Sites of genetic instability in mitosis and cancer

Annals of the New York Academy of Sciences

Volumn 1267, Issue 1, 2012, Pages 24-30

  Casper, Anne M ^a   Rosen, Danielle M ^a   Rajula, Kaveri D ^a  

^a EASTERN MICHIGAN UNIVERSITY   (United States)

Author keywords

Cancer; Flexibility peak; FRA3B; Fragile site; Loss of heterozygosity; Mitotic crossover

Indexed keywords

ARTICLE; CANCER GENETICS; CHROMOSOME BREAKAGE; CHROMOSOME DUPLICATION; CHROMOSOME FRAGILE SITE; DNA REPLICATION; DNA SEQUENCE; GENETIC STABILITY; HETEROZYGOSITY LOSS; HUMAN; MITOSIS; MITOTIC RECOMBINATION; NONHUMAN; SOMATIC CROSSING OVER; TUMOR GROWTH; YEAST ARTIFICIAL CHROMOSOME;

EID: 84865996520     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06592.x     Document Type: Article

References (34)

1. Glover, T.W. et al 1984. DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes. Hum. Genet. 67: 136-142.
2. Moore, J.M., H. Wimberly, P.C. Thornton, et al. Gross chromosomal rearrangement mediated by DNA replication in stressed cells: evidence from Escherichia coli. Ann. N.Y. Acad. Sci. 1267: 103-109. This volume.
3. Burrow, A.A. et al 2009. Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites. BMC Genomics 10: 59.
4. McAvoy, S. et al 2007. Non-random inactivation of large common fragile site genes in different cancers. Cytogenet. Genome. Res. 118: 260-269.
5. Drusco, A. et al 2011. Common fragile site tumor suppressor genes and corresponding mouse models of cancer. J. Biomed. Biotechnol. 2011: 984505.
6. Blumrich, A. et al 2011. The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancers. Hum. Mol. Genet. 20: 1488-1501.
7. Pelliccia, F., N. Bosco & A. Rocchi 2010. Breakages at common fragile sites set boundaries of amplified regions in two leukemia cell lines K562-Molecular characterization of FRA2H and localization of a new CFS FRA2S. Cancer Lett. 299: 37-44.
8. Miller, C.T. et al 2006. Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma. Oncogene 25: 409-418.
9. Durkin, S.G. & T.W. Glover 2007. Chromosome fragile sites. Annu. Rev. Genet. 41: 169-192.
10. Barbera, M.A. & T.D. Petes 2006. Selection and analysis of spontaneous reciprocal mitotic cross-overs in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 103: 12819-12824.
11. Lee, P.S. et al 2009. A fine-structure map of spontaneous mitotic crossovers in the yeast Saccharomyces cerevisiae. PLoS Genet. 5: e1000410.
12. Dillon, L.W., A.A. Burrow & Y.H. Wang 2010. DNA instability at chromosomal fragile sites in cancer. Curr. Genomics 11: 326-337.
13. Pelliccia, F. et al 2008. Replication timing of two human common fragile sites: FRA1H and FRA2G. Cytogenet. Genome. Res. 121: 196-200.
14. Le Beau, M.M. et al 1998. Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction. Hum. Mol. Genet. 7: 755-761.
15. Hellman, A. et al 2000. Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability. Mol. Cell Biol. 20: 4420-4427.
16. Palakodeti, A. et al 2004. The role of late/slow replication of the FRA16D in common fragile site induction. Gen. Chromo. Cancer 39: 71-76.
17. Chan, K.L. et al 2009. Replication stress induces sister-chromatid bridging at fragile site loci in mitosis. Nat. Cell Biol. 11: 753-760.
18. El Achkar, E. et al 2005. Premature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites. Proc. Natl. Acad. Sci. USA 102: 18069-18074.
19. Palumbo, E. et al 2010. Replication dynamics at common fragile site FRA6E. Chromosoma 119: 575-587.
20. Letessier, A. et al 2011. Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site. Nature 470: 120-123.
21. Helmrich, A., M. Ballarino & L. Tora 2011. Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes. Mol. Cell 44: 966-977.
22. Mishmar, D. et al 1998. Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site. Proc. Natl. Acad. Sci. USA 95: 8141-8146.
23. Zlotorynski, E. et al 2003. Molecular basis for expression of common and rare fragile sites. Mol. Cell Biol. 23: 7143-7151.
24. Lemoine, F.J. et al 2005. Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sites. Cell 120: 587-598.
25. Wilke, C.M. et al 1996. FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites. Hum. Mol. Genet. 5: 187-195.
26. Zimonjic, D.B. et al 1997. Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene. Cancer Res. 57: 1166-1170.
27. Albertsen, H.M. et al 1990. Construction and characterization of a yeast artificial chromosome library containing seven haploid human genome equivalents. Proc. Natl. Acad. Sci. USA 87: 4256-4260.
28. Dausset, J. et al 1992. The CEPH YAC library. Behring Inst. Mitt. 91: 13-20.
29. Zhou, J. et al 2000. Pif1p helicase, a catalytic inhibitor of telomerase in yeast. Science 289: 771-774.
30. Chung, W.H. et al 2010. Defective resection at DNA double-strand breaks leads to de novo telomere formation and enhances gene targeting. PLoS Genet. 6: e1000948.
31. Marrero, V.A. & L.S. Symington 2010. Extensive DNA end processing by exo1 and sgs1 inhibits break-induced replication. PLoS Genet. 6: e1001007.
32. Lydeard, J.R. et al 2010. Sgs1 and exo1 redundantly inhibit break-induced replication and de novo telomere addition at broken chromosome ends. PLoS Genet. 6: e1000973.
33. Berger, A.H., A.G. Knudson & P.P. Pandolfi 2011. A continuum model for tumour suppression. Nature 476: 163-169.
34. Cole, F., S. Keeney & M. Jasin 2012. Preaching about the converted: how meiotic gene conversion influences genomic diversity. Ann. N.Y. Acad. Sci. 1267: 95-102. This volume.