A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential

Journal of Experimental Medicine

Volumn 200, Issue 2, 2004, Pages 123-135

  Kögler, Gesine ^a,f   Sensken, Sandra ^a   Airey, Judith A ^b   Trapp, Thorsten ^a   Müschen, Markus ^a   Feldhahn, Niklas ^a   Liedtke, Stefanie ^a   Sorg, Rüdiger V ^a   Fischer, Johannes ^a   Rosenbaum, Claudia ^a   Greschat, Susanne ^a   Knipper, Andreas ^a,c   Bender, Jörg ^c   Degistirici, Özer ^a,c   Gao, Jizong ^d   Caplan, Arnold I ^d   Colletti, Evan J ^b   Almeida Porada, Gra̧a ^e   Müller, Hans W ^a   Zanjani, Esmail ^e   Wernet, Peter ^a   more..

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^c Kourion Therapeutics AG   (Germany)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

^e UNIVERSITY OF NEVADA   (United States)

^f UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

Cord blood; Developmental potential; Ex vivo expansion; Regenerative medicine

Indexed keywords

ALBUMIN; GELFOAM; NEUROTRANSMITTER; SODIUM CHANNEL; TAU PROTEIN;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN; CARCINOGENESIS; CARTILAGE CELL; CELL DIFFERENTIATION; CELL FUSION; CELL POPULATION; CELL STRUCTURE; CHONDROGENESIS; CONTROLLED STUDY; ENDODERM; HEART ATRIUM; HEART VENTRICLE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER CELL; LIVER PARENCHYMA; MALE; MESODERM; NEUROFILAMENT; NONHUMAN; OSTEOBLAST; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; SHEEP; STEREOTAXIC SURGERY; UMBILICAL CORD BLOOD; UNRESTRICTED SOMATIC STEM CELL;

ADIPOCYTES; ALBUMINS; ANIMALS; ANTIGENS, CD45; BLOTTING, WESTERN; BONE AND BONES; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL TRANSPLANTATION; CORD BLOOD STEM CELL TRANSPLANTATION; FEMUR; FETAL BLOOD; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEMATOPOIETIC STEM CELLS; HIPPOCAMPUS; HUMANS; IMMUNOPHENOTYPING; LEUKOCYTES, MONONUCLEAR; MYOCARDIUM; MYOCYTES, CARDIAC; NEUROTRANSMITTER AGENTS; OSTEOBLASTS; PHENOTYPE; PLACENTA; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SHEEP; STEM CELLS; TIME FACTORS; UMBILICAL VEINS;

EID: 3242755834     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20040440     Document Type: Article

References (49)

1. Kuehnle, I., and M.A. Goodell. 2002. The therapeutic potential of stem cells from adults. BMJ. 325:372-376.
2. Thomson, J.A., J. Itskovitz-Eldor, S.S. Shapiro, M.A. Waknitz, J.J. Swiergiel, V.S. Marshall, and J.M. Jones. 1998. Embryonic stem cell lines derived from human blastocysts. Science. 282:1145-1147.
3. Erdo, F., C. Buhrle, J. Blunk, M. Hoehn, Y. Xia, B. Fleischmann, M. Focking, E. Kustermann, E. Kolossov, J. Hescheler, et al. 2003. Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke. J. Cereb. Blood Flow Metab. 23:780-785.
4. Sapienza, C. 2002. Imprinted gene expression, transplantation medicine, and the "other" human embryonic stem cell. Proc. Natl. Acad. Sci. USA. 99:10243-10245.
5. Gussoni, E., Y. Soneoka, C.D. Strickland, E.A. Buzney, M.K. Khan, A.F. Flint, L.M. Kunkel, and R.C. Mulligan. 1999. Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature. 401:390-394.
6. Petersen, B.E., W.C. Bowen, K.D. Patrene, W.M. Mars, A.K. Sullivan, N. Murase, S.S. Boggs, J.S. Greenberger, and J.P. Goff. 1999. Bone marrow as a potential source of hepatic oval cells. Science. 284:1168-1170.
7. Mezey, E., K.J. Chandross, G. Harta, R.A. Maki, and S.R. McKercher. 2000. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science. 290:1779-1782.
8. Krause, D.S., N.D. Theise, M.I. Collector, O. Henegariu, S. Hwang, R. Gardner, S. Neutzel, and S.J. Sharkis. 2001. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell. 105:369-377.
9. Korbling, M., R.L. Katz, A. Khanna, A.C. Ruifrok, G. Rondon, M. Albitar, R.E. Champlin, and Z. Estrov. 2002. Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N. Engl. J. Med. 346:738-746.
10. Wagers, A.J., R.I. Sherwood, J.L. Christensen, and I.L. Weissman. 2002. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science. 297:2256-2259.
11. Wang, X., H. Willenbring, Y. Akkari, Y. Torimaru, M. Foster, M. Al-Dhalimy, E. Lagasse, M. Finegold, S. Olson, and M. Grompe. 2003. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature. 422:897-901.
12. Jiang, Y., B.N. Jahagirdar, R.L. Reinhardt, R.E. Schwartz, C.D. Keene, X.R. Ortiz-Gonzalez, M. Reyes, T. Lenvik, T. Lund, M. Blackstad, et al. 2002. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 418:41-49.
13. Reyes, M., T. Lund, T. Lenvik, D. Aguiar, L. Koodie, and C.M. Verfaillie. 2001. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood. 98:2615-2625.
14. Geiger, H., and G. Van Zant. 2002. The aging of lymphohematopoietic stem cells. Nat. Immunol. 3:329-333.
15. Mendes, S.C., J.M. Tibbe, M. Veenhof, K. Bakker, S. Both, P.P. Platenburg, F.C. Oner, J.D. De Bruijn, and C.A. Van Blitterswijk. 2002. Bone tissue-engineered implants using human bone marrow stromal cells: effect of culture conditions and donor age. Tissue Eng. 8:911-920.
16. Szilvassy, S.J., T.E. Meyerrose, P.L. Ragland, and B. Grimes. 2001. Differential homing and engraftment properties of hematopoietic progenitor cells from murine bone marrow, mobilized peripheral blood, and fetal liver. Blood. 98:2108-2115.
17. Vaziri, H., W. Dragowska, R.C. Allsopp, T.E. Thomas, C.B. Harley, and P.M. Lansdorp. 1994. Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc. Natl. Acad. Sci. USA. 91:9857-9860.
18. Migliaccio, G., A.R. Migliaccio, S. Petti, F. Mavilio, G. Russo, D. Lazzaro, U. Testa, M. Marinucci, and C. Peschle. 1986. Human embryonic hemopoiesis. Kinetics of progenitors and precursors underlying the yolk sac-liver transition. J. Clin. Invest. 78:51-60.
19. Zanjani, E.D., J.L. Ascensao, and M. Tavassoli. 1993. Liver-derived fetal hematopoietic stem cells selectively and preferentially home to the fetal bone marrow. Blood. 81:399-404.
20. Rubinstein, P., R.E. Rosenfield, J.W. Adamson, and C.E. Stevens. 1993. Stored placental blood for unrelated bone marrow reconstitution. Blood. 81:1679-1690.
21. Kogler, G., J. Callejas, P. Hakenberg, J. Enczmann, O. Adams, W. Daubener, C. Krempe, U. Gobel, T. Somville, and P. Wernet. 1996. Hematopoietic transplant potential of unrelated cord blood: critical issues. J. Hematother. 5:105-116.
22. Harley, C.B., A.B. Futcher, and C.W. Greider. 1990. Telomeres shorten during ageing of human fibroblasts. Nature. 345:458-460.
23. Paxinos, G. and C. Watson. 1982. The Rat Brain in Stereotaxic Coordinates. Academic Press, Sydney, Australia.
24. Jaiswal, N., S.E. Haynesworth, A.I. Caplan, and S.P. Bruder. 1997. Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro. J. Cell. Biochem. 64:295-312.
25. Johnstone, B., T.M. Hering, A.I. Caplan, V.M. Goldberg, and J.U. Yoo. 1998. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp. Cell Res. 238:265-272.
26. Pittenger, M.F., A.M. Mackay, S.C. Beck, R.K. Jaiswal, R. Douglas, J.D. Mosca, M.A. Moorman, D.W. Simonetti, S. Craig, and D.R. Marshak. 1999. Multilineage potential of adult human mesenchymal stem cells. Science. 284:143-147.
27. Bruder, S.P., N. Jaiswal, N.S. Ricalton, J.D. Mosca, K.H. Kraus, and S. Kadiyala. 1998. Mesenchymal stem cells in osteobiology and applied bone regeneration. Clin. Orthop. 355:S247-S256.
28. Ponticiello, M.S., R.M. Schinagl, S. Kadiyala, and F.P. Barry. 2000. Gelatin-based resorbable sponge as a carrier matrix for human mesenchymal stem cells in cartilage regeneration therapy. J. Biomed. Mater. Res. 52:246-255.
29. Kogler, G., J. Callejas, R.V. Sorg, J. Fischer, A.R. Migliaccio, and P. Wernet. 1998. The effect of different thawing methods, growth factor combinations and media on the ex vivo expansion of umbilical cord blood primitive and committed progenitors. Bone Marrow Transplant. 21:233-241.
30. Airey, J.A., G. Almeida-Porada, E.J. Colletti, C.D. Porada, J. Chamberlain, M. Movsesian, J.L. Sutko, and E.D. Zanjani. 2004. Human mesenchymal stem cells from purkinje fibers in fetal sheep heart. Circulation. 109:1401-1407.
31. Klein, F., N. Feldhahn, S. Lee, H. Wang, F. Ciuffi, M. von Elstermann, M.L. Toribio, H. Sauer, M. Wartenberg, V.S. Barath, et al. 2003. T lymphoid differentiation in human bone marrow. Proc. Natl. Acad. Sci. USA. 100:6747-6752.
32. Schousboe, A., and D.A. Redburn. 1995. Modulatory actions of gamma aminobutyric acid (GABA) on GABA type A receptor subunit expression and function. J. Neurosci. Res. 41:1-7.
33. Allay, J.A., J.E. Dennis, S.E. Haynesworth, M.K. Majumdar, D.W. Clapp, L.D. Shultz, A.I. Caplan, and S.L. Gerson. 1997. LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors. Hum. Gene Ther. 8:1417-1427.
34. Flake, A.W., M.R. Harrison, N.S. Adzick, and E.D. Zanjani. 1986. Transplantation of fetal hematopoietic stem cells in utero: the creation of hematopoietic chimeras. Science. 233:776-778.
35. Zanjani, E.D., A.W. Flake, H. Rice, M. Hedrick, and M. Tavassoli. 1994. Long-term repopulating ability of xenogeneic transplanted human fetal liver hematopoietic stem cells in sheep. J. Clin. Invest. 93:1051-1055.
36. Leger, J.P., F.M. Smith, and R.W. Currie. 2000. Confocal microscopic localization of constitutive and heat shock-induced proteins HSP70 and HSP27 in the rat heart. Circulation. 102:1703-1709.
37. Chevron, M.P., F. Girard, M. Claustres, and J. Demaille. 1994. Expression and subcellular localization of dystrophin in skeletal, cardiac and smooth muscles during the human development. Neuromuscul. Disord. 4:419-432.
38. Torelli, S., A. Ferlini, L. Obici, C. Sewry, and F. Muntoni. 1999. Expression, regulation and localisation of dystrophin isoforms in human foetal skeletal and cardiac muscle. Neuromuscul. Disord. 9:541-551.
39. Erices, A., P. Conget, and J.J. Minguell. 2000. Mesenchymal progenitor cells in human umbilical cord blood. Br. J. Haematol. 109:235-242.
40. Romanov, Y.A., V.A. Svintsitskaya, and V.N. Smirnov. 2003. Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord. Stem Cells. 21:105-110.
41. Goodwin, H.S., A.R. Bicknese, S.N. Chien, B.D. Bogucki, C.O. Quinn, and D.A. Wall. 2001. Multilineage differentiation activity by cells isolated from umbilical cord blood: expression of bone, fat, and neural markers. Biol. Blood Marrow Transplant. 7:581-588.
42. Wexler, S.A., C. Donaldson, P. Denning-Kendall, C. Rice, B. Bradley, and J.M. Hows. 2003. Adult bone marrow is a rich source of human mesenchymal 'stem' cells but umbilical cord and mobilized adult blood are not. Br. J. Haematol. 121:368-374.
43. Mareschi, K., E. Biasin, W. Piacibello, M. Aglietta, E. Madon, and F. Fagioli. 2001. Isolation of human mesenchymal stem cells: bone marrow versus umbilical cord blood. Haematologica. 86:1099-1100.
44. Deans, R.J., and A.B. Moseley. 2000. Mesenchymal stem cells: biology and potential clinical uses. Exp. Hematol. 28:875-884.
45. Nilsson, S.K., D.N. Haylock, H.M. Johnston, T. Occhiodoro, T.J. Brown, and P.J. Simmons. 2003. Hyaluronan is synthesized by primitive hemopoietic cells, participates in their lodgment at the endosteum following transplantation, and is involved in the regulation of their proliferation and differentiation in vitro. Blood. 101:856-862.
46. Lewis, I.D., G. Almeida-Porada, J. Du, I.R. Lemischka, K.A. Moore, E.D. Zanjani, and C.M. Verfaillie. 2001. Umbilical cord blood cells capable of engrafting in primary, secondary, and tertiary xenogeneic hosts are preserved after ex vivo culture in a noncontact system. Blood. 97:3441-3449.
47. Alvarez-Dolado, M., R. Pardal, J.M. Garcia-Verdugo, J.R. Fike, H.O. Lee, K. Pfeffer, C. Lois, S.J. Morrison, and A. Alvarez-Buylla. 2003. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature. 425:968-973.
48. Le Blanc, K. 2003. Immunomodulatory effects of fetal and adult mesenchymal stem cells. Cytotherapy. 5:485-489.
49. Zanjani, E.D., E.F. Srour, and R. Hoffman. 1995. Retention of long-term repopulating ability of xenogeneic transplanted purified adult human bone marrow hematopoietic stem cells in sheep. J. Lab. Clin. Med. 126:24-28.