Estrogen inhibits Fas-mediated apoptosis in experimental stroke

Experimental Neurology

Volumn 215, Issue 1, 2009, Pages 48-52

  Jia, Jia ^a,b   Guan, Dening ^a   Zhu, Wenjing ^a   Alkayed, Nabil J ^c   Wang, Michael M ^d   Hua, Zichun ^b   Xu, Yun ^a,b  

^a THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

^b NANJING UNIVERSITY   (China)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Estrogen; Fas mediated apoptosis; Ischemia; Neuroprotection

Indexed keywords

CASPASE 3; CASPASE 8; ESTRADIOL; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CELL; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL DEATH; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROKE;

ANALYSIS OF VARIANCE; ANIMALS; ANTIGENS, CD95; APOPTOSIS; BRAIN INFARCTION; CASPASE 3; CASPASE 8; CELLS, CULTURED; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; ESTRADIOL; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; INFARCTION, MIDDLE CEREBRAL ARTERY; NEURONS; OVARIECTOMY; RATS;

EID: 57449090234     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2008.09.015     Document Type: Article

References (25)

1. Alkayed N.J., Goto S., Sugo N., Joh H.D., Klaus J., Crain B.J., Bernard O., Traystman R.J., and Hurn P.D. Estrogen and Bcl-2: gene induction and effect of transgene in experimental stroke. J. Neurosci. 21 (2001) 7543-7550
2. Bharhani M.S., Borojevic R., Basak S., Ho E., Zhou P., and Croitoru K. IL-10 protects mouse intestinal epithelial cells from Fas-induced apoptosis via modulating Fas expression and altering caspase-8 and FLIP expression. Am. J. Physiol Gastrointest.Liver Physiol 291 (2006) G820-G829
3. Dimayuga F.O., Reed J.L., Carnero G.A., Wang C., Dimayuga E.R., Dimayuga V.M., Perger A., Wilson M.E., Keller J.N., and Bruce-Keller A.J. Estrogen and brain inflammation: effects on microglial expression of MHC, costimulatory molecules and cytokines. J. Neuroimmunol. 161 (2005) 123-136
4. Dirnagl U., Iadecola C., and Moskowitz M.A. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 22 (1999) 391-397
5. Felderhoff-Mueser U., Buhrer C., Groneck P., Obladen M., Bartmann P., and Heep A. Soluble Fas (CD95/Apo-1), soluble Fas ligand, and activated caspase 3 in the cerebrospinal fluid of infants with posthemorrhagic and nonhemorrhagic hydrocephalus. Pediatr. Res. 54 (2003) 659-664
6. Felderhoff-Mueser U., Taylor D.L., Greenwood K., Kozma M., Stibenz D., Joashi U.C., Edwards A.D., and Mehmet H. Fas/CD95/APO-1 can function as a death receptor for neuronal cells in vitro and in vivo and is upregulated following cerebral hypoxic-ischemic injury to the developing rat brain. Brain Pathol. 10 (2000) 17-29
7. Gerstner B., Sifringer M., Dzietko M., Schuller A., Lee J., Simons S., Obladen M., Volpe J.J., Rosenberg P.A., and Felderhoff-Mueser U. Estradiol attenuates hyperoxia-induced cell death in the developing white matter. Ann. Neurol. 61 (2007) 562-573
8. Hoffman G.E., Merchenthaler I., and Zup S.L. Neuroprotection by ovarian hormones in animal models of neurological disease. Endocrine. 29 2 (2006) 217-231
9. Hurn P.D., and Brass L.M. Estrogen and stroke: a balanced analysis. Stroke 34 (2003) 338-341
10. Hurn P.D., and Macrae I.M. Estrogen as a neuroprotectant in stroke. J. Cereb. Blood Flow Metab 20 (2000) 631-652
11. Jin K., Graham S.H., Mao X., Nagayama T., Simon R.P., and Greenberg D.A. Fas (CD95) may mediate delayed cell death in hippocampal CA1 sector after global cerebral ischemia. J. Cereb. Blood Flow Metab. 21 (2001) 1411-1421
12. Liu L., Kim J.Y., Koike M.A., Yoon Y.J., Tang X.N., Ma H., Lee H., Steinberg G.K., Lee J.E., and Yenari M.A. FasL shedding is reduced by hypothermia in experimental stroke. J. Neurochem. 106 2 (2008) 541-550
13. Martin-Villalba A., Hahne M., Kleber S., Vogel J., Falk W., Schenkel J., and Krammer P.H. Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke. Cell Death. Differ. 8 (2001) 679-686
14. Martin-Villalba A., Herr I., Jeremias I., Hahne M., Brandt R., Vogel J., Schenkel J., Herdegen T., and Debatin K.M. CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons. J. Neurosci. 19 (1999) 3809-3817
15. Matsuyama T., Hata R., Yamamoto Y., Tagaya M., Akita H., Uno H., Wanaka A., Furuyama J., and Sugita M. Localization of Fas antigen mRNA induced in postischemic murine forebrain by in situ hybridization. Brain Res. Mol. Brain Res. 34 (1995) 166-172
16. McCullough L.D., Blizzard K., Simpson E.R., Oz O.K., and Hurn P.D. Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection. J. Neurosci. 23 (2003) 8701-8705
17. Mehmet H. Stroke treatment enters the Fas lane. Cell Death. Differ. 8 (2001) 659-661
18. Merchenthaler I., Dellovade T.L., and Shughrue P.J. Neuroprotection by estrogen in animal models of global and focal ischemia. Ann. N.Y. Acad. Sci. 1007 (2003) 89-100
19. Rosenbaum D.M., Gupta G., D'Amore J., Singh M., Weidenheim K., Zhang H., and Kessler J.A. Fas (CD95/APO-1) plays a role in the pathophysiology of focal cerebral ischemia. J. Neurosci. Res. 61 (2000) 686-692
20. Ruan W., Lee C.T., and Desbarats J. A novel juxtamembrane domain in tumor necrosis factor receptor superfamily molecules activates rac1 and controls neurite growth. Mol. Biol. Cell. 19 8 (2008) 3192-3202
21. Saito M., Yoshigae Y., Nakayama J., Ogawa Y., Ohtsuki M., Kurihara A., and Ikeda T. Tissue distribution of humanized anti-human Fas monoclonal antibody (R-125224) based on Fas antigen-antibody reaction in collagen-induced arthritis monkeys. Life Sci. 80 (2007) 2005-2014
22. Xu Y., Traystman R.J., Hurn P.D., and Wang M.M. Neurite-localized estrogen receptor-alpha mediates rapid signaling by estrogen. J. Neurosci. Res. 74 (2003) 1-11
23. Xu Y., Zhang W., Klaus J., Young J., Koerner I., Sheldahl L.C., Hurn P.D., Martinez-Murillo F., and Alkayed N.J. Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection. Proc. Natl. Acad. Sci. U.S.A 103 (2006) 14489-14494
24. Yang S.H., Shi J., Day A.L., and Simpkins J.W. 2000. Estradiol exerts neuroprotective effects when administered after ischemic insult. Stroke 31 (2007) 745-749
25. Zhang W., Koerner I.P., Noppens R., Grafe M., Tsai H.J., Morisseau C., Luria A., Hammock B.D., Falck J.R., and Alkayed N.J. Soluble epoxide hydrolase: a novel therapeutic target in stroke. J. Cereb. Blood Flow Metab 27 (2007) 1931-1940