Antioxidant activities of saponins extracted from Radix Trichosanthis: An in vivo and in vitro evaluation

BMC Complementary and Alternative Medicine

Volumn 14, Issue , 2014, Pages

  Chen, Ying ^a   Miao, Yonghong ^b   Huang, Liyong ^c   Li, Juxiang ^c   Sun, Haiyan ^a   Zhao, Yuanzeng ^a   Yang, Jing ^a   Zhou, Wenke ^c  

^a HENAN INSTITUTE OF SCIENCE AND TECHNOLOGY   (China)

^b HENAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^c The Third Hospital of Xinxiang Medical University   (China)

Author keywords

Antioxidant; Liver; Radical scavenger; Radix trichosanthis; Saponins

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ACETIC ACID ETHYL ESTER; BUTANOL; CARBON TETRACHLORIDE; FREE RADICAL; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; MALONALDEHYDE; PLANT EXTRACT; SAPONIN; SUPEROXIDE DISMUTASE; ANTIOXIDANT; HERBACEOUS AGENT; RADIX TRICHOSANTHIS;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG CYTOTOXICITY; ENZYME BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; OXIDATIVE STRESS; TRICHOSANTHES ROOT; ANIMAL; CHEMISTRY; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; METABOLISM;

ANIMALS; ANTIOXIDANTS; CARBON TETRACHLORIDE; DRUG-INDUCED LIVER INJURY; DRUGS, CHINESE HERBAL; L-LACTATE DEHYDROGENASE; MALE; MICE; OXIDATIVE STRESS; PLANT EXTRACTS; SAPONINS;

EID: 84897954210     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-14-86     Document Type: Article

References (29)

1. Hensley K, Robinson KA, Gabbita SP, Salsman S, Floyd RA. Reactive oxygen species, cell signaling, and cell injury. Free Radic Biol Med 2000, 28(10):1456-1462. 10.1016/S0891-5849(00)00252-5, 10927169.
2. Gupta SC, Hevia D, Patchva S, Park B, Koh W, Aggarwal BB. Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy. Antioxid Redox Signal 2012, 16(11):1295-1322. 10.1089/ars.2011.4414, 3324815, 22117137.
3. Manea A, Fortuno A, Martin-Ventura JL. Oxidative stress in cardiovascular pathologies: genetics, cellular, and molecular mechanisms and future antioxidant therapies. Oxid Med Cell Longev 2012, 2012:373450. 3549365, 23346282.
4. Turrens JF. Mitochondrial formation of reactive oxygen species. J Physiol 2003, 552(2):335-344. 10.1113/jphysiol.2003.049478, 2343396, 14561818.
5. Lin HM, Tseng HC, Wang CJ, Lin JJ, Lo CW, Chou FP. Hepatoprotective effects of Solanum nigrum Linn extract against CCl4-induced oxidative damage in rats. Chem Biol Interact 2008, 171(3):283-293. 10.1016/j.cbi.2007.08.008, 18045581.
6. Hung MY, Fu TY, Shih PH, Lee CP, Yen GC. Du-Zhong (Eucommia ulmoides Oliv.) leaves inhibits CCl4-induced hepatic damage in rats. Food Chem Toxicol 2006, 44:1424-1431. 10.1016/j.fct.2006.03.009, 16707202.
7. Shen X, Tang Y, Yang R, Yu L, Fang T, Duan JA. The protective effect of Zizyphus jujube fruit on carbon tetrachloride- induced hepatic injury in mice by antioxidative activities. J Ethnopharmacol 2009, 122(3):555-560. 10.1016/j.jep.2009.01.027, 19429327.
8. Li ZH, Lu Y, Liu JX. The chemical composition and pharmacological activity of radix trichosanthis. World Phytomed 2003, 18(1):1-4.
9. Song HM, Huang LM, Wang YL, Han Y, You CC, Peng PP, Cao WH. The effect of trichosanthin on the expression and enzyme activity of DNMT1 gene in Caski cervical cancer cell line. Chin Pharm Bull 2010, 26(10):1312-1315.
10. Chen J, Xu ZF, OuYang HT, Peng MY, Wu T, Liu J, Liu YP, Yan W. Effect of extracts from Radix Trichosanthis on the expression of HBsAg and HBeAg in HepG2.2.14 cells. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2012, 37(1):38-41.
11. Sun S, Wang Y, Zhou Y. Research progress on immunosuppressive activity of monomers extracted from Chinese medicine. Zhongguo Zhong Yao Za Zhi 2010, 35(3):393-396.
12. Li CT, Lin CH, Kao TY, Wu MF, Yeh CS, Yeh KT, Ko JL. The mechanisms of action of Tianhua(TM) on antitumor activity in lung cancer cells. Pharm Biol 2010, 48(11):1302-1309. 10.3109/13880201003789432, 20738166.
13. Lee EO, Lee JR, Kim KH, Baek NI, Lee SJ, Lee BH, Cho KD, Ahn KS, Kim SH. The methylene chloride fraction of trichosanthis fructus induces apoptosis in U937 cells through the mitochondrial pathway. Biol Pharm Bull 2006, 29(1):21-25. 10.1248/bpb.29.21, 16394503.
14. Im SJ, Kim KN, Yun YG, Lee JC, Mun YJ, Kim JH, Woo WH. Effect of radix ginseng and radix trichosanthis on the melanogenesis. Biol Pharm Bull 2003, 26(6):849-853. 10.1248/bpb.26.849, 12808298.
15. Hassan SB, Gullbo J, Hu K, Berenjian S, Morein B, Nygren P. The nanoparticulate quilaja saponin BBE is selectively active towards renal cell carcinoma. Anticancer Res 2013, 33(1):143-151.
16. Zhang W, Wang X, Tang H, Wang M, Ji L, Wen A, Wang J. Triterpenoid saponins from Clematis tangutica and their cardioprotective activities. Fitoterapia 2013, 84:326-331.
17. Sun HX, Xie Y, Ye YP. Advances in saponin-based adjuvants. Vaccine 2009, 27(12):1787-1796. 10.1016/j.vaccine.2009.01.091, 19208455.
18. Güçlüc-Ustündag O, Mazza G. Saponins: properties, applications and processing. Crit Rev Food Sci Nutr 2007, 47(3):231-258. 10.1080/10408390600698197, 17453922.
19. Bi L, Tian X, Dou F, Hong L, Tang H, Wang S. New antioxidant and antiglycation active triterpenoid saponins from the root bark of Aralia taibaiensis. Fitoterapia 2012, 83(1):234-240. 10.1016/j.fitote.2011.11.002, 22088497.
20. Tapondjou LA, Nyaa LB, Tane P, Ricciutelli M, Quassinti L, Bramucci M, Lupidi G, Ponou BK, Barboni L. Cytotoxic and antioxidant triterpene saponins from Butyrospermum parkii (Sapotaceae). Carbohydr Res 2011, 346(17):2699-2704. 10.1016/j.carres.2011.09.014, 21996603.
21. Bang SC, Lee JH, Song GY, Kim DH, Yoon MY, Ahn BZ. Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship. Chem Pharm Bull (Tokyo) 2005, 53(11):1451-1454. 10.1248/cpb.53.1451, 16272730.
22. Fiore C, Eisenhut M, Ragazzi E, Zanchin G, Armanini D. A history of the therapeutic use of liquorice in Europe. J Ethnopharmacol 2005, 99(3):317-324. 10.1016/j.jep.2005.04.015, 15978760.
23. Hiai S, Oura H, Nakajima T. Color reaction of some sapogenins and saponins with vanillin and sulfuric acid. Planta Med 1976, 29:116-122. 10.1055/s-0028-1097639, 948509.
24. Chen YF, Yang CH, Chang MS, Ciou YP, Huang YC. Foam properties and detergent abilities of the saponins from Camellia oleifera. Int J Mol Sci 2010, 11(11):4417-4425. 10.3390/ijms11114417, 3000090, 21151446.
25. Nazari QA, Kume T, Izuo N, Takada-Takatori Y, Imaizumi A, Hashimoto T, Izumi Y, Akaike A. Neuroprotective effects of curcumin and highly bioavailable curcumin on oxidative stress induced by sodium nitroprusside in rat striatal cell culture. Biol Pharm Bull 2013, 36(8):1356-1362. 10.1248/bpb.b13-00300, 23902979.
26. Heo SJ, Park EJ, Lee KW, Jeon YJ. Antioxidant activities of enzymatic extracts from brown seaweeds. Bioresour Technol 2005, 96(14):1613-1623. 10.1016/j.biortech.2004.07.013, 15978995.
27. Han L, Li L, Li B, Zhao D, Li Y, Xu Z, Liu G. Hydroxyl radical induced by lipid in Maillard reaction model system promotes diet-derived N(ε)-carboxymethyllysine formation. Food Chem Toxicol 2013, 60:536-541.
28. Tian Y, Tang HF, Qiu F, Wang XJ, Chen XL, Wen AD. Triterpenoid saponins from Ardisia pusilla and their cytotoxic activity. Planta Med 2009, 75:70-75. 10.1055/s-0028-1088369, 19039733.
29. Podolak I, Galanty A, Sobolewska D. Saponins as cytotoxic agents: a review. Phytochem Rev 2010, 9(3):425-474. 10.1007/s11101-010-9183-z, 2928447, 20835386.