메뉴 건너뛰기




Volumn 6, Issue 3, 2015, Pages 276-286

Intracellular acidosis promotes mitochondrial apoptosis pathway: Role of EMMPRIN down-regulation via specific single-chain fv intrabody

Author keywords

Apoptosis; Carcinoembryonic antigen (CEA); Colorectal cancer cells; EMMPRIN; scFv M6 1B9 intrabody

Indexed keywords

ADENOVIRUS VECTOR; CARCINOEMBRYONIC ANTIGEN; CASPASE 3; CD147 ANTIGEN; CYTOCHROME C; MESSENGER RNA; PHOSPHATIDYLSERINE; PROTEIN BCL 2; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

EID: 84923677656     PISSN: None     EISSN: 18379664     Source Type: Journal    
DOI: 10.7150/jca.10879     Document Type: Article
Times cited : (14)

References (68)
  • 1
    • 79951847989 scopus 로고    scopus 로고
    • Principles and current strategies for targeting autophagy for cancer treatment
    • Amaravadi RK, Lippincott-Schwartz J, Yin XM, et al. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res. 2011; 17: 654-66.
    • (2011) Clin Cancer Res , vol.17 , pp. 654-666
    • Amaravadi, R.K.1    Lippincott-Schwartz, J.2    Yin, X.M.3
  • 2
    • 84898451880 scopus 로고    scopus 로고
    • Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: the role of inflammation
    • Lee CS, Ryan EJ, and Doherty GA. Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: the role of inflammation. World J Gastroenterol. 2014; 20: 3751-61.
    • (2014) World J Gastroenterol , vol.20 , pp. 3751-3761
    • Lee, C.S.1    Ryan, E.J.2    Doherty, G.A.3
  • 3
    • 84879713633 scopus 로고    scopus 로고
    • Targeted cancer therapies: the future of cancer treatment
    • Kumar M, Nagpal R, Hemalatha R, et al. Targeted cancer therapies: the future of cancer treatment. Acta Biomed. 2012; 83: 220-33.
    • (2012) Acta Biomed , vol.83 , pp. 220-233
    • Kumar, M.1    Nagpal, R.2    Hemalatha, R.3
  • 4
  • 5
    • 33645760938 scopus 로고    scopus 로고
    • Chemotherapeutic approaches for targeting cell death pathways
    • Ricci MS and Zong WX. Chemotherapeutic approaches for targeting cell death pathways. Oncologist. 2006; 11: 342-57.
    • (2006) Oncologist , vol.11 , pp. 342-357
    • Ricci, M.S.1    Zong, W.X.2
  • 6
    • 78649251524 scopus 로고    scopus 로고
    • Roles of autophagy in cetuximab-mediated cancer therapy against EGFR
    • Li X, Lu Y, Pan T, et al. Roles of autophagy in cetuximab-mediated cancer therapy against EGFR. Autophagy. 2010; 6: 1066-77.
    • (2010) Autophagy , vol.6 , pp. 1066-1077
    • Li, X.1    Lu, Y.2    Pan, T.3
  • 7
    • 34548472408 scopus 로고    scopus 로고
    • Change in expression of apoptosis genes after hyperthermia, chemotherapy and radiotherapy in human colon cancer transplanted into nude mice
    • Liang H, Zhan HJ, Wang BG, et al. Change in expression of apoptosis genes after hyperthermia, chemotherapy and radiotherapy in human colon cancer transplanted into nude mice. World J Gastroenterol. 2007; 13: 4365-71.
    • (2007) World J Gastroenterol , vol.13 , pp. 4365-4371
    • Liang, H.1    Zhan, H.J.2    Wang, B.G.3
  • 8
    • 84901770556 scopus 로고    scopus 로고
    • Elevated expression of CD147 in patients with endometriosis and its role in regulating apoptosis and migration of human endometrial cells
    • Jin A, Chen H, Wang C, et al. Elevated expression of CD147 in patients with endometriosis and its role in regulating apoptosis and migration of human endometrial cells. Fertil Steril. 2014; 101: 1681-7.
    • (2014) Fertil Steril , vol.101 , pp. 1681-1687
    • Jin, A.1    Chen, H.2    Wang, C.3
  • 9
    • 84875428431 scopus 로고    scopus 로고
    • Propranolol induces apoptosis of human umbilical vein endothelial cells through downregulation of CD147
    • Xie W, Xie H, Liu F, et al. Propranolol induces apoptosis of human umbilical vein endothelial cells through downregulation of CD147. Br J Dermatol. 2013; 168: 739-48.
    • (2013) Br J Dermatol , vol.168 , pp. 739-748
    • Xie, W.1    Xie, H.2    Liu, F.3
  • 10
    • 84861567084 scopus 로고    scopus 로고
    • CD147 regulates apoptosis in mouse spermatocytes but not spermatogonia
    • Chen H, Fok KL, Jiang X, et al. CD147 regulates apoptosis in mouse spermatocytes but not spermatogonia. Hum Reprod. 2012; 27: 1568-76.
    • (2012) Hum Reprod , vol.27 , pp. 1568-1576
    • Chen, H.1    Fok, K.L.2    Jiang, X.3
  • 11
    • 0037478612 scopus 로고    scopus 로고
    • Regulation of multidrug resistance in cancer cells by hyaluronan
    • Misra S, Ghatak S, Zoltan-Jones A, et al. Regulation of multidrug resistance in cancer cells by hyaluronan. J Biol Chem. 2003; 278: 25285-8.
    • (2003) J Biol Chem , vol.278 , pp. 25285-25288
    • Misra, S.1    Ghatak, S.2    Zoltan-Jones, A.3
  • 12
    • 0025718981 scopus 로고
    • The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen
    • Miyauchi T, Masuzawa Y, and Muramatsu T. The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen. J Biochem. 1991; 110: 770-4.
    • (1991) J Biochem , vol.110 , pp. 770-774
    • Miyauchi, T.1    Masuzawa, Y.2    Muramatsu, T.3
  • 13
    • 0026659128 scopus 로고
    • Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule
    • Kasinrerk W, Fiebiger E, Stefanova I, et al. Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule. J Immunol. 1992; 149: 847-54.
    • (1992) J Immunol , vol.149 , pp. 847-854
    • Kasinrerk, W.1    Fiebiger, E.2    Stefanova, I.3
  • 15
    • 33646933890 scopus 로고    scopus 로고
    • Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim
    • Yang JM, O'Neill P, Jin W, et al. Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. J Biol Chem. 2006; 281: 9719-27.
    • (2006) J Biol Chem , vol.281 , pp. 9719-9727
    • Yang, J.M.1    O'Neill, P.2    Jin, W.3
  • 16
    • 4143121134 scopus 로고    scopus 로고
    • Intrabodies as therapeutic agents
    • Kontermann RE. Intrabodies as therapeutic agents. Methods. 2004; 34: 163-70.
    • (2004) Methods , vol.34 , pp. 163-170
    • Kontermann, R.E.1
  • 17
    • 10744224116 scopus 로고    scopus 로고
    • Regression of cutaneous tumor lesions in patients intratumorally injected with a recombinant single-chain antibody-toxin targeted to ErbB2/HER2
    • Azemar M, Djahansouzi S, Jager E, et al. Regression of cutaneous tumor lesions in patients intratumorally injected with a recombinant single-chain antibody-toxin targeted to ErbB2/HER2. Breast Cancer Res Treat. 2003; 82: 155-64.
    • (2003) Breast Cancer Res Treat , vol.82 , pp. 155-164
    • Azemar, M.1    Djahansouzi, S.2    Jager, E.3
  • 18
    • 84894202694 scopus 로고    scopus 로고
    • RP215 single chain fragment variable and single domain recombinant antibodies induce cell cycle arrest at G0/G1 phase in breast cancer
    • Yu F, Wang Y, Xiao Y, et al. RP215 single chain fragment variable and single domain recombinant antibodies induce cell cycle arrest at G0/G1 phase in breast cancer. Mol Immunol. 2014; 59: 100-9.
    • (2014) Mol Immunol , vol.59 , pp. 100-109
    • Yu, F.1    Wang, Y.2    Xiao, Y.3
  • 19
    • 13444249481 scopus 로고    scopus 로고
    • Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody
    • Popkov M, Jendreyko N, McGavern DB, et al. Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody. Cancer Res. 2005; 65: 972-81.
    • (2005) Cancer Res , vol.65 , pp. 972-981
    • Popkov, M.1    Jendreyko, N.2    McGavern, D.B.3
  • 20
    • 84893829723 scopus 로고    scopus 로고
    • Antiproliferative and apoptotic effects of a specific antiprostate stem cell single chain antibody on human prostate cancer cells
    • Nejatollahi F, Abdi S, and Asgharpour M. Antiproliferative and apoptotic effects of a specific antiprostate stem cell single chain antibody on human prostate cancer cells. J Oncol. 2013; 2013: 1-8.
    • (2013) J Oncol , vol.2013 , pp. 1-8
    • Nejatollahi, F.1    Abdi, S.2    Asgharpour, M.3
  • 21
    • 79956197243 scopus 로고    scopus 로고
    • A new disulfide-linked dimer of a single-chain antibody fragment against human CD47 induces apoptosis in lymphoid malignant cells via the hypoxia inducible factor-1alpha pathway
    • Sagawa M, Shimizu T, Fukushima N, et al. A new disulfide-linked dimer of a single-chain antibody fragment against human CD47 induces apoptosis in lymphoid malignant cells via the hypoxia inducible factor-1alpha pathway. Cancer Sci. 2011; 102: 1208-15.
    • (2011) Cancer Sci , vol.102 , pp. 1208-1215
    • Sagawa, M.1    Shimizu, T.2    Fukushima, N.3
  • 22
    • 77951675122 scopus 로고    scopus 로고
    • Potent inhibition of OKT3-induced T cell proliferation and suppression of CD147 cell surface expression in HeLa cells by scFv-M6-1B9
    • Intasai N, Tragoolpua K, Pingmuang P, et al. Potent inhibition of OKT3-induced T cell proliferation and suppression of CD147 cell surface expression in HeLa cells by scFv-M6-1B9. Immunobiology. 2009; 214: 410-21.
    • (2009) Immunobiology , vol.214 , pp. 410-421
    • Intasai, N.1    Tragoolpua, K.2    Pingmuang, P.3
  • 23
    • 39849084770 scopus 로고    scopus 로고
    • Generation of functional scFv intrabody to abate the expression of CD147 surface molecule of 293A cells
    • Tragoolpua K, Intasai N, Kasinrerk W, et al. Generation of functional scFv intrabody to abate the expression of CD147 surface molecule of 293A cells. BMC Biotechnol. 2008; 8: 1-13.
    • (2008) BMC Biotechnol , vol.8 , pp. 1-13
    • Tragoolpua, K.1    Intasai, N.2    Kasinrerk, W.3
  • 24
    • 0033974016 scopus 로고    scopus 로고
    • Latest developments in gene transfer technology: achievements, perspectives, and controversies over therapeutic applications
    • Romano G, Michell P, Pacilio C, et al. Latest developments in gene transfer technology: achievements, perspectives, and controversies over therapeutic applications. Stem Cells. 2000; 18: 19-39.
    • (2000) Stem Cells , vol.18 , pp. 19-39
    • Romano, G.1    Michell, P.2    Pacilio, C.3
  • 25
    • 68549087056 scopus 로고    scopus 로고
    • Viral vectors: from virology to transgene expression
    • Bouard D, Alazard-Dany D, and Cosset FL. Viral vectors: from virology to transgene expression. Br J Pharmacol. 2009; 157: 153-65.
    • (2009) Br J Pharmacol , vol.157 , pp. 153-165
    • Bouard, D.1    Alazard-Dany, D.2    Cosset, F.L.3
  • 26
    • 0036953575 scopus 로고    scopus 로고
    • Lentiviruses in gene therapy clinical research
    • Connolly JB. Lentiviruses in gene therapy clinical research. Gene Ther. 2002; 9: 1730-4.
    • (2002) Gene Ther , vol.9 , pp. 1730-1734
    • Connolly, J.B.1
  • 27
    • 11144222645 scopus 로고    scopus 로고
    • Adenovirus structure
    • Rux JJ and Burnett RM. Adenovirus structure. Hum Gene Ther. 2004; 15: 1167-76.
    • (2004) Hum Gene Ther , vol.15 , pp. 1167-1176
    • Rux, J.J.1    Burnett, R.M.2
  • 28
    • 4043092812 scopus 로고    scopus 로고
    • Gene transfer to cervical cancer with fiber-modified adenoviruses
    • Rein DT, Breidenbach M, Wu H, et al. Gene transfer to cervical cancer with fiber-modified adenoviruses. Int J Cancer. 2004; 111: 698-704.
    • (2004) Int J Cancer , vol.111 , pp. 698-704
    • Rein, D.T.1    Breidenbach, M.2    Wu, H.3
  • 29
    • 0034955129 scopus 로고    scopus 로고
    • Efficient infection of primitive hematopoietic stem cells by modified adenovirus
    • Yotnda P, Onishi H, Heslop HE, et al. Efficient infection of primitive hematopoietic stem cells by modified adenovirus. Gene Ther. 2001; 8: 930-7.
    • (2001) Gene Ther , vol.8 , pp. 930-937
    • Yotnda, P.1    Onishi, H.2    Heslop, H.E.3
  • 30
    • 1642578443 scopus 로고    scopus 로고
    • Development of an adenoviral vector system with adenovirus serotype 35 tropism; efficient transient gene transfer into primary malignant hematopoietic cells
    • Nilsson M, Ljungberg J, Richter J, et al. Development of an adenoviral vector system with adenovirus serotype 35 tropism; efficient transient gene transfer into primary malignant hematopoietic cells. J Gene Med. 2004; 6: 631-41.
    • (2004) J Gene Med , vol.6 , pp. 631-641
    • Nilsson, M.1    Ljungberg, J.2    Richter, J.3
  • 31
    • 84903593918 scopus 로고    scopus 로고
    • EMMPRIN reduction via scFv-M6-1B9 intrabody affects alpha3beta1-integrin and MCT1 functions and results in suppression of progressive phenotype in the colorectal cancer cell line Caco-2
    • Sangboonruang S, Thammasit P, Intasai N, et al. EMMPRIN reduction via scFv-M6-1B9 intrabody affects alpha3beta1-integrin and MCT1 functions and results in suppression of progressive phenotype in the colorectal cancer cell line Caco-2. Cancer Gene Ther. 2014; 21: 246-55.
    • (2014) Cancer Gene Ther , vol.21 , pp. 246-255
    • Sangboonruang, S.1    Thammasit, P.2    Intasai, N.3
  • 32
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ and Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001; 25: 402-8.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 33
    • 84862994613 scopus 로고    scopus 로고
    • Regulation of carcinoembryonic antigen release from colorectal cancer cells
    • Pakdel A, Naghibalhossaini F, Mokarram P, et al. Regulation of carcinoembryonic antigen release from colorectal cancer cells. Mol Biol Rep. 2012; 39: 3695-704.
    • (2012) Mol Biol Rep , vol.39 , pp. 3695-3704
    • Pakdel, A.1    Naghibalhossaini, F.2    Mokarram, P.3
  • 34
    • 0030478986 scopus 로고    scopus 로고
    • Allen-Mersh. Identification of carcinoembryonic antigen-producing cells circulating in the blood of patients with colorectal carcinoma by reverse transcriptase polymerase chain reaction
    • Jonas S, Windeatt S, A OB, et al. Allen-Mersh. Identification of carcinoembryonic antigen-producing cells circulating in the blood of patients with colorectal carcinoma by reverse transcriptase polymerase chain reaction. Gut. 1996; 39: 717-21.
    • (1996) Gut , vol.39 , pp. 717-721
    • Jonas, S.1    Windeatt, S.A.O.B.2
  • 35
    • 0036605095 scopus 로고    scopus 로고
    • Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts
    • Kanekura T, Chen X, and Kanzaki T. Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts. Int J Cancer. 2002; 99: 520-8.
    • (2002) Int J Cancer , vol.99 , pp. 520-528
    • Kanekura, T.1    Chen, X.2    Kanzaki, T.3
  • 36
    • 84871009308 scopus 로고    scopus 로고
    • CD147 induces UPR to inhibit apoptosis and chemosensitivity by increasing the transcription of Bip in hepatocellular carcinoma
    • Tang J, Guo YS, Zhang Y, et al. CD147 induces UPR to inhibit apoptosis and chemosensitivity by increasing the transcription of Bip in hepatocellular carcinoma. Cell Death Differ. 2012; 19: 1779-90.
    • (2012) Cell Death Differ , vol.19 , pp. 1779-1790
    • Tang, J.1    Guo, Y.S.2    Zhang, Y.3
  • 37
    • 0036588233 scopus 로고    scopus 로고
    • Beta blockade induces apoptosis in cultured capillary endothelial cells
    • Sommers Smith SK and Smith DM. Beta blockade induces apoptosis in cultured capillary endothelial cells. In Vitro Cell Dev Biol Anim. 2002; 38: 298-304.
    • (2002) In Vitro Cell Dev Biol Anim , vol.38 , pp. 298-304
    • Sommers Smith, S.K.1    Smith, D.M.2
  • 38
    • 60849110255 scopus 로고    scopus 로고
    • RNA interference targeting the CD147 induces apoptosis of multi-drug resistant cancer cells related to XIAP depletion
    • Kuang YH, Chen X, Su J, et al. RNA interference targeting the CD147 induces apoptosis of multi-drug resistant cancer cells related to XIAP depletion. Cancer Lett. 2009; 276: 189-95.
    • (2009) Cancer Lett , vol.276 , pp. 189-195
    • Kuang, Y.H.1    Chen, X.2    Su, J.3
  • 39
    • 0034057320 scopus 로고    scopus 로고
    • Apoptosis in cancer
    • Lowe SW and Lin AW. Apoptosis in cancer. Carcinogenesis. 2000; 21: 485-95.
    • (2000) Carcinogenesis , vol.21 , pp. 485-495
    • Lowe, S.W.1    Lin, A.W.2
  • 40
    • 0038684626 scopus 로고    scopus 로고
    • Reversion of transformed phenotype in ovarian cancer cells by intracellular expression of anti folate receptor antibodies
    • Figini M, Ferri R, Mezzanzanica D, et al. Reversion of transformed phenotype in ovarian cancer cells by intracellular expression of anti folate receptor antibodies. Gene Ther. 2003; 10: 1018-25.
    • (2003) Gene Ther , vol.10 , pp. 1018-1025
    • Figini, M.1    Ferri, R.2    Mezzanzanica, D.3
  • 41
    • 79551685528 scopus 로고    scopus 로고
    • Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody
    • Walsh R, Nuttall S, Revill P, et al. Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody. Virology. 2011; 411: 132-41.
    • (2011) Virology , vol.411 , pp. 132-141
    • Walsh, R.1    Nuttall, S.2    Revill, P.3
  • 42
    • 84884801582 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a novel anti-TLR9 intrabody
    • Reimer E, Somplatzki S, Zegenhagen D, et al. Molecular cloning and characterization of a novel anti-TLR9 intrabody. Cell Mol Biol Lett. 2013; 18: 433-46.
    • (2013) Cell Mol Biol Lett , vol.18 , pp. 433-446
    • Reimer, E.1    Somplatzki, S.2    Zegenhagen, D.3
  • 43
    • 84880733066 scopus 로고    scopus 로고
    • Overexpression of CD147 contributes to the chemoresistance of head and neck squamous cell carcinoma cells
    • Huang Z, Wang L, Wang Y, et al. Overexpression of CD147 contributes to the chemoresistance of head and neck squamous cell carcinoma cells. J Oral Pathol Med. 2013; 42: 541-6.
    • (2013) J Oral Pathol Med , vol.42 , pp. 541-546
    • Huang, Z.1    Wang, L.2    Wang, Y.3
  • 44
    • 0026557696 scopus 로고
    • Propidium iodide staining correlates with the extent of DNA degradation in isolated nuclei
    • Crompton T, Peitsch MC, MacDonald HR, et al. Propidium iodide staining correlates with the extent of DNA degradation in isolated nuclei. Biochem Biophys Res Commun. 1992; 183: 532-7.
    • (1992) Biochem Biophys Res Commun , vol.183 , pp. 532-537
    • Crompton, T.1    Peitsch, M.C.2    MacDonald, H.R.3
  • 45
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO. The biochemistry of apoptosis. Nature. 2000; 407: 770-6.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 46
    • 0031057656 scopus 로고    scopus 로고
    • Bcl-2 gene family in the nervous system
    • Merry DE and Korsmeyer SJ. Bcl-2 gene family in the nervous system. Annu Rev Neurosci. 1997; 20: 245-67.
    • (1997) Annu Rev Neurosci , vol.20 , pp. 245-267
    • Merry, D.E.1    Korsmeyer, S.J.2
  • 47
    • 33745957572 scopus 로고    scopus 로고
    • Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities
    • Reed JC. Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities. Cell Death Differ. 2006; 13: 1378-86.
    • (2006) Cell Death Differ , vol.13 , pp. 1378-1386
    • Reed, J.C.1
  • 48
    • 0032404536 scopus 로고    scopus 로고
    • The central executioners of apoptosis: caspases or mitochondria?
    • Green D and Kroemer G. The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol. 1998; 8: 267-71.
    • (1998) Trends Cell Biol , vol.8 , pp. 267-271
    • Green, D.1    Kroemer, G.2
  • 49
    • 0035059972 scopus 로고    scopus 로고
    • Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful?
    • Duffy MJ. Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful? Clin Chem. 2001; 47: 624-30.
    • (2001) Clin Chem , vol.47 , pp. 624-630
    • Duffy, M.J.1
  • 50
    • 84871815222 scopus 로고    scopus 로고
    • Elevated preoperative carcinoembryonic antigen (CEA) and Ki67 is predictor of decreased survival in IIA stage colon cancer
    • Peng Y, Wang L, and Gu J. Elevated preoperative carcinoembryonic antigen (CEA) and Ki67 is predictor of decreased survival in IIA stage colon cancer. World J Surg. 2013; 37: 208-13.
    • (2013) World J Surg , vol.37 , pp. 208-213
    • Peng, Y.1    Wang, L.2    Gu, J.3
  • 51
    • 84864284352 scopus 로고    scopus 로고
    • High extracellular matrix metalloproteinase inducer/CD147 expression is strongly and independently associated with poor prognosis in colorectal cancer
    • Stenzinger A, Wittschieber D, Winterfeld M, et al. High extracellular matrix metalloproteinase inducer/CD147 expression is strongly and independently associated with poor prognosis in colorectal cancer. Hum Pathol. 2012; 43: 1471-81.
    • (2012) Hum Pathol , vol.43 , pp. 1471-1481
    • Stenzinger, A.1    Wittschieber, D.2    Winterfeld, M.3
  • 52
    • 84875216566 scopus 로고    scopus 로고
    • Overexpressions of RACK1 and CD147 associated with poor prognosis in stage T1 pulmonary adenocarcinoma
    • Zhong X, Li M, Nie B, et al. Overexpressions of RACK1 and CD147 associated with poor prognosis in stage T1 pulmonary adenocarcinoma. Ann Surg Oncol. 2013; 20: 1044-52.
    • (2013) Ann Surg Oncol , vol.20 , pp. 1044-1052
    • Zhong, X.1    Li, M.2    Nie, B.3
  • 53
    • 84873330496 scopus 로고    scopus 로고
    • EMMPRIN/CD147 expression is associated with disease-free survival of patients with colorectal cancer
    • Zhu S, Chu D, Zhang Y, et al. EMMPRIN/CD147 expression is associated with disease-free survival of patients with colorectal cancer. Med Oncol. 2013; 30: 369.
    • (2013) Med Oncol , vol.30 , pp. 369
    • Zhu, S.1    Chu, D.2    Zhang, Y.3
  • 54
    • 84864868843 scopus 로고    scopus 로고
    • EMMPRIN is associated with S100A4 and predicts patient outcome in colorectal cancer
    • Boye K, Nesland JM, Sandstad B, et al. EMMPRIN is associated with S100A4 and predicts patient outcome in colorectal cancer. Br J Cancer. 2012; 107: 667-74.
    • (2012) Br J Cancer , vol.107 , pp. 667-674
    • Boye, K.1    Nesland, J.M.2    Sandstad, B.3
  • 55
    • 28044456306 scopus 로고    scopus 로고
    • Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia
    • Deora AA, Philp N, Hu J, et al. Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia. Proc Natl Acad Sci U S A. 2005; 102: 16245-50.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 16245-16250
    • Deora, A.A.1    Philp, N.2    Hu, J.3
  • 56
    • 0034254638 scopus 로고    scopus 로고
    • CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression
    • Kirk P, Wilson MC, Heddle C, et al. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J. 2000; 19: 3896-904.
    • (2000) EMBO J , vol.19 , pp. 3896-3904
    • Kirk, P.1    Wilson, M.C.2    Heddle, C.3
  • 57
    • 0033569442 scopus 로고    scopus 로고
    • The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation
    • Halestrap AP and Price NT. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J. 1999; 343: 281-99.
    • (1999) Biochem J , vol.343 , pp. 281-299
    • Halestrap, A.P.1    Price, N.T.2
  • 58
    • 78249286217 scopus 로고    scopus 로고
    • Cancer metabolism: the Warburg effect today
    • Ferreira LM. Cancer metabolism: the Warburg effect today. Exp Mol Pathol. 2010; 89: 372-80.
    • (2010) Exp Mol Pathol , vol.89 , pp. 372-380
    • Ferreira, L.M.1
  • 59
    • 84875890762 scopus 로고    scopus 로고
    • Targeting cellular metabolism to improve cancer therapeutics
    • Zhao Y, Butler EB, and Tan M Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis. 2013; 4: 1-10.
    • (2013) Cell Death Dis , vol.4 , pp. 1-10
    • Zhao, Y.1    Butler, E.B.2    Tan, M.3
  • 60
    • 0030698096 scopus 로고    scopus 로고
    • Role of intracellular pH in proliferation, transformation, and apoptosis
    • Shrode LD, Tapper H, and Grinstein S. Role of intracellular pH in proliferation, transformation, and apoptosis. J Bioenerg Biomembr. 1997; 29: 393-9.
    • (1997) J Bioenerg Biomembr , vol.29 , pp. 393-399
    • Shrode, L.D.1    Tapper, H.2    Grinstein, S.3
  • 61
    • 0029989610 scopus 로고    scopus 로고
    • Effect of intracellular acidity and ionomycin on apoptosis in HL-60 cells
    • Park HJ, Makepeace CM, Lyons JC, et al. Effect of intracellular acidity and ionomycin on apoptosis in HL-60 cells. Eur J Cancer. 1996; 32: 540-6.
    • (1996) Eur J Cancer , vol.32 , pp. 540-546
    • Park, H.J.1    Makepeace, C.M.2    Lyons, J.C.3
  • 62
    • 0033776271 scopus 로고    scopus 로고
    • Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis
    • Matsuyama S, Llopis J, Deveraux QL, et al. Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol. 2000; 2: 318-25.
    • (2000) Nat Cell Biol , vol.2 , pp. 318-325
    • Matsuyama, S.1    Llopis, J.2    Deveraux, Q.L.3
  • 63
    • 0026702883 scopus 로고
    • Endonuclease activation during apoptosis: the role of cytosolic Ca2+ and pH
    • Barry MA and Eastman A. Endonuclease activation during apoptosis: the role of cytosolic Ca2+ and pH. Biochem Biophys Res Commun. 1992; 186: 782-9.
    • (1992) Biochem Biophys Res Commun , vol.186 , pp. 782-789
    • Barry, M.A.1    Eastman, A.2
  • 64
    • 0032788570 scopus 로고    scopus 로고
    • Acidic environment causes apoptosis by increasing caspase activity
    • Park HJ, Lyons JC, Ohtsubo T, et al. Acidic environment causes apoptosis by increasing caspase activity. Br J Cancer. 1999; 80: 1892-7.
    • (1999) Br J Cancer , vol.80 , pp. 1892-1897
    • Park, H.J.1    Lyons, J.C.2    Ohtsubo, T.3
  • 65
    • 0027418622 scopus 로고
    • Transport of lactate and other monocarboxylates across mammalian plasma membranes
    • Poole RC and Halestrap AP. Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am J Physiol. 1993; 264: 761-82.
    • (1993) Am J Physiol , vol.264 , pp. 761-782
    • Poole, R.C.1    Halestrap, A.P.2
  • 66
    • 84884189755 scopus 로고    scopus 로고
    • Oridonin induces apoptosis in gastric cancer through Apaf-1, cytochrome c and caspase-3 signaling pathway
    • Sun KW, Ma YY, Guan TP, et al. Oridonin induces apoptosis in gastric cancer through Apaf-1, cytochrome c and caspase-3 signaling pathway. World J Gastroenterol. 2012; 18: 7166-74.
    • (2012) World J Gastroenterol , vol.18 , pp. 7166-7174
    • Sun, K.W.1    Ma, Y.Y.2    Guan, T.P.3
  • 67
    • 84861488719 scopus 로고    scopus 로고
    • Luffa echinata Roxb. induces human colon cancer cell (HT-29) death by triggering the mitochondrial apoptosis pathway
    • Shang LH, Li CM, Yang ZY, et al. Luffa echinata Roxb. induces human colon cancer cell (HT-29) death by triggering the mitochondrial apoptosis pathway. Molecules. 2012; 17: 5780-94.
    • (2012) Molecules , vol.17 , pp. 5780-5794
    • Shang, L.H.1    Li, C.M.2    Yang, Z.Y.3
  • 68
    • 5444255183 scopus 로고    scopus 로고
    • Housekeeping genes as internal standards in cancer research
    • Janssens N, Janicot M, Perera T, et al. Housekeeping genes as internal standards in cancer research. Mol Diagn. 2004; 8: 107-13.
    • (2004) Mol Diagn , vol.8 , pp. 107-113
    • Janssens, N.1    Janicot, M.2    Perera, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.