Echinacea purpurea up-regulates CYP1A2, CYP3A4 and MDR1 gene expression by activation of pregnane X receptor pathway

Xenobiotica

Volumn 45, Issue 3, 2015, Pages 218-229

  Awortwe, Charles ^a   Manda, Vamshi K ^b   Avonto, Cristina ^b   Khan, Shabana I ^b,c   Khan, Ikhlas A ^b,c   Walker, Larry A ^b,d   Bouic, Patrick J ^a,e   Rosenkranz, Bernd ^a  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c Division of Pharmacognosy Department of Biomolecular Sciences   (United States)

^d UNIVERSITY OF MISSISSIPPI   (United States)

^e Stellenbosch University Synexa Life Sciences   (South Africa)

Author keywords

Activation; Cytochrome P450 enzymes (CYPs); E. purpurea; Human liver carcinoma (HepG2); Human pregnane xenobiotic receptor (hPXR)

Indexed keywords

CYTOCHROME P450 1A2; CYTOCHROME P450 3A4; ECHINACEA PURPUREA EXTRACT; MULTIDRUG RESISTANCE PROTEIN 1; PREGNANE X RECEPTOR; CYTOCHROME P450 3A; LUCIFERASE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; PLANT EXTRACT; STEROID RECEPTOR;

ARTICLE; CONTROLLED STUDY; EC50; ECHINACEA PURPUREA; ENZYME ACTIVITY; GENE EXPRESSION; HERB DRUG INTERACTION; HUMAN; HUMAN CELL; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; BIOCATALYSIS; CELL DEATH; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; ECHINACEA; GENETICS; HEPG2 CELL LINE; METABOLISM; REPORTER GENE; TIME; TRANSCRIPTION INITIATION;

ECHINACEA PURPUREA;

BIOCATALYSIS; CELL DEATH; CELL SURVIVAL; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP3A; ECHINACEA; GENES, REPORTER; HEP G2 CELLS; HERB-DRUG INTERACTIONS; HUMANS; LUCIFERASES; P-GLYCOPROTEIN; PLANT EXTRACTS; RECEPTORS, STEROID; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84924046640     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2014.973930     Document Type: Article

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