The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's disease

Trends in Pharmacological Sciences

Volumn 36, Issue 3, 2015, Pages 181-186

  Joshi, Yash B ^a   Giannopoulos, Phillip F ^a   Praticò, Domenico ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

12 15 lipoxygenase; Alzheimers disease; amyloid b; synapse; behavior; tau protein; therapeutics.; transgenic mouse models

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; BETA SECRETASE; ENZYME INHIBITOR; NICASTRIN; PD 146176; POSTSYNAPTIC DENSITY PROTEIN 95; PRESENILIN 1; PRESENILIN 2; SYNAPTOPHYSIN; TAU PROTEIN; UNCLASSIFIED DRUG; 12-15-LIPOXYGENASE;

ALZHEIMER DISEASE; BINDING AFFINITY; CATALYSIS; DRUG ACTIVITY; DRUG EFFICACY; DRUG TARGETING; ESTERIFICATION; HISTOPATHOLOGY; HUMAN; LONG TERM DEPRESSION; MILD COGNITIVE IMPAIRMENT; NEUROFIBRILLARY TANGLE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; MEMORY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SYNAPTIC TRANSMISSION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; HUMANS; MEMORY; SYNAPTIC TRANSMISSION; TAU PROTEINS;

EID: 84923926629     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2015.01.005     Document Type: Review

References (57)

1. I. Ivanov Molecular enzymology of lipoxygenases Arch. Biochem. Biophys. 503 2010 161 174
2. H. Kuhn Mammalian lipoxygenases and their biological relevance Biochim. Biophys. Acta 2014 Published online October 12, 2014. http://dx.doi.org/10.1016/j.bbalip.2014.10.002
3. E. Skrzypczak-Jankun Human lipoxygenase: developments in its structure, function, relevance to diseases and challenges in drug development Curr. Med. Chem. 19 2012 5122 5127
4. Y.C. Joo, and D.K. Oh Lipoxygenases: potential starting biocatalysts for the synthesis of signaling compounds Biotechnol. Adv. 30 2012 1524 1532
5. H. Kuhn Mammalian arachidonate 15-lipoxygenases structure, function, and biological implications Prostaglandins Other Lipid Mediat. 68-69 2002 263 290
6. M. Berger Simultaneous expression of leukocyte-type 12-lipoxygenase and reticulocyte-type 15-lipoxygenase in rabbits J. Mol. Biol. 278 1998 935 948
7. T. Watanabe Molecular cloning of a 12-lipoxygenase cDNA from rat brain Eur. J. Biochem. 212 1993 605 612
8. M. Nishiyama Localization of arachidonate 12-lipoxygenase in canine brain tissue J. Neurochem. 58 1992 1395 1400
9. R. Natarajan, and J.L. Nadler Lipid inflammatory mediators in diabetic vascular disease Arterioscler. Thromb. Vasc. Biol. 24 2004 1542 1548
10. J.Z. Haeggström, and C.D. Funk Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease Chem. Rev. 111 2011 5866 5898
11. W. Thies, and L. Bleiler 2013 Alzheimer's disease facts and figures Alzheimers Dement. 9 2013 208 245
12. C.C. Tan Efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer's disease: a systematic review and meta-analysis J. Alzheimers Dis. 41 2014 615 631
13. F. Caraci Clinical pharmacology of novel anti-Alzheimer disease modifying medications Curr. Top. Med. Chem. 13 2013 1853 1863
14. P.F. Giannopoulos, and D. Pratico Alzheimer's disease C.R. Martin, V.R. Preddy, Diet and Nutrition in Dementia and Cognitive Decline 2014 Elsevier 13 21
15. K. Ono, and M. Yamada Low-n oligomers as therapeutic targets of Alzheimer's disease J. Neurochem. 117 2011 19 28
16. D.P. Hanger Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localization of the kinase Neurosci. Lett. 147 1992 58 62
17. K. Baumann Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5 FEBS Lett. 336 1993 417 424
18. J.J. Pei Distribution of active glycogen cynthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes J. Neuropathol. Exp. Neurol. 58 1999 1010 1019
19. S. Uderhardt, and G. Kronke 12/15-lipoxygenase during the regulation of inflammation, immunity, and self-tolerance J. Mol. Med. 90 2012 1247 1256
20. C. Sultana Lipoxygenase metabolites induced expression of adhesion molecules and transendothelial migration of monocyte-like HL-60 cells is linked to protein kinase C activation J. Cell Physiol. 167 1996 477 487
21. M.A. Reddy The oxidized lipid and lipoxygenase product 12(S)-hydroxyeicosatetraenoic acid induces hypertrophy and fibronectin transcription in vascular smooth muscle cells via p38 MAPK and cAMP response element-binding protein activation. Mediation of angiotensin II effects J. Biol. Chem. 277 2002 9920 9928
22. T. Cyrus Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein E-deficient mice Circulation 103 2001 2277 2282
23. M. McDuffie Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes Diabetes 57 2008 199 208
24. D.D. Sears 12/15-lipoxygenase is required for the early onset of high fat diet-induced adipose tissue inflammation and insulin resistance in mice PLoS ONE 4 2009 e7250
25. K.B. Reilly 12/15-Lipoxygenase activity mediates inflammatory monocyte/endothelial interactions and atherosclerosis in vivo J. Biol. Chem. 279 2004 9440 9450
26. J.B. Strosznajder Lipoxygenases and poly(ADP-ribose) polymerase in amyloid beta cytotoxicity Neurochem. Res. 36 2011 839 848
27. M. Nishiyama Arachidonate 12-lipoxygenase is localized in neurons, glial cells, and endothelial cells of the canine brain J. Histochem. Cytochem. 41 1993 111 117
28. Y. Li A role for 12-lipoxygenase in nerve cell death casued by glutathione depletion Neuron 19 1997 453 463
29. C.M. Chinnici Absence of 12/15 lipoxygenase reduces brain oxidative stress in apolipoprotein E-deficient mice Am. J. Pathol. 167 2005 1371 1377
30. D. Praticò Oxidative stress hypothesis in Alzheimer's disease: a reappraisal Trends Pharm. Sci. 29 2008 609 615
31. D. Pratico 12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress Am. J. Pathol. 164 2004 1655 1662
32. Y. Yao Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment Ann. Neurol. 58 2005 623 626
33. Y. Tajima Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer's disease Lipids Health Dis. 12 2013 68
34. F. Succol, and D. Pratico A role for 12/15 lipoxygenase in the amyloid beta precursor protein metabolism J. Neurochem. 103 2007 380 387
35. H. Yang Amelioration of the Alzheimer's disease phenotype by absence of 12/15-lipoxygenase Biol. Psychiatry 68 2010 922 929
36. J. Chu Transcriptional regulation of beta-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairments Ann. Neurol. 71 2012 57 67
37. P.F. Giannopoulos The 12-15-lipoxygenase is a modulator of Alzheimer's-related tau pathology in vivo Aging Cell 12 2013 1082 1090
38. S. Oddo Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction Neuron 39 2003 409 421
39. J. Chu Pharmacologic blockade of 12/15-Lipoxygenase ameliorates memory deficits, Aβ and tau neuropathology in the triple transgenic mouse Mol. Psychiatry. 2015 Published online January 6, 2015. http://dx/doi/org/10.1038/mp.2014.170
40. M. Normandin Involvement of the 12-lipoxygenase pathway of arachidonic acid metabolism in homosynaptic long-term depression of the rat hippocampus Brain Res. 730 1996 40 46
41. S.J. Feinmark 12-lipoxygenase metabolites of arachidonic acid mediate metabotropic glutamate receptor-dependent long-term depression at hippocampal CA3-CA1 synapses J. Neurosci. 23 2003 11427 11435
42. 2+ channels J. Neurosci. 30 2010 1822 1831
43. E.H. Lo Mechanisms, challenges and opportunities in stroke Nat. Rev. Neurosci. 4 2003 399 415
44. G.E. Hardingham, and S.A. Lipton Regulation of neuronal oxidative and nitrosative stress by endogenous protective pathways and disease processes Antioxid. Redox Signal. 14 2011 1421 1424
45. M.A. Moskowitz The science of stroke: mechanisms in search of treatments Neuron 67 2010 181 198
46. K. Niizuma Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival J. Neurochem. 109 Suppl. 1 2009 133 138
47. A. Saito Oxidative stress and neuronal death/survival signaling in cerebral ischemia Mol. Neurobiol. 31 2005 105 116
48. A.C. LeBlanc The role of apoptotic pathways in Alzheimer's disease neurodegeneration and cell death Curr. Alzheimer Res. 2 2005 389 402
49. A. Lebeau Blockade of 12-lipoxygenase expression protects cortical neurons from apoptosis induced by beta-amyloid peptide Cell Death Differ. 11 2004 875 884
50. T.C. Gamblin Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease Proc. Natl. Acad. Sci. U.S.A. 100 2003 10032 10037
51. T. Nakagomi Effect of cyclooxygenase and lipoxygenase inhibitors on delayed neuronal death in the gerbil hippocampus Stroke 20 1989 925 929
52. G. Jin Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia Stroke 39 2008 2538 2543
53. K. van Leyen Baicalein and 12/15-lipoxygenase in the ischemic brain Stroke 37 2006 3014 3018
54. K. Yigitkanli Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke Ann. Neurol. 73 2013 129 135
55. L. Sun Neuroprotection of hydroxysafflor yellow A in the transient focal ischemia: inhibition of protein oxidation/nitration, 12/15-lipoxygenase and blood-brain barrier disruption Brain Res. 1473 2012 227 235
56. S. Pallast Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway J. Cereb. Blood Flow Metab. 30 2010 1157 1167
57. P.A. Lapchak Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes Neuroscience 150 2010 585 591