Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1)

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7306-7308

  Qian, Wen Jian ^a   Park, Jung Eun ^b   Lee, Kyung S ^b   Burke Jr , Terrence R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Non proteogenic amino acids; Peptide ligands; Polo box domain; Polo like kinase; Signal transduction

Indexed keywords

ASPARAGINE; GLUTAMINE; HISTIDINE; IMIDAZOLE; NITROGEN; ORNITHINE; POLO BOX INTERACTING PROTEIN 1; POLO LIKE KINASE 1; PROTEIN; THREONINE; TYROSINE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; ISOMER; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS;

AMINO ACIDS; CELL CYCLE PROTEINS; MODELS, MOLECULAR; PEPTIDES; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS;

EID: 84870251899     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.10.093     Document Type: Article

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