Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one-week intake of broccoli sprouts

BioFactors

Volumn 22, Issue 1-4, 2004, Pages 271-275

  Murashima, Megumi ^a   Watanabe, Shaw ^a   Zhuo, Xing Gang ^a   Uehara, Mariko ^a   Kurashige, Atsushi ^b  

^a TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

^b Japan Inst for the Control of Aging   (Japan)

Author keywords

8 hydroxydeoxyguanosine; 8 isoprostane; Broccoli sprouts; Coenzyme Q10; Phase 1 study; Phosphatidylcholine hydroperoxide

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; AMINO ACID DERIVATIVE; BIOLOGICAL MARKER; CHOLESTEROL; CYSTINE; HYDROPEROXIDE DERIVATIVE; ISOPROSTANE DERIVATIVE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHATIDYLCHOLINE; UBIDECARENONE; AMINO ACID; DRUG DERIVATIVE; LIPID; PHOSPHATIDYLCHOLINE HYDROPEROXIDE; UBIQUINONE;

ADULT; AMINO ACID BLOOD LEVEL; BIOCHEMISTRY; BROCCOLI; CHOLESTEROL METABOLISM; CONFERENCE PAPER; CONTROLLED STUDY; DIET; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; METABOLISM; NATURAL KILLER CELL; NORMAL HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; ARTICLE; BLOOD; BRASSICA; CLINICAL TRIAL; IMMUNOLOGY; LIVER FUNCTION TEST; PHASE 1 CLINICAL TRIAL; REFERENCE VALUE; UREA NITROGEN BLOOD LEVEL;

BRASSICA OLERACEA VAR. BOTRYTIS;

AMINO ACIDS; BIOLOGICAL MARKERS; BLOOD UREA NITROGEN; BRASSICA; FEMALE; HUMANS; KILLER CELLS, NATURAL; LIPIDS; LIVER FUNCTION TESTS; MALE; OXIDATIVE STRESS; PHOSPHATIDYLCHOLINES; REFERENCE VALUES; UBIQUINONE;

EID: 21544451968     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.5520220154     Document Type: Conference Paper

References (15)

1. J.W. Lampe, Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies, Am J Clin Nutr 70 (1999), 475S-490S.
2. D.T. Verhoeven, R.A. Goldbohm, G. van Poppel, H. Verhagen and P.A. van den Brandt, Epidemiological studies on brassica vegetables and cancer risk, Cancer Epidemiol Biomarkers Prev 5 (1996), 733-748.
3. Y. Zhang, P. Talalay, G.G. Cho and G.H. Posner, A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure, Proc Natl Acad Sci USA 89 (1992), 2399-2403.
4. J.W. Fahey, Y. Zhang and P. Talalay, Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens, Proc Natl Acad Sci USA 94 (1997), 10367-10372.
5. B. Halliwell, Establishing the significance and optimal intake of dietary antioxidants: the biomarker concept, Nutr Rev 57 (1999), 104-113.
6. B. Halliwell, Why and how should we measure oxidative DNA damage in nutritional studies? How far have we come? Am J Clin Nutr 72 (2000), 1082-1087.
7. S. Sasaki, T. Takahashi, Y. Iitoi et al., Food and nutrient intakes assessed with dietary records for the validation study of a self-administered food frequency questionnaire in JPHC Study Cohort I, J Epidemiol 13 (2003), S23-50.
8. R. Haba, S. Watanabe, Y. Arai, H. Chiba and T. Miura, Suppression of lipid-hydroperoxide and DNA-adduct formation by isoflavone-containing soy hypocotyl tea in rats, Env Health Prevent Med 7 (2002), 64-73.
9. Y. Zhang, T.W. Kensler, C.G. Cho, G.H. Posner and P. Talalay, Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates, Proc Natl Acad Sci USA 91 (1994), 3147-3150.
10. J.D. Morrow, The isoprostanes: their quantification as an index of oxidant stress status in vivo, Drug Metab Rev 32 (2000), 377-385.
11. M. Kinoshita, S. Oikawa, K. Hayasaka et al., Age-related increases in plasma phosphatidylcholine hydroperoxide concentrations in control subjects and patients with hyperlipidemia, Clin Chem 46 (2000), 822-828.
12. J. Lagendijk, J.B. Ubbink and W.J. Vermaak, Measurement of the ratio between the reduced and oxidized forms of coenzyme Q10 in human plasma as a possible marker of oxidative stress, J Lipid Res 37 (1996), 67-75.
13. B.R. Kim, R. Hu, Y.S. Keum et al., Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane, Cancer Res 63 (2003), 7520-7525.
14. D.P. Jones, V.C. Mody, Jr., J.L. Carlson, M.J. Lynn and P. Sternberg, Jr. Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses, Free Radic Biol Med 33 (2002), 1290-1300.
15. M.N. Nanjee, H. Verhagen, G. van Poppel, C.J. Rompelberg, P.J. van Bladeren and N.E. Miller, Do dietary phytochemicals with cytochrome P-450 enzyme-inducing activity increase high-density-lipoprotein concentrations in humans? Am J Clin Nutr 64 (1996), 706-711.