Negative versus positive allosteric modulation of metabotropic glutamate receptors (mGluR5): Indices for potential pro-cognitive drug properties based on EEG network oscillations and sleep-wake organization in rats

Psychopharmacology

Volumn 232, Issue 6, 2015, Pages 1107-1122

  Ahnaou, A ^a   Langlois, X ^a   Steckler, T ^a   Bartolome Nebreda, J M ^b   Drinkenburg, W H I M ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b Janssen Cilag SA   (Spain)

Author keywords

Autoradiography; Cognition; Coherence and functional connectivity; mGluR5 allosteric modulator; Network oscillations; Sleep

Indexed keywords

(4 FLUORO PHENYL) [3 [3 (4 FLUORO PHENYL) [1,2,4] OXADIAZOL 5 YL]PIPERIDIN 1 YL]METHANONE; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3 TERT BUTYL 7 [3 (4 FLUORO PHENYL) 1,2,4 OXADIAZOL 5 YL] 5,6,7,8 TETRAHYDRO [1,2,4] TRIAZOLO [4,3 A]PYRIDINE; 3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR AGONIST; UNCLASSIFIED DRUG; 3-((2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL)PYRIDINE; 6-METHYL-2-(PHENYLETHYNYL)PYRIDINE; AMINO ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; PYRIDINE DERIVATIVE; THIAZOLE DERIVATIVE;

ADULT; ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN CORTEX; CONNECTOME; CONTROLLED STUDY; CORPUS STRIATUM; DRUG MECHANISM; DRUG POTENCY; ELECTROENCEPHALOGRAM; GAMMA RHYTHM; HIPPOCAMPUS; LIGHT DARK CYCLE; MALE; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REM SLEEP; SIGNAL TRANSDUCTION; SLEEP QUALITY; SLEEP TIME; SLEEP WAKING CYCLE; THETA RHYTHM; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; CIRCADIAN RHYTHM; COGNITION; DRUG EFFECTS; ELECTROENCEPHALOGRAPHY; METABOLISM; NERVE CELL NETWORK; PHYSIOLOGY; SLEEP; SPRAGUE DAWLEY RAT;

ALLOSTERIC REGULATION; ANIMALS; BRAIN; CIRCADIAN RHYTHM; COGNITION; ELECTROENCEPHALOGRAPHY; EXCITATORY AMINO ACID ANTAGONISTS; MALE; NERVE NET; NEUROPROTECTIVE AGENTS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, METABOTROPIC GLUTAMATE 5; SLEEP; THIAZOLES;

EID: 84923613304     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-014-3746-4     Document Type: Article

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