CD147 regulates apoptosis in mouse spermatocytes but not spermatogonia

Human Reproduction

Volumn 27, Issue 6, 2012, Pages 1568-1576

  Chen, Hao ^a,b,c   Fok, Kin Lam ^b   Jiang, Xiaohua ^b,d   Jiang, Jianli ^e   Chen, Zhinan ^e   Gui, Yaoting ^c   Chan, Hsiao Chang ^b,d   Cai, Zhiming ^a,c  

^a THE FIRST AFFILIATED HOSPITAL OF SHENZHEN UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c PEKING UNIVERSITY SHENZHEN HOSPITAL   (China)

^d Chinese University of Hong Kong   (China)

^e FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; CD147; Spermatocyte; Spermatogenesis; Spermatogonia

Indexed keywords

CASPASE 3; CD147 ANTIGEN; DNA NUCLEOTIDYLEXOTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; MALE; MOUSE; NICK END LABELING; NONHUMAN; REGULATORY MECHANISM; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOGONIUM; TESTIS SIZE; TESTIS WEIGHT; WESTERN BLOTTING;

MUS;

EID: 84861567084     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/des050     Document Type: Article

References (44)

1. Abraham D, Zins K, Sioud M, Lucas T, Aharinejad S. Host CD147 blockade by small interfering RNAs suppresses growth of human colon cancer xenografts. Front Biosci 2008;13:5571-5579.
2. Aitken RJ, Findlay JK, Hutt KJ, Kerr JB. Apoptosis in the germ line. Reproduction 2011;141:139-150.
3. Allan DJ, Harmon B, Kerr JFR. Cell death in spermatogenesis. In: Potten CS (ed.). Perspectives on Mammalian Cell Death. London: Oxford University Press, 1987,229-258.
4. Baba M, Inoue M, Itoh K, Nishizawa Y. Blocking CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism. Biochem Biophys Res Commun 2008;374:111-116.
5. Blanco-Rodrǧuez J. A matter of death and life: the significance of germ cell death during spermatogenesis. Int J Androl 1998;21:236-248.
6. Bouvard V, Zaitchouk T, Vacher M, Duthu A, Canivet M, Choisy-Rossi C, Nieruchalski M, May E. Tissue and cell-specific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice. Oncogene 2000;19:649-660.
7. Bozec A, Amara S, Guarmit B, Selva J, Albert M, Rollet J, El Sirkasi M, Vialard F, Bailly M, Benahmed M et al. Status of the executioner step of apoptosis in human with normal spermatogenesis and azoospermia. Fertil Steril 2008;90:1723-1731.
8. Burns TF, Bernhard EJ, El-Deiry WS. Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo. Oncogene 2001;20:4601-4612.
9. Chen X, Lin J, Kanekura T, Su J, Lin W, Xie H, Wu Y, Li J, Chen M, Chang J. A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma. Cancer Res 2006;66:11323-11330.
10. Chen H, Fok KL, Yu S, Jiang J, Chen Z, Gui Y, Cai Z, Chan HC. CD147 is required for matrix metalloproteinases-2 production and germ cell migration during spermatogenesis. Mol Hum Reprod 2011;17:405-414.
11. Cheng CY, Mruk DD. Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development. Physiol Rev 2002; 82:825-874.
12. Coates PJ. p53 and Mdm2: not all cells are equal. J Pathol 2007; 213:357-359.
13. Coureuil M, Fouchet P, Prat M, Letallec B, Barroca V, Dos Santos C, Racine C, Allemand I. Caspase-independent death of meiotic and postmeiotic cells overexpressing p53: calpain involvement. Cell Death Differ 2006;13:1927-1937.
14. Dai JY, Dou KF, Wang CH, Zhao P, Lau WB, Tao L, Wu YM, Tang J, Jiang JL, Chen ZN. The interaction of HAb18G/CD147 with integrin alpha6beta1 and its implications for the invasion potential of human hepatoma cells. BMC Cancer 2009;9:337.
15. de Kretser DM, Loveland KL, Meinhardt A, Simorangkir D, Wreford N. Spermatogenesis. Hum Reprod 1998;13(Suppl. 1):1-8.
16. Fridman JS, Lowe SW. Control of apoptosis by p53. Oncogene 2003; 22:9030-9040.
17. Hao JL, Cozzi PJ, Khatri A, Power CA, Li Y. CD147/EMMPRIN and CD44 are potential therapeutic targets for metastatic prostate cancer. Curr Cancer Drug Targets 2010;10:287-306.
18. Hofmann MC, Hess RA, Goldberg E, Millan JL. Immortalized germ cells undergo meiosis in vitro. Proc Natl Acad Sci USA 1994; 91:5533-5537.
19. Hou Q, Tang X, Liu H, Tang J, Yang Y, Jing X, Xiao Q, Wang W, Gou X, Wang Z. Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147. Cancer Sci 2011;102:1287-1292.
20. Huckins C. The morphology and kinetics of spermatogonial degeneration in normal adult rats: an analysis using a simplified classification of the germinal epithelium. Anat Rec 1978;190:905-926.
21. Jia J, Wang C, Shi Z, Zhao J, Jia Y, Zhao-Hui Z, Li X, Chen Z, Zhu P. Inhibitory effect of CD147/HAb18 monoclonal antibody on cartilage erosion and synovitis in the SCID mouse model for rheumatoid arthritis. Rheumatology (Oxford) 2009;48:721-726.
22. Kanekura T, Chen X. CD147/basigin promotes progression of malignant melanoma and other cancers. J Dermatol Sci 2010;57:149-154.
23. Kawamura K, Kumagai J, Sudo S, Chun SY, Pisarska M, Morita H, Toppari J, Fu P, Wade JD, Bathgate RA et al. Paracrine regulation of mammalian oocyte maturation and male germ cell survival. Proc Natl Acad Sci USA 2004;101:7323-7328.
24. Koji T, Hishikawa Y, Ando H, Nakanishi Y, Kobayashi N. Expression of Fas and Fas ligand in normal and ischemia-reperfusion testes: involvement of the Fas system in the induction of germ cell apoptosis in the damaged mouse testis. Biol Reprod 2001;64:946-954.
25. Kuang YH, Chen X, Su J, Wu LS, Liao LQ, Li D, Chen ZS, Kanekura T. RNA interference targeting the CD147 induces apoptosis of multi-drug resistant cancer cells related to XIAP depletion. Cancer Lett 2009;276:189-195.
26. Moreno RD, Lizama C, Urzua N, Vergara SP, Reyes JG. Caspase activation throughout the first wave of spermatogenesis in the rat. Cell Tissue Res 2006;325:533-540.
27. Mruk DD, Cheng CY. Tight junctions in the testis: new perspectives. Philos Trans R Soc Lond B Biol Sci 2010;365:1621-1635.
28. Ogawa T, Arechaga JM, Avarbock MR, Brinster RL. Transplantation of testis germinal cells into mouse seminiferous tubules. Int J Dev Biol 1997;41:111-122.
29. Russell LD, Ettlin R, Hikim AP, Clegg E. Histological and Histopathological Evaluation of the Testis, 1st edn. Clearwater, FL: Cache River Press, 1990.
30. Said TM, Paasch U, Glander HJ, Agarwal A. Role of caspases in male infertility. Hum Reprod Update 2004;10:39-51.
31. Scherthan H, Weich S, Schwegler H, Heyting C, Harle M, Cremer T. Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing. J Cell Biol 1996;134:1109-1125.
32. Scherthan H, Jerratsch M, Li B, Smith S, Hulten M, Lock T, de Lange T. Mammalian meiotic telomeres: protein composition and redistribution in relation to nuclear pores. Mol Biol Cell 2000;11:4189-4203.
33. Sciurano RB, Rahn MI, Pigozzi MI, Olmedo SB, Solari AJ. An azoospermic man with a double-strand DNA break-processing deficiency in the spermatocyte nuclei: case report. Hum Reprod 2006;21:1194-1203.
34. Shaha C, Tripathi R, Mishra DP. Male germ cell apoptosis: regulation and biology. Philos Trans R Soc Lond B Biol Sci 2010;365:1501-1515.
35. Sofikitis N, Giotitsas N, Tsounapi P, Baltogiannis D, Giannakis D, Pardalidis N. Hormonal regulation of spermatogenesis and spermiogenesis. J Steroid Biochem Mol Biol 2008;109:323-330.
36. Spierings DC, de Vries EG, Vellenga E, de Jong S. The attractive Achilles heel of germ cell tumours: an inherent sensitivity to apoptosis-inducing stimuli. J Pathol 2003;200:137-148.
37. Theas MS, Rival C, Dietrich SJ, Guazzone VA, Lustig L. Death receptor and mitochondrial pathways are involved in germ cell apoptosis in an experimental model of autoimmune orchitis. Hum Reprod 2006; 21:1734-1742.
38. Toyama Y, Maekawa M, Kadomatsu K, Miyauchi T, Muramatsu T, Yuasa S. Histological characterization of defective spermatogenesis in mice lacking the basigin gene. Anat Histol Embryol 1999;28:205-213.
39. Wang B, Xu YF, He BS, Pan YQ, Zhang LR, Zhu C, Qu LL, Wang SK. RNAi-mediated silencing of CD147 inhibits tumor cell proliferation, invasion and increases chemosensitivity to cisplatin in SGC7901 cells in vitro. J Exp Clin Cancer Res 2010; 29:61.
40. Weidle UH, Scheuer W, Eggle D, Klostermann S, Stockinger H. Cancer-related issues of CD147. Cancer Genomics Proteomics 2010; 7:157-169.
41. Wu GS, Burns TF, McDonald ER III, Jiang W, Meng R, Krantz ID, Kao G, Gan DD, Zhou JY, Muschel R et al. KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nat Genet 1997; 17:141-143.
42. Wu J, Ru NY, Zhang Y, Li Y, Wei D, Ren Z, Huang XF, Chen ZN, Bian H. HAb18G/CD147 promotes epithelial-mesenchymal transition through TGF-beta signaling and is transcriptionally regulated by Slug. Oncogene 2011;30:4410-4427.
43. Yin X, Ouyang S, Xu W, Zhang X, Fok KL, Wong HY, Zhang J, Qiu X, Miao S, Chan HC et al. YWK-II protein as a novel G(o)-coupled receptor for Mullerian inhibiting substance in cell survival. J Cell Sci 2007;120:1521-1528.
44. Zhu C, Pan Y, He B, Wang B, Xu Y, Qu L, Bao Q, Tian F, Wang S. Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to cisplatin in laryngeal carcinoma Hep2 cells. Oncol Rep 2011; 25:425-432.