Snooker structure-based pharmacophore model explains differences in agonist and blocker binding to bitter receptor hTAS2R39

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Roland, Wibke S U ^a,d   Sanders, Marijn P A ^b,e   Van Buren, Leo ^c   Gouka, Robin J ^c   Gruppen, Harry ^a   Vincken, Jean Paul ^a   Ritschel, Tina ^b  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

^d NIZO FOOD RESEARCH   (Netherlands)

^e Aorta Business Intelligence ^*  (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BITTER TASTE RECEPTOR HTAS2R39; CHEMICAL COMPOUND; G PROTEIN COUPLED RECEPTOR; HTAS2R39 AGONIST; HTAS2R39 BLOCKER; ISOFLAVONOID; UNCLASSIFIED DRUG; 6-METHOXYFLAVANONE; CELL SURFACE RECEPTOR; FLAVANONE DERIVATIVE; FLAVONOID; PROTEIN BINDING; TAS2R39 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; BINDING SITE; COMPUTER PROGRAM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; GEOMETRY; HUMAN; HYDROGEN BOND; LIGAND BINDING; PHARMACOPHORE; PROTEIN DOMAIN; RECEPTOR BINDING; SNOOKER; TRANS MEMBRANE DOMAIN; AGONISTS; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DESIGN; METABOLISM; MOLECULAR DOCKING; PROTEIN TERTIARY STRUCTURE; SOFTWARE;

BINDING SITES; DRUG DESIGN; FLAVANONES; FLAVONOIDS; HUMANS; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; SOFTWARE;

EID: 84923924494     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0118200     Document Type: Article

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