "Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice," Neurobiology of Aging, vol. 31, no. 12, pp. 2058-2068, 2010.
    • (2010) Neurobiology of Aging , vol.31 , Issue.12 , pp. 2058-2068
    • Garcia-Alloza, M.1    Borrelli, L.A.2    Hyman, B.T.3    Bacskai, B.J.4
  • 13
    • 70349847477 scopus 로고    scopus 로고
    • A reporter of local dendritic translocation shows plaque-related loss of neural systemfunction in APP-transgenic mice
    • M. Meyer-Luehmann, M. Mielke, T. L. Spires-Jones et al., "A reporter of local dendritic translocation shows plaque-related loss of neural systemfunction in APP-transgenic mice," Journal of Neuroscience, vol. 29, no. 40, pp. 12636-12640, 2009.
    • (2009) Journal of Neuroscience , vol.29 , Issue.40 , pp. 12636-12640
    • Meyer-Luehmann, M.1    Mielke, M.2    Spires-Jones, T.L.3
  • 14
    • 77549087116 scopus 로고    scopus 로고
    • Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice
    • E. Machová, V. Rudajev, H. Smyčková, H. Koivisto, H. Tanila, and V. Doležal, "Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice," Neurobiology of Disease, vol. 38, no. 1, pp. 27-35, 2010.
    • (2010) Neurobiology of Disease , vol.38 , Issue.1 , pp. 27-35
    • MacHová, E.1    Rudajev, V.2    Smyčková, H.3    Koivisto, H.4    Tanila, H.5    Doležal, V.6
  • 15
    • 84855271475 scopus 로고    scopus 로고
    • Utilization of APPswe/PS1dE9 transgenic mice in research of Alzheimer's disease: Focus on gene therapy and cell-based therapy applications
    • T. Malm, J. Koistinaho, and K. Kanninen, "Utilization of APPswe/PS1dE9 transgenic mice in research of Alzheimer's disease: focus on gene therapy and cell-based therapy applications," International Journal of Alzheimer's Disease, vol. 2011, Article ID 517160, 8 pages, 2011.
    • (2011) International Journal of Alzheimer's Disease , vol.2011
    • Malm, T.1    Koistinaho, J.2    Kanninen, K.3
  • 16
    • 84887963207 scopus 로고    scopus 로고
    • An update of animal models of alzheimer diseasewith a reevaluation of plaque depositions
    • J. Lee and P. Han, "An update of animal models of alzheimer diseasewith a reevaluation of plaque depositions," Experimental Neurobiology, vol. 22, pp. 84-95, 2013.
    • (2013) Experimental Neurobiology , vol.22 , pp. 84-95
    • Lee, J.1    Han, P.2
  • 17
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-β attenuates Alzheimer disease-like pathology in the PDAPP mouse
    • D. Schenk, R. Barbour, W. Dunn et al., "Immunization with amyloid-β attenuates Alzheimer disease-like pathology in the PDAPP mouse," Nature, vol. 400, no. 6740, pp. 173-177, 1999.
    • (1999) Nature , vol.400 , Issue.6740 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3
  • 20
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: A case report
    • J. A. R. Nicolll, D. Wilkinson, C. Holmes, P. Steart, H. Markham, and R. O. Weller, "Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report," Nature Medicine, vol. 9, no. 4, pp. 448-452, 2003.
    • (2003) Nature Medicine , vol.9 , Issue.4 , pp. 448-452
    • Nicolll, J.A.R.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 21
    • 1042265187 scopus 로고    scopus 로고
    • Neuropathology and pathogenesis of encephalitis following amyloid-Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease immunization in Alzheimer's disease
    • I. Ferrer, M. Boada Rovira, M. L. Sánchez Guerra, M. J. Rey, and F. Costa-Jussá, "Neuropathology and pathogenesis of encephalitis following amyloid-Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease immunization in Alzheimer's disease," Brain Pathology, vol. 14, no. 1, pp. 11-20, 2004.
    • (2004) Brain Pathology , vol.14 , Issue.1 , pp. 11-20
    • Ferrer, I.1    Boada Rovira, M.2    Sánchez Guerra, M.L.3    Rey, M.J.4    Costa-Jussá, F.5
  • 22
    • 0037384333 scopus 로고    scopus 로고
    • Adjuvantdependent modulation of Th1 and Th2 responses to immunization with β-amyloid
    • D. H. Cribbs, A. Ghochikyan, V. Vasilevko et al., "Adjuvantdependent modulation of Th1 and Th2 responses to immunization with β-amyloid," International Immunology, vol. 15, no. 4, pp. 505-514, 2003.
    • (2003) International Immunology , vol.15 , Issue.4 , pp. 505-514
    • Cribbs, D.H.1    Ghochikyan, A.2    Vasilevko, V.3
  • 23
    • 47149112621 scopus 로고    scopus 로고
    • 42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebo-controlled phase I trial
    • 42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial," The Lancet, vol. 372, no. 9634, pp. 216-223, 2008.
    • (2008) The Lancet , vol.372 , Issue.9634 , pp. 216-223
    • Holmes, C.1    Boche, D.2    Wilkinson, D.3
  • 25
    • 84884849615 scopus 로고    scopus 로고
    • Immunocytochemical characterization of Alzheimer disease hallmarks in APP/PS1 transgenic mice treated with a new anti-amyloid-β vaccine
    • I. Carrera, I. Etcheverría, Y. Li et al., "Immunocytochemical characterization of Alzheimer disease hallmarks in APP/PS1 transgenic mice treated with a new anti-amyloid-β vaccine," BioMed Research International, vol. 2013, Article ID 709145, 12 pages, 2013.
    • (2013) BioMed Research International , vol.2013
    • Carrera, I.1    Etcheverría, I.2    Li, Y.3
  • 26
    • 14844309632 scopus 로고    scopus 로고
    • Extracellular release of newly synthesized sphingosine-1-phosphate by cerebellar granule cells and astrocytes
    • V. Anelli, R. Bassi, G. Tettamanti, P. Viani, and L. Riboni, "Extracellular release of newly synthesized sphingosine-1-phosphate by cerebellar granule cells and astrocytes," Journal of Neurochemistry, vol. 92, no. 5, pp. 1204-1215, 2005.
    • (2005) Journal of Neurochemistry , vol.92 , Issue.5 , pp. 1204-1215
    • Anelli, V.1    Bassi, R.2    Tettamanti, G.3    Viani, P.4    Riboni, L.5
  • 27
    • 49049089830 scopus 로고    scopus 로고
    • Immunotherapy reduces vascular amyloid-β in PDAPP mice
    • S. Schroeter, K. Khan, R. Barbour et al., "Immunotherapy reduces vascular amyloid-β in PDAPP mice," Journal of Neuroscience, vol. 28, no. 27, pp. 6787-6793, 2008.
    • (2008) Journal of Neuroscience , vol.28 , Issue.27 , pp. 6787-6793
    • Schroeter, S.1    Khan, K.2    Barbour, R.3
  • 28
    • 35148836216 scopus 로고    scopus 로고
    • GRK5 deficiency leads to early Alzheimer-like pathology and working memory impairment
    • Z. Suo, A. Cox, N. Bartelli et al., "GRK5 deficiency leads to early Alzheimer-like pathology and working memory impairment," Neurobiology of Aging, vol. 28, no. 12, pp. 1873-1888, 2007.
    • (2007) Neurobiology of Aging , vol.28 , Issue.12 , pp. 1873-1888
    • Suo, Z.1    Cox, A.2    Bartelli, N.3
  • 29
    • 84865056621 scopus 로고    scopus 로고
    • GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer disease
    • W. Kamphuis, C. Mamber, M. Moeton et al., "GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer disease," PLoS ONE, vol. 7, no. 8, Article ID e42823, 2012.
    • (2012) PLoS ONE , vol.7 , Issue.8
    • Kamphuis, W.1    Mamber, C.2    Moeton, M.3
  • 30
    • 0025347398 scopus 로고
    • Liposomes composed of partially hydrogenated egg phosphatidylcholines: Fatty acid composition, thermal phase behavior and oxidative stability
    • J. Lang, C. Vigo-Pelfrey, and F. Martin, "Liposomes composed of partially hydrogenated egg phosphatidylcholines: fatty acid composition, thermal phase behavior and oxidative stability," Chemistry and Physics of Lipids, vol. 53, no. 1, pp. 91-101, 1990.
    • (1990) Chemistry and Physics of Lipids , vol.53 , Issue.1 , pp. 91-101
    • Lang, J.1    Vigo-Pelfrey, C.2    Martin, F.3
  • 31
    • 84984755327 scopus 로고    scopus 로고
    • A β peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    • D. Morgan, D. M. Diamond, P. E. Gottschall et al., "A β peptide vaccination prevents memory loss in an animal model of Alzheimer's disease," Nature, vol. 408, no. 6815, pp. 982-985, 2000.
    • (2000) Nature , vol.408 , Issue.6815 , pp. 982-985
    • Morgan, D.1    Diamond, D.M.2    Gottschall, P.E.3
  • 32
    • 84884177253 scopus 로고    scopus 로고
    • Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology
    • M. L. Brownlow, L. Benner, D. D'Agostino, M. N. Gordon, and D. Morgan, "Ketogenic diet improves motor performance but not cognition in two mouse models of Alzheimer's pathology," PLoS ONE, vol. 8, no. 9, Article ID e75713, 2013.
    • (2013) PLoS ONE , vol.8 , Issue.9
    • Brownlow, M.L.1    Benner, L.2    D'Agostino, D.3    Gordon, M.N.4    Morgan, D.5
  • 33
    • 40449086748 scopus 로고    scopus 로고
    • Progress in the active immunotherapeutic approach to Alzheimer's disease: Clinical investigations into AN1792-associated meningoencephalitis
    • M. Pride, P. Seubert, M. Grundman, M. Hagen, J. Eldridge, and R. S. Black, "Progress in the active immunotherapeutic approach to Alzheimer's disease: clinical investigations into AN1792-associated meningoencephalitis," Neurodegenerative Diseases, vol. 5, no. 3-4, pp. 194-196, 2008.
    • (2008) Neurodegenerative Diseases , vol.5 , Issue.3-4 , pp. 194-196
    • Pride, M.1    Seubert, P.2    Grundman, M.3    Hagen, M.4    Eldridge, J.5    Black, R.S.6
  • 34
    • 79959670013 scopus 로고    scopus 로고
    • The secondgeneration active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects
    • C. Wiessner, K.-H. Wiederhold, A. C. Tissot et al., "The secondgeneration active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects," The Journal of Neuroscience, vol. 31, no. 25, pp. 9323-9331, 2011.
    • (2011) The Journal of Neuroscience , vol.31 , Issue.25 , pp. 9323-9331
    • Wiessner, C.1    Wiederhold, K.-H.2    Tissot, A.C.3
  • 35
    • 84886281639 scopus 로고    scopus 로고
    • Advances in the development of vaccines for Alzheimer's disease
    • D. Lambracht-Washington and R. Rosenberg, "Advances in the development of vaccines for Alzheimer's disease," Discovery Medicine, vol. 15, no. 84, pp. 319-326, 2013.
    • (2013) Discovery Medicine , vol.15 , Issue.84 , pp. 319-326
    • Lambracht-Washington, D.1    Rosenberg, R.2
  • 36
    • 33846021925 scopus 로고    scopus 로고
    • 1 receptor axis in themigration of neural stem cells toward a site of spinal cord injury
    • 1 receptor axis in themigration of neural stem cells toward a site of spinal cord injury," Stem Cells, vol. 25, no. 1, pp. 115-124, 2007.
    • (2007) Stem Cells , vol.25 , Issue.1 , pp. 115-124
    • Kimura, A.1    Ohmori, T.2    Ohkawa, R.3
  • 37
    • 0037343290 scopus 로고    scopus 로고
    • Roles of Rac and cytosolic phospholipase A2 in the intracellular signalling in response to titanium particles
    • S. S. Lee, C. H. Woo, J. D. Chang, and J. H. Kim, "Roles of Rac and cytosolic phospholipase A2 in the intracellular signalling in response to titanium particles," Cellular Signalling, vol. 15, no. 3, pp. 339-345, 2003.
    • (2003) Cellular Signalling , vol.15 , Issue.3 , pp. 339-345
    • Lee, S.S.1    Woo, C.H.2    Chang, J.D.3    Kim, J.H.4
  • 38
    • 19944429065 scopus 로고    scopus 로고
    • Aβ vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease
    • E. Masliah, L. Hansen, A. Adame et al., "Aβ vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease," Neurology, vol. 64, no. 1, pp. 129-131, 2005.
    • (2005) Neurology , vol.64 , Issue.1 , pp. 129-131
    • Masliah, E.1    Hansen, L.2    Adame, A.3
  • 40
    • 79952775194 scopus 로고    scopus 로고
    • Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into themechanism of amyloid-β immunotherapy
    • A. Wang, P. Das, R. C. Switzer III, T. E. Golde, and J. L. Jankowsky, "Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into themechanism of amyloid-β immunotherapy," Journal of Neuroscience, vol. 31, no. 11, pp. 4124-4136, 2011.
    • (2011) Journal of Neuroscience , vol.31 , Issue.11 , pp. 4124-4136
    • Wang, A.1    Das, P.2    Switzer, R.C.3    Golde, T.E.4    Jankowsky, J.L.5
  • 41
    • 84876006819 scopus 로고    scopus 로고
    • Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology
    • G. Krabbe, A. Halle, V. Matyash et al., "Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology," PLoS ONE, vol. 8, no. 4, Article ID e60921, 2013.
    • (2013) PLoS ONE , vol.8 , Issue.4
    • Krabbe, G.1    Halle, A.2    Matyash, V.3
  • 42
    • 84864976166 scopus 로고    scopus 로고
    • Immunotherapy for Alzheimer disease-The challenge of adverse effects
    • Y. H. Liu, B. Giunta, H.-D. Zhou, J. Tan, and Y. J. Wang, "Immunotherapy for Alzheimer disease-the challenge of adverse effects," Nature Reviews Neurology, vol. 8, no. 8, pp. 465-469, 2012.
    • (2012) Nature Reviews Neurology , vol.8 , Issue.8 , pp. 465-469
    • Liu, Y.H.1    Giunta, B.2    Zhou, H.-D.3    Tan, J.4    Wang, Y.J.5
  • 44
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • F. Bard, C. Cannon, R. Barbour et al., "Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease," Nature Medicine, vol. 6, no. 8, pp. 916-919, 2000.
    • (2000) Nature Medicine , vol.6 , Issue.8 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3
  • 46
    • 0041332884 scopus 로고    scopus 로고
    • Evidence for peripheral clearance of cerebral Aβ protein following chronic, active Aβ immunization in PSAPP mice
    • C. A. Lemere, E. T. Spooner, J. LaFrancois et al., "Evidence for peripheral clearance of cerebral Aβ protein following chronic, active Aβ immunization in PSAPP mice," Neurobiology of Disease, vol. 14, no. 1, pp. 10-18, 2003.
    • (2003) Neurobiology of Disease , vol.14 , Issue.1 , pp. 10-18
    • Lemere, C.A.1    Spooner, E.T.2    Lafrancois, J.3
  • 48
    • 84934444326 scopus 로고    scopus 로고
    • Pharmacogenomics in Alzheimer's disease
    • R. Cacabelos, "Pharmacogenomics in Alzheimer's disease," Methods in Molecular Biology, vol. 448, pp. 213-357, 2008.
    • (2008) Methods in Molecular Biology , vol.448 , pp. 213-357
    • Cacabelos, R.1
  • 49
    • 70049083263 scopus 로고    scopus 로고
    • Pharmacogenomics and therapeutic strategies for dementia
    • R. Cacabelos, "Pharmacogenomics and therapeutic strategies for dementia," Expert Review of Molecular Diagnostics, vol. 9, no. 6, pp. 567-611, 2009.
    • (2009) Expert Review of Molecular Diagnostics , vol.9 , Issue.6 , pp. 567-611
    • Cacabelos, R.1
  • 51
    • 4644221743 scopus 로고    scopus 로고
    • Spatial learning and exploration of environmental stimuli in 24-month-old female APP23 transgenic mice with the Swedish mutation
    • M. Dumont, C. Strazielle, M. Staufenbiel, and R. Lalonde, "Spatial learning and exploration of environmental stimuli in 24-month-old female APP23 transgenic mice with the Swedish mutation," Brain Research, vol. 1024, no. 1-2, pp. 113-121, 2004.
    • (2004) Brain Research , vol.1024 , Issue.1-2 , pp. 113-121
    • Dumont, M.1    Strazielle, C.2    Staufenbiel, M.3    Lalonde, R.4
  • 52
    • 0037159635 scopus 로고    scopus 로고
    • Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation
    • R. Lalonde, M. Dumont, M. Staufenbiel, C. Sturchler-Pierrat, and C. Strazielle, "Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation," Brain Research, vol. 956, no. 1, pp. 36-44, 2002.
    • (2002) Brain Research , vol.956 , Issue.1 , pp. 36-44
    • Lalonde, R.1    Dumont, M.2    Staufenbiel, M.3    Sturchler-Pierrat, C.4    Strazielle, C.5
  • 53
  • 55
    • 77956701746 scopus 로고    scopus 로고
    • Switching from contextual to tone fear conditioning and vice versa: The key role of the glutamatergic hippocampal-lateral septal neurotransmission
    • L. Calandreau, B. Desgranges, R. Jaffard, and A. Desmedt, "Switching from contextual to tone fear conditioning and vice versa: the key role of the glutamatergic hippocampal-lateral septal neurotransmission," Learning & Memory, vol. 17, no. 9, pp. 440-443, 2010.
    • (2010) Learning & Memory , vol.17 , Issue.9 , pp. 440-443
    • Calandreau, L.1    Desgranges, B.2    Jaffard, R.3    Desmedt, A.4
  • 56
    • 2542584749 scopus 로고    scopus 로고
    • Progressive age-related development of Alzheimerlike pathology in APP/PS1 mice
    • F. Trinchese, S. Liu, F. Battaglia, S. Walter, P. M. Mathews, and O. Arancio, "Progressive age-related development of Alzheimerlike pathology in APP/PS1 mice," Annals of Neurology, vol. 55, no. 6, pp. 801-814, 2004.
    • (2004) Annals of Neurology , vol.55 , Issue.6 , pp. 801-814
    • Trinchese, F.1    Liu, S.2    Battaglia, F.3    Walter, S.4    Mathews, P.M.5    Arancio, O.6
  • 57
    • 14244255355 scopus 로고    scopus 로고
    • Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage
    • D. M. Wilcock, A. Rojiani, A. Rosenthal et al., "Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage," Journal of Neuroinflammation, vol. 1, article 24, 2004.
    • (2004) Journal of Neuroinflammation , vol.1
    • Wilcock, D.M.1    Rojiani, A.2    Rosenthal, A.3
  • 58
    • 84872542495 scopus 로고    scopus 로고
    • Longitudinal behavioral changes in the APP/PS1 transgenic Alzheimer's Disease model
    • S. A. Ferguson, S. Sarkar, and L. C. Schmued, "Longitudinal behavioral changes in the APP/PS1 transgenic Alzheimer's Disease model," Behavioural Brain Research, vol. 242, no. 1, pp. 125-134, 2013.
    • (2013) Behavioural Brain Research , vol.242 , Issue.1 , pp. 125-134
    • Ferguson, S.A.1    Sarkar, S.2    Schmued, L.C.3
  • 59
    • 65649148265 scopus 로고    scopus 로고
    • Immunotherapy, vascular pathology, and microhemorrhages in transgenic mice
    • D. Wilcock and C. Colton, "Immunotherapy, vascular pathology, and microhemorrhages in transgenic mice," CNS and Neurological Disorders-Drug Targets, vol. 8, no. 1, pp. 50-64, 2009.
    • (2009) CNS and Neurological Disorders-Drug Targets , vol.8 , Issue.1 , pp. 50-64
    • Wilcock, D.1    Colton, C.2
  • 60
    • 52449086601 scopus 로고    scopus 로고
    • An alternative method for estimating efficacy of the AN1792 vaccine for alzheimer disease
    • M. Grundman, S. Gilman, R. S. Black et al., "An alternative method for estimating efficacy of the AN1792 vaccine for alzheimer disease," Neurology, vol. 71, no. 9, pp. 697-698, 2008.
    • (2008) Neurology , vol.71 , Issue.9 , pp. 697-698
    • Grundman, M.1    Gilman, S.2    Black, R.S.3
  • 61
    • 58149129243 scopus 로고    scopus 로고
    • Consequence of Aβ immunization on the vasculature of human Alzheimer's disease brain
    • D. Boche, E. Zotova, R. O. Weller et al., "Consequence of Aβ immunization on the vasculature of human Alzheimer's disease brain," Brain, vol. 131, no. 12, pp. 3299-3310, 2008.
    • (2008) Brain , vol.131 , Issue.12 , pp. 3299-3310
    • Boche, D.1    Zotova, E.2    Weller, R.O.3
  • 62
    • 0037112201 scopus 로고    scopus 로고
    • Cerebral hemorrhage after passive anti-Aβ immunotherapy
    • M. Pfeifer, S. Boncristiano, L. Bondolfi et al., "Cerebral hemorrhage after passive anti-aβ immunotherapy," Science, vol. 298, no. 5597, p. 1379, 2002.
    • (2002) Science , vol.298 , Issue.5597 , pp. 1379
    • Pfeifer, M.1    Boncristiano, S.2    Bondolfi, L.3
  • 63
    • 19944431509 scopus 로고    scopus 로고
    • Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid β
    • M. M. Racke, L. I. Boone, D. L. Hepburn et al., "Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid β," Journal of Neuroscience, vol. 25, no. 3, pp. 629-636, 2005.
    • (2005) Journal of Neuroscience , vol.25 , Issue.3 , pp. 629-636
    • Racke, M.M.1    Boone, L.I.2    Hepburn, D.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.