A new disulfide-linked dimer of a single-chain antibody fragment against human CD47 induces apoptosis in lymphoid malignant cells via the hypoxia inducible factor-1α pathway

Cancer Science

Volumn 102, Issue 6, 2011, Pages 1208-1215

  Sagawa, Morihiko ^a,c   Shimizu, Takatsune ^a   Fukushima, Naoshi ^b   Kinoshita, Yasuko ^b   Ohizumi, Iwao ^b   Uno, Shinsuke ^b   Kikuchi, Yasufumi ^b   Ikeda, Yasuo ^a   Yamada Okabe, Hisafumi ^b   Kizaki, Masahiro ^a,c  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^c SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD47 ANTIGEN; DISULFIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN BNIP3; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER SURVIVAL; CELL PROLIFERATION; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DIMERIZATION; DOWNSTREAM PROCESSING; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYMPHOID CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEVERE COMBINED IMMUNODEFICIENCY; UPREGULATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD47; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA-BINDING PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION PROFILING; GENE KNOCKDOWN TECHNIQUES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MICE; MICE, SCID; MICROSCOPY, ELECTRON; MITOCHONDRIAL PROTEINS; PROTEIN MULTIMERIZATION; RNA, MESSENGER; RNA, SMALL INTERFERING; SINGLE-CHAIN ANTIBODIES; TRANSCRIPTION FACTORS;

EID: 79956197243     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2011.01925.x     Document Type: Article

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