Break-seq reveals hydroxyurea-induced chromosome fragility as a result of unscheduled conflict between DNA replication and transcription

Genome Research

Volumn 25, Issue 3, 2015, Pages 402-412

  Hoffman, Elizabeth A ^a,b   McCulley, Andrew ^a   Haarer, Brian ^a   Arnak, Remigiusz ^a   Feng, Wenyi ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; HYDROXYUREA; METAL ION; SINGLE STRANDED DNA; TRANSCRIPTION FACTOR; CARRIER PROTEIN; ION; METAL;

ARTICLE; BREAK SEQ METHOD; CELL CYCLE PHASE; CELL CYCLE S PHASE; CELL SYNCHRONIZATION; CHROMOSOME BREAKAGE; CHROMOSOME FRAGILE SITE; CHROMOSOME FRAGILITY; CONTROLLED STUDY; COPY NUMBER VARIATION; DNA REPLICATION; DNA TRANSCRIPTION; DOUBLE STRANDED DNA BREAK; FLOW CYTOMETRY; FUNGAL CELL; GENE EXPRESSION; GENE MAPPING; GENE ONTOLOGY; IN VITRO STUDY; IRON CHELATION; MOLECULAR CLONING; NEXT GENERATION SEQUENCING; NONHUMAN; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; RNA SEQUENCE; SACCHAROMYCES CEREVISIAE; STRESS; CELL CYCLE; DNA REPLICATION ORIGIN; DRUG EFFECTS; FUNGAL GENE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HIGH THROUGHPUT SEQUENCING; METABOLISM; PHYSIOLOGICAL STRESS; YEAST;

SACCHAROMYCES CEREVISIAE;

CELL CYCLE; CHROMOSOME BREAKAGE; CHROMOSOME FRAGILITY; DNA BREAKS, DOUBLE-STRANDED; DNA REPLICATION; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HYDROXYUREA; IONS; MEMBRANE TRANSPORT PROTEINS; METALS; REPLICATION ORIGIN; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; YEASTS;

EID: 84923883214     PISSN: 10889051     EISSN: 15495469     Source Type: Journal    
DOI: 10.1101/gr.180497.114     Document Type: Article

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