11β-hydroxysteroid dehydrogenase type 1 deficiency prevents memory deficits with aging by switching from glucocorticoid receptor to mineralocorticoid receptor-mediated cognitive control

Journal of Neuroscience

Volumn 31, Issue 11, 2011, Pages 4188-4193

  Yau, Joyce L W ^a,b   Noble, June ^b   Seckl, Jonathan R ^a,b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; CORTICOSTERONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; MIFEPRISTONE; MINERALOCORTICOID RECEPTOR; SPIRONOLACTONE; ALDOSTERONE ANTAGONIST;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LEVEL; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DRUG EFFECT; EXECUTIVE FUNCTION; GENOTYPE; HIPPOCAMPUS; MALE; MAZE TEST; MEMORY DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPATIAL MEMORY; ANALYSIS OF VARIANCE; ANIMAL; BLOOD; COGNITION; GENETICS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MEMORY; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; RADIOIMMUNOASSAY;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; AGING; ALDOSTERONE ANTAGONISTS; ANALYSIS OF VARIANCE; ANIMALS; COGNITION; CORTICOSTERONE; HIPPOCAMPUS; INFUSIONS, INTRAVENTRICULAR; MALE; MAZE LEARNING; MEMORY; MICE; MICE, KNOCKOUT; RADIOIMMUNOASSAY; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID; SPIRONOLACTONE;

EID: 79952754682     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.6145-10.2011     Document Type: Article

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