Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus

Psychoneuroendocrinology

Volumn 40, Issue 1, 2014, Pages 191-200

  Frank, Matthew G ^a   Hershman, Sarah A ^a   Weber, Michael D ^a   Watkins, Linda R ^a   Maier, Steven F ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Glucocorticoids; Inflammasome; Microglia; Neuroinflammation; Priming; Stress

Indexed keywords

CORTICOSTERONE; CRYOPYRIN; GLUCOCORTICOID; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE; GENE EXPRESSION; HIPPOCAMPUS; HORMONE ACTION; IBA 1 GENE; MALE; MHCII GENE; MICROGLIA; NERVE CELL STIMULATION; NERVOUS SYSTEM INFLAMMATION; NF KAPPABIALPHA GENE; NLRP3 GENE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIZATION; SHAM PROCEDURE;

GLUCOCORTICOIDS; INFLAMMASOME; MICROGLIA; NEUROINFLAMMATION; PRIMING; STRESS;

ANIMALS; CYTOKINES; DRUG SYNERGISM; GLUCOCORTICOIDS; HIPPOCAMPUS; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MALE; MICROGLIA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRESS, PSYCHOLOGICAL; TIME FACTORS; UP-REGULATION;

EID: 84893391788     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2013.11.006     Document Type: Article

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