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Volumn 19, Issue 4, 2013, Pages 341-347

Inhibiting autophagy: A novel approach for the treatment of renal cell carcinoma

Author keywords

autophagy; Renal cell carcinoma

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; ANTINEOPLASTIC AGENT; AUTOPHAGY INHIBITOR; BECLIN 1; CARMUSTINE; CHLOROQUINE; ERLOTINIB; EVEROLIMUS; FIBROBLAST GROWTH FACTOR; HIGH MOBILITY GROUP B1 PROTEIN; HYDROXYCHLOROQUINE; INTERLEUKIN 18; INTERLEUKIN 2; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; RECOMBINANT INTERLEUKIN 2; SORAFENIB; SUNITINIB; TEMOZOLOMIDE; TEMSIROLIMUS; UNCLASSIFIED DRUG; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR;

EID: 84880950810     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0b013e31829da0d6     Document Type: Review
Times cited : (25)

References (73)
  • 1
    • 18544365990 scopus 로고    scopus 로고
    • Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
    • Tomlinson IP, Alam NA, Rowan AJ, et al. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet. 2002;30:406-410.
    • (2002) Nat Genet , vol.30 , pp. 406-410
    • Tomlinson, I.P.1    Alam, N.A.2    Rowan, A.J.3
  • 2
    • 51749113159 scopus 로고    scopus 로고
    • Germline SDHB mutations and familial renal cell carcinoma
    • Ricketts C, Woodward ER, Killick P, et al. Germline SDHB mutations and familial renal cell carcinoma. J Natl Cancer Inst. 2008;100: 1260-1262.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 1260-1262
    • Ricketts, C.1    Woodward, E.R.2    Killick, P.3
  • 3
    • 33745713171 scopus 로고    scopus 로고
    • Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    • Degenhardt K, Mathew R, Beaudoin B, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell. 2006;10:51-64.
    • (2006) Cancer Cell , vol.10 , pp. 51-64
    • Degenhardt, K.1    Mathew, R.2    Beaudoin, B.3
  • 4
    • 66449099090 scopus 로고    scopus 로고
    • Autophagy suppresses tumorigenesis through elimination of p62
    • Mathew R, Karp CM, Beaudoin B, et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell. 2009;137:1062-1075.
    • (2009) Cell , vol.137 , pp. 1062-1075
    • Mathew, R.1    Karp, C.M.2    Beaudoin, B.3
  • 5
    • 84880918899 scopus 로고    scopus 로고
    • Secretory versus degradative autophagy: Unconventional secretion of inflammatory mediators
    • [Epub ahead of print] PubMed PMID: 23445716
    • Jiang S, Dupont N, Castillo EF, et al. Secretory versus degradative autophagy: unconventional secretion of inflammatory mediators. J Innate Immun. 2013. [Epub ahead of print] PubMed PMID: 23445716.
    • (2013) J Innate Immun
    • Jiang, S.1    Dupont, N.2    Castillo, E.F.3
  • 6
    • 56749170677 scopus 로고    scopus 로고
    • Autophagic cell death: The story of a misnomer
    • Kroemer G, Levine B. Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol. 2008;9:1004-1010.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 1004-1010
    • Kroemer, G.1    Levine, B.2
  • 7
    • 65249176304 scopus 로고    scopus 로고
    • ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
    • Jung CH, Jun CB, Ro SH, et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell. 2009;20:1992-2003.
    • (2009) Mol Biol Cell , vol.20 , pp. 1992-2003
    • Jung, C.H.1    Jun, C.B.2    Ro, S.H.3
  • 8
    • 66449083078 scopus 로고    scopus 로고
    • ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
    • Ganley IG, Lam du H, Wang J, et al. ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem. 2009;284:12297- 12305.
    • (2009) J Biol Chem , vol.284 , pp. 12297-12305
    • Ganley, I.G.1    Lam Du, H.2    Wang, J.3
  • 9
    • 79251587803 scopus 로고    scopus 로고
    • Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
    • Egan DF, Shackelford DB, Mihaylova MM, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science. 2011;331:456-461.
    • (2011) Science , vol.331 , pp. 456-461
    • Egan, D.F.1    Shackelford, D.B.2    Mihaylova, M.M.3
  • 10
    • 33947250696 scopus 로고    scopus 로고
    • The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
    • Liang J, Shao SH, Xu ZX, et al. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol. 2007;9:218-224.
    • (2007) Nat Cell Biol , vol.9 , pp. 218-224
    • Liang, J.1    Shao, S.H.2    Xu, Z.X.3
  • 11
    • 84857289515 scopus 로고    scopus 로고
    • Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress
    • Singh K, Matsuyama S, Drazba JA, et al. Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress. Autophagy. 2012;8:236-251.
    • (2012) Autophagy , vol.8 , pp. 236-251
    • Singh, K.1    Matsuyama, S.2    Drazba, J.A.3
  • 12
    • 0034707036 scopus 로고    scopus 로고
    • A ubiquitin-like system mediates protein lipidation
    • Ichimura Y, Kirisako T, Takao T, et al. A ubiquitin-like system mediates protein lipidation. Nature. 2000;408:488-492.
    • (2000) Nature , vol.408 , pp. 488-492
    • Ichimura, Y.1    Kirisako, T.2    Takao, T.3
  • 13
    • 79960878784 scopus 로고    scopus 로고
    • Atg8: An autophagyrelated ubiquitin-like protein family
    • Shpilka T, Weidberg H, Pietrokovski S, et al. Atg8: an autophagyrelated ubiquitin-like protein family. Genome biology. 2011;12:226.
    • (2011) Genome Biology , vol.12 , pp. 226
    • Shpilka, T.1    Weidberg, H.2    Pietrokovski, S.3
  • 14
    • 0344142468 scopus 로고    scopus 로고
    • Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21
    • Aita VM, Liang XH, Murty VV, et al. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics. 1999;59:59-65.
    • (1999) Genomics , vol.59 , pp. 59-65
    • Aita, V.M.1    Liang, X.H.2    Murty, V.V.3
  • 15
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • Liang XH, Jackson S, Seaman M, et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature. 1999;402:672-676.
    • (1999) Nature , vol.402 , pp. 672-676
    • Liang, X.H.1    Jackson, S.2    Seaman, M.3
  • 16
    • 9144240441 scopus 로고    scopus 로고
    • Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    • Qu X, Yu J, Bhagat G, et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 2003;112:1809-1820.
    • (2003) J Clin Invest , vol.112 , pp. 1809-1820
    • Qu, X.1    Yu, J.2    Bhagat, G.3
  • 17
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Yue Z, Jin S, Yang C, et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA. 2003;100:15077-15082.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3
  • 18
    • 84876499607 scopus 로고    scopus 로고
    • Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy
    • Takahashi Y, Hori T, Cooper TK, et al. Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy. Blood. 2013;121: 1622-1632.
    • (2013) Blood , vol.121 , pp. 1622-1632
    • Takahashi, Y.1    Hori, T.2    Cooper, T.K.3
  • 19
    • 79951847989 scopus 로고    scopus 로고
    • Principles and current strategies for targeting autophagy for cancer treatment
    • Amaravadi RK, Lippincott-Schwartz J, Yin XM, et al. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res. 2011;17:654-666.
    • (2011) Clin Cancer Res , vol.17 , pp. 654-666
    • Amaravadi, R.K.1    Lippincott-Schwartz, J.2    Yin, X.M.3
  • 20
    • 34347404887 scopus 로고    scopus 로고
    • Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
    • Karantza-Wadsworth V, Patel S, Kravchuk O, et al. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev. 2007;21:1621-1635.
    • (2007) Genes Dev , vol.21 , pp. 1621-1635
    • Karantza-Wadsworth, V.1    Patel, S.2    Kravchuk, O.3
  • 21
    • 64349123107 scopus 로고    scopus 로고
    • Autophagy mediates the mitotic senescence transition
    • Young AR, Narita M, Ferreira M, et al. Autophagy mediates the mitotic senescence transition. Genes Dev. 2009;23:798-803.
    • (2009) Genes Dev , vol.23 , pp. 798-803
    • Young, A.R.1    Narita, M.2    Ferreira, M.3
  • 22
    • 79953306808 scopus 로고    scopus 로고
    • Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival
    • Elgendy M, Sheridan C, Brumatti G, et al. Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol Cell. 2011;42:23-35.
    • (2011) Mol Cell , vol.42 , pp. 23-35
    • Elgendy, M.1    Sheridan, C.2    Brumatti, G.3
  • 23
    • 59649106359 scopus 로고    scopus 로고
    • Assessing metabolic stress and autophagy status in epithelial tumors
    • Mathew R, Karantza-Wadsworth V, White E. Assessing metabolic stress and autophagy status in epithelial tumors. Methods Enzymol. 2009; 453:53-81.
    • (2009) Methods Enzymol , vol.453 , pp. 53-81
    • Mathew, R.1    Karantza-Wadsworth, V.2    White, E.3
  • 24
    • 50149095124 scopus 로고    scopus 로고
    • Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome
    • Fujii S, Mitsunaga S, Yamazaki M, et al. Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome. Cancer Sci. 2008;99:1813-1819.
    • (2008) Cancer Sci , vol.99 , pp. 1813-1819
    • Fujii, S.1    Mitsunaga, S.2    Yamazaki, M.3
  • 25
    • 84874405394 scopus 로고    scopus 로고
    • Autophagy inhibition for chemosensitization and radiosensitization in cancer do the preclinical data support this therapeutic strategy?
    • Bristol ML, Emery SM, Maycotte P, et al. Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy? J Pharmacol Exp Ther. 2013; 344:544-552.
    • (2013) J Pharmacol Exp Ther , vol.344 , pp. 544-552
    • Bristol, M.L.1    Emery, S.M.2    Maycotte, P.3
  • 26
    • 33846794896 scopus 로고    scopus 로고
    • Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
    • Amaravadi RK, Yu D, Lum JJ, et al. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest. 2007;117:326-336.
    • (2007) J Clin Invest , vol.117 , pp. 326-336
    • Amaravadi, R.K.1    Yu, D.2    Lum, J.J.3
  • 27
    • 0035863399 scopus 로고    scopus 로고
    • A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles
    • Paglin S, Hollister T, Delohery T, et al. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res. 2001;61:439-444.
    • (2001) Cancer Res , vol.61 , pp. 439-444
    • Paglin, S.1    Hollister, T.2    Delohery, T.3
  • 28
    • 71249122207 scopus 로고    scopus 로고
    • Autophagy inhibition in combination cancer treatment
    • Livesey KM, Tang D, Zeh HJ, et al. Autophagy inhibition in combination cancer treatment. Current Opin Investig Drugs. 2009;10: 1269-1279.
    • (2009) Current Opin Investig Drugs , vol.10 , pp. 1269-1279
    • Livesey, K.M.1    Tang, D.2    Zeh, H.J.3
  • 29
    • 0030954774 scopus 로고    scopus 로고
    • Incidence of hydroxychloroquine retinopathy in 1,207 patients in a large multicenter outpatient practice
    • Levy GD, Munz SJ, Paschal J, et al. Incidence of hydroxychloroquine retinopathy in 1,207 patients in a large multicenter outpatient practice. Arthritis Rheum. 1997;40:1482-1486.
    • (1997) Arthritis Rheum , vol.40 , pp. 1482-1486
    • Levy, G.D.1    Munz, S.J.2    Paschal, J.3
  • 30
    • 84861434652 scopus 로고    scopus 로고
    • Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency
    • McAfee Q, Zhang Z, Samanta A, et al. Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc Natl Acad Sci USA. 2012;109: 8253-8258.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 8253-8258
    • McAfee, Q.1    Zhang, Z.2    Samanta, A.3
  • 31
    • 33846627302 scopus 로고    scopus 로고
    • A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    • Hampe J, Franke A, Rosenstiel P, et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet. 2007;39:207-211.
    • (2007) Nat Genet , vol.39 , pp. 207-211
    • Hampe, J.1    Franke, A.2    Rosenstiel, P.3
  • 32
    • 34247554965 scopus 로고    scopus 로고
    • Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
    • Rioux JD, Xavier RJ, Taylor KD, et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet. 2007;39:596-604.
    • (2007) Nat Genet , vol.39 , pp. 596-604
    • Rioux, J.D.1    Xavier, R.J.2    Taylor, K.D.3
  • 33
    • 84880958188 scopus 로고    scopus 로고
    • Combined mTOR inhibition and autophagy inhibition: Phase i trial of temsirolimus and hydroxchloroquine in patients with advanced solid tumors
    • Abstract 4500
    • Algazy KM, Schuchter LM, Demichele AM, et al. Combined mTOR inhibition and autophagy inhibition: phase I trial of temsirolimus and hydroxchloroquine in patients with advanced solid tumors. Proc Am Assoc Cancer Res. 2011:Abstract 4500.
    • (2011) Proc Am Assoc Cancer Res
    • Algazy, K.M.1    Schuchter, L.M.2    Demichele, A.M.3
  • 34
    • 84880962120 scopus 로고    scopus 로고
    • Combining chemotherapy with autophagy inhibition: Phase i trial of dose-intense temozolomide and hydroxchloroquine in patients with advanced solid tumors
    • Poster 26-6
    • Fecher LA, Schuchter LM, Evans T, et al. Combining chemotherapy with autophagy inhibition: phase I trial of dose-intense temozolomide and hydroxchloroquine in patients with advanced solid tumors. Proc Am Assoc Cancer Res. 2011:Poster 26-6.
    • (2011) Proc Am Assoc Cancer Res
    • Fecher, L.A.1    Schuchter, L.M.2    Evans, T.3
  • 35
    • 33645115547 scopus 로고    scopus 로고
    • Adding chloroquine to conventional treatment for glioblastoma multiforme: A randomized, double-blind, placebo-controlled trial
    • Sotelo J, Briceno E, Lopez-Gonzalez MA. Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2006;144: 337-343.
    • (2006) Ann Intern Med , vol.144 , pp. 337-343
    • Sotelo, J.1    Briceno, E.2    Ma, L.3
  • 36
    • 80052748827 scopus 로고    scopus 로고
    • Pharmacokinetic analysis and pharmacodynamic evidence of autophagy inhibition in patients with newly diagnosed glioblastoma treated on a phase i trial of hydroxychloroquine in combination with adjuvant temozolomide and radiation (ABTC 0603)
    • Abstract 3086
    • Rosenfeld MR, Grossman SA, Brem S, et al. Pharmacokinetic analysis and pharmacodynamic evidence of autophagy inhibition in patients with newly diagnosed glioblastoma treated on a phase I trial of hydroxychloroquine in combination with adjuvant temozolomide and radiation (ABTC 0603). J Clin Oncol. 2010;28(suppl):Abstract 3086.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Rosenfeld, M.R.1    Grossman, S.A.2    Brem, S.3
  • 37
    • 84866601508 scopus 로고    scopus 로고
    • A phase i study of erlotinib and hydroxychloroquine in advanced nonYsmall-cell lung cancer
    • Goldberg SB, Supko JG, Neal JW, et al. A phase I study of erlotinib and hydroxychloroquine in advanced nonYsmall-cell lung cancer. J Thorac Oncol. 2012;7:1602-1608.
    • (2012) J Thorac Oncol , vol.7 , pp. 1602-1608
    • Goldberg, S.B.1    Supko, J.G.2    Neal, J.W.3
  • 38
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of antiYPD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of antiYPD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366:2455-2465.
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 39
    • 84875640226 scopus 로고    scopus 로고
    • Self-eating and self-defense: Autophagy controls innate immunity and adaptive immunity
    • Liu G, Bi Y, Wang R, et al. Self-eating and self-defense: autophagy controls innate immunity and adaptive immunity. J Leukoc Biol. 2013; 93:511-519.
    • (2013) J Leukoc Biol , vol.93 , pp. 511-519
    • Liu, G.1    Bi, Y.2    Wang, R.3
  • 40
    • 20344361954 scopus 로고    scopus 로고
    • Autophagy promotes MHC class II presentation of peptides from intracellular source proteins
    • Dengjel J, Schoor O, Fischer R, et al. Autophagy promotes MHC class II presentation of peptides from intracellular source proteins. Proc Natl Acad Sci USA. 2005;102:7922-7927.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 7922-7927
    • Dengjel, J.1    Schoor, O.2    Fischer, R.3
  • 41
    • 0037960005 scopus 로고    scopus 로고
    • Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy
    • Nimmerjahn F, Milosevic S, Behrends U, et al. Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy. Eur J Immunol. 2003;33:1250-1259.
    • (2003) Eur J Immunol , vol.33 , pp. 1250-1259
    • Nimmerjahn, F.1    Milosevic, S.2    Behrends, U.3
  • 42
    • 81255138298 scopus 로고    scopus 로고
    • Tumor-derived autophagosome vaccine: Mechanism of cross-presentation and therapeutic efficacy
    • Li Y, Wang LX, Pang P, et al. Tumor-derived autophagosome vaccine: mechanism of cross-presentation and therapeutic efficacy. Clin Cancer Res. 2011;17:7047-7057.
    • (2011) Clin Cancer Res , vol.17 , pp. 7047-7057
    • Li, Y.1    Wang, L.X.2    Pang, P.3
  • 43
    • 52049102433 scopus 로고    scopus 로고
    • Efficient cross-presentation depends on autophagy in tumor cells
    • Li Y, Wang LX, Yang G, et al. Efficient cross-presentation depends on autophagy in tumor cells. Cancer Res. 2008;68:6889-6895.
    • (2008) Cancer Res , vol.68 , pp. 6889-6895
    • Li, Y.1    Wang, L.X.2    Yang, G.3
  • 44
    • 33748331335 scopus 로고    scopus 로고
    • CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagydependent fusion of pathogen-containing vacuoles and lysosomes
    • Andrade RM, Wessendarp M, Gubbels MJ, et al. CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagydependent fusion of pathogen-containing vacuoles and lysosomes. J Clin Invest. 2006;116:2366-2377.
    • (2006) J Clin Invest , vol.116 , pp. 2366-2377
    • Andrade, R.M.1    Wessendarp, M.2    Gubbels, M.J.3
  • 45
    • 8344247016 scopus 로고    scopus 로고
    • Autophagy defends cells against invading group A Streptococcus
    • Nakagawa I, Amano A, Mizushima N, et al. Autophagy defends cells against invading group A Streptococcus. Science. 2004;306: 1037-1040.
    • (2004) Science , vol.306 , pp. 1037-1040
    • Nakagawa, I.1    Amano, A.2    Mizushima, N.3
  • 46
    • 13244256806 scopus 로고    scopus 로고
    • Escape of intracellular Shigella from autophagy
    • Ogawa M, Yoshimori T, Suzuki T, et al. Escape of intracellular Shigella from autophagy. Science. 2005;307:727-731.
    • (2005) Science , vol.307 , pp. 727-731
    • Ogawa, M.1    Yoshimori, T.2    Suzuki, T.3
  • 47
    • 37549043217 scopus 로고    scopus 로고
    • Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis
    • Sanjuan MA, Dillon CP, Tait SW, et al. Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature. 2007;450:1253-1257.
    • (2007) Nature , vol.450 , pp. 1253-1257
    • Sanjuan, M.A.1    Dillon, C.P.2    Tait, S.W.3
  • 48
    • 52149099867 scopus 로고    scopus 로고
    • Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
    • Nedjic J, Aichinger M, Emmerich J, et al. Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature. 2008;455:396-400.
    • (2008) Nature , vol.455 , pp. 396-400
    • Nedjic, J.1    Aichinger, M.2    Emmerich, J.3
  • 49
    • 29144530630 scopus 로고    scopus 로고
    • Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death
    • Casares N, Pequignot MO, Tesniere A, et al. Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med. 2005;202:1691-1701.
    • (2005) J Exp Med , vol.202 , pp. 1691-1701
    • Casares, N.1    Pequignot, M.O.2    Tesniere, A.3
  • 50
    • 33846057130 scopus 로고    scopus 로고
    • Calreticulin exposure dictates the immunogenicity of cancer cell death
    • Obeid M, Tesniere A, Ghiringhelli F, et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med. 2007;13: 54-61.
    • (2007) Nat Med , vol.13 , pp. 54-61
    • Obeid, M.1    Tesniere, A.2    Ghiringhelli, F.3
  • 51
    • 70350569295 scopus 로고    scopus 로고
    • Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors
    • Ghiringhelli F, Apetoh L, Tesniere A, et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med. 2009;15:1170-1178.
    • (2009) Nat Med , vol.15 , pp. 1170-1178
    • Ghiringhelli, F.1    Apetoh, L.2    Tesniere, A.3
  • 52
    • 84861865743 scopus 로고    scopus 로고
    • Cell-mediated autophagy promotes cancer cell survival
    • Buchser WJ, Laskow TC, Pavlik PJ, et al. Cell-mediated autophagy promotes cancer cell survival. Cancer Res. 2012;72:2970-2979.
    • (2012) Cancer Res , vol.72 , pp. 2970-2979
    • Buchser, W.J.1    Laskow, T.C.2    Pavlik, P.J.3
  • 53
    • 84861615385 scopus 로고    scopus 로고
    • Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapse
    • e6
    • Wildenberg ME, Vos AC, Wolfkamp SC, et al. Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapse. Gastroenterology. 2012;142:1493-1503 e6.
    • (2012) Gastroenterology , vol.142 , pp. 1493-1503
    • Wildenberg, M.E.1    Vos, A.C.2    Wolfkamp, S.C.3
  • 54
    • 65449154326 scopus 로고    scopus 로고
    • The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis
    • Noman MZ, Buart S, Van Pelt J, et al. The cooperative induction of hypoxia-inducible factor-1 alpha and STAT3 during hypoxia induced an impairment of tumor susceptibility to CTL-mediated cell lysis. J Immunol. 2009;182:3510-3521.
    • (2009) J Immunol , vol.182 , pp. 3510-3521
    • Noman, M.Z.1    Buart, S.2    Van Pelt, J.3
  • 55
    • 80052806536 scopus 로고    scopus 로고
    • Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression
    • Noman MZ, Janji B, Kaminska B, et al. Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression. Cancer Res. 2011;71:5976-5986.
    • (2011) Cancer Res , vol.71 , pp. 5976-5986
    • Noman, M.Z.1    Janji, B.2    Kaminska, B.3
  • 56
    • 84861893781 scopus 로고    scopus 로고
    • Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression
    • Liang X, De Vera ME, BuchserWJ, et al. Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression. Cancer Res. 2012;72:2791-2801.
    • (2012) Cancer Res , vol.72 , pp. 2791-2801
    • Liang, X.1    De Vera, M.E.2    Buchser, W.J.3
  • 57
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med. 2007;356: 2271-2281.
    • (2007) N Engl J Med , vol.356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 58
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebocontrolled phase III trial
    • Motzer RJ, Escudier B, Oudard S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebocontrolled phase III trial. Lancet. 2008;372:449-456.
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 59
    • 84864389175 scopus 로고    scopus 로고
    • Autophagy suppresses RIP kinaseYdependent necrosis enabling survival to mTOR inhibition
    • Bray K, Mathew R, Lau A, et al. Autophagy suppresses RIP kinaseYdependent necrosis enabling survival to mTOR inhibition. PLoS One. 2012;7:e41831.
    • (2012) PLoS One , vol.7
    • Bray, K.1    Mathew, R.2    Lau, A.3
  • 60
    • 84873867668 scopus 로고    scopus 로고
    • Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma
    • Xie X, White EP, Mehnert JM. Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma. PLoS One. 2013;8:e55096.
    • (2013) PLoS One , vol.8
    • Xie, X.1    White, E.P.2    Mehnert, J.M.3
  • 61
    • 78149475478 scopus 로고    scopus 로고
    • Akt and autophagy cooperate to promote survival of drug-resistant glioma
    • Fan QW, Cheng C, Hackett C, et al. Akt and autophagy cooperate to promote survival of drug-resistant glioma. Science signaling. 2010; 3:ra81.
    • (2010) Science Signaling. , vol.3
    • Fan, Q.W.1    Cheng, C.2    Hackett, C.3
  • 62
    • 80052823576 scopus 로고    scopus 로고
    • Augmentation of NVP-BEZ235's anticancer activity against human lung cancer cells by blockage of autophagy
    • Xu CX, Zhao L, Yue P, et al. Augmentation of NVP-BEZ235's anticancer activity against human lung cancer cells by blockage of autophagy. Cancer Biol Ther. 2011;12:549-555.
    • (2011) Cancer Biol Ther , vol.12 , pp. 549-555
    • Xu, C.X.1    Zhao, L.2    Yue, P.3
  • 63
    • 84876397501 scopus 로고    scopus 로고
    • Dual PI3K/mTOR inhibitor NVP-BEZ235-induced apoptosis of hepatocellular carcinoma cell lines is enhanced by inhibitors of autophagy
    • Chang Z, Shi G, Jin J, et al. Dual PI3K/mTOR inhibitor NVP-BEZ235-induced apoptosis of hepatocellular carcinoma cell lines is enhanced by inhibitors of autophagy. Int J Mol Med. 2013;31:1449-1456.
    • (2013) Int J Mol Med , vol.31 , pp. 1449-1456
    • Chang, Z.1    Shi, G.2    Jin, J.3
  • 64
    • 84873809376 scopus 로고    scopus 로고
    • Inhibition of autophagy enhances sunitinib-induced cytotoxicity in rat pheochromocytoma PC12 cells
    • Ikeda T, Ishii KA, Saito Y, et al. Inhibition of autophagy enhances sunitinib-induced cytotoxicity in rat pheochromocytoma PC12 cells. J Pharmacol Sci. 2013;121:67-73.
    • (2013) J Pharmacol Sci , vol.121 , pp. 67-73
    • Ikeda, T.1    Ishii, K.A.2    Saito, Y.3
  • 65
    • 84869460494 scopus 로고    scopus 로고
    • Autophagic activation potentiates the antiproliferative effects of tyrosine kinase inhibitors in medullary thyroid cancer
    • Lin CI, Whang EE, Lorch JH, et al. Autophagic activation potentiates the antiproliferative effects of tyrosine kinase inhibitors in medullary thyroid cancer. Surgery. 2012;152:1142-1149.
    • (2012) Surgery , vol.152 , pp. 1142-1149
    • Lin, C.I.1    Whang, E.E.2    Lorch, J.H.3
  • 66
    • 79960357893 scopus 로고    scopus 로고
    • A phase II study of bevacizumab (B) and high-dose aldesleukin (IL-2) in patients (p) with metastatic renal cell carcinoma (mRCC): A Cytokine Working Group Study (CWGS)
    • abstr 4530
    • Dandamudi UB, Ghebremichael MS, Sosman JA, et al. A phase II study of bevacizumab (B) and high-dose aldesleukin (IL-2) in patients (p) with metastatic renal cell carcinoma (mRCC): A Cytokine Working Group Study (CWGS). J Clin Oncol. 2010;28(suppl):abstr 4530.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Dandamudi, U.B.1    Ghebremichael, M.S.2    Sosman, J.A.3
  • 67
    • 33746930794 scopus 로고    scopus 로고
    • Succinate dehydrogenase and fumarate hydratase: Linking mitochondrial dysfunction and cancer
    • King A, Selak MA, Gottlieb E. Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer. Oncogene. 2006;25:4675-4682.
    • (2006) Oncogene , vol.25 , pp. 4675-4682
    • King, A.1    Selak, M.A.2    Gottlieb, E.3
  • 68
    • 43649104579 scopus 로고    scopus 로고
    • Mitochondrial autophagy is an HIF-1Ydependent adaptive metabolic response to hypoxia
    • Zhang H, Bosch-Marce M, Shimoda LA, et al. Mitochondrial autophagy is an HIF-1Ydependent adaptive metabolic response to hypoxia. J Biol Chem. 2008;283:10892-10903.
    • (2008) J Biol Chem , vol.283 , pp. 10892-10903
    • Zhang, H.1    Bosch-Marce, M.2    Shimoda, L.A.3
  • 69
    • 84859857694 scopus 로고    scopus 로고
    • VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma
    • Mikhaylova O, Stratton Y, Hall D, et al. VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma. Cancer Cell. 2012;21:532-546.
    • (2012) Cancer Cell , vol.21 , pp. 532-546
    • Mikhaylova, O.1    Stratton, Y.2    Hall, D.3
  • 70
    • 84862648897 scopus 로고    scopus 로고
    • Damage associated molecular pattern molecule-induced microRNAs (DAMPmiRs) in human peripheral blood mononuclear cells
    • Unlu S, Tang S, Wang E, et al. Damage associated molecular pattern molecule-induced microRNAs (DAMPmiRs) in human peripheral blood mononuclear cells. PLoS One. 2012;7:e38899.
    • (2012) PLoS One , vol.7
    • Unlu, S.1    Tang, S.2    Wang, E.3
  • 71
    • 84878346810 scopus 로고    scopus 로고
    • HMGB1: The central cytokine for all lymphoid cells
    • Li G, Liang X, Lotze MT. HMGB1: the central cytokine for all lymphoid cells. Front Immunol. 2013;4:68.
    • (2013) Front Immunol , vol.4 , pp. 68
    • Li, G.1    Liang, X.2    Lotze, M.T.3
  • 72
    • 84877328234 scopus 로고    scopus 로고
    • DAMPs and autophagy: Cellular adaptation to injury and unscheduled cell death
    • Zhang Q, Kang R, Zeh HJ 3rd, et al. DAMPs and autophagy: cellular adaptation to injury and unscheduled cell death. Autophagy. 2013;9: 451-458.
    • (2013) Autophagy , vol.9 , pp. 451-458
    • Zhang, Q.1    Kang, R.2    Zeh III, H.J.3
  • 73
    • 84879651810 scopus 로고    scopus 로고
    • Life after death: Targeting high mobility group box 1 in emergent cancer therapies
    • Guo ZS, Liu Z, Bartlett DL, et al. Life after death: targeting high mobility group box 1 in emergent cancer therapies. Am J Cancer Res. 2013;3:1-20.
    • (2013) Am J Cancer Res , vol.3 , pp. 1-20
    • Guo, Z.S.1    Liu, Z.2    Bartlett, D.L.3


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