The relationship between metabolism and the autophagy machinery during the innate immune response

Cell Metabolism

Volumn 17, Issue 6, 2013, Pages 895-900

  Martinez, Jennifer ^a   Verbist, Katherine ^a   Wang, Ruoning ^a   Green, Douglas R ^a  

^a St Jude Children's Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE; ADENOSINE TRIPHOSPHATE; GAMMA INTERFERON; GLUCOSE TRANSPORTER 1; HEXOKINASE; INITIATION FACTOR 4E BINDING PROTEIN 1; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; NITRIC OXIDE; PHOSPHOGLYCERATE KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TUMOR NECROSIS FACTOR ALPHA;

ATHEROSCLEROSIS; AUTOPHAGY; CANCER CELL; CARCINOGENESIS; CELL FUNCTION; CELL METABOLISM; CELL STRESS; CELLULAR DISTRIBUTION; CYTOPLASM; FATTY ACID OXIDATION; GLYCOLYSIS; HOST RESISTANCE; IMMUNE RESPONSE; INNATE IMMUNITY; MACROPHAGE; MITOCHONDRION; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT;

AUTOPHAGY; ENERGY METABOLISM; HUMANS; IMMUNITY, INNATE; MACROPHAGES; MICROTUBULE-ASSOCIATED PROTEINS; PHAGOCYTOSIS; PHAGOSOMES; SIGNAL TRANSDUCTION;

EID: 84878793136     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2013.05.012     Document Type: Review

References (24)

1. T. Cramer, Y. Yamanishi, B.E. Clausen, I. Förster, R. Pawlinski, N. Mackman, V.H. Haase, R. Jaenisch, M. Corr, and V. Nizet HIF-1alpha is essential for myeloid cell-mediated inflammation Cell 112 2003 645 657
2. P.T. Doulias, M. Tenopoulou, J.L. Greene, K. Raju, and H. Ischiropoulos Nitric oxide regulates mitochondrial fatty acid metabolism through reversible protein S-nitrosylation Sci. Signal. 6 2013 rs1
3. J. Hampe, A. Franke, P. Rosenstiel, A. Till, M. Teuber, K. Huse, M. Albrecht, G. Mayr, F.M. De La Vega, and J. Briggs A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 Nat. Genet. 39 2007 207 211
4. C.Z. Han, and K.S. Ravichandran Metabolic connections during apoptotic cell engulfment Cell 147 2011 1442 1445
5. J. Henault, J. Martinez, J.M. Riggs, J. Tian, P. Mehta, L. Clarke, M. Sasai, E. Latz, M.M. Brinkmann, and A. Iwasaki Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes Immunity 37 2012 986 997
6. J. Huang, V. Canadien, G.Y. Lam, B.E. Steinberg, M.C. Dinauer, M.A. Magalhaes, M. Glogauer, S. Grinstein, and J.H. Brumell Activation of antibacterial autophagy by NADPH oxidases Proc. Natl. Acad. Sci. USA 106 2009 6226 6231
7. J. Kim, M. Kundu, B. Viollet, and K.L. Guan AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 Nat. Cell Biol. 13 2011 132 141
8. J. Kim, Y.C. Kim, C. Fang, R.C. Russell, J.H. Kim, W. Fan, R. Liu, Q. Zhong, and K.L. Guan Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy Cell 152 2013 290 303
9. B. Levine, and V. Deretic Unveiling the roles of autophagy in innate and adaptive immunity Nat. Rev. Immunol. 7 2007 767 777
10. B. Levine, N. Mizushima, and H.W. Virgin Autophagy in immunity and inflammation Nature 469 2011 323 335
11. X. Liao, J.C. Sluimer, Y. Wang, M. Subramanian, K. Brown, J.S. Pattison, J. Robbins, J. Martinez, and I. Tabas Macrophage autophagy plays a protective role in advanced atherosclerosis Cell Metab. 15 2012 545 553
12. X.M. Ma, and J. Blenis Molecular mechanisms of mTOR-mediated translational control Nat. Rev. Mol. Cell Biol. 10 2009 307 318
13. G. Majai, Z. Sarang, K. Csomós, G. Zahuczky, and L. Fésüs PPARgamma-dependent regulation of human macrophages in phagocytosis of apoptotic cells Eur. J. Immunol. 37 2007 1343 1354
14. J. Martinez, J. Almendinger, A. Oberst, R. Ness, C.P. Dillon, P. Fitzgerald, M.O. Hengartner, and D.R. Green Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells Proc. Natl. Acad. Sci. USA 108 2011 17396 17401
15. L. Mukundan, J.I. Odegaard, C.R. Morel, J.E. Heredia, J.W. Mwangi, R.R. Ricardo-Gonzalez, Y.P. Goh, A.R. Eagle, S.E. Dunn, and J.U. Awakuni PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance Nat. Med. 15 2009 1266 1272
16. V. Nizet, and R.S. Johnson Interdependence of hypoxic and innate immune responses Nat. Rev. Immunol. 9 2009 609 617
17. L.A. O'Neill, and D.G. Hardie Metabolism of inflammation limited by AMPK and pseudo-starvation Nature 493 2013 346 355
18. J.E. Qualls, C. Subramanian, W. Rafi, A.M. Smith, L. Balouzian, A.A. DeFreitas, K.A. Shirey, B. Reutterer, E. Kernbauer, and S. Stockinger Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1 Cell Host Microbe 12 2012 313 323
19. J.C. Rodríguez-Prados, P.G. Través, J. Cuenca, D. Rico, J. Aragonés, P. Martín-Sanz, M. Cascante, and L. Boscá Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation J. Immunol. 185 2010 605 614
20. T. Saitoh, N. Fujita, M.H. Jang, S. Uematsu, B.G. Yang, T. Satoh, H. Omori, T. Noda, N. Yamamoto, and M. Komatsu Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production Nature 456 2008 264 268
21. M.A. Sanjuan, C.P. Dillon, S.W. Tait, S. Moshiach, F. Dorsey, S. Connell, M. Komatsu, K. Tanaka, J.L. Cleveland, S. Withoff, and D.R. Green Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis Nature 450 2007 1253 1257
22. M.A. Sanjuan, S. Milasta, and D.R. Green Toll-like receptor signaling in the lysosomal pathways Immunol. Rev. 227 2009 203 220
23. N.P. Shanware, K. Bray, and R.T. Abraham The PI3K, metabolic, and autophagy networks: interactive partners in cellular health and disease Annu. Rev. Pharmacol. Toxicol. 53 2013 89 106
24. Y. Yan, G.X. Zhang, B. Gran, F. Fallarino, S. Yu, H. Li, M.L. Cullimore, A. Rostami, and H. Xu IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis J. Immunol. 185 2010 5953 5961