Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease

Journal of Clinical Investigation

Volumn 125, Issue 3, 2015, Pages 981-992

  Gentric, Géraldine ^a,b,c   Maillet, Vanessa ^a,b,c   Paradis, Valérie ^d   Couton, Dominique ^a,b,c   L'Hermitte, Antoine ^a,b,c   Panasyuk, Ganna ^c,e,f   Fromenty, Bernard ^g   Celton Morizur, Séverine ^a,b,c   Desdouets, Chantal ^a,b,c  

^a INSTITUT COCHIN   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d BEAUJON HOSPITAL   (France)

^e CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

^f INSTITUT NECKER ENFANTS MALADES   (France)

^g INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MINICHROMOSOME MAINTENANCE PROTEIN 7;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CHROMATIN; CONTROLLED STUDY; DNA DAMAGE; DNA DAMAGE CHECKPOINT; DNA REPLICATION; FEMALE; LIVER CELL; LIVER CELL CARCINOMA; LIVER DEVELOPMENT; LIVER PARENCHYMA; M PHASE CELL CYCLE CHECKPOINT; MONONUCLEAR CELL; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE STRESS; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RISK FACTOR; SIGNAL TRANSDUCTION; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; GENETICS; HUMAN; LIPID DIET; LIVER; LIVER TUMOR; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY;

ANIMALS; CARCINOMA, HEPATOCELLULAR; DIET, HIGH-FAT; DNA DAMAGE; HEPATOCYTES; HUMANS; LIVER; LIVER NEOPLASMS; MALE; MICE, INBRED C57BL; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; OXIDATIVE STRESS; POLYPLOIDY; RISK FACTORS;

EID: 84924026861     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI73957     Document Type: Article

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