Neuroprotection of hydroxysafflor yellow A in the transient focal ischemia: Inhibition of protein oxidation/nitration, 12/15-lipoxygenase and bloodbrain barrier disruption

Brain Research

Volumn 1473, Issue , 2012, Pages 227-235

  Sun, Li ^a   Yang, Li ^a   Xu, Yan Wei ^a   Liang, Hao ^a   Han, Jing ^a   Zhao, Rui Jie ^a   Cheng, Yan ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

12 15 Lipoxygenase; Bloodbrain barrier; Hydroxysafflor yellow A; Ischemia reperfusion; Nitrotyrosine; Protein carbonylation

Indexed keywords

15 HYDROXYICOSATETRAENOIC ACID; 3 NITROTYROSINE; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; BRAIN PROTEIN; CARBONYL DERIVATIVE; EVANS BLUE; HYDROXYSAFFLOR YELLOW A; IMMUNOGLOBULIN G; PIGMENT; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN WATER; CONTROLLED STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NITRATION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; UPREGULATION;

ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; CHALCONE; DISEASE MODELS, ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE; ISCHEMIC ATTACK, TRANSIENT; MALE; NEUROPROTECTIVE AGENTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; QUINONES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

CARTHAMUS TINCTORIUS; RATTUS;

EID: 84865461003     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2012.07.047     Document Type: Article

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