Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells

Biopolymers - Peptide Science Section

Volumn 102, Issue 6, 2014, Pages 444-455

  Qian, Wen Jian ^a   Park, Jung Eun ^b   Lim, Dan ^c   Lai, Christopher C ^a   Kelley, James A ^a   Park, Suk Youl ^d   Lee, Ki Won ^d,e   Yaffe, Michael B ^c   Lee, Kyung S ^b   Burke, Terrence R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d Seoul National University   (South Korea)

^e Seoul National University   (South Korea)

Author keywords

Cationic dialkyl histidine; Crystal structure; Intramolecular charge masking; Phosphopeptides; Plk1; Polo kinase; Polo box domain

Indexed keywords

ALKYLATION; AMINO ACIDS; BINDING ENERGY; BUDGET CONTROL; CRYSTAL STRUCTURE; CYTOLOGY; ENZYMES; CELL MEMBRANES; POLYPEPTIDES;

CATIONIC DIALKYL HISTIDINE; INTRAMOLECULAR CHARGE; PHOSPHOPEPTIDES; PLK1; POLO KINASE; POLO-BOX DOMAIN;

PEPTIDES;

HISTIDINE; PHOSPHOPEPTIDE; POLO LIKE KINASE 1; POLO LIKE KINASE 2; POLO LIKE KINASE 3; ALKYL GROUP; IMIDAZOLE DERIVATIVE; PEPTIDOMIMETIC AGENT; PHOSPHOSERINE; PHOSPHOTHREONINE; RESIN; ANION; CELL CYCLE PROTEIN; ESTERASE; ONCOPROTEIN; POLO-LIKE KINASE 1; PRODRUG; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE;

ALKYLATION; ANTIPROLIFERATIVE ACTIVITY; CELL MEMBRANE PERMEABILITY; CONFERENCE PAPER; CONTROLLED STUDY; DERIVATIZATION; FLUORESCENCE POLARIZATION; HELA CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; MASS SPECTROMETRY; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN HYDROLYSIS; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; X RAY CRYSTALLOGRAPHY; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG EFFICACY; DRUG PROTEIN BINDING; PROTEIN DOMAIN; REACTION ANALYSIS; CELL PROLIFERATION; CHEMISTRY; CRYSTALLIZATION; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME STABILITY; LIQUID CHROMATOGRAPHY; METABOLISM; PROTEIN TERTIARY STRUCTURE; SYNTHESIS; TANDEM MASS SPECTROMETRY;

ALKYLATION; ANIONS; CELL CYCLE PROTEINS; CELL PROLIFERATION; CHROMATOGRAPHY, LIQUID; CRYSTALLIZATION; ENZYME STABILITY; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTERASES; FLUORESCENCE POLARIZATION; HELA CELLS; HISTIDINE; HUMANS; PHOSPHOPEPTIDES; PRODRUGS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; TANDEM MASS SPECTROMETRY;

EID: 84924096008     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.22569     Document Type: Conference Paper

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