Longitudinal behavioral changes in the APP/PS1 transgenic Alzheimer's Disease model

Behavioural Brain Research

Volumn 242, Issue 1, 2013, Pages 125-134

  Ferguson, Sherry A ^a   Sarkar, Sumit ^a   Schmued, Larry C ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Alzheimer's Disease; APP PS1; Longitudinal; Male; Transgenic; Water maze

Indexed keywords

AGE; ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR CHANGE; BODY WEIGHT; CONTROLLED STUDY; FLOATING BEHAVIOR; HYPOACTIVITY; LONGITUDINAL STUDY; MALE; MAZE TEST; MEASUREMENT; MOTOR COORDINATION; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; MOUSE; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; SWIMMING; THIGMOTACTIC BEHAVIOR; TRANSGENIC MOUSE;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BEHAVIOR, ANIMAL; BODY WEIGHT; EXPLORATORY BEHAVIOR; MALE; MAZE LEARNING; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; MUTATION; PLAQUE, AMYLOID; PRESENILIN-1; PSYCHOMOTOR PERFORMANCE; REACTION TIME;

EID: 84872542495     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.12.055     Document Type: Article

References (56)

1. Billings L.M., Green K.N., McGaugh J.L., LaFerla F.M. Learning decreases A beta*56 and tau pathology and ameliorates behavioral decline in 3xTg-AD mice. Journal of Neuroscience 2007, 27:751-761.
2. Epis R., Gardoni F., Marcello E., Genazzani A., Canonico P.L., Di Luca M. Searching for new animal models of Alzheimer's disease. European Journal of Pharmacology 2010, 626:57-63.
3. Ashe K.H., Zahs K.R. Probing the biology of Alzheimer's disease in mice. Neuron 2010, 66:631-645.
4. Bertram L., Lill C.M., Tanzi R.E. The genetics of Alzheimer disease: back to the future. Neuron 2010, 68:270-281.
5. Bird T.D. Genetic aspects of Alzheimer disease. Genetics in Medicine 2008, 10:231-239.
6. Hussain I. APP transgenic mouse models and their use in drug discovery to evaluate amyloid- lowering therapeutics. CNS & Neurological Disorders - Drug Targets 2010, 9:395-402.
7. Wilcock D.M. The usefulness and challenges of transgenic mouse models in the study of Alzheimer's disease. CNS & Neurological Disorders - Drug Targets 2010, 9:386-394.
8. Ding Y., Qiao A., Wang Z., Goodwin J.S., Lee E.S., Block M.L., et al. Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model. Journal of Neuroscience 2008, 28:11622-11634.
9. Lalonde R., Kim H.D., Maxwell J.A., Fukuchi K. Exploratory activity and spatial learning in 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice with amyloid plaques. Neuroscience Letters 2005, 390:87-92.
10. Timmer N.M., van Dijk L., van der Zee C.E., Kiliaan A., de Waal R.M., Verbeek M.M. Enoxaparin treatment administered at both early and late stages of amyloid beta deposition improves cognition of APPswe/PS1dE9 mice with differential effects on brain A beta levels. Neurobiology of Disease 2010, 40:340-347.
11. Park J.H., Widi G.A., Gimbel D.A., Harel N.Y., Lee D.H., Strittmatter S.M. Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice. Journal of Neuroscience 2006, 26:13279-13286.
12. Sood A., Warren Beach J., Webster S.J., Terry A.V., Buccafusco J.J. The effects of JWB1-84-1 on memory-related task performance by amyloid Abeta transgenic mice and by young and aged monkeys. Neuropharmacology 2007, 53:588-600.
13. O'Leary T.P., Brown R.E. Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease. Behavioural Brain Research 2009, 201:120-127.
14. Kilgore M., Miller C.A., Fass D.M., Hennig K.M., Haggarty S.J., Sweatt J.D., et al. Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 2010, 35:870-880.
15. Lalonde R., Kim H.D., Fukuchi K. Exploratory activity, anxiety, and motor coordination in bigenic APPswe+PS1/DeltaE9 mice. Neuroscience Letters 2004, 369:156-161.
16. Cao D., Lu H., Lewis T.L., Li L. Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease. Journal of Biological Chemistry 2007, 282:36275-36282.
17. Yoshiike Y., Kimura T., Yamashita S., Furudate H., Mizoroki T., Murayama M., et al. GABA(A) receptor-mediated acceleration of aging-associated memory decline in APP/PS1 mice and its pharmacological treatment by picrotoxin. PLoS One 2008, 3:e3029.
18. Volianskis A., Kostner R., Molgaard M., Hass S., Jensen M.S. Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1deltaE9-deleted transgenic mice model of ss-amyloidosis. Neurobiology of Aging 2010, 31:1173-1187.
19. Hooijmans C.R., Van der Zee C.E., Dederen P.J., Brouwer K.M., Reijmer Y.D., van Groen T., et al. DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice. Neurobiology of Disease 2009, 33:482-498.
20. Richardson J.C., Kendal C.E., Anderson R., Priest F., Gower E., Soden P., et al. Ultrastructural and behavioural changes precede amyloid deposition in a transgenic model of Alzheimer's disease. Neuroscience 2003, 122:213-228.
21. Lau J.C., Lerch J.P., Sled J.G., Henkelman R.M., Evans A.C., Bedell B.J. Longitudinal neuroanatomical changes determined by deformation-based morphometry in a mouse model of Alzheimer's disease. Neuroimage 2008, 42:19-27.
22. Muskulus M., Scheenstra A.E., Braakman N., Dijkstra J., Verduyn-Lunel S., Alia A., et al. Prospects for early detection of Alzheimer's disease from serial MR images in transgenic mice. Current Alzheimer Research 2009, 6:503-518.
23. Zahs K.R., Ashe K.H. 'Too much good news' - are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?. Trends in Neurosciences 2010, 33:381-389.
24. Gerlai R. Behavioral tests of hippocampal function: simple paradigms complex problems. Behavioural Brain Research 2001, 125:269-277.
25. Wahlsten D., Rustay N.R., Metten P., Crabbe J.C. In search of a better mouse test. Trends in Neurosciences 2003, 26:132-136.
26. Wolfer D.P., Stagljar-Bozicevic M., Errington M.L., Lipp H.P. Spatial memory and learning in transgenic mice: fact or artifact?. News in Physiological Sciences 1998, 13:118-123.
27. Iivonen H., Nurminen L., Harri M., Tanila H., Puolivali J. Hypothermia in mice tested in Morris water maze. Behavioural Brain Research 2003, 141:207-213.
28. Stasko M.R., Costa A.C. Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome. Behavioural Brain Research 2004, 154:1-17.
29. Roder J.K., Roder J.C., Gerlai R. Memory and the effect of cold shock in the water maze in S100 beta transgenic mice. Physiology and Behavior 1996, 60:611-615.
30. Wolfer D.P., Lipp H.P. Dissecting the behaviour of transgenic mice: is it the mutation, the genetic background, or the environment?. Experimental Physiology 2000, 85:627-634.
31. Lipp H.P., Wolfer D.P. Genetically modified mice and cognition. Current Opinion in Neurobiology 1998, 8:272-280.
32. Jankowsky J.L., Slunt H.H., Ratovitski T., Jenkins N.A., Copeland N.G., Borchelt D.R. Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomolecular Engineering 2001, 17:157-165.
33. van Groen T., Kiliaan A.J., Kadish I. Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice. Neurobiology of Disease 2006, 23:653-662.
34. Garcia-Alloza M., Robbins E.M., Zhang-Nunes S.X., Purcell S.M., Betensky R.A., Raju S., et al. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiology of Disease 2006, 24:516-524.
35. Jankowsky J.L., Fadale D.J., Anderson J., Xu G.M., Gonzales V., Jenkins N.A., et al. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Human Molecular Genetics 2004, 13:159-170.
36. Guide for the care and use of laboratory animals 1996, National Research Council, National Academy Press, Washington DC.
37. Means L.W., Alexander S.R., O'Neal M.F. Those cheating rats: male and female rats use odor trails in a water-escape "working memory" task. Behavioral and Neural Biology 1992, 58:144-151.
38. Hodges H. Maze procedures: the radial-arm and water maze compared. Brain Research. Cognitive Brain Research 1996, 3:167-181.
39. de Fiebre N.C., Sumien N., Forster M.J., de Fiebre C.M. Spatial learning and psychomotor performance of C57BL/6 mice: age sensitivity and reliability of individual differences. Age 2006, 28:235-253.
40. Schmued L., Raymick J., Tolleson W., Sarkar S., Zhang Y.H., Bell-Cohn A. Introducing Amylo-Glo, a novel fluorescent amyloid specific histochemical tracer especially suited for multiple labeling and large scale quantification studies. Journal of Neuroscience Methods 2012, 209:120-126.
41. McIlwain K.L., Merriweather M.Y., Yuva-Paylor L.A., Paylor R. The use of behavioral test batteries: effects of training history. Physiology and Behavior 2001, 73:705-717.
42. Jardanhazi-Kurutz D., Kummer M.P., Terwel D., Vogel K., Dyrks T., Thiele A., et al. Induced LC, degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits. Neurochemistry International 2010, 57:375-382.
43. Yue M., Hanna A., Wilson J., Roder H., Janus C. Sex difference in pathology and memory decline in rTg4510 mouse model of tauopathy. Neurobiology of Aging 2011, 32:590-603.
44. Brody D.L., Holtzman D.M. Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury. Experimental Neurology 2006, 197:330-340.
45. Janus C. Search strategies used by APP transgenic mice during navigation in the Morris water maze. Learning and Memory 2004, 11:337-346.
46. Wolfer D.P., Muller U., Stagliar M., Lipp H.P. Assessing the effects of the 129/Sv genetic background on swimming navigation learning in transgenic mutants: a study using mice with a modified beta-amyloid precursor protein gene. Brain Research 1997, 771:1-13.
47. Paul C.M., Magda G., Abel S. Spatial memory: theoretical basis and comparative review on experimental methods in rodents. Behavioural Brain Research 2009, 203:151-164.
48. Bianchi S.L., Tran T., Liu C., Lin S., Li Y., Keller J.M., et al. Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics. Neurobiology of Aging 2008, 29:1002-1010.
49. Melnikova T., Savonenko A., Wang Q., Liang X., Hand T., Wu L., et al. Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern. Neuroscience 2006, 141:1149-1162.
50. Reiserer R.S., Harrison F.E., Syverud D.C., McDonald M.P. Impaired spatial learning in the APPSwe+PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. Genes, Brain and Behavior 2007, 6:54-65.
51. Vicens P., Redolat R., Carrasco M.C. Effects of early spatial training on water maze performance: a longitudinal study in mice. Experimental Gerontology 2002, 37:575-581.
52. Vicens P., Bernal M.C., Carrasco M.C., Redolat R. Previous training in the water maze: differential effects in NMRI and C57BL mice. Physiology and Behavior 1999, 67:197-203.
53. Dellu F., Mayo W., Vallee M., Le Moal M., Simon H. Facilitation of cognitive performance in aged rats by past experience depends on the type of information processing involved: a combined cross-sectional and longitudinal study. Neurobiology of Learning and Memory 1997, 67:121-128.
54. Bellush L.L., Wright A.M., Walker J.P., Kopchick J., Colvin R.A. Caloric restriction and spatial learning in old mice. Physiology and Behavior 1996, 60:541-547.
55. Magnusson K.R., Scruggs B., Aniya J., Wright K.C., Ontl T., Xing Y., et al. Age-related deficits in mice performing working memory tasks in a water maze. Behavioral Neuroscience 2003, 117:485-495.
56. Harburger L.L., Lambert T.J., Frick K.M. Age-dependent effects of environmental enrichment on spatial reference memory in male mice. Behavioural Brain Research 2007, 185:43-48.