메뉴 건너뛰기




Volumn 127, Issue 1, 2015, Pages 83-91

TRAIL pathway is associated with inhibition of colon cancer by protopanaxadiol

Author keywords

Apoptosis; Gene expression; Human colorectal cancer; Microarray; Panax quinquefolius; Protopanaxadiol; Tumor necrosis factor; Xenograft

Indexed keywords

DEATH RECEPTOR 4; DEATH RECEPTOR 5; MESSENGER RNA; PROTEIN P53; PROTOPANAXADIOL; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; ANTINEOPLASTIC AGENT; SAPOGENIN;

EID: 84924070743     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1016/j.jphs.2014.11.003     Document Type: Article
Times cited : (25)

References (48)
  • 1
    • 72449176846 scopus 로고    scopus 로고
    • Molecular origins of cancer: Molecular basis of colorectal cancer
    • S.D. Markowitz, and M.M. Bertagnolli Molecular origins of cancer: Molecular basis of colorectal cancer N Engl J Med 361 2009 2449 2460
    • (2009) N Engl J Med , vol.361 , pp. 2449-2460
    • Markowitz, S.D.1    Bertagnolli, M.M.2
  • 2
    • 77949726422 scopus 로고    scopus 로고
    • Declining death rates reflect progress against cancer
    • A. Jemal, E. Ward, and M. Thun Declining death rates reflect progress against cancer PLoS One 5 2010 e9584
    • (2010) PLoS One , vol.5 , pp. e9584
    • Jemal, A.1    Ward, E.2    Thun, M.3
  • 3
    • 84880810771 scopus 로고    scopus 로고
    • Influence of novel supramolecular substance, [2] rotaxane, on the caspase signaling pathway in melanoma and colon cancer cells in vitro
    • K. Hara, T. Beppu, M. Kimura, Y. Fujita, T. Takata, and K. Nishio Influence of novel supramolecular substance, [2] rotaxane, on the caspase signaling pathway in melanoma and colon cancer cells in vitro J Pharm Sci 122 2013 153 157
    • (2013) J Pharm Sci , vol.122 , pp. 153-157
    • Hara, K.1    Beppu, T.2    Kimura, M.3    Fujita, Y.4    Takata, T.5    Nishio, K.6
  • 4
    • 34548329530 scopus 로고    scopus 로고
    • A perspective on DNA microarrays in pathology research and practice
    • J.R. Pollack A perspective on DNA microarrays in pathology research and practice Am J Pathol 171 2007 375 385
    • (2007) Am J Pathol , vol.171 , pp. 375-385
    • Pollack, J.R.1
  • 5
    • 2142705747 scopus 로고    scopus 로고
    • Gene expression of 5-fluorouracil metabolic enzymes in primary colorectal cancer and corresponding liver metastasis
    • M. Inokuchi, H. Uetake, Y. Shirota, H. Yamada, M. Tajima, and K. Sugihara Gene expression of 5-fluorouracil metabolic enzymes in primary colorectal cancer and corresponding liver metastasis Cancer Chemother Pharmacol 53 2004 391 396
    • (2004) Cancer Chemother Pharmacol , vol.53 , pp. 391-396
    • Inokuchi, M.1    Uetake, H.2    Shirota, Y.3    Yamada, H.4    Tajima, M.5    Sugihara, K.6
  • 6
    • 0036227125 scopus 로고    scopus 로고
    • Complementary and alternative therapies in cancer symptom management
    • M.J. Ott Complementary and alternative therapies in cancer symptom management Cancer Pract 10 2002 162 166
    • (2002) Cancer Pract , vol.10 , pp. 162-166
    • Ott, M.J.1
  • 7
    • 34548166013 scopus 로고    scopus 로고
    • Ganodermataceae: Natural products and their related pharmacological functions
    • X. Zhou, J. Lin, Y. Yin, J. Zhao, X. Sun, and K. Tang Ganodermataceae: natural products and their related pharmacological functions Am J Chin Med 35 2007 559 574
    • (2007) Am J Chin Med , vol.35 , pp. 559-574
    • Zhou, X.1    Lin, J.2    Yin, Y.3    Zhao, J.4    Sun, X.5    Tang, K.6
  • 8
    • 38049028234 scopus 로고    scopus 로고
    • Western-medicine-validated anti-tumor agents and traditional Chinese medicine
    • X.J. Li, and H.Y. Zhang Western-medicine-validated anti-tumor agents and traditional Chinese medicine Trends Mol Med 14 2008 1 2
    • (2008) Trends Mol Med , vol.14 , pp. 1-2
    • Li, X.J.1    Zhang, H.Y.2
  • 9
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • D.J. Newman, and G.M. Cragg Natural products as sources of new drugs over the last 25 years J Nat Prod 70 2007 461 477
    • (2007) J Nat Prod , vol.70 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 10
    • 78650509813 scopus 로고    scopus 로고
    • Synthesis of protopanaxadiol derivatives and evaluation of their anticancer activities
    • G.J. Du, Q. Dai, S. Williams, C.Z. Wang, and C.S. Yuan Synthesis of protopanaxadiol derivatives and evaluation of their anticancer activities Anticancer Drugs 22 2011 35 45
    • (2011) Anticancer Drugs , vol.22 , pp. 35-45
    • Du, G.J.1    Dai, Q.2    Williams, S.3    Wang, C.Z.4    Yuan, C.S.5
  • 11
    • 56649094497 scopus 로고    scopus 로고
    • Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects
    • X. Luo, J. Chen, W.X. Song, N. Tang, J. Luo, and Z.L. Deng Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects Lab Invest 88 2008 1264 1277
    • (2008) Lab Invest , vol.88 , pp. 1264-1277
    • Luo, X.1    Chen, J.2    Song, W.X.3    Tang, N.4    Luo, J.5    Deng, Z.L.6
  • 12
    • 77951021015 scopus 로고    scopus 로고
    • Synergistic antitumor effect of the activated PPARgamma and retinoid receptors on human osteosarcoma
    • B.C. He, L. Chen, G.W. Zuo, W. Zhang, Y. Bi, and J. Huang Synergistic antitumor effect of the activated PPARgamma and retinoid receptors on human osteosarcoma Clin Cancer Res 16 2010 2235 2245
    • (2010) Clin Cancer Res , vol.16 , pp. 2235-2245
    • He, B.C.1    Chen, L.2    Zuo, G.W.3    Zhang, W.4    Bi, Y.5    Huang, J.6
  • 13
    • 78751559362 scopus 로고    scopus 로고
    • Tetrandrine inhibits Wnt/beta-catenin signaling and suppresses tumor growth of human colorectal cancer
    • B.C. He, J.L. Gao, B.Q. Zhang, Q. Luo, Q. Shi, and S.H. Kim Tetrandrine inhibits Wnt/beta-catenin signaling and suppresses tumor growth of human colorectal cancer Mol Pharmacol 79 2011 211 219
    • (2011) Mol Pharmacol , vol.79 , pp. 211-219
    • He, B.C.1    Gao, J.L.2    Zhang, B.Q.3    Luo, Q.4    Shi, Q.5    Kim, S.H.6
  • 14
    • 84857582110 scopus 로고    scopus 로고
    • Nicotine- and tar-free cigarette smoke induces cell damage through reactive oxygen species newly generated by PKC-dependent activation of NADPH oxidase
    • H. Asano, T. Horinouchi, Y. Mai, O. Sawada, S. Fujii, and T. Nishiya Nicotine- and tar-free cigarette smoke induces cell damage through reactive oxygen species newly generated by PKC-dependent activation of NADPH oxidase J Pharmacol Sci 118 2012 275 287
    • (2012) J Pharmacol Sci , vol.118 , pp. 275-287
    • Asano, H.1    Horinouchi, T.2    Mai, Y.3    Sawada, O.4    Fujii, S.5    Nishiya, T.6
  • 15
    • 84863055306 scopus 로고    scopus 로고
    • Echinacoside stimulates cell proliferation and prevents cell apoptosis in intestinal epithelial MODE-K cells by up-regulation of transforming growth factor-beta1 expression
    • Y. Jia, Q. Guan, Y. Guo, and C. Du Echinacoside stimulates cell proliferation and prevents cell apoptosis in intestinal epithelial MODE-K cells by up-regulation of transforming growth factor-beta1 expression J Pharmacol Sci 118 2012 99 108
    • (2012) J Pharmacol Sci , vol.118 , pp. 99-108
    • Jia, Y.1    Guan, Q.2    Guo, Y.3    Du, C.4
  • 19
    • 33846469565 scopus 로고    scopus 로고
    • Steamed American ginseng berry: Ginsenoside analyses and anticancer activities
    • C.Z. Wang, B. Zhang, W.X. Song, A. Wang, M. Ni, and X. Luo Steamed American ginseng berry: ginsenoside analyses and anticancer activities J Agric Food Chem 54 2006 9936 9942
    • (2006) J Agric Food Chem , vol.54 , pp. 9936-9942
    • Wang, C.Z.1    Zhang, B.2    Song, W.X.3    Wang, A.4    Ni, M.5    Luo, X.6
  • 20
    • 34447511713 scopus 로고    scopus 로고
    • Red American ginseng: Ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius roots
    • C.Z. Wang, H.H. Aung, M. Ni, J.A. Wu, R. Tong, and S. Wicks Red American ginseng: ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius roots Planta Med 73 2007 669 674
    • (2007) Planta Med , vol.73 , pp. 669-674
    • Wang, C.Z.1    Aung, H.H.2    Ni, M.3    Wu, J.A.4    Tong, R.5    Wicks, S.6
  • 21
    • 0036403187 scopus 로고    scopus 로고
    • Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line
    • D.G. Popovich, and D.D. Kitts Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line Arch Biochem Biophys 406 2002 1 8
    • (2002) Arch Biochem Biophys , vol.406 , pp. 1-8
    • Popovich, D.G.1    Kitts, D.D.2
  • 22
    • 4043137428 scopus 로고    scopus 로고
    • Mechanistic studies on protopanaxadiol, Rh2, and ginseng (Panax quinquefolius) extract induced cytotoxicity in intestinal Caco-2 cells
    • D.G. Popovich, and D.D. Kitts Mechanistic studies on protopanaxadiol, Rh2, and ginseng (Panax quinquefolius) extract induced cytotoxicity in intestinal Caco-2 cells J Biochem Mol Toxicol 18 2004 143 149
    • (2004) J Biochem Mol Toxicol , vol.18 , pp. 143-149
    • Popovich, D.G.1    Kitts, D.D.2
  • 23
    • 84879030692 scopus 로고    scopus 로고
    • 20(S)-Protopanaxadiol (PPD) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs
    • J. Liu, X. Wang, P. Liu, R. Deng, M. Lei, and W. Chen 20(S)-Protopanaxadiol (PPD) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs Bioorg Med Chem 21 2013 4279 4287
    • (2013) Bioorg Med Chem , vol.21 , pp. 4279-4287
    • Liu, J.1    Wang, X.2    Liu, P.3    Deng, R.4    Lei, M.5    Chen, W.6
  • 24
    • 84885907483 scopus 로고    scopus 로고
    • 20(S)-protopanaxadiol triggers mitochondrial-mediated apoptosis in human lung adenocarcinoma A549 cells via inhibiting the PI3K/Akt signaling pathway
    • Y.L. Zhang, R. Zhang, H.L. Xu, X.F. Yu, S.C. Qu, and D.Y. Sui 20(S)-protopanaxadiol triggers mitochondrial-mediated apoptosis in human lung adenocarcinoma A549 cells via inhibiting the PI3K/Akt signaling pathway Am J Chin Med 41 2013 1137 1152
    • (2013) Am J Chin Med , vol.41 , pp. 1137-1152
    • Zhang, Y.L.1    Zhang, R.2    Xu, H.L.3    Yu, X.F.4    Qu, S.C.5    Sui, D.Y.6
  • 25
    • 45349085085 scopus 로고    scopus 로고
    • Experimental therapy of prostate cancer with novel natural product anti-cancer ginsenosides
    • W. Wang, E.R. Rayburn, M. Hao, Y. Zhao, D.L. Hill, and R. Zhang Experimental therapy of prostate cancer with novel natural product anti-cancer ginsenosides Prostate 68 2008 809 819
    • (2008) Prostate , vol.68 , pp. 809-819
    • Wang, W.1    Rayburn, E.R.2    Hao, M.3    Zhao, Y.4    Hill, D.L.5    Zhang, R.6
  • 26
    • 84859633021 scopus 로고    scopus 로고
    • A novel oral dosage formulation of the ginsenoside aglycone protopanaxadiol exhibits therapeutic activity against a hormone-insensitive model of prostate cancer
    • A.G. Musende, A. Eberding, C.A. Wood, H. Adomat, L. Fazli, and A. Hurtado-Coll A novel oral dosage formulation of the ginsenoside aglycone protopanaxadiol exhibits therapeutic activity against a hormone-insensitive model of prostate cancer Anticancer Drugs 23 2012 543 552
    • (2012) Anticancer Drugs , vol.23 , pp. 543-552
    • Musende, A.G.1    Eberding, A.2    Wood, C.A.3    Adomat, H.4    Fazli, L.5    Hurtado-Coll, A.6
  • 27
    • 72449153399 scopus 로고    scopus 로고
    • Compound K induces apoptosis via CAMK-IV/AMPK pathways in HT-29 colon cancer cells
    • Y. Kim do, M.W. Park, H.D. Yuan, H.J. Lee, S.H. Kim, and S.H. Chung Compound K induces apoptosis via CAMK-IV/AMPK pathways in HT-29 colon cancer cells J Agric Food Chem 57 2009 10573 10578
    • (2009) J Agric Food Chem , vol.57 , pp. 10573-10578
    • Kim Do, Y.1    Park, M.W.2    Yuan, H.D.3    Lee, H.J.4    Kim, S.H.5    Chung, S.H.6
  • 28
    • 78651246162 scopus 로고    scopus 로고
    • Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ss-catenin signaling
    • B.C. He, J.L. Gao, X. Luo, J. Luo, J. Shen, and L. Wang Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ss-catenin signaling Int J Oncol 38 2011 437 445
    • (2011) Int J Oncol , vol.38 , pp. 437-445
    • He, B.C.1    Gao, J.L.2    Luo, X.3    Luo, J.4    Shen, J.5    Wang, L.6
  • 29
    • 0344153913 scopus 로고    scopus 로고
    • Role of antiproliferative B cell translocation gene-1 as an apoptotic sensitizer in activation-induced cell death of brain microglia
    • H. Lee, S. Cha, M.S. Lee, G.J. Cho, W.S. Choi, and K. Suk Role of antiproliferative B cell translocation gene-1 as an apoptotic sensitizer in activation-induced cell death of brain microglia J Immunol 171 2003 5802 5811
    • (2003) J Immunol , vol.171 , pp. 5802-5811
    • Lee, H.1    Cha, S.2    Lee, M.S.3    Cho, G.J.4    Choi, W.S.5    Suk, K.6
  • 30
    • 84902656358 scopus 로고    scopus 로고
    • REDD1/DDIT4-independent mTORC1 inhibition and apoptosis by glucocorticoids in thymocytes
    • N.C. Wolff, R.M. McKay, and J. Brugarolas REDD1/DDIT4-independent mTORC1 inhibition and apoptosis by glucocorticoids in thymocytes Mol Cancer Res 12 2014 867 877
    • (2014) Mol Cancer Res , vol.12 , pp. 867-877
    • Wolff, N.C.1    McKay, R.M.2    Brugarolas, J.3
  • 31
    • 84886302360 scopus 로고    scopus 로고
    • Molecular imaging of p53 signal pathway in lung cancer cell cycle arrest induced by cisplatin
    • S. Wang, W. Li, Z. Xue, Y. Lu, K. Narsinh, and W. Fan Molecular imaging of p53 signal pathway in lung cancer cell cycle arrest induced by cisplatin Mol Carcinog 52 2013 900 907
    • (2013) Mol Carcinog , vol.52 , pp. 900-907
    • Wang, S.1    Li, W.2    Xue, Z.3    Lu, Y.4    Narsinh, K.5    Fan, W.6
  • 32
    • 80051924084 scopus 로고    scopus 로고
    • A functional single nucleotide polymorphism at the promoter region of cyclin A2 is associated with increased risk of colon, liver, and lung cancers
    • D.H. Kim, S.E. Park, M. Kim, Y.I. Ji, M.Y. Kang, and E.H. Jung A functional single nucleotide polymorphism at the promoter region of cyclin A2 is associated with increased risk of colon, liver, and lung cancers Cancer 117 2011 4080 4091
    • (2011) Cancer , vol.117 , pp. 4080-4091
    • Kim, D.H.1    Park, S.E.2    Kim, M.3    Ji, Y.I.4    Kang, M.Y.5    Jung, E.H.6
  • 33
  • 34
    • 0032931766 scopus 로고    scopus 로고
    • Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers
    • J.M. Gudas, M. Payton, S. Thukral, E. Chen, M. Bass, and M.O. Robinson Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers Mol Cell Biol 19 1999 612 622
    • (1999) Mol Cell Biol , vol.19 , pp. 612-622
    • Gudas, J.M.1    Payton, M.2    Thukral, S.3    Chen, E.4    Bass, M.5    Robinson, M.O.6
  • 35
    • 84863803266 scopus 로고    scopus 로고
    • Cyclin E2 overexpression is associated with endocrine resistance but not insensitivity to CDK2 inhibition in human breast cancer cells
    • C.E. Caldon, C.M. Sergio, J. Kang, A. Muthukaruppan, M.N. Boersma, and A. Stone Cyclin E2 overexpression is associated with endocrine resistance but not insensitivity to CDK2 inhibition in human breast cancer cells Mol Cancer Ther 11 2012 1488 1499
    • (2012) Mol Cancer Ther , vol.11 , pp. 1488-1499
    • Caldon, C.E.1    Sergio, C.M.2    Kang, J.3    Muthukaruppan, A.4    Boersma, M.N.5    Stone, A.6
  • 36
    • 0242559093 scopus 로고    scopus 로고
    • Panaxadiol selectively inhibits cyclin A-associated Cdk2 activity by elevating p21WAF1/CIP1 protein levels in mammalian cells
    • Y.H. Jin, J. Choi, S. Shin, K.Y. Lee, J.H. Park, and S.K. Lee Panaxadiol selectively inhibits cyclin A-associated Cdk2 activity by elevating p21WAF1/CIP1 protein levels in mammalian cells Carcinogenesis 24 2003 1767 1772
    • (2003) Carcinogenesis , vol.24 , pp. 1767-1772
    • Jin, Y.H.1    Choi, J.2    Shin, S.3    Lee, K.Y.4    Park, J.H.5    Lee, S.K.6
  • 37
    • 84875108087 scopus 로고    scopus 로고
    • Compound K, a ginsenoside metabolite, inhibits colon cancer growth via multiple pathways including p53-p21 interactions
    • Z. Zhang, G.J. Du, C.Z. Wang, X.D. Wen, T. Calway, and Z. Li Compound K, a ginsenoside metabolite, inhibits colon cancer growth via multiple pathways including p53-p21 interactions Int J Mol Sci 14 2013 2980 2995
    • (2013) Int J Mol Sci , vol.14 , pp. 2980-2995
    • Zhang, Z.1    Du, G.J.2    Wang, C.Z.3    Wen, X.D.4    Calway, T.5    Li, Z.6
  • 39
    • 84859183715 scopus 로고    scopus 로고
    • Malignant glioma: Lessons from genomics, mouse models, and stem cells
    • J. Chen, R.M. McKay, and L.F. Parada Malignant glioma: lessons from genomics, mouse models, and stem cells Cell 149 2012 36 47
    • (2012) Cell , vol.149 , pp. 36-47
    • Chen, J.1    McKay, R.M.2    Parada, L.F.3
  • 40
    • 84875493066 scopus 로고    scopus 로고
    • Using mouse models to explore MDM-p53 signaling in development, cell growth, and tumorigenesis
    • H.S. Gannon, and S.N. Jones Using mouse models to explore MDM-p53 signaling in development, cell growth, and tumorigenesis Genes Cancer 3 2012 209 218
    • (2012) Genes Cancer , vol.3 , pp. 209-218
    • Gannon, H.S.1    Jones, S.N.2
  • 41
    • 84864121189 scopus 로고    scopus 로고
    • Co-administration strategy to enhance brain accumulation of vandetanib by modulating P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp1/Abcg2) mediated efflux with m-TOR inhibitors
    • M. Minocha, V. Khurana, B. Qin, D. Pal, and A.K. Mitra Co-administration strategy to enhance brain accumulation of vandetanib by modulating P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp1/Abcg2) mediated efflux with m-TOR inhibitors Int J Pharm 434 2012 306 314
    • (2012) Int J Pharm , vol.434 , pp. 306-314
    • Minocha, M.1    Khurana, V.2    Qin, B.3    Pal, D.4    Mitra, A.K.5
  • 42
    • 0033662433 scopus 로고    scopus 로고
    • Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5
    • F.C. Kischkel, D.A. Lawrence, A. Chuntharapai, P. Schow, K.J. Kim, and A. Ashkenazi Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5 Immunity 12 2000 611 620
    • (2000) Immunity , vol.12 , pp. 611-620
    • Kischkel, F.C.1    Lawrence, D.A.2    Chuntharapai, A.3    Schow, P.4    Kim, K.J.5    Ashkenazi, A.6
  • 43
  • 44
    • 84867125683 scopus 로고    scopus 로고
    • Regulation of the human TRAIL gene
    • J.E. Allen, and W.S. El-Deiry Regulation of the human TRAIL gene Cancer Biol Ther 13 2012 1143 1151
    • (2012) Cancer Biol Ther , vol.13 , pp. 1143-1151
    • Allen, J.E.1    El-Deiry, W.S.2
  • 45
    • 77949670310 scopus 로고    scopus 로고
    • Death receptor agonists as a targeted therapy for cancer
    • J. Wiezorek, P. Holland, and J. Graves Death receptor agonists as a targeted therapy for cancer Clin Cancer Res 16 2010 1701 1708
    • (2010) Clin Cancer Res , vol.16 , pp. 1701-1708
    • Wiezorek, J.1    Holland, P.2    Graves, J.3
  • 47
    • 84879664923 scopus 로고    scopus 로고
    • Methanolic extract of white asparagus shoots activates TRAIL apoptotic death pathway in human cancer cells and inhibits colon carcinogenesis in a preclinical model
    • S. Bousserouel, J. Le Grandois, F. Gosse, D. Werner, S.W. Barth, and E. Marchioni Methanolic extract of white asparagus shoots activates TRAIL apoptotic death pathway in human cancer cells and inhibits colon carcinogenesis in a preclinical model Int J Oncol 43 2013 394 404
    • (2013) Int J Oncol , vol.43 , pp. 394-404
    • Bousserouel, S.1    Le Grandois, J.2    Gosse, F.3    Werner, D.4    Barth, S.W.5    Marchioni, E.6
  • 48
    • 84874859650 scopus 로고    scopus 로고
    • Sensitization of TRAIL-induced cell death by 20S-Ginsenoside Rg3 via CHOP-mediated DR5 upregulation in human hepatocellular carcinoma cells
    • J.Y. Lee, K.H. Jung, M.J. Morgan, Y.R. Kang, H.S. Lee, and G.B. Koo Sensitization of TRAIL-induced cell death by 20S-Ginsenoside Rg3 via CHOP-mediated DR5 upregulation in human hepatocellular carcinoma cells Mol Cancer Ther 12 2013 274 285
    • (2013) Mol Cancer Ther , vol.12 , pp. 274-285
    • Lee, J.Y.1    Jung, K.H.2    Morgan, M.J.3    Kang, Y.R.4    Lee, H.S.5    Koo, G.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.