Fast and efficient neural conversion of human hematopoietic cells

Stem Cell Reports

Volumn 3, Issue 6, 2014, Pages 1118-1131

  Castaño, Julio ^a   Menendez, Pablo ^a,b   Bruzos Cidon, Cristina ^c   Straccia, Marco ^d,e   Sousa, Amaia ^f   Zabaleta, Lorea ^f   Vazquez, Nerea ^f   Zubiarrain, Amaia ^f   Sonntag, Kai Christian ^g   Ugedo, Luisa ^c   Carvajal Vergara, Xonia ^f   Canals, Josep Maria ^d,e   Torrecilla, Maria ^c   Sanchez Pernaute, Rosario ^f   Giorgetti, Alessandra ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

^c UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

^e CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^f Fundacion Inbiomed   (Spain)

^g HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DINITRO 2,3 QUINOXALINEDIONE; BETA III TUBULIN; BETA TUBULIN; BRACHYURY PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CD133 ANTIGEN; CRIPTO PROTEIN; DNA METHYLTRANSFERASE 3B; DOUBLECORTIN; FIBROBLAST GROWTH FACTOR 2; GLIAL FIBRILLARY ACIDIC PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; MUSASHI PROTEIN; MYC PROTEIN; NERVE CELL ADHESION MOLECULE; NESTIN; NEUROTRANSMITTER; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN; REX1 PROTEIN; TELOMERASE REVERSE TRANSCRIPTASE; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX1; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; PEPTIDE;

ACTION POTENTIAL; ADULT; ANIMAL CELL; ARTICLE; ASTROCYTE; CELL EXPANSION; CELL MEMBRANE RESISTANCE; CELL MEMBRANE STEADY POTENTIAL; CELL SELECTION; CELL STRUCTURE; CYTOARCHITECTURE; ELECTROPHYSIOLOGY; FLUORESCENCE ACTIVATED CELL SORTING; GENE OVEREXPRESSION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INDUCED NEURAL CELL; NERVE CELL; NERVE CELL DIFFERENTIATION; NEUROBLAST; NONHUMAN; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENDAI VIRUS INFECTION; SOMATIC CELL; TARGET CELL; UPREGULATION; WHOLE CELL PATCH CLAMP; CELL AGING; CELL CULTURE; CELL PROLIFERATION; CELL TRANSDIFFERENTIATION; CYTOLOGY; FETUS BLOOD; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETICS; IMMUNOPHENOTYPING; MEMBRANE POTENTIAL; METABOLISM; MONONUCLEAR CELL; PHENOTYPE;

SENDAI VIRUS;

ANTIGENS, CD; CELL AGING; CELL PROLIFERATION; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; FETAL BLOOD; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLYCOPROTEINS; HUMANS; IMMUNOPHENOTYPING; LEUKOCYTES, MONONUCLEAR; MEMBRANE POTENTIALS; NEURONS; PEPTIDES; PHENOTYPE;

EID: 84923828573     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2014.10.008     Document Type: Article

References (55)

1. R. Ambasudhan, M. Talantova, R. Coleman, X. Yuan, S. Zhu, S.A. Lipton, and S. Ding Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions Cell Stem Cell 9 2011 113 118
2. K. Arnold, A. Sarkar, M.A. Yram, J.M. Polo, R. Bronson, S. Sengupta, M. Seandel, N. Geijsen, and K. Hochedlinger Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice Cell Stem Cell 9 2011 317 329
3. A.A. Avilion, S.K. Nicolis, L.H. Pevny, L. Perez, N. Vivian, and R. Lovell-Badge Multipotent cell lineages in early mouse development depend on SOX2 function Genes Dev. 17 2003 126 140
4. H. Ban, N. Nishishita, N. Fusaki, T. Tabata, K. Saeki, M. Shikamura, N. Takada, M. Inoue, M. Hasegawa, S. Kawamata, and S. Nishikawa Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors Proc. Natl. Acad. Sci. USA 108 2011 14234 14239
5. M. Bellin, M.C. Marchetto, F.H. Gage, and C.L. Mummery Induced pluripotent stem cells: the new patient? Nat. Rev. Mol. Cell Biol. 13 2012 713 726
6. M. Bylund, E. Andersson, B.G. Novitch, and J. Muhr Vertebrate neurogenesis is counteracted by Sox1-3 activity Nat. Neurosci. 6 2003 1162 1168
7. M. Caiazzo, M.T. Dell'Anno, E. Dvoretskova, D. Lazarevic, S. Taverna, D. Leo, T.D. Sotnikova, A. Menegon, P. Roncaglia, and G. Colciago Direct generation of functional dopaminergic neurons from mouse and human fibroblasts Nature 476 2011 224 227
8. S. Chanda, C.E. Ang, J. Davila, C. Pak, M. Mall, Q.Y. Lee, H. Ahlenius, S.W. Jung, T.C. Südhof, and M. Wernig Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1 Stem Cell Rep. 3 2014 282 296
9. L. Cheng, W. Hu, B. Qiu, J. Zhao, Y. Yu, W. Guan, M. Wang, W. Yang, and G. Pei Generation of neural progenitor cells by chemical cocktails and hypoxia Cell Res. 24 2014 665 679
10. P. Codega, V. Silva-Vargas, A. Paul, A.R. Maldonado-Soto, A.M. Deleo, E. Pastrana, and F. Doetsch Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche Neuron 82 2014 545 559
11. J.M. Encinas, T.V. Michurina, N. Peunova, J.H. Park, J. Tordo, D.A. Peterson, G. Fishell, A. Koulakov, and G. Enikolopov Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus Cell Stem Cell 8 2011 566 579
12. A.L. Ferri, M. Cavallaro, D. Braida, A. Di Cristofano, A. Canta, A. Vezzani, S. Ottolenghi, P.P. Pandolfi, M. Sala, S. DeBiasi, and S.K. Nicolis Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain Development 131 2004 3805 3819
13. A. Giorgetti, N. Montserrat, T. Aasen, F. Gonzalez, I. Rodríguez-Pizà, R. Vassena, A. Raya, S. Boué, M.J. Barrero, and B.A. Corbella Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2 Cell Stem Cell 5 2009 353 357
14. A. Giorgetti, M.C. Marchetto, M. Li, D. Yu, R. Fazzina, Y. Mu, A. Adamo, I. Paramonov, J.C. Cardoso, and M.B. Monasterio Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc Proc. Natl. Acad. Sci. USA 109 2012 12556 12561
15. V. Graham, J. Khudyakov, P. Ellis, and L. Pevny SOX2 functions to maintain neural progenitor identity Neuron 39 2003 749 765
16. Z. Guo, L. Zhang, Z. Wu, Y. Chen, F. Wang, and G. Chen In Vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model Cell Stem Cell 14 2014 188 202
17. D.W. Han, N. Tapia, A. Hermann, K. Hemmer, S. Höing, M.J. Araúzo-Bravo, H. Zaehres, G. Wu, S. Frank, and S. Moritz Direct reprogramming of fibroblasts into neural stem cells by defined factors Cell Stem Cell 10 2012 465 472
18. D.T. Harris Non-haematological uses of cord blood stem cells Br. J. Haematol. 147 2009 177 184
19. B.Y. Hu, J.P. Weick, J. Yu, L.X. Ma, X.Q. Zhang, J.A. Thomson, and S.C. Zhang Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency Proc. Natl. Acad. Sci. USA 107 2010 4335 4340
20. A. Iacoangeli, and H. Tiedge Translational control at the synapse: role of RNA regulators Trends Biochem. Sci. 38 2013 47 55
21. M.A. Johnson, J.P. Weick, R.A. Pearce, and S.C. Zhang Functional neural development from human embryonic stem cells: accelerated synaptic activity via astrocyte coculture J. Neurosci. 27 2007 3069 3077
22. M. Karow, R. Sánchez, C. Schichor, G. Masserdotti, F. Ortega, C. Heinrich, S. Gascón, M.A. Khan, D.C. Lie, and A. Dellavalle Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells Cell Stem Cell 11 2012 471 476
23. J. Kim, J.A. Efe, S. Zhu, M. Talantova, X. Yuan, S. Wang, S.A. Lipton, K. Zhang, and S. Ding Direct reprogramming of mouse fibroblasts to neural progenitors Proc. Natl. Acad. Sci. USA 108 2011 7838 7843
24. G. Kögler, S. Sensken, J.A. Airey, T. Trapp, M. Müschen, N. Feldhahn, S. Liedtke, R.V. Sorg, J. Fischer, and C. Rosenbaum A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential J. Exp. Med. 200 2004 123 135
25. J. Ladewig, J. Mertens, J. Kesavan, J. Doerr, D. Poppe, F. Glaue, S. Herms, P. Wernet, G. Kögler, and F.J. Müller Small molecules enable highly efficient neuronal conversion of human fibroblasts Nat. Methods 9 2012 575 578
26. J. Ladewig, P. Koch, and O. Brustle Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies Nat. Rev. Mol. Cell Biol. 14 2013 225 236
27. M.A. Lodato, C.W. Ng, J.A. Wamstad, A.W. Cheng, K.K. Thai, E. Fraenkel, R. Jaenisch, and L.A. Boyer SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state PLoS Genet. 9 2013 e1003288
28. J. Lu, H. Liu, C.T. Huang, H. Chen, Z. Du, Y. Liu, M.A. Sherafat, and S.C. Zhang Generation of integration-free and region-specific neural progenitors from primate fibroblasts Cell Reports 3 2013 1580 1591
29. E. Lujan, S. Chanda, H. Ahlenius, T.C. Südhof, and M. Wernig Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells Proc. Natl. Acad. Sci. USA 109 2012 2527 2532
30. S. Marro, Z.P. Pang, N. Yang, M.C. Tsai, K. Qu, H.Y. Chang, T.C. Südhof, and M. Wernig Direct lineage conversion of terminally differentiated hepatocytes to functional neurons Cell Stem Cell 9 2011 374 382
31. R. Mitchell, E. Szabo, Z. Shapovalova, L. Aslostovar, K. Makondo, and M. Bhatia Molecular evidence for OCT4-induced plasticity in adult human fibroblasts required for direct cell fate conversion to lineage specific progenitors Stem Cells 32 2014 2178 2187
32. S. Miyagi, M. Nishimoto, T. Saito, M. Ninomiya, K. Sawamoto, H. Okano, M. Muramatsu, H. Oguro, A. Iwama, and A. Okuda The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon J. Biol. Chem. 281 2006 13374 13381
33. K. Narayanan, and S. Makino Interplay between viruses and host mRNA degradation Biochim. Biophys. Acta 1829 2013 732 741
34. Z.P. Pang, N. Yang, T. Vierbuchen, A. Ostermeier, D.R. Fuentes, T.Q. Yang, A. Citri, V. Sebastiano, S. Marro, T.C. Südhof, and M. Wernig Induction of human neuronal cells by defined transcription factors Nature 476 2011 220 223
35. U. Pfisterer, A. Kirkeby, O. Torper, J. Wood, J. Nelander, A. Dufour, A. Björklund, O. Lindvall, J. Jakobsson, and M. Parmar Direct conversion of human fibroblasts to dopaminergic neurons Proc. Natl. Acad. Sci. USA 108 2011 10343 10348
36. J. Pruszak, K.C. Sonntag, M.H. Aung, R. Sanchez-Pernaute, and O. Isacson Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations Stem Cells 25 2007 2257 2268
37. L. Qiang, K. Inoue, and A. Abeliovich Instant neurons: directed somatic cell reprogramming models of central nervous system disorders Biol. Psychiatry 75 2014 945 951
38. K.L. Ring, L.M. Tong, M.E. Balestra, R. Javier, Y. Andrews-Zwilling, G. Li, D. Walker, W.R. Zhang, A.C. Kreitzer, and Y. Huang Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor Cell Stem Cell 11 2012 100 109
39. V. Rocha, M. Labopin, G. Sanz, W. Arcese, R. Schwerdtfeger, A. Bosi, N. Jacobsen, T. Ruutu, M. de Lima, J. Finke Acute Leukemia Working Party of European Blood and Marrow Transplant Group Eurocord-Netcord Registry Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia N. Engl. J. Med. 351 2004 2276 2285
40. R. Sanchez-Pernaute, H. Lee, M. Patterson, C. Reske-Nielsen, T. Yoshizaki, K.C. Sonntag, L. Studer, and O. Isacson Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease Brain 131 2008 2127 2139
41. S. Santourlidis, P. Wernet, F. Ghanjati, N. Graffmann, J. Springer, C. Kriegs, X. Zhao, J. Brands, M.J. Araúzo-Bravo, and R. Neves Unrestricted somatic stem cells (USSC) from human umbilical cord blood display uncommitted epigenetic signatures of the major stem cell pluripotency genes Stem Cell Res. (Amst.) 6 2011 60 69
42. N. Scheller, and J. Díez RNA viruses hijack the mRNA decay machinery to multiply Cell Cycle 8 2009 4013 4014
43. Z. Su, W. Niu, M.L. Liu, Y. Zou, and C.L. Zhang In vivo conversion of astrocytes to neurons in the injured adult spinal cord Nat. Commun. 5 2014 3338
44. C.K. Sun, D. Zhou, Z. Zhang, L. He, F. Zhang, X. Wang, J. Yuan, Q. Chen, L.G. Wu, and Q. Yang Senescence impairs direct conversion of human somatic cells to neurons Nat. Commun. 5 2014 4112
45. M. Thier, P. Wörsdörfer, Y.B. Lakes, R. Gorris, S. Herms, T. Opitz, D. Seiferling, T. Quandel, P. Hoffmann, and M.M. Nöthen Direct conversion of fibroblasts into stably expandable neural stem cells Cell Stem Cell 10 2012 473 479
46. O. Torper, U. Pfisterer, D.A. Wolf, M. Pereira, S. Lau, J. Jakobsson, A. Björklund, S. Grealish, and M. Parmar Generation of induced neurons via direct conversion in vivo Proc. Natl. Acad. Sci. USA 110 2013 7038 7043
47. I. Velasco, P. Salazar, A. Giorgetti, V. Ramos-Mejía, J. Castaño, D. Romero-Moya, and P. Menendez Concise review: generation of neurons from somatic cells of healthy individuals and neurological patients through induced pluripotency or direct conversion Stem Cells 32 2014 2811 2817
48. T. Vierbuchen, A. Ostermeier, Z.P. Pang, Y. Kokubu, T.C. Südhof, and M. Wernig Direct conversion of fibroblasts to functional neurons by defined factors Nature 463 2010 1035 1041
49. O.L. Wapinski, T. Vierbuchen, K. Qu, Q.Y. Lee, S. Chanda, D.R. Fuentes, P.G. Giresi, Y.H. Ng, S. Marro, and N.F. Neff Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons Cell 155 2013 621 635
50. A.S. Yoo, A.X. Sun, L. Li, A. Shcheglovitov, T. Portmann, Y. Li, C. Lee-Messer, R.E. Dolmetsch, R.W. Tsien, and G.R. Crabtree MicroRNA-mediated conversion of human fibroblasts to neurons Nature 476 2011 228 231
51. N. Yoshioka, E. Gros, H.R. Li, S. Kumar, D.C. Deacon, C. Maron, A.R. Muotri, N.C. Chi, X.D. Fu, B.D. Yu, and S.F. Dowdy Efficient generation of human iPSCs by a synthetic self-replicative RNA Cell Stem Cell 13 2013 246 254
52. X.B. Zhang Cellular reprogramming of human peripheral blood cells Genomics Proteomics Bioinformatics 11 2013 264 274
53. Y. Zhang, C. Pak, Y. Han, H. Ahlenius, Z. Zhang, S. Chanda, S. Marro, C. Patzke, C. Acuna, and J. Covy Rapid single-step induction of functional neurons from human pluripotent stem cells Neuron 78 2013 785 798
54. N. Zinin, I. Adameyko, M. Wilhelm, N. Fritz, P. Uhlén, P. Ernfors, and M.A. Henriksson MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division EMBO Rep. 15 2014 383 391
55. Q. Zou, Q. Yan, J. Zhong, K. Wang, H. Sun, X. Yi, and L. Lai Direct conversion of human fibroblasts into neuronal restricted progenitors J. Biol. Chem. 289 2014 5250 5260