Inhibition of thioredoxin-1 with siRNA exacerbates apoptosis by activating the ASK1-JNK/p38 pathway in brain of a stroke model rats

Brain Research

Volumn 1599, Issue , 2015, Pages 20-31

  Wu, Xiaoying ^a   Li, Lingyu ^a   Zhang, Luyu ^a   Wu, Jingxian ^a   Zhou, Yunchuan ^a   Zhou, Yang ^a   Zhao, Yong ^a   Zhao, Jing ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Apoptosis signal regulating kinase 1 (ASK1); Cerebral ischemia; siRNA; Thioredoxin 1

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; CASPASE 3; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE P38; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; THIOREDOXIN 1; CASP3 PROTEIN, RAT; MAP3K5 PROTEIN, HUMAN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; THIOREDOXIN; TXN1 PROTEIN, RAT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CYTOSOLIC FRACTION; DNA FRAGMENTATION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MALE; MIDDLE CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY OCCLUSION; MORTALITY; NERVE CELL NECROSIS; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TISSUE LEVEL; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; CEREBRAL ARTERY DISEASE; DISEASE MODEL; GENETICS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; APOPTOSIS; BRAIN; CASPASE 3; CYTOCHROMES C; DISEASE MODELS, ANIMAL; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MAP KINASE KINASE 4; MAP KINASE KINASE KINASE 5; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; RNA, SMALL INTERFERING; STROKE; THIOREDOXINS;

EID: 84923329770     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2014.12.033     Document Type: Article

References (42)

1. H.Y. Chang Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx Science 281 1998 1860 1863
2. Y. Chen Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells J. Biol. Chem. 277 2002 33242 33248
3. A.E. Damdimopoulos Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death J. Biol. Chem. 277 2002 33249 33257
4. R.J. Davis MAPKs: new JNK expands the group Trends Biochem. Sci. 19 1994 470 473
5. R.J. Davis Signal transduction by the JNK group of MAP kinases Cell 103 2000 239 252
6. U. Dirnagl, C. Iadecola, and M.A. Moskowitz Pathobiology of ischaemic stroke: an integrated view Trends Neurosci. 22 1999 391 397
7. G. Fujino Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1 Mol. Cell. Biol. 27 2007 8152 8163
8. T.M. Grogan Thioredoxin, a putative oncogene product, is overexpressed in gastric carcinoma and associated with increased proliferation and increased cell survival Hum. Pathol. 31 2000 475 481
9. T. Hatai Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation J. Biol. Chem. 275 2000 26576 26581
10. I. Hattori Intravenous administration of thioredoxin decreases brain damage following transient focal cerebral ischemia in mice Antioxid. Redox Signal. 6 2004 81 87
11. A. Holmgren Thioredoxin Annu. Rev. Biochem. 54 1985 237 271
12. A. Holmgren Thioredoxin and glutaredoxin systems J. Biol. Chem. 264 1989 13963 13966
13. J.R. Hwang, C. Zhang, and C. Patterson C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis Cell Stress Chaperones 10 2005 147 156
14. H. Ichijo Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways Science 275 1997 90 94
15. J. Jia Estrogen inhibits Fas-mediated apoptosis in experimental stroke Exp. Neurol. 215 2009 48 52
16. T. Kanamoto Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons Mol. Cell. Biol. 20 2000 196 204
17. H. Liu Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin Mol. Cell. Biol. 20 2000 2198 2208
18. Y. Liu, and W. Min Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent manner Circ. Res. 90 2002 1259 1266
19. E.Z. Longa Reversible middle cerebral artery occlusion without craniectomy in rats Stroke 20 1989 84 91
20. M.A. Lovell Decreased thioredoxin and increased thioredoxin reductase levels in Alzheimers disease brain Free Radic. Biol. Med. 28 2000 418 427
21. G. Malik Ischemic preconditioning triggers nuclear translocation of thioredoxin and its interaction with Ref-1 potentiating a survival signal through the PI-3-kinase-Akt pathway Antioxid. Redox Signal. 8 2006 2101 2109
22. J. Matsukawa The ASK1-MAP kinase cascades in mammalian stress response J. Biochem. 136 2004 261 265
23. A. Matsuzawa, and H. Ichijo Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1 J. Biochem. 130 2001 1 8
24. A. Matsuzawa Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice Antioxid. Redox Signal. 4 2002 415 425
25. M.P. Mattson Neurodegenerative disorders and ischemic brain diseases Apoptosis 6 2001 69 81
26. A. Patenaude, M.R. Ven Murthy, and M.E. Mirault Mitochondrial thioredoxin system: effects of TrxR2 overexpression on redox balance, cell growth, and apoptosis J. Biol. Chem. 279 2004 27302 27314
27. G. Powis, D. Mustacich, and A. Coon The role of the redox protein thioredoxin in cell growth and cancer Free Radic. Biol. Med. 29 2000 312 322
28. J. Qi Neuroprotective effects of leonurine on ischemia/ reperfusion-induced mitochondrial dysfunctions in rat cerebral cortex Biol. Pharm. Bull. 33 2010 1958 1964
29. M. Saitoh Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1 EMBO J. 17 1998 2596 2606
30. C. Senn Central administration of small interfering RNAs in rats: a comparison with antisense oligonucleotides Eur. J. Pharmacol. 522 2005 30 37
31. Y. Takagi Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage Proc. Natl. Acad. Sci. USA 96 1999 4131 4136
32. Y. Takagi Redox control of neuronal damage during brain ischemia after middle cerebral artery occlusion in the rat: immunohistochemical and hybridization studies of thioredoxin J. Cereb. Blood Flow Metab. 18 1998 206 214
33. K. Tobiume ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis EMBO Rep. 2 2001 222 228
34. T. Turoczi Thioredoxin redox signaling in the ischemic heart: an insight with transgenic mice overexpressing Trx1 J. Mol. Cell Cardiol. 35 2003 695 704
35. A.J. Waskiewicz, and J.A. Cooper Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast Curr. Opin. Cell Biol. 7 1995 798 805
36. W.H. Watson Thioredoxin and its role in toxicology Toxicol. Sci. 78 2004 3 14
37. C. Widmann Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human Physiol. Rev. 79 1999 143 180
38. X. Xu Humanin is a novel neuroprotective agent against stroke Stroke 37 2006 2613 2619
39. M. Yamamoto Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy J. Clin. Invest. 112 2003 1395 1406
40. H. Yamawaki, J. Haendeler, and B.C. Berk Thioredoxin: a key regulator of cardiovascular homeostasis Circ. Res. 93 2003 1029 1033
41. J. Zhao Curcumin improves outcomes and attenuates focal cerebral ischemic injury via antiapoptotic mechanisms in rats Neurochem. Res. 35 2010 374 379
42. F. Zhou Attenuation of neuronal degeneration in thioredoxin-1 overexpressing mice after mild focal ischemia Brain Res. 1272 2009 62 70