Impact of autophagy inhibition at different stages on cytotoxic effect of autophagy inducer in glioblastoma cells

Cellular Physiology and Biochemistry

Volumn 35, Issue 4, 2015, Pages 1303-1316

  Li, Chenguang ^a   Liu, Yaohua ^a   Liu, Huailei ^a   Zhang, Weiguang ^a   Shen, Chen ^a   Cho, Kenka ^b   Chen, Xin ^a   Peng, Fei ^a   Bi, Yunke ^a   Hou, Xu ^a   Yang, Zhuowen ^a   Zheng, Zhixing ^a   Wang, Kaikai ^a   Wang, Xiaoxiong ^a   Zhang, Jiakang ^a   Zhong, Chen ^a   Zou, Huichao ^a   Zhang, Xinjian ^a   Zhao, Shiguang ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b TAKARAZUKA UNIVERSITY OF MEDICAL AND HEALTH CARE   (Japan)

Author keywords

Apoptosis; Autophagic vacuole; Autophagy inducer; Autophagy inhibition; Glioblastoma multiforme

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 METHYLADENINE; ARSENIC TRIOXIDE; BECLIN 1; CHLOROQUINE; RAB7 PROTEIN; RAPAMYCIN; SHORT HAIRPIN RNA; 3-METHYLADENINE; ADENINE; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; CASPASE 3; MEMBRANE PROTEIN; ORGANOARSENIC DERIVATIVE; OXIDE; RAB PROTEIN; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL VACUOLE; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENTIATION; FLOW CYTOMETRY; GENE SILENCING; GLIOBLASTOMA; GLIOBLASTOMA CELL LINE; HUMAN; HUMAN CELL; MTT ASSAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BRAIN TUMOR; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY; RNA INTERFERENCE; TUMOR CELL LINE;

ADENINE; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ARSENICALS; AUTOPHAGY; BLOTTING, WESTERN; BRAIN NEOPLASMS; CASPASE 3; CELL LINE, TUMOR; CHLOROQUINE; DRUG SYNERGISM; FLOW CYTOMETRY; GLIOBLASTOMA; HUMANS; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON, TRANSMISSION; OXIDES; RAB GTP-BINDING PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84924098386     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000373952     Document Type: Article

References (41)

1. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114:97-109.
2. Chen Y, Chou WC, Ding YM, Wu YC: Caffeine inhibits migration in glioma cells through the ROCK-FAK pathway. Cell Physiol Biochem 2014;33:1888-1898.
3. Park JK, Hodges T, Arko L, Shen M, Dello Iacono D, McNabb A, Olsen Bailey N, Kreisl TN, Iwamoto FM, Sul J, Auh S, Park GE, Fine HA, Black PM: Scale to predict survival after surgery for recurrent glioblastoma multiforme. J Clin Oncol 2010;28:3838-3843.
4. Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK: Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev 2007;21:2683-2710.
5. Kaza N, Kohli L, Roth KA: Autophagy in brain tumors: a new target for therapeutic intervention. Brain Pathol 2012;22:89-98.
6. Mora R, Regnier-Vigouroux A: Autophagy-driven cell fate decision maker: activated microglia induce specific death of glioma cells by a blockade of basal autophagic flux and secondary apoptosis/necrosis. Autophagy 2009;5:419-421.
7. Tanida I: Autophagosome formation and molecular mechanism of autophagy. Antioxid Redox Signal 2011;14:2201-2214.
8. Wei Y, Zou Z, Becker N, Anderson M, Sumpter R, Xiao G, Kinch L, Koduru P, Christudass CS, Veltri RW, Grishin NV, Peyton M, Minna J, Bhagat G, Levine B: EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance. Cell 2013;154:1269-1284.
9. Chen N, Debnath J: Autophagy and tumorigenesis. FEBS Lett 2010;584:1427-1435.
10. Shimizu S, Yoshida T, Tsujioka M, Arakawa S: Autophagic cell death and cancer. Int J Mol Sci 2014;15:3145-3153.
11. Maycotte P, Aryal S, Cummings CT, Thorburn J, Morgan MJ, Thorburn A: Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Autophagy 2012;8:200-212.
12. Chiu HW, Ho YS, Wang YJ: Arsenic trioxide induces autophagy and apoptosis in human glioma cells in vitro and in vivo through downregulation of survivin. J Mol Med (Berl) 2011;89:927-941.
13. Carminati PO, Donaires FS, Marques MM, Donadi EA, Passos GA, Sakamoto-Hojo ET: Cisplatin associated with LY294002 increases cytotoxicity and induces changes in transcript profiles of glioblastoma cells. Mol Biol Rep 2014;41:165-177.
14. Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S: Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene 2005;24:980-991.
15. Kanzawa T, Kondo Y, Ito H, Kondo S, Germano I: Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res 2003;63:2103-2108.
16. Smith DM, Patel S, Raffoul F, Haller E, Mills GB, Nanjundan M: Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells. Cell Death Differ 2010;17:1867-1881.
17. Chiu HW, Lin JH, Chen YA, Ho SY, Wang YJ: Combination treatment with arsenic trioxide and irradiation enhances cell-killing effects in human fibrosarcoma cells in vitro and in vivo through induction of both autophagy and apoptosis. Autophagy 2010;6:353-365.
18. Cohen KJ, Gibbs IC, Fisher PG, Hayashi RJ, Macy ME, Gore L: A phase I trial of arsenic trioxide chemoradiotherapyfor infiltrating astrocytomas of childhood. Neuro Oncol 2013;15:783-787.
19. Schmukler E, Wolfson E, Haklai R, Elad-Sfadia G, Kloog Y, Pinkas-Kramarski R: Chloroquine synergizes with FTS to enhance cell growth inhibition and cell death. Oncotarget 2013;5:173-184.
20. Adiseshaiah PP, Clogston JD, McLeland CB, Rodriguez J, Potter TM, Neun BW, Skoczen SL, Shanmugavelandy SS, Kester M, Stern ST, McNeil SE: Synergistic combination therapy with nanoliposomal C6-ceramide and vinblastine is associated with autophagy dysfunction in hepatocarcinoma and colorectal cancer models. Cancer Lett 2013;337:254-265.
21. Kanzawa T, Germano IM, Komata T, Ito H, Kondo Y, Kondo S: Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ 2004;11:448-457.
22. Goldberg SB, Supko JG, Neal JW, Muzikansky A, Digumarthy S, Fidias P, Temel JS, Heist RS, Shaw AT, McCarthy PO, Lynch TJ, Sharma S, Settleman JE, Sequist LV: A phase I study of erlotinib and hydroxychloroquine in advanced non-small-cell lung cancer. J Thorac Oncol 2012;7:1602-1608.
23. Lotze MT, Maranchie J, Appleman L: Inhibiting autophagy: a novel approach for the treatment of renal cell carcinoma. Cancer J 2013;19:341-347.
24. Mancias JD, Kimmelman AC: Targeting autophagy addiction in cancer. Oncotarget 2011;2:1302-1306.
25. Rangwala R, Leone R, Chang YC, Fecher LA, Schuchter LM, Kramer A, Tan KS, Heitjan DF, Rodgers G, Gallagher M, Piao S, Troxel AB, Evans TL, DeMichele AM, Nathanson KL, O'Dwyer PJ, Kaiser J, Pontiggia L, Davis LE, Amaravadi RK: Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma. Autophagy 2014;10:1369-1379.
26. Rosenfeld MR, Ye X, Supko JG, Desideri S, Grossman SA, Brem S, Mikkelson T, Wang D, Chang YC, Hu J, McAfee Q, Fisher J, Troxel AB, Piao S, Heitjan DF, Tan KS, Pontiggia L, O'Dwyer PJ, Davis LE, Amaravadi RK: A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme. Autophagy 2014;10:1359-1368.
27. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, et al: Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012;8:445-544.
28. Gurkar AU, Chu K, Raj L, Bouley R, Lee SH, Kim YB, Dunn SE, Mandinova A, Lee SW: Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress. Nat Commun 2013;4:2189.
29. Kimura T, Takabatake Y, Takahashi A, Isaka Y: Chloroquine in cancer therapy: a double-edged sword of autophagy. Cancer Res 2013;73:3-7.
30. Lizaso A, Tan KT, Lee YH: beta-adrenergic receptor-stimulated lipolysis requires the RAB7-mediated autolysosomal lipid degradation. Autophagy 2013;9:1228-1243.
31. Carroll B, Mohd-Naim N, Maximiano F, Frasa MA, McCormack J, Finelli M, Thoresen SB, Perdios L, Daigaku R, Francis RE, Futter C, Dikic I, Braga VM: The TBC/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy. Dev Cell 2013;25:15-28.
32. Alonso-Curbelo D, Riveiro-Falkenbach E, Perez-Guijarro E, Cifdaloz M, Karras P, Osterloh L, Megias D, Canon E, Calvo TG, Olmeda D, Gomez-Lopez G, Grana O, Sanchez-Arevalo Lobo VJ, Pisano DG, Wang HW, Ortiz-Romero P, Tormo D, Hoek K, Rodriguez-Peralto JL, Joyce JA, Soengas MS: RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway. Cancer Cell 2014;26:61-76.
33. Takeuchi H, Kondo Y, Fujiwara K, Kanzawa T, Aoki H, Mills GB, Kondo S: Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors. Cancer Res 2005;65:3336-3346.
34. Codogno P, Meijer AJ: Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ 2005;12 Suppl 2:1509-1518.
35. Marino G, Niso-Santano M, Baehrecke EH, Kroemer G: Self-consumption: the interplay of autophagy and apoptosis. Nat Rev Mol Cell Biol 2014;15:81-94.
36. Booth LA, Tavallai S, Hamed HA, Cruickshanks N, Dent P: The role of cell signalling in the crosstalk between autophagy and apoptosis. Cell Signal 2014;26:549-555.
37. Fan YJ, Zong WX: The cellular decision between apoptosis and autophagy. Chin J Cancer 2013;32:121-129.
38. Ma X, Liu H, Foyil SR, Godar RJ, Weinheimer CJ, Hill JA, Diwan A: Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury. Circulation 2012;125:3170-3181.
39. Geng Y, Kohli L, Klocke BJ, Roth KA: Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent. Neuro Oncol 2010;12:473-481.
40. Szatmari Z, Sass M: The autophagic roles of Rab small GTPases and their upstream regulators: a review. Autophagy 2014;10:1154-1166.
41. Steffan JJ, Dykes SS, Coleman DT, Adams LK, Rogers D, Carroll JL, Williams BJ, Cardelli JA: Supporting a role for the GTPase Rab7 in prostate cancer progression. PLoS One 2014;9:e87882.