Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in asian alcoholics, heterozygous for the variant ALDH2*2 gene allele

Pharmacogenetics and Genomics

Volumn 19, Issue 8, 2009, Pages 588-599

  Chen, Yi Chyan ^a   Peng, Giia Sheun ^b   Tsao, Tien Ping ^b   Wang, Ming Fang ^c   Lu, Ru Band ^a   Yin, Shih Jiun ^c  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Acetaldehydism; Alcohol sensitivity; Alcoholism; Aldehyde dehydrogenase 2; Asian alcoholics; Blood ethanol acetaldehyde acetate; Cardiovascular response; Genetic polymorphism; Partial protection; Subjective sensation

Indexed keywords

ACETALDEHYDE; ACETIC ACID; ALCOHOL; ALDEHYDE DEHYDROGENESE 2; ALDEHYDE DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; AGE DISTRIBUTION; ALCOHOL BLOOD LEVEL; ALCOHOL METABOLISM; ALCOHOLISM; ALLELE; ARTICLE; BODY MASS; BRAIN CIRCULATION; CARDIOVASCULAR EFFECT; CARDIOVASCULAR FUNCTION; CHINESE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; GENETIC ASSOCIATION; GENOTYPE; HEMODYNAMIC PARAMETERS; HETEROZYGOTE; HOMOZYGOTE; HUMAN; LIVER; LIVER FUNCTION; MALE; PERCEPTION; PHARMACODYNAMICS; PHARMACOGENETICS; PRIORITY JOURNAL; SELF CONCEPT; SENSATION;

ACETALDEHYDE; ADULT; ALCOHOLISM; ALDEHYDE DEHYDROGENASE; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; ETHANOL; GENETIC VARIATION; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MALE; PHARMACOGENETICS;

EID: 68849086604     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e32832ecf2e     Document Type: Article

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