Neuroprotective effects of leonurine on ischemia/reperfusion-induced mitochondrial dysfunctions in rat cerebral cortex

Biological and Pharmaceutical Bulletin

Volumn 33, Issue 12, 2010, Pages 1958-1964

  Qi, Jia ^a,b   Hong, Zhen Yi ^a   Xin, Hong ^a   Zhu, Yi Zhun ^a,c  

^a FUDAN UNIVERSITY   (China)

^b XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Apoptosis; Ischemia; Leonurine; Mitochondrial dysfunction

Indexed keywords

CYTOCHROME C; LEONURINE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; CELL SWELLING; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRIAL ENCEPHALOPATHY; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROPROTECTION; NICK END LABELING; NONHUMAN; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; REPERFUSION INJURY; TREATMENT DURATION; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; BRAIN ISCHEMIA; CEREBRAL CORTEX; CEREBRAL INFARCTION; CYTOCHROMES C; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; GALLIC ACID; IN SITU NICK-END LABELING; LEONURUS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PHYTOTHERAPY; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY;

EID: 78751503416     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.33.1958     Document Type: Article

References (29)

1. Lees K. R., Zivin J. A., Ashwood T., N. Engl. J. Med., 354, 588-600 (2006).
2. Wardlaw J. M., Warlow C. P., Counsell C., Lancet, 350, 607-614 (1997).
3. Janardhan V., Qureshi A. I., Curr. Cardiol. Rep., 6, 117-123 (2004).
4. Broughton B. R., Reutens D. C., Stroke, 40, e331-e339 (2009).
5. Hu S., Am. J. Chin. Med., 4, 18 (1976).
6. Loh K. P., Huang S. H., Tan B. K., Zhu Y. Z., J. Ethnopharmacol., 125, 337-343 (2009).
7. Kong Y. C., Yeung H. W., Cheung Y. M., Am. J. Chin. Med., 4, 373-382 (1976).
8. Liu X. H., Chen P. F., Pan L. L., Zhu Y. Z., J. Cardiovasc. Pharmacol., 54, 437-444 (2009).
9. Liu X. H., Xin H., Hou A. J., Zhu Y. Z., Clin. Exp. Pharmacol. Physiol., 36, 696-703 (2009).
10. Zhu R. F., Sun D. N., Wang X. S., J. Anhui University Natural Science Edition, 29, 3 (2005).
11. Yang G. Y., Chen S. F., Kinouchi H., Chan P. H., Weinstein P. R., Stroke, 23, 1331-1336 (1992).
12. Wang H., Joseph J. A., Free Radic. Biol. Med., 27, 612-616 (1999).
13. Halestrap A. P., Davidson A. M., Biochem. J., 268, 153-160 (1990).
14. Zhang J. T., "Modern Experimental Methods of Pharmacology," ed. by Zhang J. T., PUMP Press, Beijing, 1998, pp. 1228-1229.
15. Horbinski C., Chu C. T., Free Radic. Biol. Med., 38, 2-11 (2005).
16. Wang X., Figueroa B. E., Stavrovskaya I. G., Stroke, 40, 1877-1885 (2009).
17. Christophe M., Nicolas S., Curr. Pharm. Des., 12, 739-757 (2006).
18. Chan P. H., J. Cereb. Blood Flow Metab., 21, 2-14 (2001).
19. Li C., Jackson R. M., Am. J. Physiol. Cell. Physiol., 282, 227-241 (2002).
20. Fiskum G., Rosenthal R. E., Vereczki V., J. Bioenerg. Biomembr., 36, 347-352 (2004).
21. Sun K., Liu Z. S., Sun Q., World J. Gastroenterol., 10, 1934-1938 (2004).
22. Skulachev V. P., FEBS Lett., 397, 7-10 (1996).
23. Bergner C. L., Smolinsky A. N., Hart P. C., Methods Mol. Biol., 602, 267-282 (2010).
24. Oltvai Z. N., Milliman C. L., Korsmeyer S. J., Cell, 74, 609-619 (1993).
25. Hsu Y. T., Wolter K. G., Youle R. J., Proc. Natl. Acad. Sci. U.S.A., 94, 3668-3672 (1997).
26. Fiskum G., Murphy A. N., Beal M. F., J. Cereb. Blood Flow Metab., 19, 351-369 (1999).
27. Gross A., Jockel J., Wei M. C., Korsmeyer S. J., EMBO J., 17, 3878-3885 (1998).
28. Khaspekov L., Friberg H., Halestrap A., Viktorov I., Wieloch T., Eur. J. Neurosci., 11, 3194-3198 (1999).
29. Doyle K. P., Simon R. P., Stenzel-Poore M. P., Neuropharmacology, 55, 310-318 (2008).