-
1
-
-
0001341562
-
High-content screening: A new approach to easing key bottlenecks in the drug discovery process
-
Giuliano KA, DeBiasio RL, Dunlay RT, Gough A, Volosky JM, Zock J, Pavlakis G, Taylor DL. High-content screening: A new approach to easing key bottlenecks in the drug discovery process. J Biomol Screen 1997; 2: 249-259.
-
(1997)
J Biomol Screen
, vol.2
, pp. 249-259
-
-
Giuliano, K.A.1
DeBiasio, R.L.2
Dunlay, R.T.3
Gough, A.4
Volosky, J.M.5
Zock, J.6
Pavlakis, G.7
Taylor, D.L.8
-
4
-
-
74249084687
-
Discovery of selective probes and antagonists for G-protein-coupled receptors FPR/FPRL1 and GPR30
-
Arterburn JB, Oprea TI, Prossnitz ER, Edwards BS, Sklar LA. Discovery of selective probes and antagonists for G-protein-coupled receptors FPR/FPRL1 and GPR30. Curr Top Med Chem 2009; 9: 1227-1236.
-
(2009)
Curr Top Med Chem
, vol.9
, pp. 1227-1236
-
-
Arterburn, J.B.1
Oprea, T.I.2
Prossnitz, E.R.3
Edwards, B.S.4
Sklar, L.A.5
-
5
-
-
84860013857
-
HTS flow cytometry, small molecule discovery, and the NIH Molecular Libraries Initative
-
Litvin V,Marder P, editors., Hoboken, NJ: John Wiley & Sons
-
Sklar LA, Edwards BS. HTS flow cytometry, small molecule discovery, and the NIH Molecular Libraries Initative. In: Litvin V, Marder P, editors. Flow Cytometry in Drug Discovery and Development, Hoboken, NJ: John Wiley & Sons; 2010. pp 71-98.
-
(2010)
Flow Cytometry in Drug Discovery and Development
, pp. 71-98
-
-
Sklar, L.A.1
Edwards, B.S.2
-
6
-
-
0036654991
-
Performance of in-line microfluidic mixers in laminar flow for high-throughput flow cytometry
-
Jackson WC, Bennett TA, Edwards BS, Prossnitz E, Lopez GP, Sklar LA. Performance of in-line microfluidic mixers in laminar flow for high-throughput flow cytometry. Biotechniques 2002; 33: 220-226.
-
(2002)
Biotechniques
, vol.33
, pp. 220-226
-
-
Jackson, W.C.1
Bennett, T.A.2
Edwards, B.S.3
Prossnitz, E.4
Lopez, G.P.5
Sklar, L.A.6
-
7
-
-
0036491599
-
Mixing small volumes for continuous high-throughput flow cytometry: Performance of a mixing Y and peristaltic sample delivery
-
Jackson WC, Kuckuck F, Edwards BS, Mammoli A, Gallegos CM, Lopez GP, Buranda T, Sklar LA. Mixing small volumes for continuous high-throughput flow cytometry: Performance of a mixing Y and peristaltic sample delivery. Cytometry 2002; 47: 183-191.
-
(2002)
Cytometry
, vol.47
, pp. 183-191
-
-
Jackson, W.C.1
Kuckuck, F.2
Edwards, B.S.3
Mammoli, A.4
Gallegos, C.M.5
Lopez, G.P.6
Buranda, T.7
Sklar, L.A.8
-
8
-
-
33646366423
-
Virtual and biomolecular screening converge on a selective agonist for GPR30
-
Bologa CG, Revankar CM, Young SM, Edwards BS, Arterburn JB, Kiselyov AS, Parker MA, Tkachenko SE, Savchuck NP, Sklar LA, Oprea TI, and Prossnitz ER. Virtual and biomolecular screening converge on a selective agonist for GPR30. Nat Chem Biol 2006;2:207-212.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 207-212
-
-
Bologa, C.G.1
Revankar, C.M.2
Young, S.M.3
Edwards, B.S.4
Arterburn, J.B.5
Kiselyov, A.S.6
Parker, M.A.7
Tkachenko, S.E.8
Savchuck, N.P.9
Sklar, L.A.10
Oprea, T.I.11
Prossnitz, E.R.12
-
9
-
-
3042820388
-
An investigation of liquid carryover and sample residual for a high-throughput flow cytometer sample delivery system
-
Bartsch JW, Tran HD, Waller A, Mammoli AA, Buranda T, Sklar LA, Edwards BS. An investigation of liquid carryover and sample residual for a high-throughput flow cytometer sample delivery system. Anal Chem 2004; 76: 3810-3817.
-
(2004)
Anal Chem
, vol.76
, pp. 3810-3817
-
-
Bartsch, J.W.1
Tran, H.D.2
Waller, A.3
Mammoli, A.A.4
Buranda, T.5
Sklar, L.A.6
Edwards, B.S.7
-
10
-
-
3042824068
-
High-throughput microfluidic mixing and multiparametric cell sorting for bioactive compound screening
-
Young SM, Curry MS, Ransom JT, Ballesteros JA, Prossnitz ER, Sklar LA, Edwards BS. High-throughput microfluidic mixing and multiparametric cell sorting for bioactive compound screening. J Biomol Screen 2004; 9: 103-111.
-
(2004)
J Biomol Screen
, vol.9
, pp. 103-111
-
-
Young, S.M.1
Curry, M.S.2
Ransom, J.T.3
Ballesteros, J.A.4
Prossnitz, E.R.5
Sklar, L.A.6
Edwards, B.S.7
-
11
-
-
67651027288
-
Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high throughput flow cytometry system
-
Haynes MK, Strouse JJ, Waller A, Leitao A, Curpan RF, Bologa C, Oprea TI, Prossnitz ER, Edwards BS, Sklar LA, Thompson TA. Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high throughput flow cytometry system. J Biomol Screen 2009;14:596-609.
-
(2009)
J Biomol Screen
, vol.14
, pp. 596-609
-
-
Haynes, M.K.1
Strouse, J.J.2
Waller, A.3
Leitao, A.4
Curpan, R.F.5
Bologa, C.6
Oprea, T.I.7
Prossnitz, E.R.8
Edwards, B.S.9
Sklar, L.A.10
Thompson, T.A.11
-
12
-
-
20444374044
-
High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands
-
Young SM, Bologa C, Prossnitz ER, Oprea TI, Sklar LA, Edwards BS. High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands. J Biomol Screen 2005; 10: 374-382.
-
(2005)
J Biomol Screen
, vol.10
, pp. 374-382
-
-
Young, S.M.1
Bologa, C.2
Prossnitz, E.R.3
Oprea, T.I.4
Sklar, L.A.5
Edwards, B.S.6
-
13
-
-
34250678990
-
Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform
-
Edwards BS, Young SM, Oprea TI, Bologa CG, Prossnitz ER, Sklar LA. Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform. Nat Protoc 2006; 1: 59-66.
-
(2006)
Nat Protoc
, vol.1
, pp. 59-66
-
-
Edwards, B.S.1
Young, S.M.2
Oprea, T.I.3
Bologa, C.G.4
Prossnitz, E.R.5
Sklar, L.A.6
-
14
-
-
33745792627
-
Microsphere-based protease assays and screening application for lethal factor and factor Xa
-
Saunders MJ, Kim H, Woods TA, Nolan JP, Sklar LA, Edwards BS, Graves SW. Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry Part A 2006; 69A: 342-352.
-
(2006)
Cytometry Part A
, vol.69 A
, pp. 342-352
-
-
Saunders, M.J.1
Kim, H.2
Woods, T.A.3
Nolan, J.P.4
Sklar, L.A.5
Edwards, B.S.6
Graves, S.W.7
-
16
-
-
34447129552
-
Duplexed, bead-based competitive assay for inhibitors of protein kinases
-
Simons PC, Young SM, Gibaja V, Lee WC, Josiah S, Edwards BS, Sklar LA. Duplexed, bead-based competitive assay for inhibitors of protein kinases. Cytometry Part A 2007; 71A: 451-459.
-
(2007)
Cytometry Part A
, vol.71 A
, pp. 451-459
-
-
Simons, P.C.1
Young, S.M.2
Gibaja, V.3
Lee, W.C.4
Josiah, S.5
Edwards, B.S.6
Sklar, L.A.7
-
17
-
-
42949089745
-
A multifunctional androgen receptor screening assay using the high-throughput Hypercyt flow cytometry system
-
Dennis MK, Bowles HJ, MacKenzie DA, Burchiel SW, Edwards BS, Sklar LA, Prossnitz ER, Thompson TA. A multifunctional androgen receptor screening assay using the high-throughput Hypercyt flow cytometry system. Cytometry Part A 2008; 73A: 390-399.
-
(2008)
Cytometry Part A
, vol.73 A
, pp. 390-399
-
-
Dennis, M.K.1
Bowles, H.J.2
MacKenzie, D.A.3
Burchiel, S.W.4
Edwards, B.S.5
Sklar, L.A.6
Prossnitz, E.R.7
Thompson, T.A.8
-
18
-
-
43449096618
-
High-throughput flow cytometry to detect selective inhibitors of ABCB1, ABCC1, and ABCG2 transporters
-
Ivnitski-Steele I, Larson RS, Lovato DM, Khawaja HM, Winter SS, Oprea TI, Sklar LA, Edwards BS. High-throughput flow cytometry to detect selective inhibitors of ABCB1, ABCC1, and ABCG2 transporters. Assay Drug Dev Technol 2008; 6: 263-276.
-
(2008)
Assay Drug Dev Technol
, vol.6
, pp. 263-276
-
-
Ivnitski-Steele, I.1
Larson, R.S.2
Lovato, D.M.3
Khawaja, H.M.4
Winter, S.S.5
Oprea, T.I.6
Sklar, L.A.7
Edwards, B.S.8
-
19
-
-
40049099575
-
High-throughput screening for daunorubicin-mediated drug resistance identifies mometasone furoate as a novel ABCB1-reversal agent
-
Winter SS, Lovato DM, Khawaja HM, Edwards BS, Steele ID, Young SM, Oprea TI, Sklar LA, Larson RS. High-throughput screening for daunorubicin-mediated drug resistance identifies mometasone furoate as a novel ABCB1-reversal agent. J Biomol Screen 2008; 13: 185-193.
-
(2008)
J Biomol Screen
, vol.13
, pp. 185-193
-
-
Winter, S.S.1
Lovato, D.M.2
Khawaja, H.M.3
Edwards, B.S.4
Steele, I.D.5
Young, S.M.6
Oprea, T.I.7
Sklar, L.A.8
Larson, R.S.9
-
20
-
-
77949351405
-
Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay
-
Surviladze Z, Waller A, Wu Y, Romero E, Edwards BS, Wandinger-Ness A, Sklar LA. Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay. J Biomol Screen 2010;15:10-20.
-
(2010)
J Biomol Screen
, vol.15
, pp. 10-20
-
-
Surviladze, Z.1
Waller, A.2
Wu, Y.3
Romero, E.4
Edwards, B.S.5
Wandinger-Ness, A.6
Sklar, L.A.7
-
21
-
-
0031008155
-
Desensitization of N-formylpeptide receptor-mediated activation is dependent upon receptor phosphorylation
-
Prossnitz ER. Desensitization of N-formylpeptide receptor-mediated activation is dependent upon receptor phosphorylation. J Biol Chem 1997; 272: 15213-15219.
-
(1997)
J Biol Chem
, vol.272
, pp. 15213-15219
-
-
Prossnitz, E.R.1
-
22
-
-
65349145196
-
A novel fluorescent cross-reactive formylpeptide receptor/formylpeptide receptor-like 1 hexapeptide ligand
-
Strouse JJ, Young SM, Mitchell HD, Ye RD, Prossnitz ER, Sklar LA, Edwards BS. A novel fluorescent cross-reactive formylpeptide receptor/formylpeptide receptor-like 1 hexapeptide ligand. Cytometry Part A 2009; 75A: 264-270.
-
(2009)
Cytometry Part A
, vol.75 A
, pp. 264-270
-
-
Strouse, J.J.1
Young, S.M.2
Mitchell, H.D.3
Ye, R.D.4
Prossnitz, E.R.5
Sklar, L.A.6
Edwards, B.S.7
-
23
-
-
34250678990
-
Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform
-
Edwards BS, Young SM, Oprea TI, Bologa C, Prossnitz E, Sklar LA. Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform. Nat Protoc 2006; 1: 59-66.
-
(2006)
Nat Protoc
, vol.1
, pp. 59-66
-
-
Edwards, B.S.1
Young, S.M.2
Oprea, T.I.3
Bologa, C.4
Prossnitz, E.5
Sklar, L.A.6
-
24
-
-
65349097903
-
Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes
-
Young SM, Bologa CM, Fara D, Bryant BK, Strouse JJ, Arterburn JB, Ye RD, Oprea TI, Prossnitz ER, Sklar LA, et al. Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes. Cytometry Part A 2009; 75A: 253-263.
-
(2009)
Cytometry Part A
, vol.75 A
, pp. 253-263
-
-
Young, S.M.1
Bologa, C.M.2
Fara, D.3
Bryant, B.K.4
Strouse, J.J.5
Arterburn, J.B.6
Ye, R.D.7
Oprea, T.I.8
Prossnitz, E.R.9
Sklar, L.A.10
-
25
-
-
79953214396
-
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening
-
Chapter 13:Unit 13.12.1-13.12.17.
-
Saunders MJ, Edwards BS, Zhu J, Sklar LA, Graves SW. Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. Curr Protoc Cytometry 2010; Chapter 13:Unit 13.12.1-13.12.17.
-
(2010)
Curr Protoc Cytometry
-
-
Saunders, M.J.1
Edwards, B.S.2
Zhu, J.3
Sklar, L.A.4
Graves, S.W.5
-
26
-
-
77649152201
-
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors
-
Saunders MJ, Graves SW, Sklar LA, Oprea TI, Edwards BS. High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. Assay Drug Dev Technol 2010; 8: 37-46.
-
(2010)
Assay Drug Dev Technol
, vol.8
, pp. 37-46
-
-
Saunders, M.J.1
Graves, S.W.2
Sklar, L.A.3
Oprea, T.I.4
Edwards, B.S.5
-
27
-
-
0033003760
-
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
-
Zhang JH, Chung TD, Oldenburg KR. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J Biomol Screen 1999; 4: 67-73.
-
(1999)
J Biomol Screen
, vol.4
, pp. 67-73
-
-
Zhang, J.H.1
Chung, T.D.2
Oldenburg, K.R.3
-
28
-
-
27544444375
-
Integration of virtual screening with high throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists
-
Edwards BS, Bologa C, Young SM, Balakin KV, Prossnitz E, Savchuck NP, Sklar LA, Oprea TI. Integration of virtual screening with high throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists. Mol Pharmacol 2005; 68: 1301-1310.
-
(2005)
Mol Pharmacol
, vol.68
, pp. 1301-1310
-
-
Edwards, B.S.1
Bologa, C.2
Young, S.M.3
Balakin, K.V.4
Prossnitz, E.5
Savchuck, N.P.6
Sklar, L.A.7
Oprea, T.I.8
-
29
-
-
66849143114
-
High-content screening: Flow cytometry analysis
-
Edwards BS, Young SM, Ivnitsky-Steele I, Ye RD, Prossnitz ER, Sklar LA. High-content screening: Flow cytometry analysis. Methods Mol Biol 2009; 486: 151-165.
-
(2009)
Methods Mol Biol
, vol.486
, pp. 151-165
-
-
Edwards, B.S.1
Young, S.M.2
Ivnitsky-Steele, I.3
Ye, R.D.4
Prossnitz, E.R.5
Sklar, L.A.6
-
30
-
-
0346124149
-
High-throughput flow cytometry: Validation in microvolume bioassays
-
Ramirez S, Aiken CT, Andrzejewski B, Sklar LA, Edwards BS. High-throughput flow cytometry: Validation in microvolume bioassays. Cytometry A 2003; 53A: 55-65.
-
(2003)
Cytometry A
, vol.53 A
, pp. 55-65
-
-
Ramirez, S.1
Aiken, C.T.2
Andrzejewski, B.3
Sklar, L.A.4
Edwards, B.S.5
-
31
-
-
0032499733
-
Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice
-
Rockman HA, Chien KR, Choi DJ, Iaccarino G, Hunter JJ, Ross J, Jr., Lefkowitz RJ, Koch WJ. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proc Natl Acad Sci USA 1998; 95: 7000-7005.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7000-7005
-
-
Rockman, H.A.1
Chien, K.R.2
Choi, D.J.3
Iaccarino, G.4
Hunter, J.J.5
Ross Jr., J.6
Lefkowitz, R.J.7
Koch, W.J.8
-
32
-
-
0036137357
-
Suspension array technology: Evolution of the flat-array paradigm
-
Nolan JP, Sklar LA. Suspension array technology: Evolution of the flat-array paradigm. Trends Biotechnol 2002; 20: 9-12.
-
(2002)
Trends Biotechnol
, vol.20
, pp. 9-12
-
-
Nolan, J.P.1
Sklar, L.A.2
-
33
-
-
33646029128
-
Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling
-
Krutzik PO, Nolan GP. Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling. Nat Methods 2006; 3: 361-368.
-
(2006)
Nat Methods
, vol.3
, pp. 361-368
-
-
Krutzik, P.O.1
Nolan, G.P.2
-
34
-
-
84862786284
-
Identification of a small molecular inhibitor of yeast TORC1 using a flow cytometry based multiplex screen
-
Feb 1 [Epub ahead of print].
-
Chen J, Young SM, Allen CP, Seeber A, Péli-Gulli M-P, Panchaud N, Waller A, Ursu O, Yao T, Golden JE, et al. Identification of a small molecular inhibitor of yeast TORC1 using a flow cytometry based multiplex screen. ACS Chem Biol 2012; Feb 1 [Epub ahead of print].
-
(2012)
ACS Chem Biol
-
-
Chen, J.1
Young, S.M.2
Allen, C.P.3
Seeber, A.4
Péli-Gulli, M.-P.5
Panchaud, N.6
Waller, A.7
Ursu, O.8
Yao, T.9
Golden, J.E.10
-
35
-
-
80053351708
-
High-throughput screen for the chemical inhibitors of antiapoptotic Bcl-2 family proteins by multiplex flow cytometry
-
Curpan RF, Simons PC, Zhai D, Young SM, Carter MB, Bologa CG, Oprea TI, Satterthwait AC, Reed JC, Edwards BS, et al. High-throughput screen for the chemical inhibitors of antiapoptotic Bcl-2 family proteins by multiplex flow cytometry. Assay Drug Dev Technol 2011;9:465-474.
-
(2011)
Assay Drug Dev Technol
, vol.9
, pp. 465-474
-
-
Curpan, R.F.1
Simons, P.C.2
Zhai, D.3
Young, S.M.4
Carter, M.B.5
Bologa, C.G.6
Oprea, T.I.7
Satterthwait, A.C.8
Reed, J.C.9
Edwards, B.S.10
-
36
-
-
79959900394
-
Simultaneous in vitro molecular screening of protein-peptide interactions by flow cytometry, using six Bcl-2 family proteins as examples
-
Simons PC, Young SM, Carter MB, Waller A, Zhai D, Reed JC, Edwards BS, Sklar LA. Simultaneous in vitro molecular screening of protein-peptide interactions by flow cytometry, using six Bcl-2 family proteins as examples. Nat Protoc 2011; 6: 943-952.
-
(2011)
Nat Protoc
, vol.6
, pp. 943-952
-
-
Simons, P.C.1
Young, S.M.2
Carter, M.B.3
Waller, A.4
Zhai, D.5
Reed, J.C.6
Edwards, B.S.7
Sklar, L.A.8
|