Self-reported flushing and genotypes of ALDH2, ADH2, and ADH3 among Taiwanese han

Alcoholism: Clinical and Experimental Research

Volumn 22, Issue 5, 1998, Pages 1048-1052

  Chen, Wei J ^a   Chen, Chiao Chicy ^b   Yu, Jeng Ming ^b   Cheng, Andrew T A ^c  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b TAIPEI CITY PSYCHIATRIC CENTER   (Taiwan)

^c INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

Acetaldehyde; Alcohol Sensitivity; Alcoholism; Nausea

Indexed keywords

ACETALDEHYDE; ALCOHOL DEHYDROGENASE;

ADULT; ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; DNA POLYMORPHISM; ENZYME ACTIVITY; FEMALE; FLUSHING; GENOTYPE; HUMAN; MALE; NAUSEA; POPULATION RESEARCH; PRIORITY JOURNAL; SELF REPORT; TAIWAN;

EID: 0031655769     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1998.tb03697.x     Document Type: Article

References (41)

1. Wolff PH: Ethnic differences in alcohol sensitivity. Science 175: 449-450, 1972
2. Chan AWK: Racial differences in alcohol sensitivity. Alcohol Alcohol 21:93-104, 1986
3. Akusta PD, Sue S, Zane NWS, Nakamura CY: Ethnic differences in alcohol consumption among Asians and Caucasians in the United States: An investigation of cultural and physiological factors. J Stud Alcohol 50:261-267, 1989
4. Higuchi S, Parrish KM, Dufour MC, Towle LH, Harford TC: The relationship between three subtypes of the flushing response and DSM-III alcohol abuse in Japanese. J Stud Alcohol 53:553-560, 1992
5. Li HZ, Rosenblood L: Exploring factors influencing alcohol consumption patterns among Chinese and Caucasians. J Stud Alcohol 55:427-433, 1994
6. Nakawatase TV, Yamamoto J, Sasao T: The association between fast-flushing response and alcohol use among Japanese Americans. J Stud Alcohol 54:48-53, 1993
7. Schwitters SY, Johnson RC, McClearn GE, Wilson JR: Alcohol use and the flushing response in different racial-ethnic groups. J Stud Alcohol 43:1259-1262, 1982
8. Suwaki H, Phara H: Alcohol-induced facial flushing and drinking behavior in Japanese men. J Stud Alcohol 46:196-198, 1985
9. Chen C-C, Hwu H-G, Yeh E-K, Morimoto K, Otsuki S: Aldehyde dehydrogenase deficiency, flush patterns and prevalence of alcoholism: An interethnic comparison. Acta Med Okayama 45:409-416, 1991
10. Nagoshi CT, Dixon LK, Johnson RC, Yuen SHL: Familial transmission of alcohol consumption and the flushing response to alcohol in three Oriental groups. J Stud Alcohol 49:261-267, 1988
11. Schwitters SY, Johnson RC, Johnson SB, Ahern FM: Familial resemblances in flushing following alcohol use. Behav Genet 12:349-352, 1982
12. Johnson RC, Nagoshi CT, Schwitters SY, Bowman KS, Ahern FM, Wilson JR: Further investigation of racial/ethnic differences and of familial resemblances in flushing response to alcohol. Behav Genet 14:171-178, 1984
13. Park JY, Huang Y-H, Nagoshi CT, Yuen S, Johnson RC, Ching CA, Bowman KS: The flushing response to alcohol use among Koreans and Taiwanese. J Stud Alcohol 45:481-485, 1984
14. Stamatoyannopoulos G, Chen S-H, Fukui M: Liver alcohol dehydrogenase in Japanese: High population frequency of atypical form and its possible role in alcohol sensitivity. Am J Hum Genet 27:789-796, 1975
15. Korsten MA, Matsuzaki S, feinman L, Lieber CS: High blood acetaldehyde levels after ethanol administration: Difference between alcoholic and nonalcoholic subjects. N Engl J Med 292:386-389, 1975
16. Goedde HW, Harada S, Agarwal DP: Racial differences in alcohol sensitivity: A new hypothesis. Hum Genet 51:331-334, 1979
17. Smith M: Genetics of human alcohol and aldehyde dehydrogenases. Adv Hum Genet 15:249-290, 1986
18. Bosron WF, Li T-K: Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases, and their relationship to alcohol metabolism and alcoholism. Hepatology 6:502-510, 1986
19. Enomoto N, Takase S, Yasuhara M, Takada A: Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes. Alcohol Clin Exp Res 15:141-144, 1991
20. Harada S, Agarwal DP, Goedde HW, Tagaki S, Ishikawa B: Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency. Lancet ii:827, 1982
21. Thomasson HR, Edenberg HJ, Crabb DW, Mai XL, Jerome RE, Li TK, Wang SP, Lin YT, Lu RB, Yin SJ: Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 48:677-681, 1991
22. Thomasson HR, Crabb DW, Edenberg HJ, Li TK, Hwu H-G, Chen C-C, Yeh E-K, Yin S-J: Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders. Alcohol Clin Exp Res 18:640-643, 1994
23. Higuchi S, Matsushita S, Murayama M, Takagi S, Hayashida M: Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism. Am J Psychiatry 152:1219-1221, 1995
24. Maezawa Y, Yamauchi M, Toda G, Suzuki H, Sakurai S: Alcohol-metabolizing enzyme polymorphisms and alcoholism in Japan. Alcohol Clin Exp Res 19:951-954, 1995
25. Chen WJ, Loh EW, Hsu Y-PP, Chen C-C, Yu J-M, Cheng ATA: Alcohol-metabolizing genes and alcoholism among Taiwanese Han Men: Independent effect of ADH2, ADH3, and ALDH2. Br J Psychiatry 168: 762-767, 1996
26. Shibuya A, Yasunami M, Yoshida A: Genotypes of alcohol dehydrogenase and aldehyde dehydrogenase loci in Japanese alcohol flushers and nonflushers. Hum Genet 82:14-16, 1989
27. m aldehyde dehydrogenase in a Japanese population. Hum Genet 94:217-223, 1994
28. Wall T, Thomasson HR, Ehlers CL: Investigator-observed alcohol-induced flushing but not self-report of flushing is a valid predictor of ALDH2 genotype. J Stud Alcohol 57:267-272, 1996
29. Chen WJ, Loh EW, Hsu Y-PP, Chen C-C, Yu J-M, Cheng ATA: Dopamine D2 receptor gene and alcoholism among four aboriginal groups and Han in Taiwan. Am J Med Genet (Neuropsychiatr Genet) 74:129-136, 1997
30. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders. 3rd ed rev. Washington, DC, American Psychiatric Association 1987
31. Cheng TA, Chen WJ: Alcoholism among four aboriginal groups in Taiwan: High prevalences and their implications. Alcohol Clin Exp Res 19:81-91, 1995
32. Xu Y, Carr L, Bosron WF, Li T-K, Edenberg HJ: Genotyping of human alcohol dehydrogenases at the ADH2 and ADH3 loci following DNA sequence amplification. Genomics 2:209-214, 1988
33. Walzer C, Turler H, Balant L, Golaz O, Hochstrasser DF, Monteiro M, von Wartburg J-P: Determination of human alcohol dehydrogenase and acetaldehyde dehydrogenase genotypes by single strand conformation polymorphism in discontinuous buffer electrophoresis. Electrophoresis 14:566-569, 1993
34. Tu G-C, Israel Y: A new approach for the rapid detection of common and atypical aldehyde dehydrogenase alleles. Eur J Clin Chem Clin Biochem 31:591-594, 1993
35. Sackett DL, Haynes RB, Guyatt GH, Tugwell P: Clinical Epidemiology: A Basic Science for Clinical Medicine. 2nd ed. Boston, Little, Brown 1991
36. Thomasson HR, Crabb DW, Edenberg HJ, Li TK: Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism. Behav Genet 23:131-136, 1993
37. Chao HM: Alcohol and the mystique of flushing. Alcohol Clin Exp Res 19:104-109, 1995
38. Di Padova C, Worner TM, Lieber CS: Effect of abstinence on the blood acetaldehyde response to a test dose of alcohol in alcoholics. Alcohol Clin Exp Res 11:559-561, 1987
39. Schuckit MA: Low level of response to alcohol as a predictor of future alcoholism. Am J Psychiatry 151:184-189, 1994
40. Schuckit MA, Smith TL: Assessing the risk for alcoholism among sons of alcoholics. J Stud Alcohol 58:141-145, 1997
41. Gilder FJ, Hodgkinson S, Murray RM: ADH and ALDH genotype profiles in Caucasians with alcohol-related problems and controls. Addiction 88:383-388, 1993