Changing the peptide specificity of a human T-cell receptor by directed evolution

Nature Communications

Volumn 5, Issue , 2014, Pages

  Smith, Sheena N ^a   Wang, Yuhang ^a   Baylon, Javier L ^a   Singh, Nishant K ^b   Baker, Brian M ^b   Tajkhorshid, Emad ^a   Kranz, David M ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA A2 ANTIGEN; MELAN A; T LYMPHOCYTE RECEPTOR; COMPLEMENTARITY DETERMINING REGION; EPITOPE; LEUCYL-LEUCYL-PHENYLALANYL-GLYCYL-TYROSYL-PROLYL-VALYL-TYROSYL-VALINE; LYMPHOCYTE ANTIGEN RECEPTOR; OLIGOPEPTIDE; PROTEIN BINDING;

ANTIGEN; BIOTECHNOLOGY; GERM CELL; HISTOLOGY; MOLECULAR ANALYSIS; MUTATION; PEPTIDE;

AMINO ACID SEQUENCE; ANTIGEN PRESENTING CELL; ARTICLE; CODON; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; EC50; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SURFACE PLASMON RESONANCE; CELL CLONE; CHEMISTRY; GENETICS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR GENETICS; MOLECULAR MODEL; MUTATION; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; CLONE CELLS; COMPLEMENTARITY DETERMINING REGIONS; EPITOPES; EVOLUTION, MOLECULAR; HLA-A2 ANTIGEN; HUMANS; IN VITRO TECHNIQUES; MAJOR HISTOCOMPATIBILITY COMPLEX; MART-1 ANTIGEN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; OLIGOPEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, ANTIGEN, T-CELL;

EID: 84923359790     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms6223     Document Type: Article

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