A high-throughput phenotypic screen of cytotoxic T lymphocyte lytic granule exocytosis reveals candidate immunosuppressants

Journal of Biomolecular Screening

Volumn 20, Issue 3, 2015, Pages 359-371

  Zhao, Ziyan ^a   Haynes, Mark K ^b   Ursu, Oleg ^b   Edwards, Bruce S ^b   Sklar, Larry A ^b   Zweifach, Adam ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

chemical biology; high throughput screening (HTS); immunosuppressor; lymphocyte; signal transduction

Indexed keywords

CALCINEURIN; IMMUNOSUPPRESSIVE AGENT; LYSOSOMAL MEMBRANE PROTEIN 1; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; UNCLASSIFIED DRUG; CALCIUM; MOLECULAR LIBRARY; PROTEIN KINASE C;

ANTIGEN BINDING; ARTICLE; CALCIUM CELL LEVEL; CATALYSIS; CELL MEMBRANE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG MECHANISM; ENZYME PHOSPHORYLATION; EXOCYTOSIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LYMPHOCYTE FUNCTION; PRIORITY JOURNAL; DRUG EFFECTS; ENZYME ACTIVATION; IMMUNOLOGY; METABOLISM; MOLECULAR LIBRARY; PHOSPHORYLATION; PRECLINICAL STUDY; REPRODUCIBILITY; SIGNAL TRANSDUCTION;

CALCINEURIN; CALCIUM; CATALYSIS; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; EXOCYTOSIS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; PHOSPHORYLATION; PROTEIN KINASE C; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84923371816     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057114557620     Document Type: Article

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