The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion

Journal of Clinical Investigation

Volumn 98, Issue 9, 1996, Pages 2027-2032

  Xiao, Qing ^a   Weiner, Henry ^b   Crabb, David W ^a,c  

^a INDIANA UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

aldehyde; enzyme; ethanol; liver; protein degradation

Indexed keywords

ALCOHOL; ALDEHYDE DEHYDROGENASE; MITOCHONDRIAL ENZYME; PUROMYCIN;

ALCOHOL CONSUMPTION; ALLELE; ARTICLE; ENZYME DEFICIENCY; ENZYME SUBUNIT; FLUSHING; GENE EXPRESSION; GENE MUTATION; HALF LIFE TIME; HELA CELL; HUMAN; HUMAN CELL; LIVER MITOCHONDRION; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 0029992535     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119007     Document Type: Article

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