Clinical and molecular evidence of the consumption of broccoli, glucoraphanin and sulforaphane in humans;Evidencias Clínicas y moleculares del consumo de brócoli, glucorafanina y sulforafano en humanos

Nutricion Hospitalaria

Volumn 31, Issue 2, 2015, Pages 559-569

  Conzatti, Adriana ^a   Fróes, Fernanda Carolina Telles da Silva ^a   Perry, Ingrid Dalira Schweigert ^b,c   de Souza, Carolina Guerini ^a,c  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

^c HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

Broccoli; Glucoraphanin; Isothiocyanates; Sulforaphane

Indexed keywords

ANIMALIA; BRASSICA OLERACEA VAR. ITALICA; HELICOBACTER PYLORI;

ANTINEOPLASTIC AGENT; GLUCORAPHANIN; GLUCOSINOLATE; IMIDOESTER; ISOTHIOCYANIC ACID DERIVATIVE; SULFORAFAN;

BRASSICA; DIET; HUMAN; META ANALYSIS; MYOCARDIAL INFARCTION; NEOPLASMS;

ANTICARCINOGENIC AGENTS; BRASSICA; DIET; GLUCOSINOLATES; HUMANS; IMIDOESTERS; ISOTHIOCYANATES; MYOCARDIAL INFARCTION; NEOPLASMS;

EID: 84923770686     PISSN: 02121611     EISSN: 16995198     Source Type: Journal    
DOI: 10.3305/nh.2015.31.2.7685     Document Type: Review

References (54)

1. Cornelis MC, El-Sohemy A, Campos H. GSTT1 genotype modifies the association between cruciferous vegetable intake and the risk of myocardial infarction. Am J Clin Nutr 2007; 86(3):752-758.
2. Wu QJ, Yang Y, Vogtamann E, Wang J, Han LH, Li HL, Xiang YB. Cruciferous vegetables intake and the risk of colorectal cancer: a meta-analysis of observational studies. Ann Oncol 2013; 24(4):1079–1087.
3. Liu B, Mao Q, Cao M, Xie L. Cruciferous vegetables intake and risk of prostate cancer: A meta-analysis. Int J of Urol 2012; 19(2):134–141.
4. Liu X, Lv K. Cruciferous vegetables intake is inversely associated with risk of breast cancer: A meta-analysis. Breast 2013; 22(3):309-313.
5. Lam TK, Lam TK, Gallicchio L, Lindsley K, Shiels M, Hammond E, Tao XG, et al. Cruciferous Vegetable Consumption and Lung Cancer Risk: A Systematic Review. Cancer Epidemiol Biomarkers Prev 2009; 18(1):184–195.
6. Tarozzi A, Angeloni C, Malaguti M, Morroni F, Hrelia S, Hrelia P. Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases. Oxid Med Cell Longev 2013; 2013:1-10.
7. Bahadoran Z, Mirmiran P, Azizi F. Potential Efficacy of Broccoli Sprouts as a Unique Supplement for Management of Type 2 Diabetes and Its Complications. J Med Food 2013; 16(5):375–382.
8. Evans PC. The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease. EPMA J 2011; 2(1):9–14.
9. Buck PA. Origin and taxonomy of broccoli. Econ. Bot 1956; 10:250–253.
10. Manchali S, Murthy KNC, Patil BS. Crucial facts about health benefits of popular cruciferous vegetables. J. of Functional Foods 2012; 4(1):94-106.
11. Verhoeven DTH, Verhagen H, Goldbohm RA, Van Den Bramdt PA, Van Poppel G. A review of mechanisms underlying anticarcinogenicity by brassica vegetables. Chem Biol Interact. 1997; 103:79-129.
12. Latté KP, Appel K-E, Lampen A. Health benefits and possible risks of broccoli – An overview. Food Chem Toxicol 2011; 49(12):3287–3309.
13. Fahey JF, Zalcmann AT, Talalay P. The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry. 2001; 56(1):5-51.
14. Bones AM, Rossiter JT. The enzymic and chemically induced decomposition of glucosinolates. Phytochemistry 2006; 67(11):1053–1067.
15. Fahey JW, Wehage SL, Holtzclaw WD, Kensler TW, Egner PA, Shapiro TA, Talalay P. Protection of humans by plant glucosinolates: efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora. Cancer Prev Res 2012; 5(4):603-611.
16. Ares AM, Nozal MJ, Bernal J. Extraction, chemical characterization and biological activity determination of broccoli health promoting compounds. J Chromatogr A 2013; 1313:78-95.
17. Kushad MM, Brown AF, Kurilich AC, Juvik JA, Klein BP, Wallig MA, Jeffery EH. Variation of Glucosinolates in Vegetable Crops of Brassica oleracea. J Agric Food Chem 1999; 47(4):1541-1548.
18. Fimognari C, Hrelia P. Sulforaphane as a promising molecule for fighting cancer. Mutat Res 2007; 635(2-3):90–104.
19. Tang L, Zirpoli GR, Guru K, Moysich KB, Zhang Y, Ambrosone CB, McCann SE. Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival. Cancer Epidemiol Biomarkers Prev 2010; 19:1806-1811.
20. Kensler TW, Egner PA, Agyeman SA, Visvanathan K, Groopman JD, Chen JG, Chen TY, Fahey JW, Talalay P. Keap1–Nrf2 Signaling: A Target for Cancer Prevention by Sulforaphane. Top Curr Chem 2013; 329:163–178.
21. Vomhof-Dekrey EE, Picklo SR MJ. The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism. J Nutr Biochem 2012; 23(10):1201–1206.
22. Turpaev KT. Keap1-Nrf2 Signaling Pathway: Mechanisms of Regulation and Role in Protection of Cells against Toxicity Caused by Xenobiotics and Electrophiles. Biochemistry 2013; 78(2):111-126.
23. Guerrero-Beltrán CE, Calderón-Oliver M, Pedraza-Chaverri J, Chirinho YI. Protective effect of sulforaphane against oxidative stress: Recent advances. Exp Toxicol Pathol 2013; 64(5): 503–508.
24. Collaboration C. Cochrane handbook for systematic reviews of interventions. 2009.
25. Liberati A, Alteman DG, Tetzlaff J, Mulrow C, Gotzche C, Gotzche PC, Ionanidis JP, Clarke M, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 2009; 62(10):e1-34.
26. Bahadoran Z, Tohidi M, Nazeri P, Mehran M, Azizi F, Mirmiran P. Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial. Int J Food Sci N 2012; 63(7):767-771.
27. Mirmiran P, Bahadoran Z, Hosseinpanah F, Keyzad A, Azizi F. Effects of broccoli sprout with high sulforaphane concentration on inflammatory markers in type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial. J Func Foods 2012; 4(4):837-841.
28. Bahadoran Z, Mirmiran P, Hosseinpanah F, Rajab A, Asghari G, Azizi, F. Broccoli sprouts powder could improve serum triglyceride and oxidized LDL/LDL-cholesterol ratio in type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial. Diabetes Res and Clin Pract 2012; 96(3):348-354.
29. Bahadoran Z, Mirmiran, P, Hosseinpanah F, Hedayati M, Hosseinpour-Niazi S, Azizi, F. Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial. Eur J Clin Nutr 2011; 65(8):972-977.
30. Armah CN, Traka MH, Dainty JR, Defernez M, Janssens A, Leung W, Doleman JF, et al. A diet rich in high-glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles by modulating mitochondrial function. Am J Clin Nutr 2013; 98(3):712-722.
31. Christiansen B, Bellostas Muguerza N, Petersen AM, Kveiborg B, Madsen CR, Thomas H, et al. Ingestion of Broccoli Sprouts Does Not Improve Endothelial Function in Humans with Hypertension. PLoS One 2010; 5(8):e12461.
32. Murashima M, Watanabe S, Zhuo XG, Uehara M, Kurasshige A. Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one-week intake of broccoli sprouts. Bio-Factors 2004; 22(1-4):271-275.
33. Kensler TW, Ng D, Carmella SG, Chen M, Jacobson LP, Muñoz, A. Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China. Carcinogenesis 2012; 33(1):101–107.
34. Riso P, Martini D, Moller P, Loft S, Bonacina G, Moro G, Porrini M. DNA damage and repair activity after broccoli intake in young healthy smokers. Mutagenesis 2010; 25(6):595–602.
35. Riso P, Martini D, Visioli F, Martinetti A, Porrini M. Effect of Broccoli Intake on Markers Related to Oxidative Stress and Cancer Risk in Healthy Smokers and Nonsmokers. Nutr Cancer 2009; 61(2):232–237.
36. Riedl MA, Saxon, A Diaz-Sanchez D. Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. Clin Immunol 2009; 130(3):244–251.
37. Traka M, Gasper AV, Melchini A, Bacon JR, Needs PW, Frost V, et al. Broccoli Consumption Interacts with GSTM1 to Perturb Oncogenic Signalling Pathways in the Prostate. PLoS ONE 2008; 3(7):e2568.
38. Gasper AV, Traka M, Bacon JR, Smith JA, Taylor MA, Hawkey CJ, Barret DA, Mithen RF. Consuming Broccoli Does Not Induce Genes Associated with Xenobiotic Metabolism and Cell Cycle Control in Human Gastric Mucosa. J Nutr 2007; 137(7):1718–1724.
39. Hakooz N, Hamban I. Effects of Dietary Broccoli on Human in Vivo Caffeine Metabolism: A Pilot Study on a Group of Jordanian Volunteers. Curr Drug Metab 2007; 8(1):9-15.
40. Kensler TW, Chen JG, Egner PA, Fahey JW, Jacobson, LP, Stephenson KK, et al. Effects of Glucosinolate-Rich Broccoli Sprouts on Urinary Levels of Aflatoxin-DNA Adducts and Phenanthrene Tetraols in a Randomized Clinical Trial in He Zuo Township, Qidong, People’s Republic of China. Cancer Epidemiol Biomarkers Prev 2005; 14(11 Pt 1):2605-2613.
41. Galan MV, Kishan AA, Silverman AL. Oral Broccoli Sprouts for the Treatment of Helicobacter pylori Infection: A Preliminary Report. Dig Dis Sci 2004; 49(7-8):1088-1090.
42. Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue M, Zhang S, et al. Dietary Sulforaphane-Rich Broccoli Sprouts Reduce Colonization and Attenuate Gastritis in Helicobacter pylori-Infected Mice and Humans. Cancer Prev Res 2009; 2(4):353-360.
43. Turner RC, Cull CA, Frighi V, Holman RR. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA 1999; 281(21):2005-2012.
44. Souza CG, Sattler JA, de Assis AM, Rech A, Perry ML, Souza DO. Metabolic Effects of Sulforaphane Oral Treatment in Streptozotocin-Diabetic Rats. J Med Food 2012; 15(9):795–801.
45. Hu R, Xu C, Shen G, Jain MR, Khor TO, Gopalkrishan A, et al. Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (K/K) mice. Cancer Lett 2006; 243(2):170-192.
46. Global atlas on cardiovascular disease prevention and control. Geneva, World Health Organization,2011.Disponível em: http://www.who.int/cardiovascular_diseases/publications/atlas_cvd/en/, acesso realizado em 15 de maio de 2013.
47. Hybertson BM, Gao B, Bose SK, Mccord MJ. Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation. Mol Aspects Med 2011; 32(4-6):234–246.
48. Choi SW, Benzie IF, Ma SW, Strain JJ, Hanningan BM. Acute hyperglycemia and oxidative stress: Direct cause and effect? Free Radic Biol Med 2008; 44(7):1217-1231.
49. Peluso I, Morabito G, Urban L, Ioannone F, Serafini M. Oxidative stress in atherosclerosis development: the central role of LDL and oxidative burst. Endocr Metab Immune Disord Drug Targets 2012;12(4):351-360.
50. Agyeman AS, Chaerkady R, Shaw PG, Davidson, NE, Visvanathan K, Pandey A, Kensler TW. Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles. Breast Cancer Res Treat 2012; 132(1):175-187.
51. Watson GW, Beaver ML, Williams ED, Dashwood R, Ho E. Phytochemicals from Cruciferous Vegetables, Epigenetics, and Prostate Cancer Prevention. AAPS J 2013; 15(4):951-961.
52. Gatta L, Nimish V, Vaira D, Scarpignato C. Global eradication rates for Helicobacter pylori infection: systematic review and meta-analysis of sequential therapy BMJ 2013; 347:f4587.
53. Moon JK, Kim JR, Ahn YJ, Shibamoto T. Analysis and Anti-Helicobacter Activity of Sulforaphane and Related Compounds Present in Broccoli (Brassica oleracea L.) Sprouts. J Agric Food Chem 2010; 58(11):6672-6677.
54. Fahey JW, Stephenson KK, Wade KL, Talalay P. Urease from Helicobacter pylori is inactivated by sulforaphane and other isothiocyanates. Biochem Biophys Res Commun 2013; 435(1):1-7.