Nicotine- and tar-free cigarette smoke induces cell damage through reactive oxygen species newly generated by PKC-dependent activation of NADPH oxidase

Journal of Pharmacological Sciences

Volumn 118, Issue 2, 2012, Pages 275-287

  Asano, Hiroshi ^a   Horinouchi, Takahiro ^a   Mai, Yosuke ^a   Sawada, Osamu ^a   Fujii, Shunsuke ^a   Nishiya, Tadashi ^a   Minami, Masabumi ^b   Katayama, Takahiro ^b   Iwanaga, Toshihiko ^a   Terada, Koji ^a   Miwa, Soichi ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cigarette smoke extract (CSE); NADPH oxidase (NOX); Protein kinase C (PKC); Reactive oxygen species (ROS)

Indexed keywords

ACETYLCYSTEINE; BISINDOLYLMALEIMIDE; CATALASE; DIPHENYLIODONIUM SALT; GLUTATHIONE; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; NICOTINE; NORPHENAZONE; PROPIDIUM IODIDE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE DISMUTASE; TAR; XANTHINE; XANTHINE OXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL MEMBRANE; CIGARETTE SMOKING; COCULTURE; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; GLIOMA CELL; MEMBRANE DAMAGE; NONHUMAN; RAT;

EID: 84857582110     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.11166FP     Document Type: Article

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